| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Susanne Nikolaus, Hans-Wilhelm Müller, Hubertus Hautze. Different patterns of 5-HT receptor and transporter dysfunction in neuropsychiatric disorders--a comparative analysis of in vivo imaging findings. Reviews in the neurosciences. vol 27. issue 1. 2016-10-20. PMID:26376220. |
impairment of serotonin receptor and transporter function is increasingly recognized to play a major role in the pathophysiology of neuropsychiatric diseases including anxiety disorder (ad), major depressive disorder (mdd), bipolar disorder (bd) and schizophrenia (sz). |
2016-10-20 |
2023-08-13 |
Not clear |
| Pei-Ken Hsu, Bin Xu, Jun Mukai, Maria Karayiorgou, Joseph A Gogo. The BDNF Val66Met variant affects gene expression through miR-146b. Neurobiology of disease. vol 77. 2016-01-06. PMID:25771167. |
the bdnf val66met snp has been associated with a number of psychiatric disorders such as depression, anxiety disorders, schizophrenia and related traits. |
2016-01-06 |
2023-08-13 |
mouse |
| Laura Altweck, Tara C Marshall, Nelli Ferenczi, Katharina Lefringhause. Mental health literacy: a cross-cultural approach to knowledge and beliefs about depression, schizophrenia and generalized anxiety disorder. Frontiers in psychology. vol 6. 2015-10-07. PMID:26441699. |
mental health literacy: a cross-cultural approach to knowledge and beliefs about depression, schizophrenia and generalized anxiety disorder. |
2015-10-07 |
2023-08-13 |
Not clear |
| Anna Comparelli, Antonella De Carolis, Emanuele Emili, Silvia Rigucci, Ilaria Falcone, Valentina Corigliano, Martina Curto, Giada Trovini, Julia Dehning, Giorgio D Kotzalidis, Paolo Girard. Basic symptoms and psychotic symptoms: their relationships in the at risk mental states, first episode and multi-episode schizophrenia. Comprehensive psychiatry. vol 55. issue 4. 2015-09-07. PMID:24556516. |
to explore the relationship between basic symptoms (bss) and other symptom domains in different phases of the psychotic illness 32 at ultra-high risk (uhr), 49 first episode schizophrenia (fes), 42 multiple episode schizophrenia (mes), and 28 generalized anxiety disorder (gad) patients were enrolled. |
2015-09-07 |
2023-08-12 |
human |
| S Nikolaus, H Hautzel, H-W Mülle. Focus on GABA(A) receptor function. A comparative analysis of in vivo imaging studies in neuropsychiatric disorders. Nuklearmedizin. Nuclear medicine. vol 53. issue 6. 2015-08-19. PMID:25483111. |
impairment of gaba(a) receptor function is increasingly recognized to play a major role in the pathophysiology of neuropsychiatric diseases including anxiety disorder (ad), major depressive disorder (mdd) and schizophrenia (sz). |
2015-08-19 |
2023-08-13 |
Not clear |
| Justine M Gatt, Karen L O Burton, Leanne M Williams, Peter R Schofiel. Specific and common genes implicated across major mental disorders: a review of meta-analysis studies. Journal of psychiatric research. vol 60. 2015-08-04. PMID:25287955. |
here we undertook a review of genes that have been identified in prior meta-analyses examining specific genes and specific mental disorders that have core disruptions to emotional and cognitive function and contribute most to burden of illness- major depressive disorder (mdd), anxiety disorders (ad, including panic disorder and obsessive compulsive disorder), schizophrenia (sz) and bipolar disorder (bd) and attention deficit hyperactivity disorder (adhd). |
2015-08-04 |
2023-08-13 |
Not clear |
| Eduardo R Zimmer, Vitor R Torrez, Eduardo Kalinine, Marina C Augustin, Kamila C Zenki, Roberto F Almeida, Gisele Hansel, Alexandre P Muller, Diogo O Souza, Rodrigo Machado-Vieira, Luis V Portel. Long-term NMDAR antagonism correlates reduced astrocytic glutamate uptake with anxiety-like phenotype. Frontiers in cellular neuroscience. vol 9. 2015-06-19. PMID:26089779. |
the role of glutamate n-methyl-d-aspartate receptor (nmdar) hypofunction has been extensively studied in schizophrenia; however, less is known about its role in anxiety disorders. |
2015-06-19 |
2023-08-13 |
mouse |
| Paul R A Stokes, Jim F Myers, Nicola J Kalk, Ben J Watson, David Erritzoe, Sue J Wilson, Vincent J Cunningham, Daniela Riano Barros, Alexander Hammers, Federico E Turkheimer, David J Nutt, Anne R Lingford-Hughe. Acute increases in synaptic GABA detectable in the living human brain: a [¹¹C]Ro15-4513 PET study. NeuroImage. vol 99. 2015-04-13. PMID:24844747. |
the inhibitory γ-aminobutyric acid (gaba) neurotransmitter system is associated with the regulation of normal cognitive functions and dysregulation has been reported in a number of neuropsychiatric disorders including anxiety disorders, schizophrenia and addictions. |
2015-04-13 |
2023-08-13 |
human |
| Andrii Rudenko, Jinsoo Seo, Ji Hu, Susan C Su, Froylan Calderon de Anda, Omer Durak, Maria Ericsson, Marie Carlén, Li-Huei Tsa. Loss of cyclin-dependent kinase 5 from parvalbumin interneurons leads to hyperinhibition, decreased anxiety, and memory impairment. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 6. 2015-04-13. PMID:25673832. |
our findings suggest that cdk5 can be considered a promising therapeutic target in a variety of conditions attributed to inhibitory interneuronal dysfunction, such as epilepsy, anxiety disorders, and schizophrenia. |
2015-04-13 |
2023-08-13 |
mouse |
| Rachel Hershenberg, Daniel F Gros, Olga Brawman-Mintze. Role of atypical antipsychotics in the treatment of generalized anxiety disorder. CNS drugs. vol 28. issue 6. 2015-01-22. PMID:24794100. |
atypical antipsychotics such as quetiapine, aripiprazole, olanzapine, and risperidone have been shown to be helpful in addressing a range of anxiety and depressive symptoms in individuals with schizophrenia and schizoaffective disorders, and have since been used in the treatment of a range of mood and anxiety disorders. |
2015-01-22 |
2023-08-13 |
human |
| Frauke Nees, Sebastian T Pohlac. Functional MRI studies of the hippocampus. Frontiers of neurology and neuroscience. vol 34. 2014-12-16. PMID:24777133. |
besides the importance of such studies for basic research, the investigation of hippocampal (dys)function has clinical relevance for diseases ranging from neurological disorders such as alzheimer's disease or epilepsy to mental disorders such as schizophrenia or anxiety disorders. |
2014-12-16 |
2023-08-13 |
human |
| Man Luo, Xiang Simon Wang, Bryan L Roth, Alexander Golbraikh, Alexander Tropsh. Application of quantitative structure-activity relationship models of 5-HT1A receptor binding to virtual screening identifies novel and potent 5-HT1A ligands. Journal of chemical information and modeling. vol 54. issue 2. 2014-10-23. PMID:24410373. |
the 5-hydroxytryptamine 1a (5-ht1a) serotonin receptor has been an attractive target for treating mood and anxiety disorders such as schizophrenia. |
2014-10-23 |
2023-08-12 |
Not clear |
| Hani Zainal, Iliana Magiati, Julianne Wen-Li Tan, Min Sung, Daniel S S Fung, Patricia Howli. A preliminary investigation of the Spence Children's Anxiety Parent Scale as a screening tool for anxiety in young people with autism spectrum disorders. Journal of autism and developmental disorders. vol 44. issue 8. 2014-10-20. PMID:24573336. |
this study investigated the use of the spence children's anxiety scale-parent version (scas-p) as a screening tool for anxiety disorders when compared to a standardized dsm-iv-tr-based clinical interview, the kiddie-schedule for schizophrenia and affective disorders-present and lifetime version (k-sads-pl). |
2014-10-20 |
2023-08-12 |
Not clear |
| María García-Amado, Lucía Prens. Distribution of dopamine transporter immunoreactive fibers in the human amygdaloid complex. The European journal of neuroscience. vol 38. issue 11. 2014-07-16. PMID:24102648. |
these detailed quantitative data on dopamine transporter-positive innervation in the human amygdaloid complex can offer a useful reference in future studies aimed at analysing putative dysfunctions of this system in diseases involving brain dopamine, such as certain anxiety disorders, parkinson's disease and schizophrenia. |
2014-07-16 |
2023-08-12 |
human |
| Toshimasa Marut. [Recent development of the ICD-11 focusing on the draft of its linear structure]. Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica. vol 116. issue 1. 2014-05-20. PMID:24640551. |
in the draft of the linear structure, 25 major categories were classified: neurodevelopmental disorders, disorders of speech and language, schizophrenia and other primary psychotic disorders, catatonia, bipolar and related disorders, depressive disorders, anxiety and fear-related disorders, obsessive-compulsive and related disorders, disorders specifically associated with stress, dissociative disorders, bodily distress disorders, and behavioural factors associated with disorders or diseases classified elsewhere, feeding and eating disorders, elimination disorders, substance intoxication, harmful use of substances, substance dependence, substance withdrawal syndrome, substance-induced mental and behavioural disorders, impulse control disorders, disruptive behaviour and dissocial disorders, disorders of personality, paraphilic disorders, factitious disorders, neurocognitive disorders, and mental and behavioural disorders associated with disorders or diseases classified elsewhere. |
2014-05-20 |
2023-08-12 |
Not clear |
| Clara Passmann Carr, Camilla Maria Severi Martins, Ana Maria Stingel, Vera Braga Lemgruber, Mario Francisco Juruen. The role of early life stress in adult psychiatric disorders: a systematic review according to childhood trauma subtypes. The Journal of nervous and mental disease. vol 201. issue 12. 2014-01-21. PMID:24284634. |
forty-four articles were selected, and most of these articles demonstrate that the subtypes of els are associated with several psychiatric disorders, more specifically: physical abuse, sexual abuse, and unspecified neglect with mood disorders and anxiety disorders; emotional abuse with personality disorders and schizophrenia; and physical neglect with personality disorders. |
2014-01-21 |
2023-08-12 |
Not clear |
| C N J Meunier, M Amar, L Lanfumey, M Hamon, P Fossie. 5-HT(1A) receptors direct the orientation of plasticity in layer 5 pyramidal neurons of the mouse prefrontal cortex. Neuropharmacology. vol 71. 2014-01-10. PMID:23523560. |
this brings a new way to intervene on neuronal networks of the pfc in anxiety disorders and schizophrenia. |
2014-01-10 |
2023-08-12 |
mouse |
| Rebecca A Wright, Bryan G Johnson, Ce Zhang, Craig Salhoff, Ann E Kingston, David O Calligaro, James A Monn, Darryle D Schoepp, Gerard J Mare. CNS distribution of metabotropic glutamate 2 and 3 receptors: transgenic mice and [³H]LY459477 autoradiography. Neuropharmacology. vol 66. 2013-07-02. PMID:22313530. |
group ii metabotropic glutamate (mglu) receptor agonists were efficacious in randomized clinical research trials for schizophrenia and generalized anxiety disorder. |
2013-07-02 |
2023-08-12 |
mouse |
| K Macdonald, D Feife. Helping oxytocin deliver: considerations in the development of oxytocin-based therapeutics for brain disorders. Frontiers in neuroscience. vol 7. 2013-03-20. PMID:23508240. |
from one perspective, the wellspring of bedrock medications for anxiety disorders, depression, and schizophrenia was serendipitously discovered over 30 year ago, the swell of pharmaceutical investment in drug discovery has receded, and the pipeline's flow of medications with unique mechanisms of action (i.e., glutamatergic agents, crf antagonists) has slowed to a trickle. |
2013-03-20 |
2023-08-12 |
human |
| Erica Kirsten Rapp, Mandi Lynn White-Ajmani, Daniel Antonius, Raymond Richard Goetz, Jill Martine Harkavy-Friedman, Adam Jonathan Savitz, Dolores Malaspina, Jeffrey Paul Kah. Schizophrenia comorbid with panic disorder: evidence for distinct cognitive profiles. Psychiatry research. vol 197. issue 3. 2012-11-13. PMID:22417926. |
a total of 255 schizophrenia patients with panic disorder (n=39), non-panic anxiety disorder (n=51), or no anxiety disorder (n=165) were assessed with the wechsler adult intelligence scale-revised, the wisconsin card sorting test, the trail making test, the controlled oral word association test, the animal naming subtest of the boston diagnostic aphasia examination, and the wechsler memory scale-revised. |
2012-11-13 |
2023-08-12 |
Not clear |