| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jacqueline Shehadeh, Herman B Fernandes, Melinda M Zeron Mullins, Rona K Graham, Blair R Leavitt, Michael R Hayden, Lynn A Raymon. Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease. Neurobiology of disease. vol 21. issue 2. 2006-03-29. PMID:16165367. |
huntington disease (hd), caused by expansion >35 of a polyglutamine tract in huntingtin, results in degeneration of striatal medium spiny neurons (msns). |
2006-03-29 |
2023-08-12 |
mouse |
| Rona K Graham, Elizabeth J Slow, Yu Deng, Nagat Bissada, Ge Lu, Jacqueline Pearson, Jacqueline Shehadeh, Blair R Leavitt, Lynn A Raymond, Michael R Hayde. Levels of mutant huntingtin influence the phenotypic severity of Huntington disease in YAC128 mouse models. Neurobiology of disease. vol 21. issue 2. 2006-03-29. PMID:16230019. |
levels of mutant huntingtin influence the phenotypic severity of huntington disease in yac128 mouse models. |
2006-03-29 |
2023-08-12 |
mouse |
| Jeremy M Van Raamsdonk, Zoe Murphy, Elizabeth J Slow, Blair R Leavitt, Michael R Hayde. Selective degeneration and nuclear localization of mutant huntingtin in the YAC128 mouse model of Huntington disease. Human molecular genetics. vol 14. issue 24. 2006-03-10. PMID:16278236. |
selective degeneration and nuclear localization of mutant huntingtin in the yac128 mouse model of huntington disease. |
2006-03-10 |
2023-08-12 |
mouse |
| Jeremy M Van Raamsdonk, Zoe Murphy, Elizabeth J Slow, Blair R Leavitt, Michael R Hayde. Selective degeneration and nuclear localization of mutant huntingtin in the YAC128 mouse model of Huntington disease. Human molecular genetics. vol 14. issue 24. 2006-03-10. PMID:16278236. |
huntington disease (hd) is an adult onset neurodegenerative disorder that predominantly affects the striatum and cortex despite ubiquitous expression of mutant huntingtin (htt). |
2006-03-10 |
2023-08-12 |
mouse |
| Kazuya Omi, Naomi S Hachiya, Katsushi Tokunaga, Kiyotoshi Kanek. siRNA-mediated inhibition of endogenous Huntington disease gene expression induces an aberrant configuration of the ER network in vitro. Biochemical and biophysical research communications. vol 338. issue 2. 2006-01-12. PMID:16256944. |
huntingtin is a ubiquitously expressed cytoplasmic protein encoded by the huntington disease (hd) gene, in which a cag expansion induces an autosomal dominant progressive neurodegenerative disorder; however, its biological function has not been completely elucidated. |
2006-01-12 |
2023-08-12 |
mouse |
| Pieter H Anborgh, Christina Godin, Macarena Pampillo, Gurpreet K Dhami, Lianne B Dale, Sean P Cregan, Ray Truant, Stephen S G Ferguso. Inhibition of metabotropic glutamate receptor signaling by the huntingtin-binding protein optineurin. The Journal of biological chemistry. vol 280. issue 41. 2005-12-13. PMID:16091361. |
huntington disease is caused by a polyglutamine expansion in the huntingtin protein (htt) and is associated with excitotoxic death of striatal neurons. |
2005-12-13 |
2023-08-12 |
mouse |
| Xiao-Jian Sun, Ju Wei, Xin-Yan Wu, Ming Hu, Lan Wang, Hai-Hong Wang, Qing-Hua Zhang, Sai-Juan Chen, Qiu-Hua Huang, Zhu Che. Identification and characterization of a novel human histone H3 lysine 36-specific methyltransferase. The Journal of biological chemistry. vol 280. issue 42. 2005-12-13. PMID:16118227. |
the hspc069/hypb gene was originally isolated from the human hematopoietic stem/progenitor cells (hspcs), and it was also identified as a huntingtin interacting protein, implicated in the pathogenesis of huntington disease (hd). |
2005-12-13 |
2023-08-12 |
human |
| Simon C Warby, Edmond Y Chan, Martina Metzler, Lu Gan, Roshni R Singaraja, Susan F Crocker, Harold A Robertson, Michael R Hayde. Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo. Human molecular genetics. vol 14. issue 11. 2005-11-28. PMID:15843398. |
huntington disease (hd) results from polyglutamine expansion in the huntingtin protein (htt). |
2005-11-28 |
2023-08-12 |
mouse |
| Larissa Arning, Peter H Kraus, Carsten Saft, Jürgen Andrich, Jörg T Epple. Age at onset of Huntington disease is not modulated by the R72P variation in TP53 and the R196K variation in the gene coding for the human caspase activated DNase (hCAD). BMC medical genetics. vol 6. 2005-10-25. PMID:16202123. |
tp53 is an attractive candidate for modifying age of onset (ao) in huntington disease (hd): the amino-terminus of the mutated huntingtin (htt) exon 1 translation product has functional properties which may affect critically the tp53 pathway in hd neurons. |
2005-10-25 |
2023-08-12 |
human |
| Jeremy M Van Raamsdonk, Jacqueline Pearson, Daniel A Rogers, Nagat Bissada, A Wayne Vogl, Michael R Hayden, Blair R Leavit. Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of Huntington disease. Human molecular genetics. vol 14. issue 10. 2005-09-26. PMID:15829505. |
loss of wild-type huntingtin influences motor dysfunction and survival in the yac128 mouse model of huntington disease. |
2005-09-26 |
2023-08-12 |
mouse |
| Jeremy M Van Raamsdonk, Jacqueline Pearson, Daniel A Rogers, Nagat Bissada, A Wayne Vogl, Michael R Hayden, Blair R Leavit. Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of Huntington disease. Human molecular genetics. vol 14. issue 10. 2005-09-26. PMID:15829505. |
huntington disease (hd) is an adult-onset neurodegenerative disease caused by a toxic gain of function in the huntingtin (htt) protein. |
2005-09-26 |
2023-08-12 |
mouse |
| Hélène Rangone, Raúl Pardo, Emilie Colin, Jean-Antoine Girault, Frédéric Saudou, Sandrine Humber. Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment. The Journal of biological chemistry. vol 280. issue 23. 2005-08-02. PMID:15809304. |
huntington disease (hd) is caused by an abnormal expanded polyglutamine repeat in the huntingtin protein. |
2005-08-02 |
2023-08-12 |
Not clear |
| Flaviano Giorgini, Paolo Guidetti, QuangVu Nguyen, Simone C Bennett, Paul J Muchowsk. A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease. Nature genetics. vol 37. issue 5. 2005-06-03. PMID:15806102. |
huntington disease is a fatal neurodegenerative disorder caused by expansion of a polyglutamine tract in the protein huntingtin (htt), which leads to its aggregation in nuclear and cytoplasmic inclusion bodies. |
2005-06-03 |
2023-08-12 |
Not clear |
| Svetlana Kotliarova, Nihar R Jana, Naoaki Sakamoto, Masaru Kurosawa, Haruko Miyazaki, Munenori Nekooki, Hiroshi Doi, Yoko Machida, Hon Kit Wong, Taishi Suzuki, Chiharu Uchikawa, Yuri Kotliarov, Kazuyo Uchida, Yoshiro Nagao, Utako Nagaoka, Akira Tamaoka, Kiyomitsu Oyanagi, Fumitaka Oyama, Nobuyuki Nukin. Decreased expression of hypothalamic neuropeptides in Huntington disease transgenic mice with expanded polyglutamine-EGFP fluorescent aggregates. Journal of neurochemistry. vol 93. issue 3. 2005-06-03. PMID:15836623. |
huntington disease is caused by polyglutamine (polyq) expansion in huntingtin. |
2005-06-03 |
2023-08-12 |
mouse |
| Zongyu J Chen, Betsy T Kren, Phillip Y-P Wong, Walter C Low, Clifford J Stee. Sleeping Beauty-mediated down-regulation of huntingtin expression by RNA interference. Biochemical and biophysical research communications. vol 329. issue 2. 2005-05-05. PMID:15737634. |
huntington disease (hd) is a devastating neurologic disorder that is characterized by abnormal expansion of a cag nt repeat in the first exon of the huntingtin (htt) gene, producing a mutant protein with an elongated polyglutamine stretch. |
2005-05-05 |
2023-08-12 |
mouse |
| Akira San. [Hereditary chorea--update]. Rinsho shinkeigaku = Clinical neurology. vol 44. issue 11. 2005-03-04. PMID:15651335. |
triplet repeat expansion diseases including, huntington disease, in which cag expansion has been identified in the it-15 or huntingtin gene, and huntington disease like-2, in which ctg expansion in junctophilin-3 (jph3) gene occurs, causes selective degeneration of striatum in the brain. |
2005-03-04 |
2023-08-12 |
Not clear |
| Gina M Zainelli, Nichole L Dudek, Christopher A Ross, Soo-Youl Kim, Nancy A Mum. Mutant huntingtin protein: a substrate for transglutaminase 1, 2, and 3. Journal of neuropathology and experimental neurology. vol 64. issue 1. 2005-03-03. PMID:15715085. |
the most prominent neuropathologic hallmarks of huntington disease (hd) are cortical and striatal perinuclear cytoplasmic aggregates and intranuclear inclusions of mutant huntingtin. |
2005-03-03 |
2023-08-12 |
Not clear |
| Zheng-Hong Qin, Zhen-Lun G. Huntingtin processing in pathogenesis of Huntington disease. Acta pharmacologica Sinica. vol 25. issue 10. 2005-01-28. PMID:15456523. |
huntingtin processing in pathogenesis of huntington disease. |
2005-01-28 |
2023-08-12 |
Not clear |
| Lijun Li, Timothy H Murphy, Michael R Hayden, Lynn A Raymon. Enhanced striatal NR2B-containing N-methyl-D-aspartate receptor-mediated synaptic currents in a mouse model of Huntington disease. Journal of neurophysiology. vol 92. issue 5. 2005-01-21. PMID:15240759. |
huntington disease (hd) is an inherited neurodegenerative disease caused by expansion of a polyglutamine tract near the n terminus of the protein huntingtin, leading to dramatic loss of striatal medium-sized spiny gabaergic projection neurons (msns). |
2005-01-21 |
2023-08-12 |
mouse |
| Laura Kennedy, Elizabeth Evans, Chiung-Mei Chen, Lyndsey Craven, Peter J Detloff, Margaret Ennis, Peggy F Shelbourn. Dramatic tissue-specific mutation length increases are an early molecular event in Huntington disease pathogenesis. Human molecular genetics. vol 12. issue 24. 2004-09-23. PMID:14570710. |
huntington disease is caused by the expansion of a cag repeat encoding an extended glutamine tract in a protein called huntingtin. |
2004-09-23 |
2023-08-12 |
mouse |