| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Radwa S Raafat, Mohamed Z Habib, Amany A AbdElfattah, Nouran K Olama, Sahar M Abdelraouf, Nevien Hendawy, Khaled A Kamal, Salwa A Nawishy, Sawsan Aboul-Fotou. Amisulpride attenuates 5-fluorouracil-induced cognitive deficits via modulating hippocampal Wnt/GSK-3β/β-catenin signaling in Wistar rats. International immunopharmacology. vol 124. issue Pt A. 2023-09-16. PMID:37716161. |
amisulpride enhanced wnt/gsk-3β/β-catenin signaling, increased bdnf levels, and abrogated 5-fu-induced neuroinflammation, apoptosis, β-amyloid accumulation, and neurodegenerative changes with an improvement of cognitive performance. |
2023-09-16 |
2023-10-07 |
human |
| Hao Lv, Ziang Gao, Yunfei Wang, Siyuan Chen, Peiqiang Liu, Yulie Xie, Mengting Guan, Jianchao Cong, Yu X. Metformin Improves Comorbid Depressive Symptoms in Mice with Allergic Rhinitis by Reducing Olfactory Bulb Damage. Neurochemical research. 2023-08-13. PMID:37574530. |
in conclusion, our findings suggest that metformin might be a viable strategy for treating ar-related depression, possibly by modulating neuroplasticity, neurogenesis, apoptosis, and bdnf signaling in the ob via the ampk/tet2 pathway. |
2023-08-13 |
2023-08-16 |
mouse |
| A S Oreshko, A Ya Rodnyy, D V Bazovkina, V S Naumenk. Effects of central administration of the human Tau protein on the Bdnf, Trkb, p75, Mapt, Bax and Bcl-2 genes expression in the mouse brain. Vavilovskii zhurnal genetiki i selektsii. vol 27. issue 4. 2023-07-19. PMID:37465194. |
it was found that five days after administration of the protein into the fourth lateral ventricle, significant changes occurred in the expression of the genes involved in apoptosis and neurogenesis regulation, e. g., a notable decrease in the mrna level of the gene encoding the most important neurotrophic factor bdnf (brain-derived neurotrophic factor) was observed in the frontal cortex which could play an important role in neurodegeneration caused by pathological tau protein aggregation. |
2023-07-19 |
2023-08-14 |
mouse |
| Bita Firouzan, Farideh Iravanpour, Fatemeh Abbaszadeh, Valery Akparov, Jalal Zaringhalam, Rasoul Ghasemi, Nader Maghsoud. Dipeptide mimetic of BDNF ameliorates motor dysfunction and striatal apoptosis in 6-OHDA-induced Parkinson's rat model: Considering Akt and MAPKs signaling. Behavioural brain research. 2023-07-19. PMID:37467964. |
dipeptide mimetic of bdnf ameliorates motor dysfunction and striatal apoptosis in 6-ohda-induced parkinson's rat model: considering akt and mapks signaling. |
2023-07-19 |
2023-08-14 |
rat |
| Zhi Ma, Yue Wu, Juan Xu, Hui Cao, Mingyang Du, Haibo Jiang, Feng Qi. Sodium Tanshinone IIA Sulfonate Ameliorates Oxygen-glucose Deprivation/Reoxygenation-induced Neuronal Injury via Protection of Mitochondria and Promotion of Autophagy. Neurochemical research. 2023-07-12. PMID:37436612. |
silencing of pp2a or administration of 3-methyladenine inhibited autophagy and decreased the production of anti-inflammatory factors (il-10, tgf-β and bdnf) and induced the release of proinflammatory cytokines (il-1β, il-2 and tnf-α) by sts-treated microglia, thereby inducing mitochondrial dysfunction and apoptosis of sts-treated neurons. |
2023-07-12 |
2023-08-14 |
Not clear |
| Yu Cai, Hua Yang, Zhen Wan, Pei-Yong Chen, Zhi-Bo Wang, Jin-Jing Guo, Daxiang Wang, Feng Wang, Yanli Zhan. A novel lncRNA LOC105613571 binding with BDNF in pituitary promotes gonadotropin secretion by AKT/ERK-mTOR pathway in sheep associated with prolificacy. BioFactors (Oxford, England). 2023-07-11. PMID:37431985. |
notably, either lncrna loc105613571 or bdnf silencing inhibited cell proliferation while promoted cell apoptosis. |
2023-07-11 |
2023-08-14 |
Not clear |
| Igor Henrique Rodrigues de Paiva, Rodrigo Soares da Silva, Ingrid Prata Mendonça, Eduardo Duarte-Silva, José Roberto Botelho de Souza, Christina Alves Peixot. Fructooligosaccharide (FOS) and Galactooligosaccharide (GOS) Improve Neuroinflammation and Cognition By Up-regulating IRS/PI3K/AKT Signaling Pathway in Diet-induced Obese Mice. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2023-06-29. PMID:37382830. |
these obese mice also showed activation of microglia and astrocytes and significant immunoreactivity of neuroinflammatory and apoptosis markers, such as tnf-α, cox-2, and caspase-3, in addition to lower expression of neurogenesis and synaptic plasticity markers, such as neun, ki-67, creb-p, and bdnf. |
2023-06-29 |
2023-08-14 |
mouse |
| Qing-Qing Zhang, Yi Q. Brain-derived neurotrophic factor in degenerative retinal diseases: Update and novel perspective. Journal of neuroscience research. 2023-06-19. PMID:37334646. |
although disorder of bdnf, whether depletion or augmentation, has been connected with neuronal apoptosis and neuroinflammation, the exact mechanisms underlying the effect of impaired bdnf expression on degenerative retinal diseases remain unclear. |
2023-06-19 |
2023-08-14 |
Not clear |
| Abhinav Anand, Navneet Khurana, Satinder Kaur, Nemat Ali, Abdullah F AlAsmari, Mohammad Waseem, Muzaffar Iqbal, Faris M Alzahrani, Neha Sharm. The multifactorial role of vanillin in amelioration of aluminium chloride and D-galactose induced Alzheimer's disease in mice. European journal of pharmacology. 2023-06-17. PMID:37329974. |
these include oxidative stress, overexpression of acetylcholinesterase (ache), depletion of acetylcholine levels, increased beta-secretase mediated conversion of amyloid precursor protein (app) to amyloid beta (abeta), accumulation of abeta oligomers, decrease in brain derived neurotrophic factor (bdnf) and accelerated neuronal apoptosis due to elevated levels of caspase-3. |
2023-06-17 |
2023-08-14 |
mouse |
| Naomi Lomeli, Diana C Pearre, Maureen Cruz, Kaijun Di, Daniela A Bot. Cisplatin Induces BDNF Downregulation in Middle-Aged Female Rat Model while BDNF Enhancement Attenuates Cisplatin Neurotoxicity. bioRxiv : the preprint server for biology. 2023-06-09. PMID:37293048. |
our previous crci rodent studies have shown that cisplatin reduces hippocampal neurogenesis and bdnf expression and increases hippocampal apoptosis, which is associated with cognitive impairments. |
2023-06-09 |
2023-08-14 |
rat |
| Yuanlong Li, Hua Fan, Ming Ni, Wei Zhang, Fengqin Fang, Jun Sun, Pin Lyu, Peizhi M. Targeting lncRNA NEAT1 hampers Alzheimer's disease progression. Neuroscience. 2023-06-07. PMID:37286157. |
besides, lnc-neat1 knockdown reduced injury and apoptosis, decreased inflammatory cytokine levels, repressed oxidative stress level, and activated adenosine cyclophosphate response element-binding protein (creb)/brain-derived neurotrophic factor (bdnf) and nuclear factor erythroid 2-related factor 2 (nrf2)/nicotinamide adenine dinucleotide phosphate dehydrogenase 1 (nqo1) pathways in hippocampi of ad mice. |
2023-06-07 |
2023-08-14 |
mouse |
| Xiaonan Cao, Mengxiao Fu, Qiyan Du, Zhongjie Chan. Developmental toxicity of black phosphorus quantum dots in zebrafish (Danio rerio) embryos. Chemosphere. 2023-05-27. PMID:37244547. |
at the molecular level, the mrna transcript levels of key genes related to skeletal development (igf1, gh, myod and lox), neurodevelopment (gfap, pomca, bdnf and mbpa), cardiovascular development (myh6, nkx2.5, myl7, tbx2b, tbx5 and gata4) and apoptosis (p53, bax, bcl-2, apaf1, caspase-3 and caspase-9) were abnormal after bpqds exposure. |
2023-05-27 |
2023-08-14 |
cat |
| Qinxiang Zhou, Yu Chen, Hao Tang, Lei Zhang, Yue Ma, Dingqun Bai, Yuhan Kon. Transcranial direct current stimulation alleviated ischemic stroke induced injury involving the BDNF-TrkB signaling axis in rats. Heliyon. vol 9. issue 4. 2023-04-24. PMID:37089354. |
the current study investigated the neuroprotective effects and potential mechanisms of tdcs by brain-derived neurotrophic factor (bdnf) and its related receptor tropomyosin-receptor kinase b (trkb) against apoptosis following ischemic injury |
2023-04-24 |
2023-08-14 |
rat |
| Mohamed Jamal Saad. Potential protective effects of red grape seed extract in a rat model of malathion-induced neurotoxicity. Veterinary world. vol 16. issue 2. 2023-04-12. PMID:37042003. |
this study aimed to determine whether red grape seed extract (rgse, which is 95% bioflavonoids and equal to 12,000 mg of fresh red grape seed, and 150 mg of vitamin c) alleviated the changes in brain-derived neurotrophic factor (bdnf) level, acetylcholinesterase activity, oxidative stress, and apoptosis induced by orally administered malathion in a rat model of malathion-induced neurotoxicity. |
2023-04-12 |
2023-08-14 |
rat |
| Xue Zheng, Lu Chen, Tong Chen, Maosheng Cao, Boqi Zhang, Chenfeng Yuan, Zijiao Zhao, Chunjin Li, Xu Zho. The Mechanisms of BDNF Promoting the Proliferation of Porcine Follicular Granulosa Cells: Role of miR-127 and Involvement of the MAPK-ERK1/2 Pathway. Animals : an open access journal from MDPI. vol 13. issue 6. 2023-03-29. PMID:36978655. |
however, bdnf knockdown in gcs decreased cell viability and s-phase cells proportion-and bdnf simultaneously regulated the expression of genes linked with cell proliferation (ccnd1, p21 and bcl2) and apoptosis (bax). |
2023-03-29 |
2023-08-14 |
Not clear |
| Simona Terzo, Pasquale Calvi, Domenico Nuzzo, Pasquale Picone, Mario Allegra, Flavia Mulè, Antonella Amat. Long-Term Ingestion of Sicilian Black Bee Chestnut Honey and/or D-Limonene Counteracts Brain Damage Induced by High Fat-Diet in Obese Mice. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36834882. |
the hfd animals showed higher neuronal apoptosis, upregulation of pro-apoptotic genes fas-l, bim p27 and downregulation of anti-apoptotic factors bdnf and bcl2; increased gene expression of the pro-inflammatory il-1β, il-6 and tnf-α and elevated oxidative stress markers cox-2, inos, ros and nitrite. |
2023-02-25 |
2023-08-14 |
mouse |
| Wenhui Yan, Tingli Guo, Na Liu, Xin Cui, Xiaotong Wei, Yuzhuo Sun, Hao Hu, Lina Che. Erythropoietin ameliorates cognitive deficits by improving hippocampal and synaptic damage in streptozotocin-induced diabetic mice. Cellular signalling. 2023-02-05. PMID:36739954. |
our findings revealed that epo impedes hippocampal and synaptic damage and neuronal apoptosis by regulating bdnf and psd-95 expression through nmda receptors, thereby ameliorating cognitive impairments in mice with t1dm. |
2023-02-05 |
2023-08-14 |
mouse |
| Ya-Jen Chiu, Yu-Shan Teng, Chiung-Mei Chen, Ying-Chieh Sun, Hsiu Mei Hsieh-Li, Kuo-Hsuan Chang, Guey-Jen Lee-Che. A Neuroprotective Action of Quercetin and Apigenin through Inhibiting Aggregation of Aβ and Activation of TRKB Signaling in a Cellular Experiment. Biomolecules & therapeutics. 2023-01-16. PMID:36646447. |
treatments with quercetin and apigenin increased trkb tyr516 and tyr817 and downstream camp-response-element binding protein (creb) ser133 to activate transcription of bdnf and bcl2 apoptosis regulator (bcl2), as well as reduced the expression of pro-apoptotic bcl2 associated x protein (bax). |
2023-01-16 |
2023-08-14 |
Not clear |
| Abdulla M A Mahmoud, Eman M Mantawy, Sara A Wahdan, Ramy M Ammar, Ebtehal El-Demerdas. Vildagliptin restores cognitive function and mitigates hippocampal neuronal apoptosis in cisplatin-induced chemo-brain: Imperative roles of AMPK/Akt/CREB/ BDNF signaling cascades. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 159. 2023-01-14. PMID:36640673. |
vildagliptin restores cognitive function and mitigates hippocampal neuronal apoptosis in cisplatin-induced chemo-brain: imperative roles of ampk/akt/creb/ bdnf signaling cascades. |
2023-01-14 |
2023-08-14 |
human |
| Abdulla M A Mahmoud, Eman M Mantawy, Sara A Wahdan, Ramy M Ammar, Ebtehal El-Demerdas. Vildagliptin restores cognitive function and mitigates hippocampal neuronal apoptosis in cisplatin-induced chemo-brain: Imperative roles of AMPK/Akt/CREB/ BDNF signaling cascades. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 159. 2023-01-14. PMID:36640673. |
in addition, the neuroprotective mechanisms of vilda include diminishing oxidative stress by reducing mda levels while raising gsh levels and sod activity, repressing neuronal apoptosis as shown by elevated bcl-2 levels together with diminished bax and caspase-3 expressions, inhibiting neuroinflammation as shown by decreased gfap expression, and finally boosting hippocampal neurogenesis and survival by upregulating expressions of bdnf and pcna. |
2023-01-14 |
2023-08-14 |
human |