| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jayvik Joshi, Minmin Yao, Aaron Kakazu, Yuxiao Ouyang, Wenzhen Duan, Manisha Aggarwa. Distinguishing microgliosis and tau deposition in the mouse brain using paramagnetic and diamagnetic susceptibility source separation. bioRxiv : the preprint server for biology. 2024-04-25. PMID:38659855. |
tauopathies, including alzheimer's disease (ad), are neurodegenerative disorders characterized by hyperphosphorylated tau protein aggregates in the brain. |
2024-04-25 |
2024-04-28 |
mouse |
| Nathalie Kyalu Ngoie Zola, Clémence Balty, Didier Vertommen, Bernard Jimmy Hanseeu. [Specific modifications of the soluble tau protein distinguish Alzheimer's disease from other tauopathies]. Medecine sciences : M/S. vol 40. issue 4. 2024-04-23. PMID:38651955. |
[specific modifications of the soluble tau protein distinguish alzheimer's disease from other tauopathies]. |
2024-04-23 |
2024-04-26 |
Not clear |
| Madia Lozupone, Vittorio Dibello, Antonio Daniele, Vincenzo Solfrizzi, Emanuela Resta, Francesco Panz. How can we manage progressive supranuclear palsy syndrome with pharmacotherapy? Expert opinion on pharmacotherapy. 2024-04-23. PMID:38653731. |
tauopathies are a spectrum of clinicopathological neurodegenerative disorders with increased aggregates included in glia and/or neurons of hyperphosphorylated insoluble tau protein, a microtubule-associated protein. |
2024-04-23 |
2024-04-26 |
Not clear |
| Sheng-Jie Hou, Ya-Ru Huang, Jie Zhu, Ying-Bo Jia, Xiao-Yun Niu, Jin-Ju Yang, Xiao-Lin Yu, Xiao-Yu Du, Shi-Yu Liang, Fang Cui, Ling-Jie Li, Chen Tian, Rui-Tian Li. Mouse serum albumin induces neuronal apoptosis and tauopathies. Acta neuropathologica communications. vol 12. issue 1. 2024-04-23. PMID:38654316. |
overall, our study here revealed that msa induced tau phosphorylation and neuron apoptosis based on msa-activated microglia and astrocytes, respectively, showing the critical roles of msa in initiating the occurrence of tauopathies and cognitive decline, and providing potential therapeutic targets for msa-induced neuropathology in multiple neurodegenerative disorders. |
2024-04-23 |
2024-04-26 |
mouse |
| Jonathan Hulse, Nicole Maphis, Julianne Peabody, Bryce Chackerian, Kiran Bhaska. Virus-like particle (VLP)-based vaccine targeting tau phosphorylated at Ser396/Ser404 (PHF1) site outperforms phosphorylated S199/S202 (AT8) site in reducing tau pathology and restoring cognitive deficits in the rTg4510 mouse model of tauopathy. bioRxiv : the preprint server for biology. 2024-04-22. PMID:38644999. |
tauopathies, including alzheimer's disease (ad) and frontotemporal dementia (ftd), are histopathologically defined by the aggregation of hyperphosphorylated pathological tau (ptau) as neurofibrillary tangles in the brain. |
2024-04-22 |
2024-04-24 |
mouse |
| Hariharan Moorthy, Madhu Ramesh, Dikshaa Padhi, Prayasee Baruah, Thimmaiah Govindaraj. Polycatechols inhibit ferroptosis and modulate tau liquid-liquid phase separation to mitigate Alzheimer's disease. Materials horizons. 2024-04-22. PMID:38647314. |
interestingly, pldp promotes tau llps, and modulates their intermolecular interactions to inhibit the formation of toxic tau aggregates, offering a conceptually innovative approach to tackle tauopathies. |
2024-04-22 |
2024-04-26 |
Not clear |
| Thomas Comptdaer, Meryem Tardivel, Claire Schirmer, Luc Buée, Marie-Christine Gala. Cell redistribution of G quadruplex-structured DNA is associated with morphological changes of nuclei and nucleoli in neurons during tau pathology progression. Brain pathology (Zurich, Switzerland). 2024-04-22. PMID:38649330. |
using immunofluorescence coupled to confocal microscopy analysis we investigated the impact of tau pathology, a hallmark of tauopathies including ad, on the distribution of g4 dna in murine neurons and its relevance to ad brains. |
2024-04-22 |
2024-04-26 |
mouse |
| Jana Ackmann, Alina Brüge, Lizaveta Gotina, Sungsu Lim, Kathrin Jahreis, Anna-Lena Vollbrecht, Yun Kyung Kim, Ae Nim Pae, Josephine Labus, Evgeni Ponimaski. Structural determinants for activation of the Tau kinase CDK5 by the serotonin receptor 5-HT7R. Cell communication and signaling : CCS. vol 22. issue 1. 2024-04-19. PMID:38641599. |
in particular, the microtubule-associated protein tau leads to the development of so-called tauopathies characterized by the aggregation of hyperphosphorylated tau within neurons. |
2024-04-19 |
2024-04-22 |
Not clear |
| Chenxi Qiu, Zhixiong Li, David A Leigh, Bingbing Duan, Joseph E Stucky, Nami Kim, George Xie, Kun Ping Lu, Xiao Zhen Zho. The role of the Pin1- Frontiers in cell and developmental biology. vol 12. 2024-04-17. PMID:38628595. |
the role of the pin1- tauopathies are neurodegenerative diseases characterized by deposits of abnormal tau protein in the brain. |
2024-04-17 |
2024-04-19 |
Not clear |
| Chenxi Qiu, Zhixiong Li, David A Leigh, Bingbing Duan, Joseph E Stucky, Nami Kim, George Xie, Kun Ping Lu, Xiao Zhen Zho. The role of the Pin1- Frontiers in cell and developmental biology. vol 12. 2024-04-17. PMID:38628595. |
conventional tauopathies are often defined by a limited number of tau epitopes, notably neurofibrillary tangles, but emerging evidence suggests structural heterogeneity among tauopathies. |
2024-04-17 |
2024-04-19 |
Not clear |
| Liara Rizzi, Lea T Grinber. Publisher Correction: Exploring the significance of caspase-cleaved tau in tauopathies and as a complementary pathology to phospho-tau in Alzheimer's disease: implications for biomarker development and therapeutic targeting. Acta neuropathologica communications. vol 12. issue 1. 2024-04-12. PMID:38610041. |
publisher correction: exploring the significance of caspase-cleaved tau in tauopathies and as a complementary pathology to phospho-tau in alzheimer's disease: implications for biomarker development and therapeutic targeting. |
2024-04-12 |
2024-04-15 |
Not clear |
| Dmytro Morderer, Melissa C Wren, Feilin Liu, Naomi Kouri, Anastasiia Maistrenko, Bilal Khalil, Nora Pobitzer, Michelle Salemi, Brett S Phinney, Dennis W Dickson, Melissa E Murray, Wilfried Rossol. Probe-dependent Proximity Profiling (ProPPr) Uncovers Similarities and Differences in Phospho-Tau-Associated Proteomes Between Tauopathies. bioRxiv : the preprint server for biology. 2024-04-08. PMID:38585836. |
tauopathies represent a diverse group of neurodegenerative disorders characterized by the abnormal aggregation of the microtubule-associated protein tau. |
2024-04-08 |
2024-04-10 |
human |
| Dmytro Morderer, Melissa C Wren, Feilin Liu, Naomi Kouri, Anastasiia Maistrenko, Bilal Khalil, Nora Pobitzer, Michelle Salemi, Brett S Phinney, Dennis W Dickson, Melissa E Murray, Wilfried Rossol. Probe-dependent Proximity Profiling (ProPPr) Uncovers Similarities and Differences in Phospho-Tau-Associated Proteomes Between Tauopathies. bioRxiv : the preprint server for biology. 2024-04-08. PMID:38585836. |
to comprehensively investigate the common and unique protein interactors associated with the variety of tau lesions present across different human tauopathies, alzheimer's disease (ad), corticobasal degeneration (cbd), pick's disease (pid), and progressive supranuclear palsy (psp), were selected to represent the major tauopathy diseases. |
2024-04-08 |
2024-04-10 |
human |
| Dmytro Morderer, Melissa C Wren, Feilin Liu, Naomi Kouri, Anastasiia Maistrenko, Bilal Khalil, Nora Pobitzer, Michelle Salemi, Brett S Phinney, Dennis W Dickson, Melissa E Murray, Wilfried Rossol. Probe-dependent Proximity Profiling (ProPPr) Uncovers Similarities and Differences in Phospho-Tau-Associated Proteomes Between Tauopathies. bioRxiv : the preprint server for biology. 2024-04-08. PMID:38585836. |
our findings provide valuable insights into the proteomic landscape of tauopathies, shedding light on the molecular mechanisms underlying tau pathology. |
2024-04-08 |
2024-04-10 |
human |
| Neha Basheer, Luc Buee, Jean-Pierre Brion, Tomas Smolek, Muhammad Khalid Muhammadi, Jozef Hritz, Tomas Hromadka, Ilse Dewachter, Susanne Wegmann, Isabelle Landrieu, Petr Novak, Amritpal Mudher, Norbert Zilk. Shaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models. Acta neuropathologica communications. vol 12. issue 1. 2024-04-04. PMID:38576010. |
the transcellular propagation of the aberrantly modified protein tau along the functional brain network is a key hallmark of alzheimer's disease and related tauopathies. |
2024-04-04 |
2024-04-07 |
Not clear |
| Nikki McArthur, Bokyung Kang, Felix G Rivera Moctezuma, Akber T Shaikh, Kathryn Loeffler, Nemil N Bhatt, Madison Kidd, Jennifer M Zupancic, Alec A Desai, Naima Djeddar, Anton Bryksin, Peter M Tessier, Rakez Kayed, Levi B Wood, Ravi S Kan. Development of a pan-tau multivalent nanobody that binds tau aggregation motifs and recognizes pathological tau aggregates. Biotechnology progress. 2024-04-03. PMID:38568030. |
alzheimer's disease and other tauopathies are characterized by the misfolding and aggregation of the tau protein into oligomeric and fibrillar structures. |
2024-04-03 |
2024-04-05 |
mouse |
| Andrew P Longhini, Austin DuBose, Samuel Lobo, Vishnu Vijayan, Yeran Bai, Erica Keane Rivera, Julia Sala-Jarque, Arina Nikitina, Daniel C Carrettiero, Matthew T Unger, Olivia R Sclafani, Valerie Fu, Emily R Beckett, Michael Vigers, Luc Buée, Isabelle Landrieu, Scott Shell, Joan E Shea, Songi Han, Kenneth S Kosi. Precision proteoform design for 4R tau isoform selective templated aggregation. Proceedings of the National Academy of Sciences of the United States of America. vol 121. issue 15. 2024-04-03. PMID:38568974. |
prion-like spread of disease-specific tau conformers is a hallmark of all tauopathies. |
2024-04-03 |
2024-04-06 |
Not clear |
| Sarah Buchholz, Hans Zempe. The six brain-specific TAU isoforms and their role in Alzheimer's disease and related neurodegenerative dementia syndromes. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-04-01. PMID:38556838. |
tauopathies, characterized by intracellular aggregates of hyperphosphorylated tau, exhibit extensive neurodegeneration and can be classified by the tau isoforms present in pathological accumulations. |
2024-04-01 |
2024-04-03 |
human |
| Felix Langerscheidt, Tamara Wied, Mohamed Aghyad Al Kabbani, Thilo van Eimeren, Gilbert Wunderlich, Hans Zempe. Genetic forms of tauopathies: inherited causes and implications of Alzheimer's disease-like TAU pathology in primary and secondary tauopathies. Journal of neurology. 2024-03-30. PMID:38554150. |
genetic forms of tauopathies: inherited causes and implications of alzheimer's disease-like tau pathology in primary and secondary tauopathies. |
2024-03-30 |
2024-04-02 |
Not clear |
| Felix Langerscheidt, Tamara Wied, Mohamed Aghyad Al Kabbani, Thilo van Eimeren, Gilbert Wunderlich, Hans Zempe. Genetic forms of tauopathies: inherited causes and implications of Alzheimer's disease-like TAU pathology in primary and secondary tauopathies. Journal of neurology. 2024-03-30. PMID:38554150. |
tauopathies are a heterogeneous group of neurologic diseases characterized by pathological axodendritic distribution, ectopic expression, and/or phosphorylation and aggregation of the microtubule-associated protein tau, encoded by the gene mapt. |
2024-03-30 |
2024-04-02 |
Not clear |