| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yi Tan, Carmelo Sgobio, Thomas Arzberger, Felix Machleid, Qilin Tang, Elisabeth Findeis, Jorg Tost, Tasnim Chakroun, Pan Gao, Mathias Höllerhage, Kai Bötzel, Jochen Herms, Günter Höglinger, Thomas Koeglsperge. Loss of fragile X mental retardation protein precedes Lewy pathology in Parkinson's disease. Acta neuropathologica. vol 139. issue 2. 2021-01-12. PMID:31768670. |
parkinson's disease (pd) is the most common neurodegenerative movement disorder and is characterized by the progressive loss of dopaminergic (da) neurons in the substantia nigra pars compacta (snc) and the gradual appearance of α-synuclein (α-syn)-containing neuronal protein aggregates. |
2021-01-12 |
2023-08-13 |
mouse |
| Aubrey M Schonhoff, Gregory P Williams, Zachary D Wallen, David G Standaert, Ashley S Harm. Innate and adaptive immune responses in Parkinson's disease. Progress in brain research. vol 252. 2021-01-11. PMID:32247364. |
parkinson's disease (pd) has classically been defined as a movement disorder, in which motor symptoms are explained by the aggregation of alpha-synuclein (α-syn) and subsequent death of dopaminergic neurons of the substantia nigra pars compacta (snpc). |
2021-01-11 |
2023-08-13 |
human |
| Mahboubeh Manouchehrabadi, Mona Farhadi, Zahra Azizi, Anahita Torkaman-Boutorab. Carvacrol Protects Against 6-Hydroxydopamine-Induced Neurotoxicity in In Vivo and In Vitro Models of Parkinson's Disease. Neurotoxicity research. vol 37. issue 1. 2020-12-21. PMID:31364033. |
parkinson's disease (pd) is a progressive neurodegenerative movement disorder characterized by selective loss of dopaminergic neurons that project from the substantia nigra pars compacta to the striatum. |
2020-12-21 |
2023-08-13 |
human |
| Liting Hang, John Thundyil, Geraldine W Y Goh, Kah-Leong Li. AMP Kinase Activation is Selectively Disrupted in the Ventral Midbrain of Mice Deficient in Parkin or PINK1 Expression. Neuromolecular medicine. vol 21. issue 1. 2020-10-02. PMID:30411223. |
parkinson's disease (pd) is a prevalent neurodegenerative movement disorder that is characterized pathologically by the progressive loss of dopaminergic (da) neurons in the substantia nigra pars compacta (snpc) of the midbrain. |
2020-10-02 |
2023-08-13 |
mouse |
| Andrew C Peterson, Sheng Zhang, Sien Hu, Herta H Chao, Chiang-Shan R L. The Effects of Age, from Young to Middle Adulthood, and Gender on Resting State Functional Connectivity of the Dopaminergic Midbrain. Frontiers in human neuroscience. vol 11. 2020-09-30. PMID:28223929. |
dysfunction of the dopaminergic ventral tegmental area (vta) and substantia nigra pars compacta (snc) is implicated in psychiatric disorders including attention-deficit/ hyperactivity disorder (adhd), addiction, schizophrenia and movement disorders such as parkinson's disease (pd). |
2020-09-30 |
2023-08-13 |
Not clear |
| Feiyi Sun, Yulin Deng, Xiaowei Han, Qingqing Liu, Peng Zhang, Robina Manzoor, Hong M. A secret that underlies Parkinson's disease: The damaging cycle. Neurochemistry international. vol 129. 2020-05-11. PMID:31173779. |
parkinson's disease (pd) is a movement disorder, and its common characteristics include the loss of dopaminergic neurons and the accumulation of a special type of cytoplasmic inclusions called lewy bodies in the substantia nigra pars compacta, which are more prevalent in the elderly. |
2020-05-11 |
2023-08-13 |
Not clear |
| Zhi Dong Zhou, Thevapriya Selvaratnam, Ji Chao Tristan Lee, Yin Xia Chao, Eng-King Ta. Molecular targets for modulating the protein translation vital to proteostasis and neuron degeneration in Parkinson's disease. Translational neurodegeneration. vol 8. 2020-02-25. PMID:30740222. |
parkinson's disease (pd) is the most common neurodegenerative movement disorder, which is characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta concomitant with lewy body formation in affected brain areas. |
2020-02-25 |
2023-08-13 |
Not clear |
| Yijuan Du, Steven M Grave. Spiny Projection Neuron Dynamics in Toxin and Transgenic Models of Parkinson's Disease. Frontiers in neural circuits. vol 13. 2020-01-13. PMID:30930753. |
parkinson's disease (pd) is the most common neurodegenerative movement disorder that results from the progressive degeneration of substantia nigra pars compacta (snc) dopamine (da) neurons. |
2020-01-13 |
2023-08-13 |
mouse |
| Navneet Ammal Kaidery, Bobby Thoma. Current perspective of mitochondrial biology in Parkinson's disease. Neurochemistry international. vol 117. 2019-09-16. PMID:29550604. |
parkinson's disease (pd) is one of the most common neurodegenerative movement disorder characterized by preferential loss of dopaminergic neurons of the substantia nigra pars compacta and the presence of lewy bodies containing α-synuclein. |
2019-09-16 |
2023-08-13 |
human |
| Han Wool Kim, Hyun-Seob Lee, Jun Mo Kang, Sang-Hun Bae, Chul Kim, Sang-Hun Lee, Johannes Schwarz, Gi Jin Kim, Jin-Su Kim, Dong Hyun Cha, Joopyung Kim, Sung Woon Chang, Tae Hee Lee, Jisook Moo. Dual Effects of Human Placenta-Derived Neural Cells on Neuroprotection and the Inhibition of Neuroinflammation in a Rodent Model of Parkinson's Disease. Cell transplantation. vol 27. issue 5. 2019-05-17. PMID:29871515. |
parkinson's disease (pd) is the second most common age-related neurodegenerative disease in the elderly and the patients suffer from uncontrolled movement disorders due to loss of dopaminergic (da) neurons on substantia nigra pars compacta (snpc). |
2019-05-17 |
2023-08-13 |
human |
| Bianca Marchett. Wnt/β-Catenin Signaling Pathway Governs a Full Program for Dopaminergic Neuron Survival, Neurorescue and Regeneration in the MPTP Mouse Model of Parkinson's Disease. International journal of molecular sciences. vol 19. issue 12. 2019-03-08. PMID:30477246. |
this review highlights a wnt/β-catenin/glial connection in parkinson's disease (pd), the most common movement disorder characterized by the selective death of midbrain dopaminergic (mdaergic) neuronal cell bodies in the subtantia nigra pars compacta (snpc) and gliosis. |
2019-03-08 |
2023-08-13 |
mouse |
| Xiufeng Wang, Heng Zhai, Fang Wan. 6-OHDA Induces Oxidation of F-box Protein Fbw7β by Chaperone-Mediated Autophagy in Parkinson's Model. Molecular neurobiology. vol 55. issue 6. 2019-02-11. PMID:28733899. |
parkinson's disease (pd) is the most common movement disorder disease, and its pathological feature is the degenerative loss of dopaminergic neurons in the substantia nigra compacta (snc). |
2019-02-11 |
2023-08-13 |
mouse |
| Thomas B Stoker, Roger A Barke. Regenerative Therapies for Parkinson's Disease: An Update. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. vol 32. issue 4. 2018-11-13. PMID:30027398. |
it is characterised by a typical movement disorder that occurs in part because of the selective degeneration of the dopaminergic neurons of the substantia nigra pars compacta. |
2018-11-13 |
2023-08-13 |
Not clear |
| Cynthia Sandor, Frantisek Honti, Wilfried Haerty, Konrad Szewczyk-Krolikowski, Paul Tomlinson, Sam Evetts, Stephanie Millin, Thomas Keane, Shane A McCarthy, Richard Durbin, Kevin Talbot, Michele Hu, Caleb Webber, Chris P Ponting, Richard Wade-Martin. Whole-exome sequencing of 228 patients with sporadic Parkinson's disease. Scientific reports. vol 7. 2018-10-29. PMID:28117402. |
parkinson's disease (pd) is the most common neurodegenerative movement disorder, affecting 1% of the population over 65 years characterized clinically by both motor and non-motor symptoms accompanied by the preferential loss of dopamine neurons in the substantia nigra pars compacta. |
2018-10-29 |
2023-08-13 |
Not clear |
| João Paulo Lima Dahe. Interaction of LRRK2 and α-Synuclein in Parkinson's Disease. Advances in neurobiology. vol 14. 2018-09-25. PMID:28353286. |
it is best described as a movement disorder characterized by motor dysfunctions, progressive degeneration of dopaminergic neurons of the substantia nigra pars compacta, and abnormal intraneuronal protein aggregates, named lewy bodies and lewy neurites. |
2018-09-25 |
2023-08-13 |
Not clear |
| Siamak Afshin-Majd, Keyhan Bashiri, Zahra Kiasalari, Tourandokht Baluchnejadmojarad, Reza Sedaghat, Mehrdad Roghan. Acetyl-l-carnitine protects dopaminergic nigrostriatal pathway in 6-hydroxydopamine-induced model of Parkinson's disease in the rat. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 89. 2018-02-27. PMID:28199883. |
parkinson's disease (pd) is a movement disorder and the second most common neurodegenerative disease worldwide in which nigrostriatal dopaminergic neurons within substantia nigra pars compacta (snc) are lost, with clinical motor and non-motor symptoms including bradykinesia, resting tremor, rigidity, stooping posture and cognitive deficits. |
2018-02-27 |
2023-08-13 |
rat |
| Alpana Singh, Poonam Verma, Gillela Balaji, Supriti Samantaray, Kochupurackal P Mohanakuma. Nimodipine, an L-type calcium channel blocker attenuates mitochondrial dysfunctions to protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice. Neurochemistry international. vol 99. 2018-01-03. PMID:27395789. |
parkinson's disease (pd), the most common progressive neurodegenerative movement disorder, results from loss of dopaminergic neurons of substantia nigra pars compacta. |
2018-01-03 |
2023-08-13 |
mouse |
| Khaled Radad, Rudolf Moldzio, Wolf-Dieter Rausc. Rapamycin protects dopaminergic neurons against rotenone-induced cell death in primary mesencephalic cell culture. Folia neuropathologica. vol 53. issue 3. 2016-12-13. PMID:26443316. |
parkinson's disease is the most common movement disorder, characterized by a progressive and extensive loss of dopaminergic neurons in the substantia nigra pars compacta and their terminals in the striatum. |
2016-12-13 |
2023-08-13 |
Not clear |
| Xiao-Yun Yang, Ethan Y Zhao, Wen-Xin Zhuang, Feng-Xiang Sun, Hai-Lin Han, Hui-Rong Han, Zhi-Juan Lin, Zhi-Fang Pan, Mei-Hua Qu, Xian-Wei Zeng, Yuchuan Din. LPA signaling is required for dopaminergic neuron development and is reduced through low expression of the LPA1 receptor in a 6-OHDA lesion model of Parkinson's disease. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 36. issue 11. 2016-08-08. PMID:26169757. |
parkinson's disease (pd) is a neurodegenerative movement disorder that results from the loss of dopaminergic (da) neurons in the substantia nigra pars compacta (snc). |
2016-08-08 |
2023-08-13 |
rat |
| Kasthuri Bai Magalingam, Ammu Kutty Radhakrishnan, Nagaraja Haleagrahar. Protective Mechanisms of Flavonoids in Parkinson's Disease. Oxidative medicine and cellular longevity. vol 2015. 2016-07-25. PMID:26576219. |
parkinson's disease is a chronic, debilitating neurodegenerative movement disorder characterized by progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta region in human midbrain. |
2016-07-25 |
2023-08-13 |
human |