| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Felix Langerscheidt, Tamara Wied, Mohamed Aghyad Al Kabbani, Thilo van Eimeren, Gilbert Wunderlich, Hans Zempe. Genetic forms of tauopathies: inherited causes and implications of Alzheimer's disease-like TAU pathology in primary and secondary tauopathies. Journal of neurology. 2024-03-30. PMID:38554150. |
tauopathies are a heterogeneous group of neurologic diseases characterized by pathological axodendritic distribution, ectopic expression, and/or phosphorylation and aggregation of the microtubule-associated protein tau, encoded by the gene mapt. |
2024-03-30 |
2024-04-02 |
Not clear |
| Felix Langerscheidt, Tamara Wied, Mohamed Aghyad Al Kabbani, Thilo van Eimeren, Gilbert Wunderlich, Hans Zempe. Genetic forms of tauopathies: inherited causes and implications of Alzheimer's disease-like TAU pathology in primary and secondary tauopathies. Journal of neurology. 2024-03-30. PMID:38554150. |
in many secondary tauopathies, including parkinson's disease (pd) and huntington's disease (hd), tau is suggested to contribute to the development of dementia, but in others (e.g. |
2024-03-30 |
2024-04-02 |
Not clear |
| Felix Langerscheidt, Tamara Wied, Mohamed Aghyad Al Kabbani, Thilo van Eimeren, Gilbert Wunderlich, Hans Zempe. Genetic forms of tauopathies: inherited causes and implications of Alzheimer's disease-like TAU pathology in primary and secondary tauopathies. Journal of neurology. 2024-03-30. PMID:38554150. |
in this review, the genetic predispositions and variants associated with both primary and secondary tauopathies are examined in detail, assessing evidence for the role of tau in these conditions. |
2024-03-30 |
2024-04-02 |
Not clear |
| Felix Langerscheidt, Tamara Wied, Mohamed Aghyad Al Kabbani, Thilo van Eimeren, Gilbert Wunderlich, Hans Zempe. Genetic forms of tauopathies: inherited causes and implications of Alzheimer's disease-like TAU pathology in primary and secondary tauopathies. Journal of neurology. 2024-03-30. PMID:38554150. |
we highlight less common genetic forms of tauopathies to increase awareness for these disorders and the involvement of tau in their pathology. |
2024-03-30 |
2024-04-02 |
Not clear |
| Dina W Yakout, Ankit Shroff, Wei Wei, Vishrut Thaker, Zachary D Allen, Mathew Sajish, Taras Y Nazarko, Angela M Mab. Tau regulates Arc stability in neuronal dendrites via a proteasome-sensitive but ubiquitin-independent pathway. The Journal of biological chemistry. 2024-03-29. PMID:38552740. |
tauopathies are neurodegenerative disorders characterized by the deposition of aggregates of the microtubule-associated protein tau, a main component of neurofibrillary tangles. |
2024-03-29 |
2024-04-01 |
mouse |
| b' Dominika Ole\\xc5\\xa1ov\\xc3\\xa1, Dana Dobe\\xc5\\xa1ov\\xc3\\xa1, Petra Majerov\\xc3\\xa1, Radana Brumarov\\xc3\\xa1, Ale\\xc5\\xa1 Kvasni\\xc4\\x8dka, \\xc5\\xa0t\\xc4\\x9bp\\xc3\\xa1n Kou\\xc5\\x99il, Eva Stevens, Jozef Hanes, \\xc4\\xbdubica Fialov\\xc3\\xa1, Alena Michalicov\\xc3\\xa1, Juraj Pie\\xc5\\xa1\\xc5\\xa5ansk\\xc3\\xbd, Jakub \\xc5\\xa0insk\\xc3\\xbd, Petr Ka\\xc5\\x88ovsk\\xc3\\xbd, David Friedeck\\xc3\\xbd, Andrej Kov\\xc3\\xa1\\xc4\\x8. Changes in lipid metabolism track with the progression of neurofibrillary pathology in tauopathies. Journal of neuroinflammation. vol 21. issue 1. 2024-03-28. PMID:38539208.' |
accumulation of tau leads to neuroinflammation and neuronal cell death in tauopathies, including alzheimer's disease. |
2024-03-28 |
2024-03-30 |
Not clear |
| Hariharan Moorthy, Nimsha Kamala, Madhu Ramesh, Thimmaiah Govindaraj. Biphasic modulation of tau liquid-liquid phase separation by polyphenols. Chemical communications (Cambridge, England). 2024-03-28. PMID:38545836. |
molecular tools that modulate tau liquid-liquid phase separation (llps) promise to treat tauopathies. |
2024-03-28 |
2024-03-30 |
Not clear |
| Wen Li, Jia-Yi L. Overlaps and divergences between tauopathies and synucleinopathies: a duet of neurodegeneration. Translational neurodegeneration. vol 13. issue 1. 2024-03-26. PMID:38528629. |
we and other researchers have sequentially shown the cross-seeding phenomenon of α-synuclein (α-syn) and tau, reinforcing pathologies between synucleinopathies and tauopathies. |
2024-03-26 |
2024-03-28 |
Not clear |
| Tabassum Khair Barbhuiya, Dulari K Jayarathna, Raechelle Gilmour, Caroline Smet-Nocca, Neha S Gandh. Characterization of Posttranslationally Modified PHF-1 Tau Peptides Using Gaussian Accelerated Molecular Dynamics Simulation. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512658. |
of the various posttranslational modifications at ser, thr, and tyr sites, o-glcnacylation and phosphorylation are the most critical ones, playing a vital role in tau aggregation and tauopathies. |
2024-03-21 |
2024-03-24 |
Not clear |
| David Horsley, Janet E Rickard, Thomas Vorley, Matilda F Leeper, Claude M Wischik, Charles R Harringto. Assays for the Screening and Characterization of Tau Aggregation Inhibitors. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512662. |
aggregation of tau protein is a pathological hallmark of alzheimer's disease and other neurodegenerative tauopathies. |
2024-03-21 |
2024-03-24 |
Not clear |
| Léa El Hajjar, Clarisse Bridot, Marine Nguyen, François-Xavier Cantrelle, Isabelle Landrieu, Caroline Smet-Nocc. The O-GlcNAc Modification of Recombinant Tau Protein and Characterization of the O-GlcNAc Pattern for Functional Study. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512671. |
in neurodegenerative disorders referred to as tauopathies including alzheimer's disease, tau is abnormally hyperphosphorylated and forms fibrillar inclusions in neurons progressing throughout different brain area during the course of the disease. |
2024-03-21 |
2024-03-24 |
mouse |
| Parissa Fereydouni-Forouzandeh, Geoffrey Canet, Sofia Diego-Diàz, Emma Rocaboy, Serena Petry, Robert A Whittington, Emmanuel Plane. Western Blot of Tau Protein from Mouse Brains Extracts: How to Avoid Signal Artifacts. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512673. |
in alzheimer's disease and other neurodegenerative diseases known as tauopathies, tau undergoes several abnormal post-translational modifications including hyperphosphorylation, conformational changes, oligomerization, and aggregation. |
2024-03-21 |
2024-03-24 |
mouse |
| Parissa Fereydouni-Forouzandeh, Geoffrey Canet, Sofia Diego-Diàz, Emma Rocaboy, Serena Petry, Robert A Whittington, Emmanuel Plane. Western Blot of Tau Protein from Mouse Brains Extracts: How to Avoid Signal Artifacts. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512673. |
numerous mouse models of tauopathies have been developed, and western blotting remains an invaluable tool in studying tau protein physiological and pathological changes in these models. |
2024-03-21 |
2024-03-24 |
mouse |
| Léa El Hajjar, Clarisse Bridot, Marine Nguyen, François-Xavier Cantrelle, Isabelle Landrieu, Caroline Smet-Nocc. Phosphorylation of Tau Protein by CDK2/cyclin A and GSK3β Recombinant Kinases: Analysis of Phosphorylation Patterns by Nuclear Magnetic Resonance Spectroscopy. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512672. |
under its aggregated form, tau is a hallmark of alzheimer's disease and other neurodegenerative diseases named tauopathies involving tau dysfunction and/or mutations. |
2024-03-21 |
2024-03-24 |
Not clear |
| Léa El Hajjar, Clarisse Bridot, Marine Nguyen, François-Xavier Cantrelle, Isabelle Landrieu, Caroline Smet-Nocc. Phosphorylation of Tau Protein by CDK2/cyclin A and GSK3β Recombinant Kinases: Analysis of Phosphorylation Patterns by Nuclear Magnetic Resonance Spectroscopy. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512672. |
as a common feature shared by various tauopathies, tau aggregates are found into a form displaying an increased, abnormal phosphorylation, also referred to hyperphosphorylation. |
2024-03-21 |
2024-03-24 |
Not clear |
| Christopher A Ayoub, Khadijah I Moore, Jeff Kure. Quantification of Methylation and Phosphorylation Stoichiometry. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512670. |
tauopathies including alzheimer's disease (ad) are neurodegenerative disorders accompanied by the conversion of functional forms of the microtubule associated protein tau into non-functional aggregates. |
2024-03-21 |
2024-03-24 |
Not clear |
| Geoffrey Canet, Emma Rocaboy, Sofia Diego-Diàz, Robert A Whittington, Carl Julien, Emmanuel Plane. Methods for Biochemical Isolation of Insoluble Tau in Rodent Models of Tauopathies. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512674. |
methods for biochemical isolation of insoluble tau in rodent models of tauopathies. |
2024-03-21 |
2024-03-24 |
mouse |
| Geoffrey Canet, Emma Rocaboy, Sofia Diego-Diàz, Robert A Whittington, Carl Julien, Emmanuel Plane. Methods for Biochemical Isolation of Insoluble Tau in Rodent Models of Tauopathies. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512674. |
the intracellular accumulation of microtubule-associated protein tau is a characteristic feature of tauopathies, a group of neurodegenerative diseases including alzheimer's disease. |
2024-03-21 |
2024-03-24 |
mouse |
| Sarah Buchholz, Michael Bell-Simons, Cagla Cakmak, Jennifer Klimek, Li Gan, Hans Zempe. Cultivation, Differentiation, and Lentiviral Transduction of Human-Induced Pluripotent Stem Cell (hiPSC)-Derived Glutamatergic Neurons for Studying Human Tau. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512688. |
tau pathology is a major hallmark of many neurodegenerative diseases summarized under the term tauopathies. |
2024-03-21 |
2024-03-24 |
human |
| Nadine Allroggen, Helen Breuer, Sarah Bachmann, Michael Bell, Hans Zempe. Studying Microtubule Dynamics in Human Neurons: Two-Dimensional Microtubule Tracing and Kymographs in iPSC- and SH-SY5Y-Derived Neurons for Tau Research. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512690. |
these accumulations of hyperphosphorylated tau in the neurons disrupt the physiological mt-based transport machinery within the cell and can potentially lead to the development of neurodegenerative disorders, such as alzheimer's disease (ad) and related tauopathies. |
2024-03-21 |
2024-03-24 |
human |