| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bo-Kyung Son, Koichi Kozaki, Katsuya Iijima, Masato Eto, Taro Kojima, Hidetaka Ota, Yuka Senda, Koji Maemura, Toru Nakano, Masahiro Akishita, Yasuyoshi Ouch. Statins protect human aortic smooth muscle cells from inorganic phosphate-induced calcification by restoring Gas6-Axl survival pathway. Circulation research. vol 98. issue 8. 2006-06-02. PMID:16556867. |
in this study, we investigated the effect of statins on vsmc calcification by testing their effect on apoptosis, focusing in particular on regulation of the survival pathway mediated by growth arrest-specific gene 6 (gas6), a member of the vitamin k-dependent protein family, and its receptor, axl. |
2006-06-02 |
2023-08-12 |
human |
| Pier Paolo Sainaghi, Luigi Castello, Luca Bergamasco, Margherita Galletti, Paola Bellosta, Gian Carlo Avanz. Gas6 induces proliferation in prostate carcinoma cell lines expressing the Axl receptor. Journal of cellular physiology. vol 204. issue 1. 2005-07-26. PMID:15605394. |
this effect is proportional to axl expression, not due to inhibition of apoptosis, and induces akt and mapk phosphorylation. |
2005-07-26 |
2023-08-12 |
human |
| Matthew G Melaragno, Megan E Cavet, Chen Yan, Lung-Kuo Tai, Zheng-Gen Jin, Judith Haendeler, Bradford C Ber. Gas6 inhibits apoptosis in vascular smooth muscle: role of Axl kinase and Akt. Journal of molecular and cellular cardiology. vol 37. issue 4. 2005-03-01. PMID:15380678. |
gas6 inhibits apoptosis in vascular smooth muscle: role of axl kinase and akt. |
2005-03-01 |
2023-08-12 |
human |
| Matthew G Melaragno, Megan E Cavet, Chen Yan, Lung-Kuo Tai, Zheng-Gen Jin, Judith Haendeler, Bradford C Ber. Gas6 inhibits apoptosis in vascular smooth muscle: role of Axl kinase and Akt. Journal of molecular and cellular cardiology. vol 37. issue 4. 2005-03-01. PMID:15380678. |
in the present study we tested the mechanisms by which axl regulates vascular smooth muscle cell (vsmc) growth focusing on its ability to inhibit apoptosis. |
2005-03-01 |
2023-08-12 |
human |
| Matthew G Melaragno, Megan E Cavet, Chen Yan, Lung-Kuo Tai, Zheng-Gen Jin, Judith Haendeler, Bradford C Ber. Gas6 inhibits apoptosis in vascular smooth muscle: role of Axl kinase and Akt. Journal of molecular and cellular cardiology. vol 37. issue 4. 2005-03-01. PMID:15380678. |
treatment of vsmc with 100 ng/ml gas6 (the putative ligand for axl) decreased apoptosis to 8.9 +/- 0.7% (p = 0.002, n = 17) as compared to a decrease with 10% serum to 3.0 +/- 0.2% (p = 0.001, n = 17). |
2005-03-01 |
2023-08-12 |
human |
| Matthew G Melaragno, Megan E Cavet, Chen Yan, Lung-Kuo Tai, Zheng-Gen Jin, Judith Haendeler, Bradford C Ber. Gas6 inhibits apoptosis in vascular smooth muscle: role of Axl kinase and Akt. Journal of molecular and cellular cardiology. vol 37. issue 4. 2005-03-01. PMID:15380678. |
the ability of gas6 to prevent apoptosis required both gas6 binding to axl and axl kinase activity since treatment with a soluble, competitive axl extracellular domain protein or transfection of a kinase inactive mutant (axl-k567r) completely prevented the anti-apoptotic effect. |
2005-03-01 |
2023-08-12 |
human |
| Matthew G Melaragno, Megan E Cavet, Chen Yan, Lung-Kuo Tai, Zheng-Gen Jin, Judith Haendeler, Bradford C Ber. Gas6 inhibits apoptosis in vascular smooth muscle: role of Axl kinase and Akt. Journal of molecular and cellular cardiology. vol 37. issue 4. 2005-03-01. PMID:15380678. |
prevention of apoptosis by gas6-axl required activation of phosphatidyl inositol 3-kinase (pi3k) as shown by treatment with ly294002 or transfection of an axl deletion mutant that does not bind pi3k (axl- triangle up pi3k). |
2005-03-01 |
2023-08-12 |
human |
| Benjamin I Chung, S Bruce Malkowicz, Trang B Nguyen, John A Libertino, Terence W McGarve. Expression of the proto-oncogene Axl in renal cell carcinoma. DNA and cell biology. vol 22. issue 8. 2003-11-05. PMID:14565870. |
axl has also shown to have a role in apoptosis, cell adhesion, and chemotaxis. |
2003-11-05 |
2023-08-12 |
Not clear |
| Daniela D'Arcangelo, Carlo Gaetano, Maurizio C Capogross. Acidification prevents endothelial cell apoptosis by Axl activation. Circulation research. vol 91. issue 7. 2002-10-23. PMID:12364394. |
acidification prevents endothelial cell apoptosis by axl activation. |
2002-10-23 |
2023-08-12 |
human |
| Daniela D'Arcangelo, Carlo Gaetano, Maurizio C Capogross. Acidification prevents endothelial cell apoptosis by Axl activation. Circulation research. vol 91. issue 7. 2002-10-23. PMID:12364394. |
full-length axl cdna overexpression reduced serum deprivation-induced apoptosis by 64.4+/-11.9% in human umbilical vein endothelial cells cultured at ph 7.4 compared with mock-transfected cells (p<0.0004). |
2002-10-23 |
2023-08-12 |
human |
| Wei-Ping Lee, Yong Wen, Brian Varnum, Mien-Chie Hun. Akt is required for Axl-Gas6 signaling to protect cells from E1A-mediated apoptosis. Oncogene. vol 21. issue 3. 2002-02-14. PMID:11821945. |
we have previously identified that e1a suppresses the expression of axl, a transforming tyrosine kinase and that axl-gas6 receptor-ligand interaction prevents e1a transfectants from apoptosis induced by serum deprivation. |
2002-02-14 |
2023-08-12 |
Not clear |
| Wei-Ping Lee, Yong Wen, Brian Varnum, Mien-Chie Hun. Akt is required for Axl-Gas6 signaling to protect cells from E1A-mediated apoptosis. Oncogene. vol 21. issue 3. 2002-02-14. PMID:11821945. |
to determine how the axl-gas6 interaction prevents e1a-mediated apoptosis, we analysed the expression of anti-apoptotic molecules and found that the activated form of akt was suppressed in the e1a transfectant ip 1-e1a and that gas6 was able to activate akt in ip 1-e1a cells reexpressing axl (ip 1-e1a-axl). |
2002-02-14 |
2023-08-12 |
Not clear |
| W P Lee, Y Liao, D Robinson, H J Kung, E T Liu, M C Hun. Axl-gas6 interaction counteracts E1A-mediated cell growth suppression and proapoptotic activity. Molecular and cellular biology. vol 19. issue 12. 2000-01-06. PMID:10567533. |
the axl ligand gas6 triggered a greater mitogenic effect in these ip1-e1a-axl cells than in ip1-e1a control cells and protected the axl-expressing cells from serum deprivation-induced apoptosis. |
2000-01-06 |
2023-08-12 |
Not clear |
| W P Lee, Y Liao, D Robinson, H J Kung, E T Liu, M C Hun. Axl-gas6 interaction counteracts E1A-mediated cell growth suppression and proapoptotic activity. Molecular and cellular biology. vol 19. issue 12. 2000-01-06. PMID:10567533. |
these results indicate that downregulation of the axl receptor by e1a is involved in e1a-mediated growth suppression and e1a-induced apoptosis and thereby contributes to e1a's antitumor activities. |
2000-01-06 |
2023-08-12 |
Not clear |