| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Trujillo-Del Río, J Tortajada-Pérez, A P Gómez-Escribano, F Casterá, C Peiró, J M Millán, M J Herrero, R P Vázquez-Manriqu. Metformin to treat Huntington disease: a pleiotropic drug against a multi-system disorder. Mechanisms of ageing and development. 2022-04-03. PMID:35367225. |
huntington disease (hd) is a neurodegenerative disorder produced by an expansion of cag repeats in the htt gene. |
2022-04-03 |
2023-08-13 |
Not clear |
| Jong-Min Lee, Yuan Huang, Michael Orth, Tammy Gillis, Jacqueline Siciliano, Eunpyo Hong, Jayalakshmi Srinidhi Mysore, Diane Lucente, Vanessa C Wheeler, Ihn Sik Seong, Zachariah L McLean, James A Mills, Branduff McAllister, Sergey V Lobanov, Thomas H Massey, Marc Ciosi, G Bernhard Landwehrmeyer, Jane S Paulsen, E Ray Dorsey, Ira Shoulson, Cristina Sampaio, Darren G Monckton, Seung Kwak, Peter Holmans, Lesley Jones, Marcy E MacDonald, Jeffrey D Long, James F Gusell. Genetic modifiers of Huntington disease differentially influence motor and cognitive domains. American journal of human genetics. 2022-03-24. PMID:35325614. |
genome-wide association studies (gwass) of huntington disease (hd) have identified six dna maintenance gene loci (among others) as modifiers and implicated a two step-mechanism of pathogenesis: somatic instability of the causative htt cag repeat with subsequent triggering of neuronal damage. |
2022-03-24 |
2023-08-13 |
Not clear |
| Morgan E Rook, Amber L Southwel. Antisense Oligonucleotide Therapy: From Design to the Huntington Disease Clinic. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. 2022-03-07. PMID:35254632. |
huntington disease (hd) is a fatal progressive neurodegenerative disorder caused by an inherited mutation in the huntingtin (htt) gene, which encodes mutant htt protein. |
2022-03-07 |
2023-08-13 |
human |
| Todd M Greco, Christopher Secker, Eduardo Silva Ramos, Joel D Federspiel, Jeh-Ping Liu, Alma M Perez, Ismael Al-Ramahi, Jeffrey P Cantle, Jeffrey B Carroll, Juan Botas, Scott O Zeitlin, Erich E Wanker, Ileana M Criste. Dynamics of huntingtin protein interactions in the striatum identifies candidate modifiers of Huntington disease. Cell systems. 2022-02-12. PMID:35148841. |
huntington disease (hd) is a monogenic neurodegenerative disorder with one causative gene, huntingtin (htt). |
2022-02-12 |
2023-08-13 |
mouse |
| Nicholas S Caron, Raul Banos, Amirah E Aly, Yuanyun Xie, Seunghyun Ko, Nalini Potluri, Christine Anderson, Hailey Findlay Black, Lisa M Anderson, Benjamin Gordon, Amber L Southwell, Michael R Hayde. Cerebrospinal fluid mutant huntingtin is a biomarker for huntingtin lowering in the striatum of Huntington disease mice. Neurobiology of disease. 2022-02-10. PMID:35143966. |
huntington disease (hd) is a neurodegenerative disease caused by a trinucleotide repeat expansion in the htt gene encoding an elongated polyglutamine tract in the huntingtin (htt) protein. |
2022-02-10 |
2023-08-13 |
mouse |
| Ernesto Marfil-Marin, Mónica Santamaría-Olmedo, Adriana PerezGrovas-Saltijeral, Margarita Valdes-Flores, Adriana Ochoa-Morales, Aurelio Jara-Prado, Rosalba Sevilla-Montoya, Alejandra Camacho-Molina, Alberto Hidalgo-Brav. circRNA Regulates Dopaminergic Synapse, MAPK, and Long-term Depression Pathways in Huntington Disease. Molecular neurobiology. vol 58. issue 12. 2021-12-03. PMID:34476673. |
huntington disease (hd) is the most common neurogenetic disorder caused by expansion of the cag repeat in the htt gene; nevertheless, the molecular bases of the disease are not fully understood. |
2021-12-03 |
2023-08-13 |
Not clear |
| Bhagyashree S Joshi, Sameh A Youssef, Reinier Bron, Alain de Bruin, Harm H Kampinga, Inge S Zuhor. DNAJB6b-enriched small extracellular vesicles decrease polyglutamine aggregation in iScience. vol 24. issue 11. 2021-11-11. PMID:34755099. |
dnajb6b-enriched small extracellular vesicles decrease polyglutamine aggregation in huntington disease (hd) is a devastating neurodegenerative disorder characterized by aggregation of huntingtin (htt) protein containing expanded polyglutamine (polyq) tracts. |
2021-11-11 |
2023-08-13 |
Not clear |
| Wiebke Frank, Katrin S Lindenberg, Alzbeta Mühlbäck, Jan Lewerenz, G Bernhard Landwehrmeye. [Disease-modifying treatment approaches in Huntington disease : Past and future]. Der Nervenarzt. 2021-11-11. PMID:34762178. |
huntington disease (hd) is the most frequent monogenetic neurodegenerative disease and can be unequivocally diagnosed even in the preclinical stage, at least in all individuals in whom the cag expansion mutation in the huntingtin gene (htt) is in the range of full penetrance. |
2021-11-11 |
2023-08-13 |
Not clear |
| Sanaz Gabery, Jing Eugene Kwa, Rachel Y Cheong, Barbara Baldo, Costanza Ferrari Bardile, Brendan Tan, Catriona McLean, Nellie Georgiou-Karistianis, Govinda R Poudel, Glenda Halliday, Mahmoud A Pouladi, Åsa Petersé. Early white matter pathology in the fornix of the limbic system in Huntington disease. Acta neuropathologica. vol 142. issue 5. 2021-11-08. PMID:34448021. |
huntington disease (hd) is a fatal neurodegenerative disorder caused by an expanded cag repeat in the huntingtin (htt) gene. |
2021-11-08 |
2023-08-13 |
Not clear |
| R A Hickman, P L Faust, M K Rosenblum, K Marder, M F Mehler, J P Vonsatte. Developmental malformations in Huntington disease: neuropathologic evidence of focal neuronal migration defects in a subset of adult brains. Acta neuropathologica. vol 141. issue 3. 2021-11-05. PMID:33517535. |
neuropathologic hallmarks of huntington disease (hd) include the progressive neurodegeneration of the striatum and the presence of huntingtin (htt) aggregates that result from abnormal polyq expansion of the htt gene. |
2021-11-05 |
2023-08-13 |
human |
| Arianna Novati, Giuseppe Manfré, Stefanie Flunkert, Johanneke E Van der Harst, Judith R Homberg, Robert Wronski, Huu Phuc Nguye. Validation of behavioral phenotypes in the BACHD rat model. Behavioural brain research. vol 393. 2021-10-25. PMID:32574646. |
huntington disease (hd) is a neurodegenerative disorder caused by a polyglutamine expansion in the htt gene. |
2021-10-25 |
2023-08-13 |
rat |
| Fanny L Lemarié, Nicholas S Caron, Shaun S Sanders, Mandi E Schmidt, Yen T N Nguyen, Seunghyun Ko, Xiaohong Xu, Mahmoud A Pouladi, Dale D O Martin, Michael R Hayde. Rescue of aberrant huntingtin palmitoylation ameliorates mutant huntingtin-induced toxicity. Neurobiology of disease. vol 158. 2021-10-14. PMID:34390831. |
huntington disease (hd) is a neurodegenerative disorder caused by a cag expansion in the htt gene that codes for an elongated polyglutamine tract in the huntingtin (htt) protein. |
2021-10-14 |
2023-08-13 |
mouse |
| Bin Huang, Manuel Seefelder, Eva Buck, Tatjana Engler, Katrin S Lindenberg, Fabrice Klein, G Bernhard Landwehrmeyer, Stefan Kochane. HAP40 protein levels are huntingtin-dependent and decrease in Huntington disease. Neurobiology of disease. vol 158. 2021-10-14. PMID:34390835. |
cellular hap40 protein levels were reduced in primary fibroblasts and lymphoblasts of huntington disease (hd) patients and in brain tissue of a full-length htt mouse model of hd, concomitant with decreased soluble htt levels in these cell types. |
2021-10-14 |
2023-08-13 |
mouse |
| X Zhao, A Chen, Z Wang, Xiao-Han Xu, Y Ta. Biological functions and potential therapeutic applications of huntingtin-associated protein 1: progress and prospects. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 2021-09-26. PMID:34564830. |
huntington disease (hd) is a single-gene autosomal dominant inherited neurodegenerative disease caused by a polyglutamine expansion of the protein huntingtin (htt). |
2021-09-26 |
2023-08-13 |
Not clear |
| Jo B Henningsen, Rana Soylu-Kucharz, Maria Björkqvist, Åsa Petersé. Effects of excitotoxicity in the hypothalamus in transgenic mouse models of Huntington disease. Heliyon. vol 7. issue 8. 2021-08-31. PMID:34458633. |
huntington disease (hd) is a fatal neurodegenerative movement disorder caused by an expanded cag repeat in the huntingtin gene (htt). |
2021-08-31 |
2023-08-13 |
mouse |
| Galen E B Wright, Nicholas S Caron, Bernard Ng, Lorenzo Casal, William Casazza, Xiaohong Xu, Jolene Ooi, Mahmoud A Pouladi, Sara Mostafavi, Colin J D Ross, Michael R Hayde. Gene expression profiles complement the analysis of genomic modifiers of the clinical onset of Huntington disease. Human molecular genetics. vol 29. issue 16. 2021-08-27. PMID:32898862. |
huntington disease (hd) is a neurodegenerative disorder that is caused by a cag repeat expansion in htt. |
2021-08-27 |
2023-08-13 |
Not clear |
| Xue Wen, Ping An, Hexuan Li, Zijian Zhou, Yimin Sun, Jian Wang, Lixiang Ma, Boxun L. Tau Accumulation via Reduced Autophagy Mediates GGGGCC Repeat Expansion-Induced Neurodegeneration in Drosophila Model of ALS. Neuroscience bulletin. vol 36. issue 12. 2021-07-28. PMID:32500377. |
expansions of trinucleotide or hexanucleotide repeats lead to several neurodegenerative disorders, including huntington disease [caused by expanded cag repeats (cagr) in the htt gene], and amyotrophic lateral sclerosis [als, possibly caused by expanded ggggcc repeats (g4c2r) in the c9orf72 gene], of which the molecular mechanisms remain unclear. |
2021-07-28 |
2023-08-13 |
human |
| Barbara J Bailus, Stephen M Scheeler, Jesse Simons, Maria A Sanchez, Kizito-Tshitoko Tshilenge, Jordi Creus-Muncunill, Swati Naphade, Alejandro Lopez-Ramirez, Ningzhe Zhang, Kuruwitage Lakshika Madushani, Stanislav Moroz, Ashley Loureiro, Katherine H Schreiber, Felix Hausch, Brian K Kennedy, Michelle E Ehrlich, Lisa M Ellerb. Modulating FKBP5/FKBP51 and autophagy lowers HTT (huntingtin) levels. Autophagy. 2021-07-11. PMID:34024231. |
current disease-modifying therapies for huntington disease (hd) focus on lowering mutant htt (huntingtin; mhtt) levels, and the immunosuppressant drug rapamycin is an intriguing therapeutic for aging and neurological disorders. |
2021-07-11 |
2023-08-13 |
mouse |
| Stefania Magri, Lorenzo Nanetti, Alessia Mongelli, Elena Rizzo, Franco Taroni, Caterina Mariotti, Cinzia Geller. Missing the pathological expansion in Huntington disease: de novo c.51C>G variant on the expanded allele causing intrafamilial allele dropout. American journal of medical genetics. Part A. vol 185. issue 2. 2021-07-07. PMID:33247537. |
huntington disease (hd) is an autosomal dominant disease characterized by motor, behavioral, and cognitive symptoms, caused by the pathological expansion of more than 35 cag/caa repeats in the htt gene. |
2021-07-07 |
2023-08-13 |
Not clear |
| Sarah J Tabrizi, Michael D Flower, Christopher A Ross, Edward J Wil. Huntington disease: new insights into molecular pathogenesis and therapeutic opportunities. Nature reviews. Neurology. vol 16. issue 10. 2021-06-24. PMID:32796930. |
huntington disease (hd) is a neurodegenerative disease caused by cag repeat expansion in the huntingtin gene (htt) and involves a complex web of pathogenic mechanisms. |
2021-06-24 |
2023-08-13 |
human |