| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Nakahara, Y Iga, F Mizobe, G Kawanish. Effects of intracerebroventricular injection of AF64A on learning behaviors in rats. Japanese journal of pharmacology. vol 48. issue 1. 1989-01-18. PMID:3199599. |
these findings suggested that icv injection of af64a may be useful for producing an experimental amnesia model with hippocampal cholinergic hypofunction like senile dementia of the alzheimer type (sdat), if appropriate learning tests are selected. |
1989-01-18 |
2023-08-11 |
rat |
| M F Beal, R A Clevens, G K Chattha, U M MacGarvey, M F Mazurek, S M Gabrie. Galanin-like immunoreactivity is unchanged in Alzheimer's disease and Parkinson's disease dementia cerebral cortex. Journal of neurochemistry. vol 51. issue 6. 1988-12-20. PMID:2460590. |
recent studies have shown that galanin inhibits both acetylcholine release in the hippocampus and memory acquisition; therefore, preserved galanin may exacerbate the cholinergic and cognitive deficits that accompany dementia. |
1988-12-20 |
2023-08-11 |
human |
| A Represa, C Duyckaerts, E Tremblay, J J Hauw, Y Ben-Ar. [Is Alzheimer's senile dementia associated with the phenomena of reactive synaptogenesis in the hippocampus?]. Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie. vol 306. issue 19. 1988-12-15. PMID:2902911. |
[is alzheimer's senile dementia associated with the phenomena of reactive synaptogenesis in the hippocampus?]. |
1988-12-15 |
2023-08-11 |
Not clear |
| A Represa, C Duyckaerts, E Tremblay, J J Hauw, Y Ben-Ar. [Is Alzheimer's senile dementia associated with the phenomena of reactive synaptogenesis in the hippocampus?]. Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie. vol 306. issue 19. 1988-12-15. PMID:2902911. |
these results indicate a lack of hippocampal plasticity in senile dementia of alzheimer type. |
1988-12-15 |
2023-08-11 |
Not clear |
| A Probst, R Cortés, J Ulrich, J M Palacio. Differential modification of muscarinic cholinergic receptors in the hippocampus of patients with Alzheimer's disease: an autoradiographic study. Brain research. vol 450. issue 1-2. 1988-09-15. PMID:3401711. |
we have used quantitative light microscopic autoradiographic techniques to analyze changes in muscarinic cholinergic receptors in the hippocampus in alzheimer type dementia (atd). |
1988-09-15 |
2023-08-11 |
Not clear |
| P L McGeer, S Itagaki, B E Boyes, E G McGee. Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology. vol 38. issue 8. 1988-08-30. PMID:3399080. |
all dementia cases with a premortem diagnosis of dat or pd showed large numbers of hla-dr-positive reactive microglia and significant plaque and tangle counts in the hippocampus, as well as reduced cortical choline acetyltransferase activity. |
1988-08-30 |
2023-08-11 |
Not clear |
| S Shimohama, T Taniguchi, M Fujiwara, M Kameyam. Changes in benzodiazepine receptors in Alzheimer-type dementia. Annals of neurology. vol 23. issue 4. 1988-07-27. PMID:2837978. |
compared with controls, 3h-flunitrazepam binding sites were significantly reduced in number in frontal and temporal cortex and hippocampus in the alzheimer-type dementia brains. |
1988-07-27 |
2023-08-11 |
Not clear |
| M L Schmidt, R E Gur, R C Gur, J Q Trojanowsk. Intraneuronal and extracellular neurofibrillary tangles exhibit mutually exclusive cytoskeletal antigens. Annals of neurology. vol 23. issue 2. 1988-07-14. PMID:3377439. |
we examined the possibility that neurofibrillary tangles (nfts) were heterogeneous in postmortem hippocampus from 22 patients with or without senile dementia of the alzheimer type. |
1988-07-14 |
2023-08-11 |
Not clear |
| J B Gramsbergen, C Q Mountjoy, M N Rossor, G P Reynolds, M Roth, J Kor. A correlative study on hippocampal cation shifts and amino acids and clinico-pathological data in Alzheimer's disease. Neurobiology of aging. vol 8. issue 6. 1988-03-10. PMID:3431623. |
amino acid transmitters and cations were assessed in the frontal cortex and hippocampus of 12 alzheimer's disease (ad), 4 multi-infarct dementia (mid) patients, and 12 age-matched controls. |
1988-03-10 |
2023-08-11 |
Not clear |
| J B Gramsbergen, C Q Mountjoy, M N Rossor, G P Reynolds, M Roth, J Kor. A correlative study on hippocampal cation shifts and amino acids and clinico-pathological data in Alzheimer's disease. Neurobiology of aging. vol 8. issue 6. 1988-03-10. PMID:3431623. |
hippocampal na and k levels correlated also highly with gamma-aminobutyrate, cholineacetyltransferase and noradrenaline levels in the hippocampus and dementia scores. |
1988-03-10 |
2023-08-11 |
Not clear |
| M J Bal. Morphometric analyses of neuronal populations and dendritic extent in normal aging and dementia of Alzheimer type: a frank appraisal of the difficulties. Neurobiology of aging. vol 8. issue 6. 1988-03-10. PMID:3431632. |
of special interest are data from flood and coleman's own laboratory in which the unique behaviour of hippocampal nerve cells in autopsy studies suggests that hippocampal pyramidal neurones are a key to the neurobiology of dementia of the alzheimer type. |
1988-03-10 |
2023-08-11 |
human |
| S Nakamura, T Kawamata, I Akiguchi, M Kameyama, H Kimur. [Reduced nicotinamide adenine dinucleotide phosphate diaphorase histochemistry in neocortex and hippocampus in patients with Alzheimer type dementia and aged controls]. Rinsho shinkeigaku = Clinical neurology. vol 27. issue 8. 1988-02-16. PMID:3690919. |
[reduced nicotinamide adenine dinucleotide phosphate diaphorase histochemistry in neocortex and hippocampus in patients with alzheimer type dementia and aged controls]. |
1988-02-16 |
2023-08-11 |
Not clear |
| D C Chu, J B Penney, A B Youn. Quantitative autoradiography of hippocampal GABAB and GABAA receptor changes in Alzheimer's disease. Neuroscience letters. vol 82. issue 3. 1988-01-28. PMID:2827074. |
gabab and gabaa receptors were examined by quantitative [3h]gaba autoradiography in postmortem human hippocampus from 6 histopathologically verified cases of dementia of the alzheimer type (dat) and 6 normal controls. |
1988-01-28 |
2023-08-11 |
human |
| C P Mauriz. Dementia--the failure of hippocampal plasticity and dreams. Is there a preventative role for melatonin? Medical hypotheses. vol 24. issue 1. 1987-12-08. PMID:3312972. |
dementia--the failure of hippocampal plasticity and dreams. |
1987-12-08 |
2023-08-11 |
Not clear |
| C P Mauriz. Dementia--the failure of hippocampal plasticity and dreams. Is there a preventative role for melatonin? Medical hypotheses. vol 24. issue 1. 1987-12-08. PMID:3312972. |
anatomic, chemical, physiologic, pathologic and clinical evidence suggests that senile dementia (alzheimer's disease) is a dysfunction of the hippocampus. |
1987-12-08 |
2023-08-11 |
Not clear |
| I N Bogolepov. [The hippocampus in patients with different forms of senile dementia]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952). vol 87. issue 7. 1987-12-08. PMID:3673394. |
[the hippocampus in patients with different forms of senile dementia]. |
1987-12-08 |
2023-08-11 |
human |
| I N Bogolepov. [The hippocampus in patients with different forms of senile dementia]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952). vol 87. issue 7. 1987-12-08. PMID:3673394. |
using cytoarchitectonic and quantitative techniques the hippocampus and dentate fascia of the adult human brain were studied in normal subjects and in patients with senile dementia and alzheimer's disease. |
1987-12-08 |
2023-08-11 |
human |
| W J Burke, H D Chung, B R Nakra, G T Grossberg, T H Jo. Phenylethanolamine N-methyltransferase activity is decreased in Alzheimer's disease brains. Annals of neurology. vol 22. issue 2. 1987-11-10. PMID:3662456. |
the degree of decrease in pnmt activity in the hippocampus correlated significantly with the degree of dementia. |
1987-11-10 |
2023-08-11 |
human |
| P K Mölsä, E Säkö, L Paljärvi, J O Rinne, U K Rinn. Alzheimer's disease: neuropathological correlates of cognitive and motor disorders. Acta neurologica Scandinavica. vol 75. issue 6. 1987-10-20. PMID:3630634. |
a multiple regression model consisting of plaques and tangles in amygdala, gyrus frontalis medius, gyrus angularis, and gyrus temporalis medius, plaques of gyrus rectus, tangles of the hippocampus, gyrus precentralis and gyrus cinguli together with brain weight, emerged to link dementia to neuropathological changes at the level of maximum significance. |
1987-10-20 |
2023-08-11 |
Not clear |
| V Chan-Pala. Somatostatin immunoreactive neurons in the human hippocampus and cortex shown by immunogold/silver intensification on vibratome sections: coexistence with neuropeptide Y neurons, and effects in Alzheimer-type dementia. The Journal of comparative neurology. vol 260. issue 2. 1987-09-15. PMID:2886516. |
somatostatin immunoreactive neurons in the human hippocampus and cortex shown by immunogold/silver intensification on vibratome sections: coexistence with neuropeptide y neurons, and effects in alzheimer-type dementia. |
1987-09-15 |
2023-08-11 |
human |