| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brinda Ravikumar, Coralie Vacher, Zdenek Berger, Janet E Davies, Shouqing Luo, Lourdes G Oroz, Francesco Scaravilli, Douglas F Easton, Rainer Duden, Cahir J O'Kane, David C Rubinsztei. Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nature genetics. vol 36. issue 6. 2004-07-01. PMID:15146184. |
this protects against polyglutamine toxicity, as the specific mtor inhibitor rapamycin attenuates huntingtin accumulation and cell death in cell models of huntington disease, and inhibition of autophagy has the converse effects. |
2004-07-01 |
2023-08-12 |
mouse |
| He Li, Travis Wyman, Zhao-Xue Yu, Shi-Hua Li, Xiao-Jiang L. Abnormal association of mutant huntingtin with synaptic vesicles inhibits glutamate release. Human molecular genetics. vol 12. issue 16. 2004-05-20. PMID:12913073. |
in huntington disease (hd), polyglutamine expansion causes the disease protein huntingtin to aggregate and accumulate in the nucleus and cytoplasm. |
2004-05-20 |
2023-08-12 |
mouse |
| Lijun Li, Mannie Fan, Carolyn D Icton, Nansheng Chen, Blair R Leavitt, Michael R Hayden, Tim H Murphy, Lynn A Raymon. Role of NR2B-type NMDA receptors in selective neurodegeneration in Huntington disease. Neurobiology of aging. vol 24. issue 8. 2004-03-11. PMID:14643383. |
n-methyl-d-aspartate receptor (nmdar)-mediated excitotoxicity has been proposed to play a role in huntington disease (hd), caused by expansion of a polyglutamine tract in the protein huntingtin. |
2004-03-11 |
2023-08-12 |
mouse |
| Chiara Zuccato, Marzia Tartari, Andrea Crotti, Donato Goffredo, Marta Valenza, Luciano Conti, Tiziana Cataudella, Blair R Leavitt, Michael R Hayden, Tõnis Timmusk, Dorotea Rigamonti, Elena Cattane. Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes. Nature genetics. vol 35. issue 1. 2003-09-25. PMID:12881722. |
huntingtin protein is mutated in huntington disease. |
2003-09-25 |
2023-08-12 |
mouse |
| Chiara Zuccato, Marzia Tartari, Andrea Crotti, Donato Goffredo, Marta Valenza, Luciano Conti, Tiziana Cataudella, Blair R Leavitt, Michael R Hayden, Tõnis Timmusk, Dorotea Rigamonti, Elena Cattane. Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes. Nature genetics. vol 35. issue 1. 2003-09-25. PMID:12881722. |
we show that wild-type huntingtin coimmunoprecipitates with rest/nrsf and that less immunoprecipitated material is found in brain tissue with huntington disease. |
2003-09-25 |
2023-08-12 |
mouse |
| Chiara Zuccato, Marzia Tartari, Andrea Crotti, Donato Goffredo, Marta Valenza, Luciano Conti, Tiziana Cataudella, Blair R Leavitt, Michael R Hayden, Tõnis Timmusk, Dorotea Rigamonti, Elena Cattane. Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes. Nature genetics. vol 35. issue 1. 2003-09-25. PMID:12881722. |
we conclude that wild-type huntingtin acts in the cytoplasm of neurons to regulate the availability of rest/nrsf to its nuclear nrse-binding site and that this control is lost in the pathology of huntington disease. |
2003-09-25 |
2023-08-12 |
mouse |
| Katharine L Sugars, David C Rubinsztei. Transcriptional abnormalities in Huntington disease. Trends in genetics : TIG. vol 19. issue 5. 2003-07-02. PMID:12711212. |
huntington disease (hd) is caused by a cag repeat expansion that is translated into an abnormally long polyglutamine (polyq) tract in the huntingtin protein. |
2003-07-02 |
2023-08-12 |
Not clear |
| Roshni R Singaraja, Shinji Hadano, Martina Metzler, Scott Givan, Cheryl L Wellington, Simon Warby, Anat Yanai, Claire-Anne Gutekunst, Blair R Leavitt, Hong Yi, Keith Fichter, Lu Gan, Krista McCutcheon, Vikramjit Chopra, Jennifer Michel, Steven M Hersch, Joh-E Ikeda, Michael R Hayde. HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis. Human molecular genetics. vol 11. issue 23. 2003-04-16. PMID:12393793. |
huntington disease (hd) is caused by polyglutamine [poly(q)] expansion in the protein huntingtin (htt). |
2003-04-16 |
2023-08-12 |
human |
| Elena Cattane. Dysfunction of wild-type huntingtin in Huntington disease. News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society. vol 18. 2003-03-24. PMID:12531930. |
dysfunction of wild-type huntingtin in huntington disease. |
2003-03-24 |
2023-08-12 |
Not clear |
| Elena Cattane. Dysfunction of wild-type huntingtin in Huntington disease. News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society. vol 18. 2003-03-24. PMID:12531930. |
huntingtin is the protein involved in huntington disease (hd), an inherited neurodegenerative disease. |
2003-03-24 |
2023-08-12 |
Not clear |
| Gina M Zainelli, Christopher A Ross, Juan C Troncoso, Nancy A Mum. Transglutaminase cross-links in intranuclear inclusions in Huntington disease. Journal of neuropathology and experimental neurology. vol 62. issue 1. 2003-02-11. PMID:12528814. |
cortical and striatal perinuclear cytoplasmic aggregates and intranuclear inclusions of mutant huntingtin are neuropathological hallmarks of huntington disease (hd). |
2003-02-11 |
2023-08-12 |
Not clear |
| François G Gervais, Roshni Singaraja, Steven Xanthoudakis, Claire-Anne Gutekunst, Blair R Leavitt, Martina Metzler, Abigail S Hackam, John Tam, John P Vaillancourt, Vicky Houtzager, Dita M Rasper, Sophie Roy, Michael R Hayden, Donald W Nicholso. Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi. Nature cell biology. vol 4. issue 2. 2002-08-08. PMID:11788820. |
in huntington disease, polyglutamine expansion of the protein huntingtin (htt) leads to selective neurodegenerative loss of medium spiny neurons throughout the striatum by an unknown apoptotic mechanism. |
2002-08-08 |
2023-08-12 |
Not clear |
| Marcela V Karpuj, Mark W Becher, Joe E Springer, Dorothee Chabas, Sawsan Youssef, Rosetta Pedotti, Dennis Mitchell, Lawrence Steinma. Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine. Nature medicine. vol 8. issue 2. 2002-05-03. PMID:11821898. |
an expanded polyglutamine domain in huntingtin underlies the pathogenic events in huntington disease (hd), characterized by chorea, dementia and severe weight loss, culminating in death. |
2002-05-03 |
2023-08-12 |
mouse |
| Aleksey Kazantsev, Heli A Walker, Natalia Slepko, James E Bear, Elizabeth Preisinger, Joan S Steffan, Ya-Zhen Zhu, Frank B Gertler, David E Housman, J Lawrence Marsh, Leslie M Thompso. A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila. Nature genetics. vol 30. issue 4. 2002-05-02. PMID:11925563. |
huntington disease is caused by the expansion of a polyglutamine repeat in the huntingtin protein (htt) that leads to degeneration of neurons in the central nervous system and the appearance of visible aggregates within neurons. |
2002-05-02 |
2023-08-12 |
drosophila_melanogaster |
| M Metzler, V Legendre-Guillemin, L Gan, V Chopra, A Kwok, P S McPherson, M R Hayde. HIP1 functions in clathrin-mediated endocytosis through binding to clathrin and adaptor protein 2. The Journal of biological chemistry. vol 276. issue 42. 2001-12-04. PMID:11517213. |
polyglutamine expansion in huntingtin is the underlying mutation leading to neurodegeneration in huntington disease. |
2001-12-04 |
2023-08-12 |
Not clear |
| V S Chopra, M Metzler, D M Rasper, A E Engqvist-Goldstein, R Singaraja, L Gan, K M Fichter, K McCutcheon, D Drubin, D W Nicholson, M R Hayde. HIP12 is a non-proapoptotic member of a gene family including HIP1, an interacting protein with huntingtin. Mammalian genome : official journal of the International Mammalian Genome Society. vol 11. issue 11. 2001-05-31. PMID:11063258. |
huntingtin-interacting protein i (hip1) is a membrane-associated protein that interacts with huntingtin, the protein altered in huntington disease. |
2001-05-31 |
2023-08-12 |
Not clear |
| C L Wellington, B R Leavitt, M R Hayde. Huntington disease: new insights on the role of huntingtin cleavage. Journal of neural transmission. Supplementum. issue 58. 2001-02-22. PMID:11128600. |
huntington disease: new insights on the role of huntingtin cleavage. |
2001-02-22 |
2023-08-12 |
mouse |
| C L Wellington, B R Leavitt, M R Hayde. Huntington disease: new insights on the role of huntingtin cleavage. Journal of neural transmission. Supplementum. issue 58. 2001-02-22. PMID:11128600. |
huntington disease (hd) results from polyglutamine expansion within the n-terminus of huntingtin. |
2001-02-22 |
2023-08-12 |
mouse |
| A S Hackam, A S Yassa, R Singaraja, M Metzler, C A Gutekunst, L Gan, S Warby, C L Wellington, J Vaillancourt, N Chen, F G Gervais, L Raymond, D W Nicholson, M R Hayde. Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain. The Journal of biological chemistry. vol 275. issue 52. 2001-01-26. PMID:11007801. |
huntington disease is a devastating neurodegenerative disease caused by the expansion of a polymorphic glutamine tract in huntingtin. |
2001-01-26 |
2023-08-12 |
Not clear |
| J Nasir, M J Lafuente, K Duan, V Colomer, S Engelender, R Ingersoll, R L Margolis, C A Ross, M R Hayde. Human huntingtin-associated protein (HAP-1) gene: genomic organisation and an intragenic polymorphism. Gene. vol 254. issue 1-2. 2000-10-30. PMID:10974549. |
the huntingtin-associated protein (hap-1) interacts with the huntington disease gene product, huntingtin. |
2000-10-30 |
2023-08-12 |
human |