| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hanns Möhle. Pathophysiological aspects of diversity in neuronal inhibition: a new benzodiazepine pharmacology. Dialogues in clinical neuroscience. vol 4. issue 3. 2012-09-10. PMID:22034214. |
on the basis of brain imaging and human genetics, a deficit in gabaergic inhibition (gaba, γ-aminobuiyric acid) has been identified as contributing to the pathophysiology of anxiety disorders, epilepsy, and schizophrenia. |
2012-09-10 |
2023-08-12 |
human |
| Christopher J Machado, Eliza Bliss-Moreau, Michael L Platt, David G Amara. Social and nonsocial content differentially modulates visual attention and autonomic arousal in Rhesus macaques. PloS one. vol 6. issue 10. 2012-03-26. PMID:22046313. |
deficits in social information processing and emotion regulation are important components of many human psychiatric illnesses, such as autism, schizophrenia and social anxiety disorder. |
2012-03-26 |
2023-08-12 |
human |
| Hanns Möhle. The rise of a new GABA pharmacology. Neuropharmacology. vol 60. issue 7-8. 2012-01-18. PMID:21035473. |
his passion for innovative science, and his quest for novel therapies for psychiatric disorders are particularly apparent in his fundamental contributions to the field of gaba research, with a focus on anxiety disorders and schizophrenia. |
2012-01-18 |
2023-08-12 |
Not clear |
| T Panigada, R-D Gosseli. Behavioural alteration in chronic pain: are brain glia involved? Medical hypotheses. vol 77. issue 4. 2011-12-29. PMID:21741179. |
indeed, in mood disorders (unipolar depression, anxiety disorders, autism or schizophrenia) glial changes in brain regions involved in mood control (prefrontal and cingulate cortices, amygdala and the hippocampus) have been recurrently described. |
2011-12-29 |
2023-08-12 |
Not clear |
| Gretchen Hermes, Nanxin Li, Catharine Duman, Ronald Duma. Post-weaning chronic social isolation produces profound behavioral dysregulation with decreases in prefrontal cortex synaptic-associated protein expression in female rats. Physiology & behavior. vol 104. issue 2. 2011-10-14. PMID:21185848. |
similar studies in male rodents have shown that this form of social deprivation results in dysregulated dopaminergic and serotonergic functions in the brain with core features of neuropsychiatric disorders including anxiety disorder and schizophrenia. |
2011-10-14 |
2023-08-12 |
rat |
| Andreas Meyer-Lindenberg, Gregor Domes, Peter Kirsch, Markus Heinrich. Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine. Nature reviews. Neuroscience. vol 12. issue 9. 2011-10-13. PMID:21852800. |
oxt and avp are emerging as targets for novel treatment approaches--particularly in synergistic combination with psychotherapy--for mental disorders characterized by social dysfunction, such as autism, social anxiety disorder, borderline personality disorder and schizophrenia. |
2011-10-13 |
2023-08-12 |
human |
| M L H J Hermes, L P Renau. Postsynaptic and presynaptic group II metabotropic glutamate receptor activation reduces neuronal excitability in rat midline paraventricular thalamic nucleus. The Journal of pharmacology and experimental therapeutics. vol 336. issue 3. 2011-04-21. PMID:21139059. |
drugs that interact with group ii metabotropic glutamate receptors (mglurs) are presently being evaluated for a role in the treatment of anxiety disorders and symptoms of schizophrenia. |
2011-04-21 |
2023-08-12 |
rat |
| Serap Erdoğa. [Quetiapine in substance use disorders, abuse and dependence possibility: a review]. Turk psikiyatri dergisi = Turkish journal of psychiatry. vol 21. issue 2. 2010-10-29. PMID:20514567. |
in addition to reports of its use in schizophrenia and bipolar disorder, many studies have examined the use of quetiapine in the treatment of anxiety disorders and substance use disorders. |
2010-10-29 |
2023-08-12 |
Not clear |
| Serge Schneider, Estelle Sibille, Michel Yegles, Hugo Neels, Robert Wennig, Annette Müh. Time resolved analysis of risperidone and 9-hydroxy-risperidone in hair using LC/MS-MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 877. issue 24. 2009-09-24. PMID:19595645. |
time resolved analysis of risperidone and 9-hydroxy-risperidone in hair using lc/ms-ms. risperidone (rsp) is a second generation anti-psychotic drug used for the treatment of schizophrenia and anxiety disorders. |
2009-09-24 |
2023-08-12 |
human |
| Gerard J Mare. Activation of adenosine(1) (A(1)) receptors suppresses head shakes induced by a serotonergic hallucinogen in rats. Neuropharmacology. vol 56. issue 8. 2009-08-28. PMID:19324062. |
modulation of glutamatergic neurotransmission by metabotropic glutamate2/3 (mglu2/3) receptor agonists effectively treats seemingly diverse neuropsychiatric illness such as generalized anxiety disorder and schizophrenia. |
2009-08-28 |
2023-08-12 |
rat |
| Ashish Dhir, S K Kulkarn. New therapeutic promises in the treatment of depression and schizophrenia. Drug news & perspectives. vol 21. issue 10. 2009-07-14. PMID:19221639. |
keeping its tradition, the cinp congress addressed the main issues related to mental depression, schizophrenia and anxiety disorders. |
2009-07-14 |
2023-08-12 |
Not clear |
| Christie D Fowler, Michael A Arends, Paul J Kenn. Subtypes of nicotinic acetylcholine receptors in nicotine reward, dependence, and withdrawal: evidence from genetically modified mice. Behavioural pharmacology. vol 19. issue 5-6. 2008-12-31. PMID:18690103. |
thus, we also briefly review data generated from genetically modified mice to support a role for discrete nachr subunits in anxiety disorders, depression, and schizophrenia. |
2008-12-31 |
2023-08-12 |
mouse |
| Kristina Zdanys, Rajesh R Tamp. A systematic review of off-label uses of memantine for psychiatric disorders. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 6. 2008-10-22. PMID:18262702. |
recent data points to glutamatergic dysfunction in mood disorders, anxiety disorders, obsessive-compulsive disorder, and schizophrenia. |
2008-10-22 |
2023-08-12 |
Not clear |
| F Markus Leweke, Dagmar Koeth. Cannabis and psychiatric disorders: it is not only addiction. Addiction biology. vol 13. issue 2. 2008-07-08. PMID:18482435. |
since the discovery of the endocannabinoid system, a growing body of psychiatric research has emerged focusing on the role of this system in major psychiatric disorders like schizophrenia (scz), bipolar disorder (bd), major depression and anxiety disorder. |
2008-07-08 |
2023-08-12 |
Not clear |
| Jean-Martin Beaulieu, Xiaodong Zhang, Ramona M Rodriguiz, Tatyana D Sotnikova, Michael J Cools, William C Wetsel, Raul R Gainetdinov, Marc G Caro. Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 4. 2008-02-25. PMID:18212115. |
dysregulation of brain serotonin (5-ht) neurotransmission is thought to underlie mental conditions as diverse as depression, anxiety disorders, bipolar disorder, autism, and schizophrenia. |
2008-02-25 |
2023-08-12 |
mouse |
| Divya Vohor. Atypical antipsychotic drugs: current issues of safety and efficacy in the management of schizophrenia. Current opinion in investigational drugs (London, England : 2000). vol 8. issue 7. 2007-09-04. PMID:17659473. |
furthermore, their differential effects on anxiety disorders, treatment-resistant depressive illness, cognitive functions and manic disorders may influence the selection of atypical antipsychotics for conditions associated with schizophrenia. |
2007-09-04 |
2023-08-12 |
Not clear |
| Simon Gilbody, Sarah Lewis, Tracy Lightfoo. Methylenetetrahydrofolate reductase (MTHFR) genetic polymorphisms and psychiatric disorders: a HuGE review. American journal of epidemiology. vol 165. issue 1. 2007-02-15. PMID:17074966. |
the authors performed a meta-analysis of studies examining the association between polymorphisms in the 5,10-methylenetetrahydrofolate reductase (mthfr) gene, including mthfr c677t and a1298c, and common psychiatric disorders, including unipolar depression, anxiety disorders, bipolar disorder, and schizophrenia. |
2007-02-15 |
2023-08-12 |
Not clear |
| Ruggero Galici, Carrie K Jones, Kamondanai Hemstapat, Yi Nong, Nicholas G Echemendia, Lilly C Williams, Tomas de Paulis, P Jeffrey Con. Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice. The Journal of pharmacology and experimental therapeutics. vol 318. issue 1. 2006-08-14. PMID:16608916. |
previous studies indicate that agonists of the group ii metabotropic glutamate receptors (mglurs), mglur2 and mglur3, may provide a novel approach for the treatment of anxiety disorders and schizophrenia. |
2006-08-14 |
2023-08-12 |
mouse |
| Paul P Bertrand, Udeni T Paranavitane, Carolina Chavez, Andrea Gogos, Margaret Jones, Maarten van den Buus. The effect of low estrogen state on serotonin transporter function in mouse hippocampus: a behavioral and electrochemical study. Brain research. vol 1064. issue 1-2. 2006-03-07. PMID:16298349. |
defects in serotonergic transmission, including serotonin transporter (sert) function, have been implicated in depression, anxiety disorders and some aspects of schizophrenia. |
2006-03-07 |
2023-08-12 |
mouse |
| Han-Joo Lee, Zoung-Soul Kim, Seok-Man Kwo. Thought disorder in patients with obsessive-compulsive disorder. Journal of clinical psychology. vol 61. issue 4. 2005-07-08. PMID:15625680. |
we compared 15 ocd patients primarily displaying autogenous obsessions (aos), 14 ocd patients primarily displaying reactive obsessions (ros), 32 patients with schizophrenia (sprs), and 28 patients with other anxiety disorders (oads) with respect to thought disorders as assessed by the comprehensive system of the rorschach inkblot test. |
2005-07-08 |
2023-08-12 |
Not clear |