| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sriram Jayabal, Lovisa Ljungberg, Alanna J Wat. Transient cerebellar alterations during development prior to obvious motor phenotype in a mouse model of spinocerebellar ataxia type 6. The Journal of physiology. vol 595. issue 3. 2017-09-21. PMID:27531396. |
spinocerebellar ataxia type 6 (sca6) is a midlife-onset neurodegenerative disease caused by a cacna1a mutation; cacna1a is also implicated in cerebellar development. |
2017-09-21 |
2023-08-13 |
mouse |
| Avraham Ashkenazi, Carla F Bento, Thomas Ricketts, Mariella Vicinanza, Farah Siddiqi, Mariana Pavel, Ferdinando Squitieri, Maarten C Hardenberg, Sara Imarisio, Fiona M Menzies, David C Rubinsztei. Polyglutamine tracts regulate beclin 1-dependent autophagy. Nature. vol 545. issue 7652. 2017-09-19. PMID:28445460. |
nine neurodegenerative diseases are caused by expanded polyglutamine (polyq) tracts in different proteins, such as huntingtin in huntington's disease and ataxin 3 in spinocerebellar ataxia type 3 (sca3). |
2017-09-19 |
2023-08-13 |
mouse |
| Ying Ding, Hiroaki Adachi, Masahisa Katsuno, Kentaro Sahashi, Naohide Kondo, Madoka Iida, Genki Tohnai, Hideaki Nakatsuji, Gen Sobu. BIIB021, a synthetic Hsp90 inhibitor, induces mutant ataxin-1 degradation through the activation of heat shock factor 1. Neuroscience. vol 327. 2017-08-31. PMID:27058144. |
spinocerebellar ataxia type 1 (sca1) is a dominantly inherited neurodegenerative disease caused by the expansion of a polyglutamine (polyq) tract in ataxin-1 (atxn1). |
2017-08-31 |
2023-08-13 |
Not clear |
| Yalan Zhang, Leonard K Kaczmare. Kv3.3 potassium channels and spinocerebellar ataxia. The Journal of physiology. vol 594. issue 16. 2017-08-29. PMID:26442672. |
kv3.3 differs from other closely related channels in that human mutations in the gene encoding kv3.3 (kcnc3) result in a unique neurodegenerative disease termed spinocerebellar ataxia type 13 (sca13). |
2017-08-29 |
2023-08-13 |
human |
| Annel Gómez-Coello, Victor Manuel Valadez-Jiménez, Bulmaro Cisneros, Paul Carrillo-Mora, Martha Parra-Cárdenas, Oscar Hernández-Hernández, Jonathan J Magañ. Voice Alterations in Patients With Spinocerebellar Ataxia Type 7 (SCA7): Clinical-Genetic Correlations. Journal of voice : official journal of the Voice Foundation. vol 31. issue 1. 2017-06-12. PMID:26992556. |
spinocerebellar ataxia type 7 (sca7) is an inherited neurodegenerative disease caused by the expansion of a cytosine-adenine-guanine triplet located in the coding region of the atxn7 gene, which is characterized by cerebellar ataxia, pigmentary macular degeneration, and dysarthria. |
2017-06-12 |
2023-08-13 |
Not clear |
| Pan P Li, Xin Sun, Guangbin Xia, Nicolas Arbez, Sharan Paul, Shanshan Zhu, H Benjamin Peng, Christopher A Ross, Arnulf H Koeppen, Russell L Margolis, Stefan M Pulst, Tetsuo Ashizawa, Dobrila D Rudnick. ATXN2-AS, a gene antisense to ATXN2, is associated with spinocerebellar ataxia type 2 and amyotrophic lateral sclerosis. Annals of neurology. vol 80. issue 4. 2017-06-05. PMID:27531668. |
spinocerebellar ataxia type 2 (sca2) is a neurodegenerative disease caused by a cag repeat expansion in the gene ataxin-2 (atxn2). |
2017-06-05 |
2023-08-13 |
Not clear |
| Megan S Keiser, Alejandro Mas Monteys, Romuald Corbau, Pedro Gonzalez-Alegre, Beverly L Davidso. RNAi prevents and reverses phenotypes induced by mutant human ataxin-1. Annals of neurology. vol 80. issue 5. 2017-06-05. PMID:27686464. |
spinocerebellar ataxia type 1 is an autosomal dominant fatal neurodegenerative disease caused by a polyglutamine expansion in the coding region of atxn1. |
2017-06-05 |
2023-08-13 |
mouse |
| Marina de Tommaso, Lars Arendt-Nielsen, Ruth Defrin, Miriam Kunz, Gisele Pickering, Massimiliano Valerian. Pain in Neurodegenerative Disease: Current Knowledge and Future Perspectives. Behavioural neurology. vol 2016. 2017-03-01. PMID:27313396. |
the management of neurodegenerative diseases such as alzheimer's disease (ad) and other dementias, parkinson's disease (pd) and pd related disorders, motor neuron diseases (mnd), huntington's disease (hd), spinocerebellar ataxia (sca), and spinal muscular atrophy (sma), is mainly addressed to motor and cognitive impairment, with special care to vital functions as breathing and feeding. |
2017-03-01 |
2023-08-13 |
Not clear |
| Adam W Avery, Jonathan Crain, David D Thomas, Thomas S Hay. A human β-III-spectrin spinocerebellar ataxia type 5 mutation causes high-affinity F-actin binding. Scientific reports. vol 6. 2016-12-26. PMID:26883385. |
spinocerebellar ataxia type 5 (sca5) is a human neurodegenerative disease that stems from mutations in the sptbn2 gene encoding the protein β-iii-spectrin. |
2016-12-26 |
2023-08-13 |
human |
| M Asher, A Johnson, B Zecevic, D Pease, M Cvetanovi. Ataxin-1 regulates proliferation of hippocampal neural precursors. Neuroscience. vol 322. 2016-12-13. PMID:26876606. |
polyglutamine expansion in the protein ataxin-1 (atxn1) causes spinocerebellar ataxia type 1 (sca1), an inherited neurodegenerative disease characterized by motor deficits, cognitive impairment and depression. |
2016-12-13 |
2023-08-13 |
mouse |
| Lipin Liang, Tao Chen, Yan W. The electrophysiology of spinocerebellar ataxias. Neurophysiologie clinique = Clinical neurophysiology. vol 46. issue 1. 2016-12-13. PMID:26947625. |
spinocerebellar ataxias (scas) are a group of autosomal dominantly inherited neurodegenerative diseases, involving the cerebellum and the brainstem. |
2016-12-13 |
2023-08-13 |
Not clear |
| Adele G Marthaler, Alisa Tubsuwan, Benjamin Schmid, Ulla B Poulsen, Poul Hyttel, Jørgen E Nielsen, Troels T Nielsen, Bjørn Hols. Generation of spinocerebellar ataxia type 2 patient-derived iPSC line H271. Stem cell research. vol 16. issue 1. 2016-12-13. PMID:27345803. |
spinocerebellar ataxia type 2 (sca2) is a neurodegenerative disease primarily affecting the cerebellum. |
2016-12-13 |
2023-08-13 |
Not clear |
| Adele G Marthaler, Benjamin Schmid, Alisa Tubsuwan, Ulla B Poulsen, Alexander F Engelbrecht, Ulrike A Mau-Holzmann, Poul Hyttel, Jørgen E Nielsen, Troels T Nielsen, Bjørn Hols. Generation of an isogenic, gene-corrected control cell line of the spinocerebellar ataxia type 2 patient-derived iPSC line H196. Stem cell research. vol 16. issue 1. 2016-12-13. PMID:27345804. |
spinocerebellar ataxia type 2 (sca2) is a neurodegenerative disease primarily affecting the cerebellum. |
2016-12-13 |
2023-08-13 |
Not clear |
| Adele G Marthaler, Benjamin Schmid, Alisa Tubsuwan, Ulla B Poulsen, Poul Hyttel, Troels T Nielsen, Jørgen E Nielsen, Bjørn Hols. Generation of spinocerebellar ataxia type 2 patient-derived iPSC line H266. Stem cell research. vol 16. issue 1. 2016-12-13. PMID:27345805. |
spinocerebellar ataxia type 2 (sca2) is a neurodegenerative disease primarily affecting the cerebellum. |
2016-12-13 |
2023-08-13 |
Not clear |
| Adele G Marthaler, Benjamin Schmid, Alisa Tubsuwan, Ulla B Poulsen, Alexander F Engelbrecht, Ulrike A Mau-Holzmann, Poul Hyttel, Jørgen E Nielsen, Troels T Nielsen, Bjørn Hols. Generation of an isogenic, gene-corrected control cell line of the spinocerebellar ataxia type 2 patient-derived iPSC line H271. Stem cell research. vol 16. issue 1. 2016-12-13. PMID:27345809. |
spinocerebellar ataxia type 2 (sca2) is a neurodegenerative disease primarily affecting the cerebellum. |
2016-12-13 |
2023-08-13 |
Not clear |
| Adele G Marthaler, Benjamin Schmid, Alisa Tubsuwan, Ulla B Poulsen, Poul Hyttel, Troels T Nielsen, Jørgen E Nielsen, Bjørn Hols. Generation of spinocerebellar ataxia type 2 patient-derived iPSC line H196. Stem cell research. vol 16. issue 1. 2016-12-13. PMID:27345814. |
spinocerebellar ataxia type 2 (sca2) is a neurodegenerative disease primarily affecting the cerebellum. |
2016-12-13 |
2023-08-13 |
Not clear |
| Adele G Marthaler, Alisa Tubsuwan, Benjamin Schmid, Ulla B Poulsen, Alexander F Engelbrecht, Ulrike A Mau-Holzmann, Poul Hyttel, Troels T Nielsen, Jørgen E Nielsen, Bjørn Hols. Generation of an isogenic, gene-corrected control cell line of the spinocerebellar ataxia type 2 patient-derived iPSC line H266. Stem cell research. vol 16. issue 1. 2016-12-13. PMID:27345815. |
spinocerebellar ataxia type 2 (sca2) is a neurodegenerative disease primarily affecting the cerebellum. |
2016-12-13 |
2023-08-13 |
Not clear |
| Nahyun Choi, Jongmin Park, Jeon-Soo Lee, Jeehyun Yoe, Guk Yeol Park, Eunjeong Kim, Hyeongrin Jeon, Yong Mee Cho, Tae-Young Roh, Yoontae Le. miR-93/miR-106b/miR-375-CIC-CRABP1: a novel regulatory axis in prostate cancer progression. Oncotarget. vol 6. issue 27. 2016-08-12. PMID:26124181. |
capicua (cic) has been implicated in pathogenesis of spinocerebellar ataxia type-1 (sca1) neurodegenerative disease and some types of cancer; however, the role of cic in prostate cancer remains unknown. |
2016-08-12 |
2023-08-13 |
human |
| Mayumi F Kohiyama, Sarita Lagalwa. Stabilization and Degradation Mechanisms of Cytoplasmic Ataxin-1. Journal of experimental neuroscience. vol 9. issue Suppl 2. 2016-05-12. PMID:27168726. |
the neurodegenerative disease spinocerebellar ataxia type 1 (sca1) is caused by a coding polyglutamine expansion in the ataxin-1 gene (atxn1), which gives rise to the aggregation-prone mutant form of atxn1 protein. |
2016-05-12 |
2023-08-13 |
Not clear |
| Stephanie Santarriaga, Amber Petersen, Kelechi Ndukwe, Anthony Brandt, Nashaat Gerges, Jamie Bruns Scaglione, Kenneth Matthew Scaglion. The Social Amoeba Dictyostelium discoideum Is Highly Resistant to Polyglutamine Aggregation. The Journal of biological chemistry. vol 290. issue 42. 2016-02-16. PMID:26330554. |
the expression, misfolding, and aggregation of long repetitive amino acid tracts are a major contributing factor in a number of neurodegenerative diseases, including c9orf72 amyotrophic lateral sclerosis/frontotemporal dementia, fragile x tremor ataxia syndrome, myotonic dystrophy type 1, spinocerebellar ataxia type 8, and the nine polyglutamine diseases. |
2016-02-16 |
2023-08-13 |
mouse |