| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Shilyansky, Y S Lee, A J Silv. Molecular and cellular mechanisms of learning disabilities: a focus on NF1. Annual review of neuroscience. vol 33. 2011-01-27. PMID:20345245. |
animal models of nf1 identified mechanisms and pathways that are required for cognition, and represent an important complement to the complex neuropsychological literature on learning disabilities associated with this condition. |
2011-01-27 |
2023-08-12 |
human |
| C Shilyansky, Y S Lee, A J Silv. Molecular and cellular mechanisms of learning disabilities: a focus on NF1. Annual review of neuroscience. vol 33. 2011-01-27. PMID:20345245. |
here, we review findings from nf1 animal models and human populations affected by nf1, highlighting areas of potential translation and discussing the implications and limitations of generalizing findings from this single-gene disease to idiopathic learning disabilities. |
2011-01-27 |
2023-08-12 |
human |
| Eric Pasmant, Audrey Sabbagh, Gill Spurlock, Ingrid Laurendeau, Elisa Grillo, Marie-José Hamel, Ludovic Martin, Sébastien Barbarot, Bruno Leheup, Diana Rodriguez, Didier Lacombe, Hélène Dollfus, Laurent Pasquier, Bertrand Isidor, Salah Ferkal, Jean Soulier, Marc Sanson, Anne Dieux-Coeslier, Ivan Bièche, Béatrice Parfait, Michel Vidaud, Pierre Wolkenstein, Meena Upadhyaya, Dominique Vidau. NF1 microdeletions in neurofibromatosis type 1: from genotype to phenotype. Human mutation. vol 31. issue 6. 2010-09-27. PMID:20513137. |
our results confirmed in an unbiased manner the existence of a contiguous gene syndrome with a significantly higher incidence of learning disabilities and facial dysmorphism in microdeleted patients compared to patients with intragenic nf1 mutations. |
2010-09-27 |
2023-08-12 |
Not clear |
| Carrie Shilyansky, Katherine H Karlsgodt, Damian M Cummings, Kyriaki Sidiropoulou, Molly Hardt, Alex S James, Dan Ehninger, Carrie E Bearden, Panayiota Poirazi, J David Jentsch, Tyrone D Cannon, Michael S Levine, Alcino J Silv. Neurofibromin regulates corticostriatal inhibitory networks during working memory performance. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 29. 2010-09-01. PMID:20624961. |
neurofibromatosis type i (nf1) is one of the most common single-gene causes of learning disabilities. |
2010-09-01 |
2023-08-12 |
mouse |
| Camille Chabernaud, Dominique Sirinelli, Charlotte Barbier, Jean-Philippe Cottier, Catherine Sembely, Bruno Giraudeau, Geraldine Deseille-Turlotte, Gerard Lorette, Marie-Anne Barthez, Pierre Castelna. Thalamo-striatal T2-weighted hyperintensities (unidentified bright objects) correlate with cognitive impairments in neurofibromatosis type 1 during childhood. Developmental neuropsychology. vol 34. issue 6. 2010-06-08. PMID:20183730. |
learning disabilities represent the main childhood complication in neurofibromatosis type 1 (nf1). |
2010-06-08 |
2023-08-12 |
human |
| Jonathan M Payne, Mahendranath D Moharir, Richard Webster, Kathryn N Nort. Brain structure and function in neurofibromatosis type 1: current concepts and future directions. Journal of neurology, neurosurgery, and psychiatry. vol 81. issue 3. 2010-03-22. PMID:20185469. |
neurofibromatosis type 1 (nf1) is a common neurogenetic condition associated with cognitive dysfunction and learning disability. |
2010-03-22 |
2023-08-12 |
Not clear |
| Chang Sin Park, Ling Zhong, Shao-Jun Tan. Aberrant expression of synaptic plasticity-related genes in the NF1+/- mouse hippocampus. Journal of neuroscience research. vol 87. issue 14. 2009-11-17. PMID:19475561. |
to test this hypothesis, we performed dna microarray analysis on the hippocampus of nf1(+/-) mice, the mouse model for nf1 learning disabilities. |
2009-11-17 |
2023-08-12 |
mouse |
| Chang Sin Park, Ling Zhong, Shao-Jun Tan. Aberrant expression of synaptic plasticity-related genes in the NF1+/- mouse hippocampus. Journal of neuroscience research. vol 87. issue 14. 2009-11-17. PMID:19475561. |
because nf1-associated learning disabilities can be reversed by lovastatin, we also determined the effect of lovastatin treatment on genome-wide expression patterns of the nf1(+/-) hippocampus. |
2009-11-17 |
2023-08-12 |
mouse |
| Kevin P Boyd, Bruce R Korf, Amy Theo. Neurofibromatosis type 1. Journal of the American Academy of Dermatology. vol 61. issue 1. 2009-09-24. PMID:19539839. |
while no medical therapies for nf1 are currently available, trials are ongoing to discover and test medical treatments for the various manifestations of nf1, primarily plexiform neurofibromas, learning disabilities, and optic pathway gliomas. |
2009-09-24 |
2023-08-12 |
Not clear |
| Mary McQueen, Mia MacCollin, James Gusella, Scott R Plotki. Patient and physician attitudes regarding clinical trials in neurofibromatosis 1. The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses. vol 40. issue 6. 2009-03-05. PMID:19170300. |
neurofibromatosis 1 (nf1) is a multisystem genetic disorder that primarily affects the skin (freckling and café-au-lait macules), nervous system (neurofibromas, optic gliomas, and learning disabilities), and skeletal system (pseudoarthroses). |
2009-03-05 |
2023-08-12 |
Not clear |
| Yijun Cui, Rui M Costa, Geoffrey G Murphy, Ype Elgersma, Yuan Zhu, David H Gutmann, Luis F Parada, Istvan Mody, Alcino J Silv. Neurofibromin regulation of ERK signaling modulates GABA release and learning. Cell. vol 135. issue 3. 2008-11-24. PMID:18984165. |
we uncovered a role for erk signaling in gaba release, long-term potentiation (ltp), and learning, and show that disruption of this mechanism accounts for the learning deficits in a mouse model for learning disabilities in neurofibromatosis type i (nf1). |
2008-11-24 |
2023-08-12 |
mouse |
| Lianne C Krab, Arja de Goede-Bolder, Femke K Aarsen, Saskia M F Pluijm, Marlies J Bouman, Jos N van der Geest, Maarten Lequin, Coriene E Catsman, Willem Frans M Arts, Steven A Kushner, Alcino J Silva, Chris I de Zeeuw, Henriëtte A Moll, Ype Elgersm. Effect of simvastatin on cognitive functioning in children with neurofibromatosis type 1: a randomized controlled trial. JAMA. vol 300. issue 3. 2008-07-23. PMID:18632543. |
neurofibromatosis type 1 (nf1) is among the most common genetic disorders that cause learning disabilities. |
2008-07-23 |
2023-08-12 |
mouse |
| Yi-Ping Hsue. Neurofibromin signaling and synapses. Journal of biomedical science. vol 14. issue 4. 2007-11-01. PMID:17370141. |
learning defects have been documented in nf1 mutant mice, and in nf1 patients, learning disabilities are common. |
2007-11-01 |
2023-08-12 |
mouse |
| Jenny Douglas, Deirdre Cilliers, Kim Coleman, Katrina Tatton-Brown, Karen Barker, Brigitte Bernhard, John Burn, Susan Huson, Dragana Josifova, Didier Lacombe, Mohsin Malik, Sahar Mansour, Evan Reid, Valerie Cormier-Daire, Trevor Cole, Nazneen Rahma. Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth. Nature genetics. vol 39. issue 8. 2007-09-19. PMID:17632510. |
we identified mutations in rnf135, which is within the nf1 microdeletion region, in six families characterized by overgrowth, learning disability, dysmorphic features and variable additional features. |
2007-09-19 |
2023-08-12 |
human |
| Shelley L Hyman, E Arthur Shores, Kathryn N Nort. Learning disabilities in children with neurofibromatosis type 1: subtypes, cognitive profile, and attention-deficit-hyperactivity disorder. Developmental medicine and child neurology. vol 48. issue 12. 2007-01-09. PMID:17109785. |
the present study examined the frequency of specific learning disabilities (slds) in nf1, using an intellect-achievement discrepancy for diagnosis, as well as general learning difficulty associated with a lowering of general intellectual ability. |
2007-01-09 |
2023-08-12 |
Not clear |
| Weidong Li, Yijun Cui, Steven A Kushner, Robert A M Brown, J David Jentsch, Paul W Frankland, Tyrone D Cannon, Alcino J Silv. The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1. Current biology : CB. vol 15. issue 21. 2006-07-21. PMID:16271875. |
importantly, nf1 causes learning disabilities and attention deficits. |
2006-07-21 |
2023-08-12 |
mouse |
| Elizabeth A Donarum, Rebecca F Halperin, Dietrich A Stephan, Vinodh Narayana. Cognitive dysfunction in NF1 knock-out mice may result from altered vesicular trafficking of APP/DRD3 complex. BMC neuroscience. vol 7. 2006-05-08. PMID:16524466. |
it has been estimated that more than 50% of patients with neurofibromatosis type 1 (nf1) have neurobehavioral impairments which include attention deficit/hyperactivity disorder, visual/spatial learning disabilities, and a myriad of other cognitive developmental problems. |
2006-05-08 |
2023-08-12 |
mouse |
| M M Mazzocc. Math learning disability and math LD subtypes: evidence from studies of Turner syndrome, fragile X syndrome, and neurofibromatosis type 1. Journal of learning disabilities. vol 34. issue 6. 2004-12-01. PMID:15503567. |
the present study examined whether indicators of math learning disability are observed in 5- and 6-year-olds with neurofibromatosis type 1 (nf1) and in 5- to 6-year-old girls with turner syndrome or fragile x syndrome. |
2004-12-01 |
2023-08-12 |
human |
| Raymond S Kand. Tuberous sclerosis complex and neurofibromatosis type 1: the two most common neurocutaneous diseases. Neurologic clinics. vol 21. issue 4. 2004-03-08. PMID:14743661. |
in children, brain symptoms cause most of the morbidity in tsc, and nerve sheath and nervous system tumors as well as learning disabilities cause major morbidity in nf1. |
2004-03-08 |
2023-08-12 |
Not clear |
| Michael R Bennett, Tilat A Rizvi, Saikumar Karyala, Randall D McKinnon, Nancy Ratne. Aberrant growth and differentiation of oligodendrocyte progenitors in neurofibromatosis type 1 mutants. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 18. 2003-09-09. PMID:12904481. |
neurofibromatosis type 1 (nf1) patients are predisposed to learning disabilities, macrocephaly, and brain tumors as well as abnormalities on magnetic resonance imaging that are postulated to result from abnormal myelination. |
2003-09-09 |
2023-08-12 |
mouse |