| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria Arbaizar-Rovirosa, Jordi Pedragosa, Juan J Lozano, Carme Casal, Albert Pol, Mattia Gallizioli, Anna M Plana. Aged lipid-laden microglia display impaired responses to stroke. EMBO molecular medicine. 2022-12-21. PMID:36541061. |
moreover, old mice with renewed microglia showed improved motor function 2 weeks after stroke. |
2022-12-21 |
2023-08-14 |
mouse |
| Corinne Benakis, Alba Simats, Sophie Tritschler, Steffanie Heindl, Simon Besson-Girard, Gemma Llovera, Kelsey Pinkham, Anna Kolz, Alessio Ricci, Fabian J Theis, Stefan Bittner, Özgün Gökce, Anneli Peters, Arthur Lies. T cells modulate the microglial response to brain ischemia. eLife. vol 11. 2022-12-13. PMID:36512388. |
neuroinflammation after stroke is characterized by the activation of resident microglia and the invasion of circulating leukocytes into the brain. |
2022-12-13 |
2023-08-14 |
mouse |
| Corinne Benakis, Alba Simats, Sophie Tritschler, Steffanie Heindl, Simon Besson-Girard, Gemma Llovera, Kelsey Pinkham, Anna Kolz, Alessio Ricci, Fabian J Theis, Stefan Bittner, Özgün Gökce, Anneli Peters, Arthur Lies. T cells modulate the microglial response to brain ischemia. eLife. vol 11. 2022-12-13. PMID:36512388. |
here, using a mouse model for ischemic stroke, we demonstrated that early activation of microglia in response to stroke is differentially regulated by distinct t cell subpopulations - with t |
2022-12-13 |
2023-08-14 |
mouse |
| Wei Liu, Zitong Qi, Wanmeng Li, Jia Liang, Liang Zhao, Yijie Sh. M1 Microglia Induced Neuronal Injury on Ischemic Stroke via Mitochondrial Crosstalk between Microglia and Neurons. Oxidative medicine and cellular longevity. vol 2022. 2022-12-08. PMID:36478988. |
traditionally, it is recognized that when stroke occurs, microglia are activated into m1 phenotype and release cytotoxic cytokines, reactive oxygen species, proteases, and other factors, thus exacerbating the injury by further destroying or killing nearby neurons. |
2022-12-08 |
2023-08-14 |
rat |
| Yu Chen, Fu Peng, Ziwei Xing, Junren Chen, Cheng Peng, Dan L. Beneficial effects of natural flavonoids on neuroinflammation. Frontiers in immunology. vol 13. 2022-11-10. PMID:36353622. |
neuroinflammation is the fundamental immune response against multiple factors in the central nervous system and is characterized by the production of inflammatory mediators, activated microglia and astrocytes, and the recruitment of innate and adaptive immune cells to inflammatory sites, that contributes to the pathological process of related brain diseases, such as alzheimer's disease, parkinson's disease, depression, and stroke. |
2022-11-10 |
2023-08-14 |
Not clear |
| Jiale Gao, Mingjiang Yao, Wei Zhang, Bin Yang, Guo Yuan, Jian-Xun Liu, Yunling Zhan. Panax notoginseng saponins alleviates inflammation induced by microglial activation and protects against ischemic brain injury via inhibiting HIF-1α/PKM2/STAT3 signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 155. 2022-10-22. PMID:36271540. |
it is believed that pns has obvious anti-inflammatory effect, however, the roles of pns on microglia after stroke have not been completely explored and the underlying mechanism of microglia-mediated inflammation remains to be clarified. |
2022-10-22 |
2023-08-14 |
mouse |
| Jiale Gao, Mingjiang Yao, Wei Zhang, Bin Yang, Guo Yuan, Jian-Xun Liu, Yunling Zhan. Panax notoginseng saponins alleviates inflammation induced by microglial activation and protects against ischemic brain injury via inhibiting HIF-1α/PKM2/STAT3 signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 155. 2022-10-22. PMID:36271540. |
here we only explored the effect of pkm2 on activated microglia, and we would further investigate the impact of pkm2 expressed in other cells on stroke outcome in the future. |
2022-10-22 |
2023-08-14 |
mouse |
| Yuan Wang, Rehana K Leak, Guodong Ca. Microglia-mediated neuroinflammation and neuroplasticity after stroke. Frontiers in cellular neuroscience. vol 16. 2022-09-02. PMID:36052339. |
microglia can exist in pro-inflammatory states and promote secondary brain damage, but they can also secrete anti-inflammatory cytokines and neurotrophic factors and facilitate recovery following stroke. |
2022-09-02 |
2023-08-14 |
Not clear |
| Elisabeth Harmon, Andrea Doan, Jesus Bautista-Garrido, Joo Eun Jung, Sean P Marrelli, Gab Seok Ki. Increased Expression of Interferon-Induced Transmembrane 3 (IFITM3) in Stroke and Other Inflammatory Conditions in the Brain. International journal of molecular sciences. vol 23. issue 16. 2022-08-26. PMID:36012150. |
in collaboration with other cell types in brains, microglia can contribute both to worsened outcome following stroke or other neurodegenerative diseases and to the recovery process by changing their phenotype toward reparative microglia. |
2022-08-26 |
2023-08-14 |
Not clear |
| Elisabeth Harmon, Andrea Doan, Jesus Bautista-Garrido, Joo Eun Jung, Sean P Marrelli, Gab Seok Ki. Increased Expression of Interferon-Induced Transmembrane 3 (IFITM3) in Stroke and Other Inflammatory Conditions in the Brain. International journal of molecular sciences. vol 23. issue 16. 2022-08-26. PMID:36012150. |
our findings on the expression of ifitm3 in microglia and in aged brains following stroke could establish the basic foundations for the role of ifitm3 in a variety of neurodegenerative diseases, particularly those that are prevalent or enhanced in the aged brain. |
2022-08-26 |
2023-08-14 |
Not clear |
| Meiling Yao, Ying Luo, Hongjie Li, Songjie Liao, Jian Y. LncRNA Tug1 Contributes Post-stroke NLRP3 Inflammasome-Dependent Pyroptosis via miR-145a-5p/Tlr4 Axis. Molecular neurobiology. 2022-08-21. PMID:35989413. |
photo-thrombosis stroke mice and ogd-treated bv-2 microglia were established respectively. |
2022-08-21 |
2023-08-14 |
mouse |
| Conelius Ngwa, Abdullah Al Mamun, Shaohua Qi, Romana Sharmeen, Yan Xu, Fudong Li. Regulation of microglial activation in stroke in aged mice: a translational study. Aging. vol 14. issue undefined. 2022-08-13. PMID:35963621. |
we found aged microglia express higher levels of irf5 and lower levels of irf4 than young microglia after stroke. |
2022-08-13 |
2023-08-14 |
mouse |
| Yehao Zhang, Lan Miao, Qing Peng, Xiaodi Fan, Wenting Song, Bin Yang, Peng Zhang, Guangyu Liu, Jianxun Li. Parthenolide modulates cerebral ischemia-induced microglial polarization and alleviates neuroinflammatory injury via the RhoA/ROCK pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 105. 2022-08-10. PMID:35947899. |
microglia can be activated as proinflammatory (m1) phenotypes and anti-inflammatory (m2) phenotypes after stroke. |
2022-08-10 |
2023-08-14 |
Not clear |
| Stefano Raffaele, Marta Fumagall. Dynamics of Microglia Activation in the Ischemic Brain: Implications for Myelin Repair and Functional Recovery. Frontiers in cellular neuroscience. vol 16. 2022-07-28. PMID:35899017. |
some molecular signals regulating the pro-regenerative functions of microglia after stroke have been highlighted to provide new possible therapeutic targets involved in the protective functions of these cells. |
2022-07-28 |
2023-08-14 |
Not clear |
| Xiao Ke, Manfei Deng, Zhuoze Wu, Hongyan Yu, Dian Yu, Hao Li, Youming Lu, Kai Shu, Lei Pe. miR-34b-3p Inhibition of eIF4E Causes Post-stroke Depression in Adult Mice. Neuroscience bulletin. 2022-07-08. PMID:35802246. |
together, our data demonstrated that insufficient mir34b-3p after stroke cannot inhibit eif4e translation, which causes psd by the activation of microglia in the hippocampus. |
2022-07-08 |
2023-08-14 |
mouse |
| Hyo Jung Shin, Ka Young Lee, Joon Won Kang, Seung Gyu Choi, Dong Woon Kim, Yoon Young Y. Perampanel Reduces Brain Damage via Induction of M2 Microglia in a Neonatal Rat Stroke Model. International journal of nanomedicine. vol 17. 2022-07-05. PMID:35782016. |
perampanel reduces brain damage via induction of m2 microglia in a neonatal rat stroke model. |
2022-07-05 |
2023-08-14 |
rat |
| Hyo Jung Shin, Ka Young Lee, Joon Won Kang, Seung Gyu Choi, Dong Woon Kim, Yoon Young Y. Perampanel Reduces Brain Damage via Induction of M2 Microglia in a Neonatal Rat Stroke Model. International journal of nanomedicine. vol 17. 2022-07-05. PMID:35782016. |
in this study, we investigated the effect of perampanel (per)-loaded poly lactic-co-glycolic acid (plga) by targeting microglia in perinatal stroke. |
2022-07-05 |
2023-08-14 |
rat |
| Shin-Shin Lee, Li Pang, Yin Cheng, Jia Xin Liu, Anson Cho Kiu Ng, Gilberto Ka Kit Leun. A previous hemorrhagic stroke protects against a subsequent stroke via microglia alternative polarization. Communications biology. vol 5. issue 1. 2022-07-02. PMID:35780249. |
a previous hemorrhagic stroke protects against a subsequent stroke via microglia alternative polarization. |
2022-07-02 |
2023-08-14 |
mouse |
| Yoshiki Hase, Kamar E Ameen-Ali, Rachel Waller, Julie E Simpson, Charlotte Stafford, Ayushi Mahesh, Lucy Ryan, Lucy Pickering, Caroline Bodman, Mai Hase, Delphine Boche, Karen Horsburgh, Stephen B Wharton, Raj N Kalari. Differential perivascular microglial activation in the deep white matter in vascular dementia developed post-stroke. Brain pathology (Zurich, Switzerland). 2022-06-24. PMID:35748290. |
with the hypothesis that perivascular microglia are involved as neuroinflammatory components of the gliovascular unit contributing to white matter hyperintensities on mri and pathophysiology, we assessed their status in stroke survivors who develop dementia. |
2022-06-24 |
2023-08-14 |
human |
| Clara Bourget, Kelsey V Adams, Cindi M Morshea. Reduced microglia activation following metformin administration or microglia ablation is sufficient to prevent functional deficits in a mouse model of neonatal stroke. Journal of neuroinflammation. vol 19. issue 1. 2022-06-15. PMID:35705953. |
reduced microglia activation following metformin administration or microglia ablation is sufficient to prevent functional deficits in a mouse model of neonatal stroke. |
2022-06-15 |
2023-08-14 |
mouse |