| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Felix Langerscheidt, Michael Bell-Simons, Hans Zempe. Differentiating SH-SY5Y Cells into Polarized Human Neurons for Studying Endogenous and Exogenous Tau Trafficking: Four Protocols to Obtain Neurons with Noradrenergic, Dopaminergic, and Cholinergic Properties. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512687. |
pathological alterations of the neuronal tau protein are characteristic for many neurodegenerative diseases, called tauopathies. |
2024-03-21 |
2024-03-24 |
human |
| Felix Langerscheidt, Michael Bell-Simons, Hans Zempe. Differentiating SH-SY5Y Cells into Polarized Human Neurons for Studying Endogenous and Exogenous Tau Trafficking: Four Protocols to Obtain Neurons with Noradrenergic, Dopaminergic, and Cholinergic Properties. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512687. |
to investigate the underlying mechanisms of tauopathies, human neuronal cell models are required to study tau physiology and pathology in vitro. |
2024-03-21 |
2024-03-24 |
human |
| Yongna Yuan, Xuqi Mao, Xiaohang Pan, Ruisheng Zhang, Wei S. Kinetic Ensemble of Tau Protein through the Markov State Model and Deep Learning Analysis. Journal of chemical theory and computation. 2024-03-19. PMID:38501645. |
the ordered assembly of tau protein into filaments characterizes alzheimer's and other neurodegenerative diseases, and thus, stabilization of tau protein is a promising avenue for tauopathies therapy. |
2024-03-19 |
2024-03-21 |
Not clear |
| Sharif Arar, Md Anzarul Haque, Nemil Bhatt, Yingxin Zhao, Rakez Kaye. Effect of Natural Osmolytes on Recombinant Tau Monomer: Propensity of Oligomerization and Aggregation. ACS chemical neuroscience. 2024-03-19. PMID:38503425. |
the pathological misfolding and aggregation of the microtubule associated protein tau (mapt), a full length tau2n4r with 441aa, is considered the principal disease relevant constituent in tauopathies including alzheimer's disease (ad) with an imbalanced ratio in 3r/4r isoforms. |
2024-03-19 |
2024-03-23 |
Not clear |
| Zerui Wang, Ling Wu, Maria Gerasimenko, Tricia Gilliland, Steven A Gunzler, Vincenzo Donadio, Rocco Liguori, Bin Xu, Wen-Quan Zo. Seeding Activity of Skin Misfolded Tau as a Biomarker for Tauopathies. Research square. 2024-03-18. PMID:38496453. |
seeding activity of skin misfolded tau as a biomarker for tauopathies. |
2024-03-18 |
2024-03-20 |
Not clear |
| Zerui Wang, Ling Wu, Maria Gerasimenko, Tricia Gilliland, Steven A Gunzler, Vincenzo Donadio, Rocco Liguori, Bin Xu, Wen-Quan Zo. Seeding Activity of Skin Misfolded Tau as a Biomarker for Tauopathies. Research square. 2024-03-18. PMID:38496453. |
background tauopathies are a group of age-related neurodegenerative diseases characterized by the accumulation of pathologically phosphorylated tau protein in the brain, leading to prion-like propagation and aggregation. |
2024-03-18 |
2024-03-20 |
Not clear |
| Zerui Wang, Ling Wu, Maria Gerasimenko, Tricia Gilliland, Steven A Gunzler, Vincenzo Donadio, Rocco Liguori, Bin Xu, Wen-Quan Zo. Seeding Activity of Skin Misfolded Tau as a Biomarker for Tauopathies. Research square. 2024-03-18. PMID:38496453. |
methods we utilized the seed-amplification assay (saa) employing ultrasensitive real-time quaking-induced conversion (rt-quic) to assess the prion-like seeding activity of pathological tau in the skin of cadavers with neuropathologically confirmed tauopathies, including ad, psp, cbd, and pid, compared to normal controls. |
2024-03-18 |
2024-03-20 |
Not clear |
| Zerui Wang, Ling Wu, Maria Gerasimenko, Tricia Gilliland, Steven A Gunzler, Vincenzo Donadio, Rocco Liguori, Bin Xu, Wen-Quan Zo. Seeding Activity of Skin Misfolded Tau as a Biomarker for Tauopathies. Research square. 2024-03-18. PMID:38496453. |
conclusions overall, our study provides proof-of-concept that the skin tau-saa can differentiate tauopathies from normal controls, suggesting that the seeding activity of misfolded tau in the skin could serve as a diagnostic biomarker for tauopathies. |
2024-03-18 |
2024-03-20 |
Not clear |
| Goonho Park, Angela Galdamez, Keon-Hyoung Song, Masako Le, Kyle Kim, Jonathan H Li. Ethnic variation and structure-function analysis of tauopathy-associated medRxiv : the preprint server for health sciences. 2024-03-18. PMID:38496636. |
in addition to its central position in intracellular stress regulation, human gwas identify eif2ak3 as a risk factor in tauopathies, neurodegenerative diseases caused by aberrant tau protein accumulation. |
2024-03-18 |
2024-03-20 |
human |
| Lun Zhang, Yongkang Gai, Yushuang Liu, Dongli Meng, Yi Zeng, Yong Luo, Huiliang Zhang, Zhuoqun Wang, Mengzhe Yang, Yunfan Li, Yi Liu, Yiwen Lai, Jiayu Yang, Gang Wu, Yu Chen, Jingtan Zhu, Shaojun Liu, Tingting Yu, Ji Zeng, Jianzhi Wang, Dan Zhu, Xiaochuan Wang, Xiaoli Lan, Rong Li. Tau induces inflammasome activation and microgliosis through acetylating NLRP3. Clinical and translational medicine. vol 14. issue 3. 2024-03-15. PMID:38488468. |
alzheimer's disease (ad) and related tauopathies are characterised by the pathologically hyperphosphorylated and aggregated microtubule-associated protein tau, which is accompanied by neuroinflammation mediated by activated microglia. |
2024-03-15 |
2024-03-17 |
Not clear |
| Yu Zou, Lulu Guan, Jingwang Tan, Bote Qi, Yunxiang Sun, Fengjuan Huang, Qingwen Zhan. Molecular Insights into the Differential Effects of Acetylation on the Aggregation of Tau Microtubule-Binding Repeats. Journal of chemical information and modeling. 2024-03-15. PMID:38489841. |
aggregation of tau protein into intracellular fibrillary inclusions is characterized as the hallmark of tauopathies, including alzheimer's disease and chronic traumatic encephalopathy. |
2024-03-15 |
2024-03-18 |
Not clear |
| Yu Zou, Lulu Guan, Jingwang Tan, Bote Qi, Yunxiang Sun, Fengjuan Huang, Qingwen Zhan. Molecular Insights into the Differential Effects of Acetylation on the Aggregation of Tau Microtubule-Binding Repeats. Journal of chemical information and modeling. 2024-03-15. PMID:38489841. |
this study uncovers the structural ensembles of tau mtb repeats and provides mechanistic insights into the influences of acetylation on tau aggregation, which may deepen the understanding of the pathogenesis of tauopathies. |
2024-03-15 |
2024-03-18 |
Not clear |
| Calina Glynn, Jose A Rodriguez, Bradley T Hyma. The structural line between prion and "prion-like": Insights from prion protein and tau. Current opinion in neurobiology. vol 86. 2024-03-15. PMID:38489865. |
in this review, we discuss current proposals for the 'prion-like' mechanisms of spread for tau and prion protein as well as discuss different influencers on structures of aggregates from tauopathies and prion diseases. |
2024-03-15 |
2024-03-18 |
Not clear |
| Hong Xu, Qi Qiu, Peng Hu, Kevt'her Hoxha, Elliot Jang, Mia O'Reilly, Christopher Kim, Zhuohao He, Nicholas Marotta, Lakshmi Changolkar, Bin Zhang, Hao Wu, Gerard D Schellenberg, Brian Kraemer, Kelvin C Luk, Edward B Lee, John Q Trojanowski, Kurt R Brunden, Virginia M-Y Le. MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons. Acta neuropathologica. vol 147. issue 1. 2024-03-13. PMID:38472475. |
inclusions comprised of microtubule-associated protein tau (tau) are implicated in a group of neurodegenerative diseases, collectively known as tauopathies, that include alzheimer's disease (ad). |
2024-03-13 |
2024-03-15 |
mouse |
| Marina Han, Aleen Saxton, Heather Currey, Sarah M Waldherr, Nicole F Liachko, Brian C Kraeme. Transgenic Dendra2::tau expression allows in vivo monitoring of tau proteostasis in C. elegans. Disease models & mechanisms. 2024-03-12. PMID:38469687. |
protein homeostasis is perturbed in aging-related neurodegenerative diseases called tauopathies, which are pathologically characterized by aggregation of the microtubule-associated protein tau. |
2024-03-12 |
2024-03-14 |
caenorhabditis_elegans |
| Cassis Varlow, Chester A Mathis, Neil Vasde. In vitro evaluation of [ Nuclear medicine and biology. vol 130-131. 2024-03-08. PMID:38458074. |
in vitro evaluation of [ alzheimer's disease (ad) and non-ad tauopathies such as chronic traumatic encephalopathy (cte), progressive supranuclear palsy (psp), and corticobasal degeneration (cbd) are characterized by the abnormal aggregation of three-repeat (3r) and/or four-repeat (4r) tau isoforms. |
2024-03-08 |
2024-03-11 |
human |
| Anuradha Venkatramani, Anvesh Ashtam, Dulal Pand. EB1 Increases the Dynamics of Tau Droplets and Inhibits Tau Aggregation: Implications in Tauopathies. ACS chemical neuroscience. 2024-03-06. PMID:38445984. |
eb1 increases the dynamics of tau droplets and inhibits tau aggregation: implications in tauopathies. |
2024-03-06 |
2024-03-08 |
Not clear |
| Wanbing Zhao, Kaien Liu, Yun Fan, Qinyue Zhao, Youqi Tao, Mengwei Zhang, Linhua Gan, Wenbo Yu, Bo Sun, Dan Li, Cong Liu, Jian Wan. Cryo-EM structures reveal variant Tau amyloid fibrils between the rTg4510 mouse model and sporadic human tauopathies. Cell discovery. vol 10. issue 1. 2024-03-06. PMID:38448404. |
cryo-em structures reveal variant tau amyloid fibrils between the rtg4510 mouse model and sporadic human tauopathies. |
2024-03-06 |
2024-03-09 |
mouse |
| YouJin Lee, Eric M Morro. Quantitative Measurement of Tau Aggregation in Genetically Modified Rats with Neurodegeneration. Methods in molecular biology (Clifton, N.J.). vol 2761. 2024-03-01. PMID:38427245. |
also, certain rat models can represent deposition of tau, which is one of the key pathological features of alzheimer's diseases and tauopathies. |
2024-03-01 |
2024-03-03 |
mouse |
| Abhay Kumar Singh, Karthikeyan Selvarasu, Siva Sundara Kumar Durairaja. Isolation and Detection of Pathological Tau Species in a Tauopathy Mouse Model. Methods in molecular biology (Clifton, N.J.). vol 2761. 2024-03-01. PMID:38427247. |
tau protein in alzheimer's disease (ad) and tauopathies becomes insoluble due to hyperphosphorylation, conformational alterations, and aggregation. |
2024-03-01 |
2024-03-03 |
mouse |