| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Naomi Lomeli, Diana C Pearre, Maureen Cruz, Kaijun Di, Daniela A Bot. Cisplatin Induces BDNF Downregulation in Middle-Aged Female Rat Model while BDNF Enhancement Attenuates Cisplatin Neurotoxicity. bioRxiv : the preprint server for biology. 2023-06-09. PMID:37293048. |
our previous crci rodent studies have shown that cisplatin reduces hippocampal neurogenesis and bdnf expression and increases hippocampal apoptosis, which is associated with cognitive impairments. |
2023-06-09 |
2023-08-14 |
rat |
| Yuanlong Li, Hua Fan, Ming Ni, Wei Zhang, Fengqin Fang, Jun Sun, Pin Lyu, Peizhi M. Targeting lncRNA NEAT1 hampers Alzheimer's disease progression. Neuroscience. 2023-06-07. PMID:37286157. |
besides, lnc-neat1 knockdown reduced injury and apoptosis, decreased inflammatory cytokine levels, repressed oxidative stress level, and activated adenosine cyclophosphate response element-binding protein (creb)/brain-derived neurotrophic factor (bdnf) and nuclear factor erythroid 2-related factor 2 (nrf2)/nicotinamide adenine dinucleotide phosphate dehydrogenase 1 (nqo1) pathways in hippocampi of ad mice. |
2023-06-07 |
2023-08-14 |
mouse |
| Xiaonan Cao, Mengxiao Fu, Qiyan Du, Zhongjie Chan. Developmental toxicity of black phosphorus quantum dots in zebrafish (Danio rerio) embryos. Chemosphere. 2023-05-27. PMID:37244547. |
at the molecular level, the mrna transcript levels of key genes related to skeletal development (igf1, gh, myod and lox), neurodevelopment (gfap, pomca, bdnf and mbpa), cardiovascular development (myh6, nkx2.5, myl7, tbx2b, tbx5 and gata4) and apoptosis (p53, bax, bcl-2, apaf1, caspase-3 and caspase-9) were abnormal after bpqds exposure. |
2023-05-27 |
2023-08-14 |
cat |
| Qinxiang Zhou, Yu Chen, Hao Tang, Lei Zhang, Yue Ma, Dingqun Bai, Yuhan Kon. Transcranial direct current stimulation alleviated ischemic stroke induced injury involving the BDNF-TrkB signaling axis in rats. Heliyon. vol 9. issue 4. 2023-04-24. PMID:37089354. |
the current study investigated the neuroprotective effects and potential mechanisms of tdcs by brain-derived neurotrophic factor (bdnf) and its related receptor tropomyosin-receptor kinase b (trkb) against apoptosis following ischemic injury |
2023-04-24 |
2023-08-14 |
rat |
| Mohamed Jamal Saad. Potential protective effects of red grape seed extract in a rat model of malathion-induced neurotoxicity. Veterinary world. vol 16. issue 2. 2023-04-12. PMID:37042003. |
this study aimed to determine whether red grape seed extract (rgse, which is 95% bioflavonoids and equal to 12,000 mg of fresh red grape seed, and 150 mg of vitamin c) alleviated the changes in brain-derived neurotrophic factor (bdnf) level, acetylcholinesterase activity, oxidative stress, and apoptosis induced by orally administered malathion in a rat model of malathion-induced neurotoxicity. |
2023-04-12 |
2023-08-14 |
rat |
| Xue Zheng, Lu Chen, Tong Chen, Maosheng Cao, Boqi Zhang, Chenfeng Yuan, Zijiao Zhao, Chunjin Li, Xu Zho. The Mechanisms of BDNF Promoting the Proliferation of Porcine Follicular Granulosa Cells: Role of miR-127 and Involvement of the MAPK-ERK1/2 Pathway. Animals : an open access journal from MDPI. vol 13. issue 6. 2023-03-29. PMID:36978655. |
however, bdnf knockdown in gcs decreased cell viability and s-phase cells proportion-and bdnf simultaneously regulated the expression of genes linked with cell proliferation (ccnd1, p21 and bcl2) and apoptosis (bax). |
2023-03-29 |
2023-08-14 |
Not clear |
| Simona Terzo, Pasquale Calvi, Domenico Nuzzo, Pasquale Picone, Mario Allegra, Flavia Mulè, Antonella Amat. Long-Term Ingestion of Sicilian Black Bee Chestnut Honey and/or D-Limonene Counteracts Brain Damage Induced by High Fat-Diet in Obese Mice. International journal of molecular sciences. vol 24. issue 4. 2023-02-25. PMID:36834882. |
the hfd animals showed higher neuronal apoptosis, upregulation of pro-apoptotic genes fas-l, bim p27 and downregulation of anti-apoptotic factors bdnf and bcl2; increased gene expression of the pro-inflammatory il-1β, il-6 and tnf-α and elevated oxidative stress markers cox-2, inos, ros and nitrite. |
2023-02-25 |
2023-08-14 |
mouse |
| Wenhui Yan, Tingli Guo, Na Liu, Xin Cui, Xiaotong Wei, Yuzhuo Sun, Hao Hu, Lina Che. Erythropoietin ameliorates cognitive deficits by improving hippocampal and synaptic damage in streptozotocin-induced diabetic mice. Cellular signalling. 2023-02-05. PMID:36739954. |
our findings revealed that epo impedes hippocampal and synaptic damage and neuronal apoptosis by regulating bdnf and psd-95 expression through nmda receptors, thereby ameliorating cognitive impairments in mice with t1dm. |
2023-02-05 |
2023-08-14 |
mouse |
| Ya-Jen Chiu, Yu-Shan Teng, Chiung-Mei Chen, Ying-Chieh Sun, Hsiu Mei Hsieh-Li, Kuo-Hsuan Chang, Guey-Jen Lee-Che. A Neuroprotective Action of Quercetin and Apigenin through Inhibiting Aggregation of Aβ and Activation of TRKB Signaling in a Cellular Experiment. Biomolecules & therapeutics. 2023-01-16. PMID:36646447. |
treatments with quercetin and apigenin increased trkb tyr516 and tyr817 and downstream camp-response-element binding protein (creb) ser133 to activate transcription of bdnf and bcl2 apoptosis regulator (bcl2), as well as reduced the expression of pro-apoptotic bcl2 associated x protein (bax). |
2023-01-16 |
2023-08-14 |
Not clear |
| Abdulla M A Mahmoud, Eman M Mantawy, Sara A Wahdan, Ramy M Ammar, Ebtehal El-Demerdas. Vildagliptin restores cognitive function and mitigates hippocampal neuronal apoptosis in cisplatin-induced chemo-brain: Imperative roles of AMPK/Akt/CREB/ BDNF signaling cascades. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 159. 2023-01-14. PMID:36640673. |
vildagliptin restores cognitive function and mitigates hippocampal neuronal apoptosis in cisplatin-induced chemo-brain: imperative roles of ampk/akt/creb/ bdnf signaling cascades. |
2023-01-14 |
2023-08-14 |
human |
| Abdulla M A Mahmoud, Eman M Mantawy, Sara A Wahdan, Ramy M Ammar, Ebtehal El-Demerdas. Vildagliptin restores cognitive function and mitigates hippocampal neuronal apoptosis in cisplatin-induced chemo-brain: Imperative roles of AMPK/Akt/CREB/ BDNF signaling cascades. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 159. 2023-01-14. PMID:36640673. |
in addition, the neuroprotective mechanisms of vilda include diminishing oxidative stress by reducing mda levels while raising gsh levels and sod activity, repressing neuronal apoptosis as shown by elevated bcl-2 levels together with diminished bax and caspase-3 expressions, inhibiting neuroinflammation as shown by decreased gfap expression, and finally boosting hippocampal neurogenesis and survival by upregulating expressions of bdnf and pcna. |
2023-01-14 |
2023-08-14 |
human |
| Guiping Xu, Yang Wang, Zhe Chen, Yuxuan Zhang, Xuexue Zhang, Guichao Zhan. Esketamine improves propofol-induced brain injury and cognitive impairment in rats. Translational neuroscience. vol 13. issue 1. 2022-12-23. PMID:36561289. |
moreover, knocking down bdnf partially reversed esketamine-mediated activation of the mbdnf/trkb/pi3k signaling pathway and inhibition of neuronal apoptosis in propofol-induced rats. |
2022-12-23 |
2023-08-14 |
human |
| Zhe Chen, Hong Fan, Zi-Yi Chen, Chao Jiang, Ming-Zhe Feng, Xin-Yu Guo, Hao Yang, Ding-Jun Ha. OECs Prevented Neuronal Cells from Apoptosis Partially Through Exosome-derived BDNF. Journal of molecular neuroscience : MN. 2022-12-17. PMID:36527597. |
oecs prevented neuronal cells from apoptosis partially through exosome-derived bdnf. |
2022-12-17 |
2023-08-14 |
Not clear |
| Zhe Chen, Hong Fan, Zi-Yi Chen, Chao Jiang, Ming-Zhe Feng, Xin-Yu Guo, Hao Yang, Ding-Jun Ha. OECs Prevented Neuronal Cells from Apoptosis Partially Through Exosome-derived BDNF. Journal of molecular neuroscience : MN. 2022-12-17. PMID:36527597. |
furthermore, we demonstrated that oecs prevented tnf-α-induced apoptosis in neurons partially through exosome-derived bdnf. our data showed that oecs attenuated tnf-α-induced apoptosis in neurons partially through oec-exo-derived bdnf, which might provide a novel strategy for the neuroprotective effect of oec-exo-based treatment. |
2022-12-17 |
2023-08-14 |
Not clear |
| Su-Su Wang, Xi Xu, An-Xin Lu, Wan-He Li, Jun-Xia Liu, Chen Liu, Chong-Huai Ya. Amelioration of cholesterol sulfate for lead-induced CTX cell apoptosis based on BDNF signaling pathway mediated cholesterol metabolism. Ecotoxicology and environmental safety. vol 248. 2022-11-24. PMID:36423370. |
amelioration of cholesterol sulfate for lead-induced ctx cell apoptosis based on bdnf signaling pathway mediated cholesterol metabolism. |
2022-11-24 |
2023-08-14 |
rat |
| Su-Su Wang, Xi Xu, An-Xin Lu, Wan-He Li, Jun-Xia Liu, Chen Liu, Chong-Huai Ya. Amelioration of cholesterol sulfate for lead-induced CTX cell apoptosis based on BDNF signaling pathway mediated cholesterol metabolism. Ecotoxicology and environmental safety. vol 248. 2022-11-24. PMID:36423370. |
however, pretreatment with cs detoxified the negative impacts of lead-invoked ctx cell damage, acting as an effective remedy for apoptosis, imbalance of cholesterol metabolism and inhibition of bdnf signaling pathway. |
2022-11-24 |
2023-08-14 |
rat |
| Rosario Baltazar-Lara, Janeth Mora Zenil, Martha Carranza, José Ávila-Mendoza, Carlos G Martínez-Moreno, Carlos Arámburo, Maricela Lun. Growth Hormone (GH) Crosses the Blood-Brain Barrier (BBB) and Induces Neuroprotective Effects in the Embryonic Chicken Cerebellum after a Hypoxic Injury. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36232848. |
additionally, gh treatment provoked a significant reduction in apoptosis and lipoperoxidation; decreased the mrna expression of the inflammatory mediators (tnfα, il-6, il-1β, and inos); and upregulated the expression of several neurotrophic factors (igf-1, vegf, and bdnf). |
2022-10-14 |
2023-08-14 |
chicken |
| Yaling Zhang, Dejian Chen, Daojuan Wang, Lei Wang, Yajing Weng, Hongwei Wang, Xiaoke Wu, Yong Wan. Moderate Aerobic Exercise Regulates Follicular Dysfunction by Initiating Brain-Derived Neurotrophic Factor (BDNF)-Mediated Anti-Apoptotic Signaling Pathways in Polycystic Ovary Syndrome. Journal of clinical medicine. vol 11. issue 19. 2022-10-14. PMID:36233452. |
our in vitro results state that treatment with bdnf ameliorated dihydrotestosterone (dht)-induced granulosa cells (gcs) apoptosis by provoking p-trkb activation and upregulating the pi3k/akt pathway. |
2022-10-14 |
2023-08-14 |
rat |
| Zhi Jiang, Jie Wang, Gaohui Sun, Meijiang Fen. BDNF-modified human umbilical cord mesenchymal stem cells-derived dopaminergic-like neurons improve rotation behavior of Parkinson's disease rats through neuroprotection and anti-neuroinflammation. Molecular and cellular neurosciences. 2022-10-13. PMID:36228967. |
results showed that transplantation of bdnf-modified huc-mscs-derived daergic-like neurons improved the apomorphine induced rotation behavior of pd rats, increased the dopamine concentration and the expression of glial fibrillary acidic protein (gfap) and ionized calcium-binding adaptor molecule-1 (iba-1) in the striatum, promoted the expression of tyrosine hydroxylase (th), nuclear receptor-related factor 1 (nurr1), pituitary homeobox 3 (pitx3), bdnf, tyrosine kinase b (trkb), phosphatidylinositol-3-hydroxykinase (pi3k), phosphorylated protein kinase b (p-akt), heat shock protein 60 (hsp60), toll-like receptor 4 (tlr4) and myeloid differentiation factor 88 (myd88) and inhibited the neural apoptosis in the substantia nigra (sn) and striatum. |
2022-10-13 |
2023-08-14 |
human |
| Chunshuai Wu, Guanhua Xu, Guofeng Bao, Hong Gao, Jiajia Chen, Jinlong Zhang, Chu Chen, Hongxiang Hong, Pengfei Xue, Jiawei Jiang, Yang Liu, Jiayi Huang, Yue Sun, Jiawei Fu, Yiqiu Li, Zhiming Cu. Ubiquitin ligase Triad1 promotes neurite outgrowth by inhibiting MDM2-mediated ubiquitination of the neuroprotective factor pleiotropin. The Journal of biological chemistry. 2022-09-02. PMID:36055408. |
we also show using flow cytometry and astrocyte/neuronal co-culture assays that triad1 overexpression promoted ptn protein levels, neurotrophic growth factor (ngf) expression, brain-derived neurotrophic factor (bdnf) expression, astrocyte and neuronal viability, and neurite outgrowth, but suppressed astrocyte apoptosis, while shrna-mediated knockdown of triad1 and ptn had the opposite effects. |
2022-09-02 |
2023-08-14 |
rat |