| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Satyan Chintawar, Raphael Hourez, Ajay Ravella, David Gall, David Orduz, Myriam Rai, Don Patrick Bishop, Stefano Geuna, Serge N Schiffmann, Massimo Pandolf. Grafting neural precursor cells promotes functional recovery in an SCA1 mouse model. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 42. 2009-11-06. PMID:19846700. |
the b05 transgenic sca1 mice, expressing human ataxin-1 with an expanded polyglutamine tract in cerebellar purkinje cells (pcs), recapitulate many pathological and behavioral characteristics of the neurodegenerative disease spinocerebellar ataxia type 1 (sca1), including progressive ataxia and pc loss. |
2009-11-06 |
2023-08-12 |
mouse |
| Jing Liu, Tie-Shan Tang, Huiping Tu, Omar Nelson, Emily Herndon, Duong P Huynh, Stefan M Pulst, Ilya Bezprozvann. Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 2. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 29. 2009-08-10. PMID:19625506. |
spinocerebellar ataxia type 2 (sca2) is an autosomal dominantly inherited, neurodegenerative disease caused by an expansion of polyglutamine tracts in the cytosolic protein ataxin-2 (atx2). |
2009-08-10 |
2023-08-12 |
mouse |
| Tohru Matsuur. [Molecular and genetic analysis of spinocerebellar ataxia type 10 (SCA10)]. Rinsho shinkeigaku = Clinical neurology. vol 48. issue 11. 2009-04-08. PMID:19198092. |
spinocerebellar ataxia type 10 (sca10) is a dominantly inherited neurodegenerative disease caused by expansion of the attct pentanucleotide repeat in intron 9 of a novel gene, atxn10, on chromosome 22q13.3. |
2009-04-08 |
2023-08-12 |
Not clear |
| Emilia Nicolaescu, Monique Beullens, Bart Lesage, Stefaan Keppens, Bernard Himpens, Mathieu Bolle. Nature of the nuclear inclusions formed by PQBP1, a protein linked to neurodegenerative polyglutamine diseases. European journal of cell biology. vol 87. issue 10. 2009-03-05. PMID:18599155. |
pqbp1, for polyglutamine tract-binding protein-1, has been linked to progressive neurodegenerative diseases, such as spinocerebellar ataxia, that are caused by the expansion of a polyglutamine repeat in a key regulatory protein. |
2009-03-05 |
2023-08-12 |
Not clear |
| Anna Sułek-Piatkowska, Wioletta Krysa, Elzbieta Zdzienicka, Walentyna Szirkowiec, Dorota Hoffman-Zacharska, Marta Rajkiewicz, Elzbieta Fidziańska, Grazyna Kowalska, Jacek Zaremb. Searching for mutation in the JPH3, ATN1 and TBP genes in Polish patients suspected of Huntington's disease and without mutation in the IT15 gene. Neurologia i neurochirurgia polska. vol 42. issue 3. 2008-11-13. PMID:18651325. |
the aim of this study was to perform dna analysis in patients with clinical diagnosis of huntington's disease (hd) after molecular exclusion of hd and further molecular examinations for other neurodegenerative diseases such as huntington's disease-like 2 (hdl-2; gene jph3), dentatorubral pallidoluysian atrophy (drpla; gene atn1) and spinocerebellar ataxia type 17 (sca17; gene tbp). |
2008-11-13 |
2023-08-12 |
Not clear |
| Tohru Matsuur. [Molecular and genetic analysis of spinocerebellar ataxia type 10 (SCA10)]. Rinsho shinkeigaku = Clinical neurology. vol 48. issue 1. 2008-05-20. PMID:18386626. |
spinocerebellar ataxia type 10 (sca10) is a dominantly inherited neurodegenerative disease caused by expansion of the attct pentanucleotide repeat in intron 9 of a novel gene, atxn10, on chromosome 22q13.3. |
2008-05-20 |
2023-08-12 |
Not clear |
| Janghoo Lim, Juan Crespo-Barreto, Paymaan Jafar-Nejad, Aaron B Bowman, Ronald Richman, David E Hill, Harry T Orr, Huda Y Zoghb. Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1. Nature. vol 452. issue 7188. 2008-05-14. PMID:18337722. |
spinocerebellar ataxia type 1 (sca1) is a dominantly inherited neurodegenerative disease caused by expansion of a glutamine-encoding repeat in ataxin 1 (atxn1). |
2008-05-14 |
2023-08-12 |
Not clear |
| Céline Moutou, Jean-Christophe Nicod, Nathalie Gardes, Stéphane Vivill. Birth after pre-implantation genetic diagnosis (PGD) of spinocerebellar ataxia 2 (Sca2). Prenatal diagnosis. vol 28. issue 2. 2008-05-13. PMID:18236424. |
spinocerebellar ataxia 2 (sca2) is an autosomal-dominant neurodegenerative disease caused by an extended polyglutamine sequence in the atxn2 protein. |
2008-05-13 |
2023-08-12 |
Not clear |
| Robert Goold, Michael Hubank, Abigail Hunt, Janice Holton, Rajesh P Menon, Tamas Revesz, Massimo Pandolfo, Antoni Matilla-Dueña. Down-regulation of the dopamine receptor D2 in mice lacking ataxin 1. Human molecular genetics. vol 16. issue 17. 2008-01-09. PMID:17599952. |
ataxin 1 (atxn1) is a protein of unknown function associated with spinocerebellar ataxia type 1 (sca1), a neurodegenerative disease of late onset with variable degrees of cerebellar ataxia, ophthalmoplegia and neuropathy. |
2008-01-09 |
2023-08-12 |
mouse |
| Ina Schmitt, Marion Linden, Hassan Khazneh, Bernd O Evert, Peter Breuer, Thomas Klockgether, Ullrich Wuellne. Inactivation of the mouse Atxn3 (ataxin-3) gene increases protein ubiquitination. Biochemical and biophysical research communications. vol 362. issue 3. 2007-11-01. PMID:17764659. |
spinocerebellar ataxia type 3 is a neurodegenerative disease caused by expansion of a polyglutamine domain in the protein ataxin-3 (atxn3). |
2007-11-01 |
2023-08-12 |
mouse |
| Ellika Schalling, Britta Hammarberg, Lena Harteliu. Perceptual and acoustic analysis of speech in individuals with spinocerebellar ataxia (SCA). Logopedics, phoniatrics, vocology. vol 32. issue 1. 2007-07-16. PMID:17454658. |
with current progress in genetic research, autosomal, dominant, hereditary, neurodegenerative diseases, affecting the cerebellum and cerebellar connections, are increasingly diagnosed as spinocerebellar ataxias (sca). |
2007-07-16 |
2023-08-12 |
human |
| Dominique Langui, François Lachapelle, Charles Duyckaert. [Animal models of neurodegenerative diseases]. Medecine sciences : M/S. vol 23. issue 2. 2007-07-02. PMID:17291428. |
transgenic mice have proven useful in reproducing lesions seen in neurodegenerative disease such as the plaques of alzheimer disease (in the app mouse which has integrated the mutated gene of the amyloid protein precursor), the tau glial and neuronal accumulation (seen in cases of frontotemporal dementias due to tau mutation), the nuclear inclusions caused by cag triplet expansion (seen in the mutation of huntington disease and autosomal dominant spinocerebellar ataxias). |
2007-07-02 |
2023-08-12 |
mouse |
| Aaron B Bowman, Yung C Lam, Paymaan Jafar-Nejad, Hung-Kai Chen, Ronald Richman, Rodney C Samaco, John D Fryer, Juliette J Kahle, Harry T Orr, Huda Y Zoghb. Duplication of Atxn1l suppresses SCA1 neuropathology by decreasing incorporation of polyglutamine-expanded ataxin-1 into native complexes. Nature genetics. vol 39. issue 3. 2007-06-20. PMID:17322884. |
spinocerebellar ataxia type 1 (sca1) is a dominantly inherited neurodegenerative disease caused by expansion of a glutamine tract in ataxin-1 (atxn1). |
2007-06-20 |
2023-08-12 |
mouse |
| Haiyan Chen, Erika S Piedras-Renterí. Altered frequency-dependent inactivation and steady-state inactivation of polyglutamine-expanded alpha1A in SCA6. American journal of physiology. Cell physiology. vol 292. issue 3. 2007-04-24. PMID:17020933. |
spinocerebellar ataxia type 6 (sca6) is a neurodegenerative disease of the cerebellum and inferior olives characterized by a late-onset cerebellar ataxia and selective loss of purkinje neurons. |
2007-04-24 |
2023-08-12 |
human |
| Morwena Latouche, Christelle Lasbleiz, Elodie Martin, Véronique Monnier, Thomas Debeir, Annick Mouatt-Prigent, Marie-Paule Muriel, Lydie Morel, Merle Ruberg, Alexis Brice, Giovanni Stevanin, Hérvé Tricoir. A conditional pan-neuronal Drosophila model of spinocerebellar ataxia 7 with a reversible adult phenotype suitable for identifying modifier genes. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 10. 2007-04-09. PMID:17344386. |
spinocerebellar ataxia 7 (sca7) is a neurodegenerative disease caused by a polyglutamine (polyq) expansion in the ataxin 7 (atxn7) protein, a member of a multiprotein complex involved in histone acetylation. |
2007-04-09 |
2023-08-12 |
drosophila_melanogaster |
| Luis Velázquez-Pérez, Juan Fernandez-Ruiz, Rosalinda Díaz, Ruth Pérez González, Nalia Canales Ochoa, Gilberto Sánchez Cruz, Luis Enrique Almaguer Mederos, Edilberto Martínez Góngora, Robyn Hudson, René Drucker-Coli. Spinocerebellar ataxia type 2 olfactory impairment shows a pattern similar to other major neurodegenerative diseases. Journal of neurology. vol 253. issue 9. 2007-03-13. PMID:16609806. |
spinocerebellar ataxia type 2 olfactory impairment shows a pattern similar to other major neurodegenerative diseases. |
2007-03-13 |
2023-08-12 |
human |
| Yung C Lam, Aaron B Bowman, Paymaan Jafar-Nejad, Janghoo Lim, Ronald Richman, John D Fryer, Eric D Hyun, Lisa A Duvick, Harry T Orr, Juan Botas, Huda Y Zoghb. ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1 neuropathology. Cell. vol 127. issue 7. 2007-01-26. PMID:17190598. |
spinocerebellar ataxia type 1 (sca1) is one of several neurodegenerative diseases caused by expansion of a polyglutamine tract in the disease protein, in this case, ataxin-1 (atxn1). |
2007-01-26 |
2023-08-12 |
mouse |
| Albert R La Spad. Neurodegeneration: a case of arrested development? Cell. vol 127. issue 4. 2006-12-22. PMID:17110325. |
the neurodegenerative disease spinocerebellar ataxia type 1 (sca1) is a polyglutamine expansion disorder characterized by the death of purkinje neurons in the brain. |
2006-12-22 |
2023-08-12 |
Not clear |
| Antoni Matilla Dueñas, Robert Goold, Paola Giunt. Molecular pathogenesis of spinocerebellar ataxias. Brain : a journal of neurology. vol 129. issue Pt 6. 2006-06-19. PMID:16613893. |
the autosomal dominant spinocerebellar ataxias (scas) are a group of neurodegenerative diseases, clinically and genetically heterogeneous, characterized by loss of balance and motor coordination due to dysfunction of the cerebellum and its afferent and efferent connections. |
2006-06-19 |
2023-08-12 |
Not clear |
| M Tsirigotis, M Y Tang, M Beyers, M Zhang, J Woulfe, D A Gra. Delayed spinocerebellar ataxia in transgenic mice expressing mutant ubiquitin. Neuropathology and applied neurobiology. vol 32. issue 1. 2006-03-14. PMID:16409551. |
spinocerebellar ataxia type 1 (sca1) is an incurable neurodegenerative disease resulting from loss of purkinje neurones within the cerebellum. |
2006-03-14 |
2023-08-12 |
mouse |