| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Donatella Romaniello, Ilaria Marrocco, Nishanth Belugali Nataraj, Irene Ferrer, Diana Drago-Garcia, Itay Vaknin, Roni Oren, Moshit Lindzen, Soma Ghosh, Matthew Kreitman, Jeanette Clarissa Kittel, Nadege Gaborit, Gretchen Bergado Baez, Belinda Sanchez, Raya Eilam, Eli Pikarsky, Luis Paz-Ares, Yosef Yarde. Targeting HER3, a Catalytically Defective Receptor Tyrosine Kinase, Prevents Resistance of Lung Cancer to a Third-Generation EGFR Kinase Inhibitor. Cancers. vol 12. issue 9. 2020-10-28. PMID:32847130. |
we found that the underlying mechanism involves posttranslational downregulation of her3, suppression of met and axl upregulation, as well as concomitant inhibition of akt signaling and upregulation of bim, which mediates apoptosis. |
2020-10-28 |
2023-08-13 |
Not clear |
| Xueming Ying, Jun Chen, Xueming Huang, Peng Huang, Shaocong Ya. Effect of AXL on the epithelial-to-mesenchymal transition in non-small cell lung cancer. Experimental and therapeutic medicine. vol 14. issue 1. 2020-09-30. PMID:28673000. |
furthermore, downregulation of axl expression by rna interference was shown to inhibit cell growth by inducing the apoptosis of pc9 cells, as demonstrated by mtt and flow cytometry analyses. |
2020-09-30 |
2023-08-13 |
Not clear |
| Fangfang Chen, Qiaoling Song, Qiang Y. Axl inhibitor R428 induces apoptosis of cancer cells by blocking lysosomal acidification and recycling independent of Axl inhibition. American journal of cancer research. vol 8. issue 8. 2020-09-30. PMID:30210917. |
axl inhibitor r428 induces apoptosis of cancer cells by blocking lysosomal acidification and recycling independent of axl inhibition. |
2020-09-30 |
2023-08-13 |
Not clear |
| Fangfang Chen, Qiaoling Song, Qiang Y. Axl inhibitor R428 induces apoptosis of cancer cells by blocking lysosomal acidification and recycling independent of Axl inhibition. American journal of cancer research. vol 8. issue 8. 2020-09-30. PMID:30210917. |
it inhibits the receptor tyrosine kinase axl and induces apoptosis of many types of cancer cells, but the relationship between the two has not been well established. |
2020-09-30 |
2023-08-13 |
Not clear |
| Fangfang Chen, Qiaoling Song, Qiang Y. Axl inhibitor R428 induces apoptosis of cancer cells by blocking lysosomal acidification and recycling independent of Axl inhibition. American journal of cancer research. vol 8. issue 8. 2020-09-30. PMID:30210917. |
we investigated the molecular mechanisms of the r428-induced apoptosis and found that r428 induced extensive cytoplasmic vacuolization and caspase activation, independent of its inhibitory effects on axl. |
2020-09-30 |
2023-08-13 |
Not clear |
| Juliano D Paccez, Kristal Duncan, Durairaj Sekar, Ricardo G Correa, Yihong Wang, Xuesong Gu, Manoj Bashin, Kelly Chibale, Towia A Libermann, Luiz F Zerbin. Dihydroartemisinin inhibits prostate cancer via JARID2/miR-7/miR-34a-dependent downregulation of Axl. Oncogenesis. vol 8. issue 3. 2020-09-29. PMID:30783079. |
dihydroartemisinin blocks axl expression leading to apoptosis, decrease in cell proliferation, migration, and tumor development of prostate cancer cells. |
2020-09-29 |
2023-08-13 |
mouse |
| Sierra A Colavit. AXL as a Target in Breast Cancer Therapy. Journal of oncology. vol 2020. 2020-09-28. PMID:32148495. |
axl is a receptor tyrosine kinase (rtk) that has been implicated in diverse tumor-promoting processes such as proliferation, migration, invasion, survival, and apoptosis. |
2020-09-28 |
2023-08-13 |
Not clear |
| Yeon-Sang Ryu, Sangyun Shin, Hong-Gyu An, Tae-Uk Kwon, Hyoung-Seok Baek, Yeo-Jung Kwon, Young-Jin Chu. Synergistic Induction of Apoptosis by the Combination of an Axl Inhibitor and Auranofin in Human Breast Cancer Cells. Biomolecules & therapeutics. vol 28. issue 5. 2020-09-28. PMID:32536618. |
synergistic induction of apoptosis by the combination of an axl inhibitor and auranofin in human breast cancer cells. |
2020-09-28 |
2023-08-13 |
human |
| b' Marie-Anne Goyette, Rebecca Cusseddu, Islam Elkholi, Afnan Abu-Thuraia, Nehme El-Hachem, Benjamin Haibe-Kains, Jean-Philippe Gratton, Jean-Fran\\xc3\\xa7ois C\\xc3\\xb4t\\xc3\\xa. AXL knockdown gene signature reveals a drug repurposing opportunity for a class of antipsychotics to reduce growth and metastasis of triple-negative breast cancer. Oncotarget. vol 10. issue 21. 2020-02-25. PMID:31007848.' |
we next tested if these drugs, similarly to axl depletion, were able to limit growth and metastatic progression of tnbc cells and found that phenothiazines are able to reduce cell invasion, proliferation, viability and increase apoptosis of tnbc cells |
2020-02-25 |
2023-08-13 |
Not clear |
| Mengfang Li, Jingjing Ye, Guangju Zhao, Guangliang Hong, Xiyi Hu, Kaiqiang Cao, You Wu, Zhongqiu L. Gas6 attenuates lipopolysaccharide‑induced TNF‑α expression and apoptosis in H9C2 cells through NF‑κB and MAPK inhibition via the Axl/PI3K/Akt pathway. International journal of molecular medicine. vol 44. issue 3. 2020-02-04. PMID:31524235. |
furthermore, the cardioprotective properties of gas6 on the suppression of lps‑induced tnf‑α release and apoptosis were abolished by treatment with tp‑0903 (an axl inhibitor) and wortmannin (a pi3k inhibitor). |
2020-02-04 |
2023-08-13 |
Not clear |
| Weihua Yu, Xiaolong Ge, Xusheng Lai, Jiemin Lv, Yong Wan. The up-regulation of Axl is associated with a poor prognosis and promotes proliferation in pancreatic ductal adenocarcinoma. International journal of clinical and experimental pathology. vol 12. issue 5. 2020-01-17. PMID:31933980. |
according to in vitro assays, the proliferation of pancreatic cancer cells decreased, and the apoptosis level increased with axl knockdown. |
2020-01-17 |
2023-08-13 |
Not clear |
| Seon Min Woo, Kyoung-Jin Min, Seung Un Seo, Shin Kim, Peter Kubatka, Jong-Wook Park, Taeg Kyu Kwo. Axl Inhibitor R428 Enhances TRAIL-Mediated Apoptosis Through Downregulation of c-FLIP and Survivin Expression in Renal Carcinoma. International journal of molecular sciences. vol 20. issue 13. 2020-01-06. PMID:31269715. |
axl inhibitor r428 enhances trail-mediated apoptosis through downregulation of c-flip and survivin expression in renal carcinoma. |
2020-01-06 |
2023-08-13 |
human |
| Seon Min Woo, Kyoung-Jin Min, Seung Un Seo, Shin Kim, Peter Kubatka, Jong-Wook Park, Taeg Kyu Kwo. Axl Inhibitor R428 Enhances TRAIL-Mediated Apoptosis Through Downregulation of c-FLIP and Survivin Expression in Renal Carcinoma. International journal of molecular sciences. vol 20. issue 13. 2020-01-06. PMID:31269715. |
moreover, knockdown of axl by sirna also increased trail-induced apoptosis. |
2020-01-06 |
2023-08-13 |
human |
| Hirokazu Sadahiro, Kyung-Don Kang, Justin T Gibson, Mutsuko Minata, Hai Yu, Junfeng Shi, Rishi Chhipa, Zhihong Chen, Songjian Lu, Yannick Simoni, Takuya Furuta, Hemragul Sabit, Suojun Zhang, Soniya Bastola, Shinobu Yamaguchi, Hebaallah Alsheikh, Svetlana Komarova, Jun Wang, Sung-Hak Kim, Dolores Hambardzumyan, Xinghua Lu, Evan W Newell, Biplab DasGupta, Mitsutoshi Nakada, L James Lee, Burt Nabors, Lyse A Norian, Ichiro Nakan. Activation of the Receptor Tyrosine Kinase AXL Regulates the Immune Microenvironment in Glioblastoma. Cancer research. vol 78. issue 11. 2019-06-13. PMID:29531161. |
we previously observed upregulation of the tam (tyro-3, axl, and mer) receptor tyrosine kinase family member axl in mesenchymal gbm and showed that knockdown of axl induced apoptosis of mesenchymal, but not proneural, glioma sphere cultures (gsc). |
2019-06-13 |
2023-08-13 |
mouse |
| Cheng Huang, Yu-Ling Huang, Chia-Chi Wang, Yi-Ling Pan, Yu-Heng Lai, Hsiu-Chen Huan. Ampelopsins A and C Induce Apoptosis and Metastasis through Downregulating AxL, TYRO3, and FYN Expressions in MDA-MB-231 Breast Cancer Cells. Journal of agricultural and food chemistry. vol 67. issue 10. 2019-03-22. PMID:30789269. |
ampelopsins a and c induce apoptosis and metastasis through downregulating axl, tyro3, and fyn expressions in mda-mb-231 breast cancer cells. |
2019-03-22 |
2023-08-13 |
Not clear |
| Annelien J M Zweemer, Cory B French, Joshua Mesfin, Simon Gordonov, Aaron S Meyer, Douglas A Lauffenburge. Apoptotic Bodies Elicit Gas6-Mediated Migration of AXL-Expressing Tumor Cells. Molecular cancer research : MCR. vol 15. issue 12. 2018-07-12. PMID:28923840. |
phosphatidylserine is only available to mediate axl activation when it is externalized on cell membranes, an event that occurs during certain physiologic processes such as apoptosis. |
2018-07-12 |
2023-08-13 |
Not clear |
| Iman H Bassyouni, Mohammed M El-Wakd, Noha A Azab, Rasha H Bassyoun. Diminished soluble levels of growth arrest specific protein 6 and tyrosine kinase receptor Axl in patients with rheumatoid arthritis. International journal of rheumatic diseases. vol 20. issue 1. 2018-03-19. PMID:24702788. |
growth arrest specific protein 6 (gas-6) and its tyrosine kinase receptor axl plays an important role in apoptosis, and regulation of innate immune response, therefore, we investigated their plasma concentrations in rheumatoid arthritis (ra) patients and correlated them to clinical, laboratory and radiological parameters of the disease. |
2018-03-19 |
2023-08-13 |
Not clear |
| Quan Hong, Ou Li, Wei Zheng, Wen-Zhen Xiao, Lu Zhang, Di Wu, Guang-Yan Cai, John Cijiang He, Xiang-Mei Che. LncRNA HOTAIR regulates HIF-1α/AXL signaling through inhibition of miR-217 in renal cell carcinoma. Cell death & disease. vol 8. issue 5. 2018-02-16. PMID:28492542. |
gain- and loss-of-function of hotair revealed that hotair functioned as a cerna for mir-217 to facilitate hif-1α expression and then upregulated axl level promoting rcc proliferation, migration, and emt process, and inhibiting apoptosis. |
2018-02-16 |
2023-08-13 |
Not clear |
| Guiling Wu, Zhiqiang Ma, Wei Hu, Dongjin Wang, Bing Gong, Chongxi Fan, Shuai Jiang, Tian Li, Jianyuan Gao, Yang Yan. Molecular insights of Gas6/TAM in cancer development and therapy. Cell death & disease. vol 8. issue 3. 2017-11-13. PMID:28333143. |
since growth arrest-specific gene 6 (gas6) was discovered in 1988, numerous studies have highlighted the role of the gas6 protein and its receptors tyro3, axl and mer (collectively referred to as tam), in proliferation, apoptosis, efferocytosis, leukocyte migration, sequestration and platelet aggregation. |
2017-11-13 |
2023-08-13 |
Not clear |
| Fei Xu, Hongling Li, Yong Su. Inhibition of Axl improves the targeted therapy against ALK-mutated neuroblastoma. Biochemical and biophysical research communications. vol 454. issue 4. 2017-09-26. PMID:25450694. |
furthermore, a small-molecule inhibitor of axl significantly enhanced alk-targeted therapy, as an increased frequency of apoptosis was observed in nb cells co-expressing alk and axl. |
2017-09-26 |
2023-08-13 |
human |