| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Samuel D Zwernik, Beau H Adams, Daniel A Raymond, Catherine M Warner, Amin B Kassam, Richard A Rovin, Parvez Akhta. AXL receptor is required for Zika virus strain MR-766 infection in human glioblastoma cell lines. Molecular therapy oncolytics. vol 23. 2021-12-13. PMID:34901388. |
additionally, crispr knockout of the axl gene in gbm cell lines completely abolished zikv infection, significantly inhibited viral replication, and significantly reduced apoptosis compared with parental lines. |
2021-12-13 |
2023-08-13 |
human |
| Kuo-Yen Huang, Tong-Hong Wang, Chin-Chuan Chen, Yann-Lii Leu, Hsin-Jung Li, Cai-Ling Jhong, Chi-Yuan Che. Growth Suppression in Lung Cancer Cells Harboring EGFR-C797S Mutation by Quercetin. Biomolecules. vol 11. issue 9. 2021-11-08. PMID:34572484. |
we demonstrated that quercetin exhibited potent cytotoxic effects on nsclc cells harboring the egfr c797s mutation by inhibiting axl and inducing apoptosis. |
2021-11-08 |
2023-08-13 |
Not clear |
| Tatyana Novoyatleva, Nabham Rai, Baktybek Kojonazarov, Swathi Veeroju, Isabel Ben-Batalla, Paola Caruso, Mazen Shihan, Nadine Presser, Elsa Götz, Carina Lepper, Sebastian Herpel, Grégoire Manaud, Frédéric Perros, Henning Gall, Hossein Ardeschir Ghofrani, Norbert Weissmann, Friedrich Grimminger, John Wharton, Martin Wilkins, Paul D Upton, Sonja Loges, Nicholas W Morrell, Werner Seeger, Ralph T Schermul. Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2. Communications biology. vol 4. issue 1. 2021-09-23. PMID:34429509. |
axl blockage inhibited bmp9 signaling and increased paec apoptosis, while bmp9 induced axl phosphorylation. |
2021-09-23 |
2023-08-13 |
rat |
| David G Covel. Bioinformatic analysis linking genomic defects to chemosensitivity and mechanism of action. PloS one. vol 16. issue 4. 2021-09-13. PMID:33909629. |
the results of this analysis find a relatively small set of defective genes, inclusive of abl1, axl, braf, cdc25a, cdkn2a, igf1r, kras, mecom, mmp1, myc, notch1, nras, pik3cg, ptk2, rptor, sptbn1, stat2, tnks and zhx2, as possible candidates for roles in chemosensitivity for compound moas that target primarily, but not exclusively, kinases, nucleic acid synthesis, protein synthesis, apoptosis and tubulin. |
2021-09-13 |
2023-08-13 |
Not clear |
| Shengda Xie, Zhenjie Liang, Xingmiao Yang, Junhui Pan, Du Yu, Tongtong Li, Ruibing Ca. Japanese Encephalitis Virus NS2B-3 Protein Complex Promotes Cell Apoptosis and Viral Particle Release by Down-Regulating the Expression of AXL. Virologica Sinica. 2021-09-06. PMID:34487337. |
japanese encephalitis virus ns2b-3 protein complex promotes cell apoptosis and viral particle release by down-regulating the expression of axl. |
2021-09-06 |
2023-08-13 |
Not clear |
| Zhao Ma, Qin Li, Peng Liu, Wei Dong, Ying Zu. METTL3 regulates m6A in endometrioid epithelial ovarian cancer independently of METTl14 and WTAP. Cell biology international. vol 44. issue 12. 2021-07-09. PMID:32869897. |
moreover, mettl3 knockdown in tov-112d and crl-11731d cells weakened the capability of cell proliferation and migration, and promoted cell apoptosis compared to negative control and cells with wtap or mettl14 knockdown using cck-8 assay, transwell assay, wound healing assay, and tunel assay. furthermore, mettl3 knockdown also reduced m6a enrichment of the genes associated with ovarian cancer including eif3c, axl, csf-1, fzd10 in tov-112d, and crl-11731d cells by rip-qpcr assay. |
2021-07-09 |
2023-08-13 |
Not clear |
| Nam-Yi Kim, In-Jun Yang, Soyoung Kim, ChuHee Le. Lotus (Nelumbo nucifera) seedpod extract inhibits cell proliferation and induces apoptosis in non-small cell lung cancer cells via downregulation of Axl. Journal of food biochemistry. vol 45. issue 2. 2021-07-08. PMID:33381866. |
lotus (nelumbo nucifera) seedpod extract inhibits cell proliferation and induces apoptosis in non-small cell lung cancer cells via downregulation of axl. |
2021-07-08 |
2023-08-13 |
Not clear |
| Nam-Yi Kim, In-Jun Yang, Soyoung Kim, ChuHee Le. Lotus (Nelumbo nucifera) seedpod extract inhibits cell proliferation and induces apoptosis in non-small cell lung cancer cells via downregulation of Axl. Journal of food biochemistry. vol 45. issue 2. 2021-07-08. PMID:33381866. |
next, we found that lpse treatment diminished the levels of protein and mrna of axl, a receptor tyrosine kinase (rtk) that transduces critical signals for cell proliferation and inhibition of apoptosis. |
2021-07-08 |
2023-08-13 |
Not clear |
| Nam-Yi Kim, In-Jun Yang, Soyoung Kim, ChuHee Le. Lotus (Nelumbo nucifera) seedpod extract inhibits cell proliferation and induces apoptosis in non-small cell lung cancer cells via downregulation of Axl. Journal of food biochemistry. vol 45. issue 2. 2021-07-08. PMID:33381866. |
taken together, we found that the lspe suppressed cell proliferation and induced apoptosis of nsclc cells, which is attenuated or augmented by overexpression or rna interference of axl expression, respectively. |
2021-07-08 |
2023-08-13 |
Not clear |
| Nam-Yi Kim, In-Jun Yang, Soyoung Kim, ChuHee Le. Lotus (Nelumbo nucifera) seedpod extract inhibits cell proliferation and induces apoptosis in non-small cell lung cancer cells via downregulation of Axl. Journal of food biochemistry. vol 45. issue 2. 2021-07-08. PMID:33381866. |
our data suggest that axl is a novel therapeutic target of lspe to inhibit cell proliferation and promote apoptosis in nsclc cells. |
2021-07-08 |
2023-08-13 |
Not clear |
| Nam-Yi Kim, In-Jun Yang, Soyoung Kim, ChuHee Le. Lotus (Nelumbo nucifera) seedpod extract inhibits cell proliferation and induces apoptosis in non-small cell lung cancer cells via downregulation of Axl. Journal of food biochemistry. vol 45. issue 2. 2021-07-08. PMID:33381866. |
lspe downregulated the axl expression at transcriptional level and the effects of lspe on cell proliferation as well as apoptosis were affected by axl protein level. |
2021-07-08 |
2023-08-13 |
Not clear |
| Sangah Lee, Jiyae Jung, Yu-Jin Lee, Seon-Kyu Kim, Jung-Ae Kim, Bo-Kyung Kim, Kyung Chan Park, Byoung-Mog Kwon, Dong Cho Ha. Targeting HSF1 as a Therapeutic Strategy for Multiple Mechanisms of EGFR Inhibitor Resistance in EGFR Mutant Non-Small-Cell Lung Cancer. Cancers. vol 13. issue 12. 2021-07-05. PMID:34203709. |
hsf1 inhibition by using hsf1 shrnas or kribb11 decreased the expression of hsf1 downstream proteins, such as hsp70 and hsp27, and also decreased the expression of hsp90/hsp70/bag3 client proteins, such as bcl2, mcl1, egfr, met, and axl, causing apoptosis of egfr-tki-resistant cancer cells. |
2021-07-05 |
2023-08-13 |
Not clear |
| Nam-Yi Kim, Young-Ah Suh, Soyoung Kim, ChuHee Le. Bufalin down-regulates Axl expression to inhibit cell proliferation and induce apoptosis in non-small-cell lung cancer cells. Bioscience reports. vol 40. issue 4. 2021-03-29. PMID:32219334. |
bufalin down-regulates axl expression to inhibit cell proliferation and induce apoptosis in non-small-cell lung cancer cells. |
2021-03-29 |
2023-08-13 |
Not clear |
| Nam-Yi Kim, Young-Ah Suh, Soyoung Kim, ChuHee Le. Bufalin down-regulates Axl expression to inhibit cell proliferation and induce apoptosis in non-small-cell lung cancer cells. Bioscience reports. vol 40. issue 4. 2021-03-29. PMID:32219334. |
axl, a member of the tam (tyro3, axl, mer) receptor tyrosine kinase family, plays critical roles in cell growth, proliferation, apoptosis, and migration. |
2021-03-29 |
2023-08-13 |
Not clear |
| Nam-Yi Kim, Young-Ah Suh, Soyoung Kim, ChuHee Le. Bufalin down-regulates Axl expression to inhibit cell proliferation and induce apoptosis in non-small-cell lung cancer cells. Bioscience reports. vol 40. issue 4. 2021-03-29. PMID:32219334. |
axl overexpression attenuated the effect of bufalin in inhibiting cell proliferation and colony formation and inducing apoptosis in h460 cells, while knockdown of axl gene expression induced the opposite effect. |
2021-03-29 |
2023-08-13 |
Not clear |
| Nam-Yi Kim, Young-Ah Suh, Soyoung Kim, ChuHee Le. Bufalin down-regulates Axl expression to inhibit cell proliferation and induce apoptosis in non-small-cell lung cancer cells. Bioscience reports. vol 40. issue 4. 2021-03-29. PMID:32219334. |
taken together, our data indicate that the anti-proliferative and pro-apoptotic effects of bufalin were associated with the protein level of axl, suggesting that axl is a potent therapeutic target of bufalin in suppressing proliferation and inducing apoptosis in nsclc cells. |
2021-03-29 |
2023-08-13 |
Not clear |
| Karine Flem-Karlsen, Erin McFadden, Nasrin Omar, Mads H Haugen, Geir Frode Øy, Truls Ryder, Hans Petter Gullestad, Robert Hermann, Gunhild Mari Mælandsmo, Vivi Ann Flørene. Targeting AXL and the DNA Damage Response Pathway as a Novel Therapeutic Strategy in Melanoma. Molecular cancer therapeutics. vol 19. issue 3. 2021-02-12. PMID:31871265. |
using melanoma cell lines, we observed that combined reduction of axl and chk1/chk2 signaling decreased proliferation, deregulated cell-cycle progression, increased apoptosis, and reduced expression of dna damage response proteins. |
2021-02-12 |
2023-08-13 |
Not clear |
| Floriana Morgillo, Carminia Maria Della Corte, Morena Fasano, Fortunato Ciardiell. Mechanisms of resistance to EGFR-targeted drugs: lung cancer. ESMO open. vol 1. issue 3. 2021-01-26. PMID:27843613. |
several mechanisms of resistance have been described to egfr-tkis, such as the occurrence of secondary mutation (t790m, c797s), the activation of alternative signalling (met, hgf, axl, hh, igf-1r), the aberrance of the downstream pathways (akt mutations, loss of pten), the impairment of the egfr-tkis-mediated apoptosis pathway (bcl2-like 11/bim deletion polymorphism) and histological transformation. |
2021-01-26 |
2023-08-13 |
Not clear |
| Andrew K Hastings, Katherine Hastings, Ryuta Uraki, Jesse Hwang, Hallie Gaitsch, Khushwant Dhaliwal, Eric Williamson, Erol Fikri. Loss of the TAM Receptor Axl Ameliorates Severe Zika Virus Pathogenesis and Reduces Apoptosis in Microglia. iScience. vol 13. 2021-01-09. PMID:30884311. |
loss of the tam receptor axl ameliorates severe zika virus pathogenesis and reduces apoptosis in microglia. |
2021-01-09 |
2023-08-13 |
mouse |
| Chun-Yu Cho, Shih-Ying Chung, Shankung Lin, Jhy-Shrian Huang, Yen-Lin Chen, Shih-Sheng Jiang, Li-Chun Cheng, Tsu-Hsiang Kuo, Jong-Ding Lay, Ya-Yu Yang, Gi-Ming Lai, Shuang-En Chuan. PTBP1-mediated regulation of AXL mRNA stability plays a role in lung tumorigenesis. Scientific reports. vol 9. issue 1. 2020-11-06. PMID:31729427. |
in addition, over-expression of axl may counteract the ptbp1-mediated apoptosis. |
2020-11-06 |
2023-08-13 |
Not clear |