| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Miao Wu, Shijuan Lu, Jianghua Zhong, Kang Huang, Saidan Zhan. Protective Effects of Pterostilbene Against Myocardial Ischemia/Reperfusion Injury in Rats. Inflammation. vol 40. issue 2. 2017-05-03. PMID:28054238. |
our findings suggest that ptb treatment exerts cardioprotection against mi/r injury via attenuating inflammatory response, oxidative stress, and apoptosis and up-regulating the expression of gas6 and axl. |
2017-05-03 |
2023-08-13 |
rat |
| Xiaoyu Jiang, Huiren Tao, Cuiting Qiu, Xiaolei Ma, Shan Li, Xian Guo, Anlin Lv, Huan L. Vitamin K2 regression aortic calcification induced by warfarin via Gas6/Axl survival pathway in rats. European journal of pharmacology. vol 786. 2017-03-10. PMID:27212383. |
alizarin red s staining measured aortic calcium depositions; alkaline phosphatase activity in serum was measured by a kit; apoptosis was evaluated by tunel assay; protein expression levels of gas6, axl, phosphorylated akt (p-akt), and bcl-2 were determined by western blotting. |
2017-03-10 |
2023-08-13 |
rat |
| Xiaoyu Jiang, Huiren Tao, Cuiting Qiu, Xiaolei Ma, Shan Li, Xian Guo, Anlin Lv, Huan L. Vitamin K2 regression aortic calcification induced by warfarin via Gas6/Axl survival pathway in rats. European journal of pharmacology. vol 786. 2017-03-10. PMID:27212383. |
100μg/g vitamin k2 treatment decreased calcium depositions, alp activity and apoptosis significantly, but increased gas6, axl, p-akt and bcl-2 expression. |
2017-03-10 |
2023-08-13 |
rat |
| Liwen Cui, Yaling Bai, Junxia Zhang, Shenglei Zhang, Jinsheng X. Effects of extracellular acid stimulation on rat vascular smooth muscle cell in Gas6/Axl or PI3K/Akt signaling pathway. Clinical and experimental hypertension (New York, N.Y. : 1993). vol 38. issue 5. 2016-12-13. PMID:27362907. |
our study demonstrated that a high concentration of phosphorus induced apoptosis and calcification of vsmcs, decreased expression of axl, and reduced phosphorylation of akt. |
2016-12-13 |
2023-08-13 |
rat |
| Liwen Cui, Yaling Bai, Junxia Zhang, Shenglei Zhang, Jinsheng X. Effects of extracellular acid stimulation on rat vascular smooth muscle cell in Gas6/Axl or PI3K/Akt signaling pathway. Clinical and experimental hypertension (New York, N.Y. : 1993). vol 38. issue 5. 2016-12-13. PMID:27362907. |
stimulation of extracellular acid counteracted the effects as above by increasing the expression of axl and akt phosphorylation and decreasing the expression of activated caspase3, which thereby decreased cell apoptosis and calcification. |
2016-12-13 |
2023-08-13 |
rat |
| Matthew Brown, James R M Black, Rohini Sharma, Justin Stebbing, David J Pinat. Gene of the month: Axl. Journal of clinical pathology. vol 69. issue 5. 2016-09-09. PMID:26951083. |
the activation of axl is overexpression-dependent and controls a number of hallmarks of cancer progression including proliferation, migration, resistance to apoptosis and survival through a complex network of intracellular second messengers. |
2016-09-09 |
2023-08-13 |
Not clear |
| Paola Ciceri, Francesca Elli, Laura Cappelletti, Delfina Tosi, Paola Braidotti, Gaetano Bulfamante, Mario Cozzolin. A new in vitro model to delay high phosphate-induced vascular calcification progression. Molecular and cellular biochemistry. vol 410. issue 1-2. 2016-08-15. PMID:26346159. |
the protective effect of is was mediated by the reduction of apoptosis as demonstrated by the action of 20 μmol/l z-vad-fmk and by the preservation of the pro-survival receptor axl expression. |
2016-08-15 |
2023-08-13 |
rat |
| Sanchaika Gaur, Yunfei Wen, Jian H Song, Nila U Parikh, Lingegowda S Mangala, Alicia M Blessing, Cristina Ivan, Sherry Y Wu, Andreas Varkaris, Yan Shi, Gabriel Lopez-Berestein, Daniel E Frigo, Anil K Sood, Gary E Gallic. Chitosan nanoparticle-mediated delivery of miRNA-34a decreases prostate tumor growth in the bone and its expression induces non-canonical autophagy. Oncotarget. vol 6. issue 30. 2016-08-04. PMID:26313360. |
expression of mir-34a induced apoptosis in pca cells, and, in accord with downregulation of targets associated with pca growth, including met and axl and c-myc, also induced a form of non-canonical autophagy that is independent of beclin-1, atg4, atg5 and atg7. |
2016-08-04 |
2023-08-13 |
Not clear |
| Chun-Yu Cho, Jhy-Shrian Huang, Shine-Gwo Shiah, Shih-Ying Chung, Jong-Ding Lay, Ya-Yu Yang, Gi-Ming Lai, Ann-Lii Cheng, Li-Tzong Chen, Shuang-En Chuan. Negative feedback regulation of AXL by miR-34a modulates apoptosis in lung cancer cells. RNA (New York, N.Y.). vol 22. issue 2. 2016-06-09. PMID:26667302. |
negative feedback regulation of axl by mir-34a modulates apoptosis in lung cancer cells. |
2016-06-09 |
2023-08-13 |
Not clear |
| Chun-Yu Cho, Jhy-Shrian Huang, Shine-Gwo Shiah, Shih-Ying Chung, Jong-Ding Lay, Ya-Yu Yang, Gi-Ming Lai, Ann-Lii Cheng, Li-Tzong Chen, Shuang-En Chuan. Negative feedback regulation of AXL by miR-34a modulates apoptosis in lung cancer cells. RNA (New York, N.Y.). vol 22. issue 2. 2016-06-09. PMID:26667302. |
in addition, ectopic overexpression of elk1 promotes apoptosis through, in part, down-regulation of axl. |
2016-06-09 |
2023-08-13 |
Not clear |
| Sutapa Sinha, Justin Boysen, Michael Nelson, Charla Secreto, Steven L Warner, David J Bearss, Connie Lesnick, Tait D Shanafelt, Neil E Kay, Asish K Ghos. Targeted Axl Inhibition Primes Chronic Lymphocytic Leukemia B Cells to Apoptosis and Shows Synergistic/Additive Effects in Combination with BTK Inhibitors. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 21. issue 9. 2016-03-31. PMID:25673699. |
targeted axl inhibition primes chronic lymphocytic leukemia b cells to apoptosis and shows synergistic/additive effects in combination with btk inhibitors. |
2016-03-31 |
2023-08-13 |
Not clear |
| Sri N Batchu, Jixiang Xia, Kyung Ae Ko, Marvin M Doyley, Jun-Ichi Abe, Craig N Morrell, Vyacheslav A Korshuno. Axl modulates immune activation of smooth muscle cells in vein graft remodeling. American journal of physiology. Heart and circulatory physiology. vol 309. issue 6. 2015-12-15. PMID:26276821. |
local depletion of axl had the greatest effect on immune activation, whereas systemic deletion of axl reduced intima due to an increase in apoptosis in vein grafts. |
2015-12-15 |
2023-08-13 |
mouse |
| Lihua Huang, Liwu F. Mechanisms of resistance to EGFR tyrosine kinase inhibitors. Acta pharmaceutica Sinica. B. vol 5. issue 5. 2015-11-20. PMID:26579470. |
resistance to egfr-tkis is inevitable due to various mechanisms, such as the secondary mutation (t790m), activation of alternative pathways (c-met, hgf, axl), aberrance of the downstream pathways (k-ras mutations, loss of pten), impairment of the egfr-tkis-mediated apoptosis pathway (bcl2-like 11/bim deletion polymorphism), histologic transformation, atp binding cassette (abc) transporter effusion, etc. |
2015-11-20 |
2023-08-13 |
Not clear |
| Gareth D Hyde, Rebecca F Taylor, Nick Ashton, Samantha J Borland, Hon Sing Geoffrey Wu, Andrew P Gilmore, Ann E Canfiel. Axl tyrosine kinase protects against tubulo-interstitial apoptosis and progression of renal failure in a murine model of chronic kidney disease and hyperphosphataemia. PloS one. vol 9. issue 7. 2015-11-17. PMID:25019319. |
axl tyrosine kinase protects against tubulo-interstitial apoptosis and progression of renal failure in a murine model of chronic kidney disease and hyperphosphataemia. |
2015-11-17 |
2023-08-13 |
mouse |
| Gareth D Hyde, Rebecca F Taylor, Nick Ashton, Samantha J Borland, Hon Sing Geoffrey Wu, Andrew P Gilmore, Ann E Canfiel. Axl tyrosine kinase protects against tubulo-interstitial apoptosis and progression of renal failure in a murine model of chronic kidney disease and hyperphosphataemia. PloS one. vol 9. issue 7. 2015-11-17. PMID:25019319. |
histological analysis of kidney remnants revealed no effect of loss of axl on glomerular hypertrophy, calcification or renal sclerosis but identified significantly increased tubulo-interstitial apoptosis in axl-/- mice. |
2015-11-17 |
2023-08-13 |
mouse |
| Clémence Feneyrolles, Aurélia Spenlinhauer, Léa Guiet, Bénédicte Fauvel, Bénédicte Daydé-Cazals, Pierre Warnault, Gwénaël Chevé, Aziz Yasr. Axl kinase as a key target for oncology: focus on small molecule inhibitors. Molecular cancer therapeutics. vol 13. issue 9. 2015-11-17. PMID:25139999. |
as a member of the tam (tyro-3, axl, mer) rtk subfamily, axl regulates key processes such as cell growth, migration, aggregation, and apoptosis through several pathways. |
2015-11-17 |
2023-08-13 |
Not clear |
| Haley Axelrod, Kenneth J Pient. Axl as a mediator of cellular growth and survival. Oncotarget. vol 5. issue 19. 2015-08-07. PMID:25344858. |
the oncogenic nature of axl is demonstrated through its activation of signaling pathways involved in proliferation, migration, inhibition of apoptosis, and therapeutic resistance. |
2015-08-07 |
2023-08-13 |
Not clear |
| Yixin Li, Xiqian Wang, Shaojie Bi, Kun Zhao, Chao Y. Inhibition of Mer and Axl receptor tyrosine kinases leads to increased apoptosis and improved chemosensitivity in human neuroblastoma. Biochemical and biophysical research communications. vol 457. issue 3. 2015-07-09. PMID:25596315. |
inhibition of mer and axl receptor tyrosine kinases leads to increased apoptosis and improved chemosensitivity in human neuroblastoma. |
2015-07-09 |
2023-08-13 |
human |
| Yixin Li, Xiqian Wang, Shaojie Bi, Kun Zhao, Chao Y. Inhibition of Mer and Axl receptor tyrosine kinases leads to increased apoptosis and improved chemosensitivity in human neuroblastoma. Biochemical and biophysical research communications. vol 457. issue 3. 2015-07-09. PMID:25596315. |
furthermore, mer and axl knockdown led to apoptosis and inhibition of migration as well as a significant increase in chemosensitivity in response to cisplatin and vincristine treatment. |
2015-07-09 |
2023-08-13 |
human |
| Olga Martinho, Luis Eduardo Zucca, Rui Manuel Rei. AXL as a modulator of sunitinib response in glioblastoma cell lines. Experimental cell research. vol 332. issue 1. 2015-04-24. PMID:25637219. |
we found that axl knockdown conferred lower sensitivity to sunitinib by rescuing migratory defects and inhibiting apoptosis in cells expressing high axl basal levels. |
2015-04-24 |
2023-08-13 |
Not clear |