| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lian Liu, Ming Liu, Wei Zhao, Yuan-Ling Zhao, Yun Wan. Tetrahydropalmatine Regulates BDNF through TrkB/CAM Interaction to Alleviate the Neurotoxicity Induced by Methamphetamine. ACS chemical neuroscience. vol 12. issue 18. 2021-09-20. PMID:34448569. |
thp attenuated the ma-induced neurotoxicity by decreasing cam, increasing trkb, phosphorylating akt, up-regulating nf-κb and bdnf, and inhibiting cell apoptosis. |
2021-09-20 |
2023-08-13 |
rat |
| Wei Ma, Xiaowei Wei, Hui Gu, Dan Liu, Wenting Luo, Dong An, Yuzuo Bai, Zhengwei Yua. Therapeutic potential of adenovirus-encoding brain-derived neurotrophic factor for spina bifida aperta by intra-amniotic delivery in a rat model. Gene therapy. vol 27. issue 12. 2021-08-18. PMID:32094517. |
we found that most of the overexpressed bdnf was present on the lesions of the spina bifida fetuses, the number of apoptosis cells in ad-gfp-bdnf-transfected spinal cords were reduced, mrna levels of bcl2/bax were upregulated and casp3 were downregulated compared with the controls, the proportion of brn3a positive neurons in drg were increased by activating the bdnf/trkb/akt signaling pathway, and most of the significant changes in cytokines in the amniotic fluid were related to the biological processes of regulation of apoptotic process and generation of neurons. |
2021-08-18 |
2023-08-13 |
rat |
| Candelaria Martín-González, Lucía Romero-Acevedo, Camino María Fernández-Rodríguez, Lilian Medina-Vega, Alen García-Rodríguez, Paula Ortega-Toledo, Lourdes González-Navarrete, Víctor Eugenio Vera-Delgado, Emilio González-Reimer. Brain-derived neurotrophic factor among patients with alcoholism. CNS spectrums. vol 26. issue 4. 2021-08-18. PMID:32423492. |
brain-derived neurotrophic factor (bdnf) is involved in neurogenesis and in the protection against oxidative damage and neuronal apoptosis. |
2021-08-18 |
2023-08-13 |
Not clear |
| Safa Sefidgari-Abrasi, Leila Roshangar, Pouran Karimi, Mohammad Morshedi, Marziyeh Rahimiyan-Heravan, Maryam Saghafi-As. From the gut to the heart: L. plantarum and inulin administration as a novel approach to control cardiac apoptosis via 5-HT2B and TrkB receptors in diabetes. Clinical nutrition (Edinburgh, Scotland). vol 40. issue 1. 2021-08-17. PMID:32446786. |
brain-derived neurotrophic factor (bdnf) and serotonin are two neurotransmitters that can control cardiomyocyte apoptosis and myocardial fibrosis through their cardiac receptors. |
2021-08-17 |
2023-08-13 |
Not clear |
| Safa Sefidgari-Abrasi, Leila Roshangar, Pouran Karimi, Mohammad Morshedi, Marziyeh Rahimiyan-Heravan, Maryam Saghafi-As. From the gut to the heart: L. plantarum and inulin administration as a novel approach to control cardiac apoptosis via 5-HT2B and TrkB receptors in diabetes. Clinical nutrition (Edinburgh, Scotland). vol 40. issue 1. 2021-08-17. PMID:32446786. |
in the present study, we investigated the impacts of l. plantarum and inulin supplementation on the inhibition of cardiac apoptosis and fibrosis by modulating intestinal, serum, and cardiac levels of serotonin and bdnf as well as their cardiac receptors. |
2021-08-17 |
2023-08-13 |
Not clear |
| Joyshikh Sonowal, Chhabi Lal Patel, Ravi Kumar Gandham, Basavaraj Sajjanar, Raja Ishaq Nabi Khan, Manas Ranjan Praharaj, Waseem Akram Malla, Deepak Kumar, Kapil Dev, N Barkathullah, Krishna Bharali, Amitesh Dubey, D Lalita, Insha Zafir, B P Mishra, Bina Mishr. Genome-wide expression analysis reveal host genes involved in immediate-early infections of different sheeppox virus strains. Gene. vol 801. 2021-08-16. PMID:34274484. |
sppv modulates the expression of several important host proteins such as cd40, fas, itgβ1, itgα1, pak1, pak2, cd14, ilk leading to viral attachment and entry; immune-related degs such as mapk, jnk, erk, nfkb, ikb, pi3k, stat which provide optimal cellular condition for early viral protein expression; and foxo3, atf, cdkna1, tcf, srf, bdnf which help in inducing apoptosis and mptp, bad and tp53 inhibits apoptosis or cell death at the immediate-early time. |
2021-08-16 |
2023-08-13 |
Not clear |
| Shotaro Otsuka, Harutoshi Sakakima, Akira Tani, Kazuki Nakanishi, Seiya Takada, Kosuke Norimatsu, Hiroshi Maejima, Ikuro Maruyam. Effects of detraining on preconditioning exercise-induced neuroprotective potential after ischemic stroke in rats. Brain structure & function. vol 226. issue 7. 2021-08-11. PMID:34114048. |
infarct volume, neurological deficits, sensorimotor function, expression levels of brain-derived neurotrophic factor (bdnf), hypoxia-induced factor-1α (hif-1α), glial fibrillary acidic protein (gfap), and p2x7 receptors, and apoptosis activity were examined using immunohistochemical and western blot analyses. |
2021-08-11 |
2023-08-13 |
rat |
| S G Kalinichenko, N Y Matveeva, A V Korobtso. Brain-Derived Neurotrophic Factor (BDNF) As a Regulator of Apoptosis under Conditions of Focal Experimental Stroke. Bulletin of experimental biology and medicine. vol 169. issue 5. 2021-08-09. PMID:32990850. |
brain-derived neurotrophic factor (bdnf) as a regulator of apoptosis under conditions of focal experimental stroke. |
2021-08-09 |
2023-08-13 |
rat |
| Vlad Dionisie, Adela Magdalena Ciobanu, Vlad Alexandru Toma, Mihnea Costin Manea, Ioana Baldea, Diana Olteanu, Alexandra Sevastre-Berghian, Simona Clichici, Mirela Manea, Sorin Riga, Gabriela Adriana Fili. Escitalopram Targets Oxidative Stress, Caspase-3, BDNF and MeCP2 in the Hippocampus and Frontal Cortex of a Rat Model of Depression Induced by Chronic Unpredictable Mild Stress. International journal of molecular sciences. vol 22. issue 14. 2021-07-30. PMID:34299103. |
the aim of this study is to investigate the effects of escitalopram on oxidative stress, apoptosis, brain-derived neurotrophic factor (bdnf), methyl-cpg-binding protein 2 (mecp2), and oligodendrocytes number in the brain of chronic unpredictable mild stress-induced depressed rats. |
2021-07-30 |
2023-08-13 |
rat |
| Mary E Dail, Meghan L M Brino, Janice E Chamber. Effects of novel brain-penetrating oxime acetylcholinesterase reactivators on sarin surrogate-induced changes in rat brain gene expression. Journal of biochemical and molecular toxicology. vol 35. issue 6. 2021-07-27. PMID:33682265. |
the hippocampus was examined via quantitative polymerase chain reaction for the expression of immediate-early genes involved in brain repair (bdnf), increasing neurotoxicity (fos), and apoptosis control (jdp2, bcl2l1, bcl2l11). |
2021-07-27 |
2023-08-13 |
rat |
| Qing-Zhi He, Bi-Qi Zhu, Xiao-Na Xu, Huai-Cai Zen. Role of the BDNF/TrkB/CREB signaling pathway in the cytotoxicity of bisphenol S in SK-N-SH cells. Journal of biochemical and molecular toxicology. vol 35. issue 6. 2021-07-27. PMID:33749030. |
the cells were treated with various concentrations of bps, and cell viability, apoptosis rate, mitochondrial membrane potential (mmp), and the bdnf, cleaved-caspase-3, b-cell lymphoma 2 (bcl-2), bcl-2-associated x protein (bax), trkb, creb, and phospho-creb (p-creb) levels were determined. |
2021-07-27 |
2023-08-13 |
Not clear |
| Xiao-Chen Yu, Zhen Li, Xin-Ran Liu, Jia-Ni Hu, Rui Liu, Na Zhu, Yong L. The Antioxidant Effects of Whey Protein Peptide on Learning and Memory Improvement in Aging Mice Models. Nutrients. vol 13. issue 6. 2021-07-23. PMID:34205338. |
its specific mechanism may be related to reducing the degeneration of hippocampal nerve cells, reducing the apoptosis of nerve cells, improving the activity of ache, reducing the expression of inflammatory factors (tnf-α and il-1β) in brain tissue, reducing oxidative stress injury, and improving the expression of p-camkⅡ and bdnf synaptic plasticity protein. |
2021-07-23 |
2023-08-13 |
mouse |
| Redouane Rebai, Luc Jasmin, Abdennacer Bouda. Agomelatine effects on fat-enriched diet induced neuroinflammation and depression-like behavior in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 135. 2021-07-19. PMID:33453676. |
immediately after the second behavioral testing we measured the proinflammatory cytokines tumor necrosis factor alpha (tnf-α), interleukin 6 (il-6) and interleukin 1 beta (il-1β), markers of oxidative stress thiobarbituric acid reactive substances (tabrs), catalase (cat) and glutathione peroxidase (gpx), the growth factor bdnf, as well as the apoptosis marker caspase-3. |
2021-07-19 |
2023-08-13 |
rat |
| Xiaowei Lu, Jingde Dong, Donghui Zheng, Xiaolin Li, Dan Ding, Huae X. Reperfusion combined with intraarterial administration of resveratrol-loaded nanoparticles improved cerebral ischemia-reperfusion injury in rats. Nanomedicine : nanotechnology, biology, and medicine. vol 28. 2021-07-15. PMID:32334100. |
res-nps attenuated the oxidative stress induced by i/r, prevented brain edema, protected neurons from undergoing apoptosis, and contributed to neurogenesis through enhanced expression of brain-derived neurotrophic factor (bdnf). |
2021-07-15 |
2023-08-13 |
rat |
| Jéssica Rosso Motta, Ivo Emilio da Cruz Jung, Verônica Farina Azzolin, Cibele Ferreira Teixeira, Luiza Elizabete Braun, Daniel Augusto De Oliveira Nerys, Marco Aurélio Echart Motano, Marta Maria Medeiros Frescura Duarte, Ednea Aguiar Maia-Ribeiro, Ivana Beatrice Mânica da Cruz, Fernanda Barbisa. Avocado oil (Persea americana) protects SH-SY5Y cells against cytotoxicity triggered by cortisol by the modulation of BDNF, oxidative stress, and apoptosis molecules. Journal of food biochemistry. vol 45. issue 2. 2021-07-08. PMID:33480081. |
avocado oil (persea americana) protects sh-sy5y cells against cytotoxicity triggered by cortisol by the modulation of bdnf, oxidative stress, and apoptosis molecules. |
2021-07-08 |
2023-08-13 |
Not clear |
| Jéssica Rosso Motta, Ivo Emilio da Cruz Jung, Verônica Farina Azzolin, Cibele Ferreira Teixeira, Luiza Elizabete Braun, Daniel Augusto De Oliveira Nerys, Marco Aurélio Echart Motano, Marta Maria Medeiros Frescura Duarte, Ednea Aguiar Maia-Ribeiro, Ivana Beatrice Mânica da Cruz, Fernanda Barbisa. Avocado oil (Persea americana) protects SH-SY5Y cells against cytotoxicity triggered by cortisol by the modulation of BDNF, oxidative stress, and apoptosis molecules. Journal of food biochemistry. vol 45. issue 2. 2021-07-08. PMID:33480081. |
cortisol can induce oxidative stress, apoptosis events, and a lowering effect on brain-derived neurotrophic factor (bdnf), a neurogenic molecule. |
2021-07-08 |
2023-08-13 |
Not clear |
| Sepideh Nazarian, Zohreh Abdolmaleki, Alireza Torfeh, Seyed Hamed Shirazi Beheshtih. Mesenchymal stem cells with modafinil (gold nanoparticles) significantly improves neurological deficits in rats after middle cerebral artery occlusion. Experimental brain research. vol 238. issue 11. 2021-07-07. PMID:32886135. |
finally, infarct volume, bdnf (brain-derived neurotrophic factor), gdnf (glial cell-derived neurotrophic factor), neun (neuronal nuclear protein) expression, and cell apoptosis in brain were analyzed. |
2021-07-07 |
2023-08-13 |
rat |
| Sepideh Nazarian, Zohreh Abdolmaleki, Alireza Torfeh, Seyed Hamed Shirazi Beheshtih. Mesenchymal stem cells with modafinil (gold nanoparticles) significantly improves neurological deficits in rats after middle cerebral artery occlusion. Experimental brain research. vol 238. issue 11. 2021-07-07. PMID:32886135. |
the brain infarct volume and apoptosis significantly decreased and bdnf, neun, and gdnf increased in c + mcao, cm + mcao, and cmn + mcao groups compared to ischemia. |
2021-07-07 |
2023-08-13 |
rat |
| Hui Yao, Hui Shen, Hao Yu, Changliang Wang, Runtao Ding, Xinze Lan, Dilichati Tash, Xu Wu, Xiaolong Wang, Guohua Zhan. Chronic ethanol exposure induced depressive-like behavior in male C57BL/6 N mice by downregulating GluA1. Physiology & behavior. vol 234. 2021-06-25. PMID:33713693. |
we confirmed that 90- and 180-day ethanol exposure can lead to depressive-like mouse behavior, cell apoptosis, neuronal degeneration, a reduction in glua1 and brain-derived neurotrophic factor (bdnf) expression, and an increase in il-6 and il-1β in the mouse hippocampus. |
2021-06-25 |
2023-08-13 |
mouse |
| Hui Yao, Hui Shen, Hao Yu, Changliang Wang, Runtao Ding, Xinze Lan, Dilichati Tash, Xu Wu, Xiaolong Wang, Guohua Zhan. Chronic ethanol exposure induced depressive-like behavior in male C57BL/6 N mice by downregulating GluA1. Physiology & behavior. vol 234. 2021-06-25. PMID:33713693. |
ethanol exposure decreased cell viability and the expression of bdnf and increased the cell apoptosis rate and the expression of bax, cleaved caspase-3, il-1β and il-6. |
2021-06-25 |
2023-08-13 |
mouse |