| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A A Lie, A Becker, K Behle, H Beck, B Malitschek, P J Conn, R Kuhn, R Nitsch, M Plaschke, J Schramm, C E Elger, O D Wiestler, I Blümck. Up-regulation of the metabotropic glutamate receptor mGluR4 in hippocampal neurons with reduced seizure vulnerability. Annals of neurology. vol 47. issue 1. 2000-02-16. PMID:10632098. |
selective hippocampal cell loss and altered neurotransmitter receptor expression have been proposed as pathogenic mechanisms in the development of chronic mesial temporal lobe epilepsy (tle). |
2000-02-16 |
2023-08-12 |
Not clear |
| E A Proper, A B Oestreicher, G H Jansen, C W Veelen, P C van Rijen, W H Gispen, P N de Graa. Immunohistochemical characterization of mossy fibre sprouting in the hippocampus of patients with pharmaco-resistant temporal lobe epilepsy. Brain : a journal of neurology. vol 123 ( Pt 1). 2000-02-14. PMID:10611117. |
immunohistochemical characterization of mossy fibre sprouting in the hippocampus of patients with pharmaco-resistant temporal lobe epilepsy. |
2000-02-14 |
2023-08-12 |
Not clear |
| E A Proper, A B Oestreicher, G H Jansen, C W Veelen, P C van Rijen, W H Gispen, P N de Graa. Immunohistochemical characterization of mossy fibre sprouting in the hippocampus of patients with pharmaco-resistant temporal lobe epilepsy. Brain : a journal of neurology. vol 123 ( Pt 1). 2000-02-14. PMID:10611117. |
hippocampal sclerosis (hs) is a common derangement in many patients with temporal lobe epilepsy. |
2000-02-14 |
2023-08-12 |
Not clear |
| E A Proper, A B Oestreicher, G H Jansen, C W Veelen, P C van Rijen, W H Gispen, P N de Graa. Immunohistochemical characterization of mossy fibre sprouting in the hippocampus of patients with pharmaco-resistant temporal lobe epilepsy. Brain : a journal of neurology. vol 123 ( Pt 1). 2000-02-14. PMID:10611117. |
here, we determined neuronal density, and synaptophysin and glial fibrillary acidic protein (gfap) immunoreactivity in hippocampal specimens from patients with pharmaco-resistant temporal lobe epilepsy. |
2000-02-14 |
2023-08-12 |
Not clear |
| E A Proper, A B Oestreicher, G H Jansen, C W Veelen, P C van Rijen, W H Gispen, P N de Graa. Immunohistochemical characterization of mossy fibre sprouting in the hippocampus of patients with pharmaco-resistant temporal lobe epilepsy. Brain : a journal of neurology. vol 123 ( Pt 1). 2000-02-14. PMID:10611117. |
our results show the following: (i) in both groups of temporal lobe epilepsy patients, there was a significant loss in cell number in all major hippocampal sub-areas compared with autopsy control tissue; (ii) in hs patients, when compared with non-hs patients, there was a further decline in the number of principal cells in all hippocampal sub-areas analysed, which was associated with an increase in gfap immunoreactivity; (iii) the decline in cell density was accompanied by a reduced number of synaptic terminals; (iv) in the hs group, there were sprouted mossy fibres in the supragranular layer (sgl) of the dentate gyrus; (v) there was an increase in synaptophysin immunostaining in the sgl indicating that functionally active nerve terminals were formed; and (vi) b-50 immunoreactivity was also increased in the sgl in the hs group compared with the non-hs and control groups. |
2000-02-14 |
2023-08-12 |
Not clear |
| G D Jackson, B R Chambers, S F Berkovi. Hippocampal sclerosis: development in adult life. Developmental neuroscience. vol 21. issue 3-5. 2000-02-10. PMID:10575244. |
hippocampal sclerosis (hs) is the most common pathological lesion underlying intractable temporal lobe epilepsy. |
2000-02-10 |
2023-08-12 |
Not clear |
| J E Kelsey, K L Sanderson, C A Fry. Perforant path stimulation in rats produces seizures, loss of hippocampal neurons, and a deficit in spatial mapping which are reduced by prior MK-801. Behavioural brain research. vol 107. issue 1-2. 2000-01-31. PMID:10628730. |
severe temporal lobe epilepsy in humans is often associated with loss of neurons in the hippocampus and memory deficits. |
2000-01-31 |
2023-08-12 |
rat |
| S Beyenburg, B Stoffel-Wagner, M Watzka, I Blümcke, J Bauer, J Schramm, F Bidlingmaier, C E Elge. Expression of cytochrome P450scc mRNA in the hippocampus of patients with temporal lobe epilepsy. Neuroreport. vol 10. issue 14. 2000-01-04. PMID:10549824. |
expression of cytochrome p450scc mrna in the hippocampus of patients with temporal lobe epilepsy. |
2000-01-04 |
2023-08-12 |
Not clear |
| S Beyenburg, B Stoffel-Wagner, M Watzka, I Blümcke, J Bauer, J Schramm, F Bidlingmaier, C E Elge. Expression of cytochrome P450scc mRNA in the hippocampus of patients with temporal lobe epilepsy. Neuroreport. vol 10. issue 14. 2000-01-04. PMID:10549824. |
we used a competitive rt-pcr assay to quantify the amount of p450scc mrna in hippocampal tissue specimens obtained at neurosurgery from patients with temporal lobe epilepsy (tle). |
2000-01-04 |
2023-08-12 |
Not clear |
| R C Martin, S Sawrie, J Hugg, F Gilliam, E Faught, R Kuznieck. Cognitive correlates of 1H MRSI-detected hippocampal abnormalities in temporal lobe epilepsy. Neurology. vol 53. issue 9. 2000-01-04. PMID:10599780. |
cognitive correlates of 1h mrsi-detected hippocampal abnormalities in temporal lobe epilepsy. |
2000-01-04 |
2023-08-12 |
Not clear |
| I Blümcke, W Zuschratter, J C Schewe, B Suter, A A Lie, B M Riederer, B Meyer, J Schramm, C E Elger, O D Wiestle. Cellular pathology of hilar neurons in Ammon's horn sclerosis. The Journal of comparative neurology. vol 414. issue 4. 1999-12-10. PMID:10531538. |
in addition to functionally affected neuronal signaling pathways, altered axonal, dendritic, and synaptic morphology may contribute to hippocampal hyperexcitability in chronic mesial temporal lobe epilepsies (mtle). |
1999-12-10 |
2023-08-12 |
Not clear |
| I Blümcke, W Zuschratter, J C Schewe, B Suter, A A Lie, B M Riederer, B Meyer, J Schramm, C E Elger, O D Wiestle. Cellular pathology of hilar neurons in Ammon's horn sclerosis. The Journal of comparative neurology. vol 414. issue 4. 1999-12-10. PMID:10531538. |
such changes may develop during cellular reorganization in the epileptogenic hippocampus and are likely to contribute to the pathogenesis or maintenance of temporal lobe epilepsy. |
1999-12-10 |
2023-08-12 |
Not clear |
| H Jokeit, A Ebner, S Arnold, M Schüller, C Antke, Y Huang, H Steinmetz, R J Seitz, O W Witt. Bilateral reductions of hippocampal volume, glucose metabolism, and wada hemispheric memory performance are related to the duration of mesial temporal lobe epilepsy. Journal of neurology. vol 246. issue 10. 1999-12-07. PMID:10552240. |
bilateral reductions of hippocampal volume, glucose metabolism, and wada hemispheric memory performance are related to the duration of mesial temporal lobe epilepsy. |
1999-12-07 |
2023-08-12 |
Not clear |
| R C Martin, J W Hugg, D L Roth, E Bilir, F G Gilliam, E Faught, R I Kuznieck. MRI extrahippocampal volumes and visual memory: correlations independent of MRI hippocampal volumes in temporal lobe epilepsy patients. Journal of the International Neuropsychological Society : JINS. vol 5. issue 6. 1999-12-07. PMID:10561935. |
mri extrahippocampal volumes and visual memory: correlations independent of mri hippocampal volumes in temporal lobe epilepsy patients. |
1999-12-07 |
2023-08-12 |
Not clear |
| P Ryvlin, S Bouvard, D Le Bars, F Mauguièr. Transient and falsely lateralizing flumazenil-PET asymmetries in temporal lobe epilepsy. Neurology. vol 53. issue 8. 1999-11-30. PMID:10563649. |
we have observed a falsely lateralizing mesial temporal [11c]-flumazenil binding asymmetry in three patients who had temporal lobe epilepsy (tle) with normal hippocampal volumes. |
1999-11-30 |
2023-08-12 |
Not clear |
| S Koh, T W Storey, T C Santos, A Y Mian, A J Col. Early-life seizures in rats increase susceptibility to seizure-induced brain injury in adulthood. Neurology. vol 53. issue 5. 1999-11-15. PMID:10496246. |
early childhood convulsions have been correlated with the finding of subsequent hippocampal neuronal loss and memory impairment in patients with intractable temporal lobe epilepsy. |
1999-11-15 |
2023-08-12 |
rat |
| F G Woermann, S L Free, M J Koepp, J Ashburner, J S Dunca. Voxel-by-voxel comparison of automatically segmented cerebral gray matter--A rater-independent comparison of structural MRI in patients with epilepsy. NeuroImage. vol 10. issue 4. 1999-11-05. PMID:10493896. |
after fully automated segmentation of cerebral gray matter from structural t1-weighted, high-resolution mri scans, we applied the automated and objective technique of statistical parametric mapping (spm) to the analysis of gray matter of 35 control subjects, 10 patients with partial seizures and mcd, 10 patients with left temporal lobe epilepsy (tle) and hs, 10 patients with left tle and normal mr quantitation of the hippocampus, and 20 patients with jme. |
1999-11-05 |
2023-08-12 |
human |
| P Molnár, J V Nadle. Mossy fiber-granule cell synapses in the normal and epileptic rat dentate gyrus studied with minimal laser photostimulation. Journal of neurophysiology. vol 82. issue 4. 1999-11-05. PMID:10515977. |
dentate granule cells become synaptically interconnected in the hippocampus of persons with temporal lobe epilepsy, forming a recurrent mossy fiber pathway. |
1999-11-05 |
2023-08-12 |
rat |
| J Webb, A Guimond, P Eldridge, D Chadwick, J Meunier, J P Thirion, N Robert. Automatic detection of hippocampal atrophy on magnetic resonance images. Magnetic resonance imaging. vol 17. issue 8. 1999-11-02. PMID:10499677. |
an automatic method for identifying hippocampal atrophy on magnetic resonance (mr) images obtained from patients with clinical evidence of temporal lobe epilepsy (tle) is described. |
1999-11-02 |
2023-08-12 |
human |
| B El Bahh, V Lespinet, D Lurton, M Coussemacq, G Le Gal La Salle, A Rougie. Correlations between granule cell dispersion, mossy fiber sprouting, and hippocampal cell loss in temporal lobe epilepsy. Epilepsia. vol 40. issue 10. 1999-10-22. PMID:10528935. |
correlations between granule cell dispersion, mossy fiber sprouting, and hippocampal cell loss in temporal lobe epilepsy. |
1999-10-22 |
2023-08-12 |
Not clear |