| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qing-Zhi He, Bi-Qi Zhu, Xiao-Na Xu, Huai-Cai Zen. Role of the BDNF/TrkB/CREB signaling pathway in the cytotoxicity of bisphenol S in SK-N-SH cells. Journal of biochemical and molecular toxicology. vol 35. issue 6. 2021-07-27. PMID:33749030. |
the cells were treated with various concentrations of bps, and cell viability, apoptosis rate, mitochondrial membrane potential (mmp), and the bdnf, cleaved-caspase-3, b-cell lymphoma 2 (bcl-2), bcl-2-associated x protein (bax), trkb, creb, and phospho-creb (p-creb) levels were determined. |
2021-07-27 |
2023-08-13 |
Not clear |
| Xiao-Chen Yu, Zhen Li, Xin-Ran Liu, Jia-Ni Hu, Rui Liu, Na Zhu, Yong L. The Antioxidant Effects of Whey Protein Peptide on Learning and Memory Improvement in Aging Mice Models. Nutrients. vol 13. issue 6. 2021-07-23. PMID:34205338. |
its specific mechanism may be related to reducing the degeneration of hippocampal nerve cells, reducing the apoptosis of nerve cells, improving the activity of ache, reducing the expression of inflammatory factors (tnf-α and il-1β) in brain tissue, reducing oxidative stress injury, and improving the expression of p-camkⅡ and bdnf synaptic plasticity protein. |
2021-07-23 |
2023-08-13 |
mouse |
| Redouane Rebai, Luc Jasmin, Abdennacer Bouda. Agomelatine effects on fat-enriched diet induced neuroinflammation and depression-like behavior in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 135. 2021-07-19. PMID:33453676. |
immediately after the second behavioral testing we measured the proinflammatory cytokines tumor necrosis factor alpha (tnf-α), interleukin 6 (il-6) and interleukin 1 beta (il-1β), markers of oxidative stress thiobarbituric acid reactive substances (tabrs), catalase (cat) and glutathione peroxidase (gpx), the growth factor bdnf, as well as the apoptosis marker caspase-3. |
2021-07-19 |
2023-08-13 |
rat |
| Xiaowei Lu, Jingde Dong, Donghui Zheng, Xiaolin Li, Dan Ding, Huae X. Reperfusion combined with intraarterial administration of resveratrol-loaded nanoparticles improved cerebral ischemia-reperfusion injury in rats. Nanomedicine : nanotechnology, biology, and medicine. vol 28. 2021-07-15. PMID:32334100. |
res-nps attenuated the oxidative stress induced by i/r, prevented brain edema, protected neurons from undergoing apoptosis, and contributed to neurogenesis through enhanced expression of brain-derived neurotrophic factor (bdnf). |
2021-07-15 |
2023-08-13 |
rat |
| Jéssica Rosso Motta, Ivo Emilio da Cruz Jung, Verônica Farina Azzolin, Cibele Ferreira Teixeira, Luiza Elizabete Braun, Daniel Augusto De Oliveira Nerys, Marco Aurélio Echart Motano, Marta Maria Medeiros Frescura Duarte, Ednea Aguiar Maia-Ribeiro, Ivana Beatrice Mânica da Cruz, Fernanda Barbisa. Avocado oil (Persea americana) protects SH-SY5Y cells against cytotoxicity triggered by cortisol by the modulation of BDNF, oxidative stress, and apoptosis molecules. Journal of food biochemistry. vol 45. issue 2. 2021-07-08. PMID:33480081. |
avocado oil (persea americana) protects sh-sy5y cells against cytotoxicity triggered by cortisol by the modulation of bdnf, oxidative stress, and apoptosis molecules. |
2021-07-08 |
2023-08-13 |
Not clear |
| Jéssica Rosso Motta, Ivo Emilio da Cruz Jung, Verônica Farina Azzolin, Cibele Ferreira Teixeira, Luiza Elizabete Braun, Daniel Augusto De Oliveira Nerys, Marco Aurélio Echart Motano, Marta Maria Medeiros Frescura Duarte, Ednea Aguiar Maia-Ribeiro, Ivana Beatrice Mânica da Cruz, Fernanda Barbisa. Avocado oil (Persea americana) protects SH-SY5Y cells against cytotoxicity triggered by cortisol by the modulation of BDNF, oxidative stress, and apoptosis molecules. Journal of food biochemistry. vol 45. issue 2. 2021-07-08. PMID:33480081. |
cortisol can induce oxidative stress, apoptosis events, and a lowering effect on brain-derived neurotrophic factor (bdnf), a neurogenic molecule. |
2021-07-08 |
2023-08-13 |
Not clear |
| Sepideh Nazarian, Zohreh Abdolmaleki, Alireza Torfeh, Seyed Hamed Shirazi Beheshtih. Mesenchymal stem cells with modafinil (gold nanoparticles) significantly improves neurological deficits in rats after middle cerebral artery occlusion. Experimental brain research. vol 238. issue 11. 2021-07-07. PMID:32886135. |
finally, infarct volume, bdnf (brain-derived neurotrophic factor), gdnf (glial cell-derived neurotrophic factor), neun (neuronal nuclear protein) expression, and cell apoptosis in brain were analyzed. |
2021-07-07 |
2023-08-13 |
rat |
| Sepideh Nazarian, Zohreh Abdolmaleki, Alireza Torfeh, Seyed Hamed Shirazi Beheshtih. Mesenchymal stem cells with modafinil (gold nanoparticles) significantly improves neurological deficits in rats after middle cerebral artery occlusion. Experimental brain research. vol 238. issue 11. 2021-07-07. PMID:32886135. |
the brain infarct volume and apoptosis significantly decreased and bdnf, neun, and gdnf increased in c + mcao, cm + mcao, and cmn + mcao groups compared to ischemia. |
2021-07-07 |
2023-08-13 |
rat |
| Hui Yao, Hui Shen, Hao Yu, Changliang Wang, Runtao Ding, Xinze Lan, Dilichati Tash, Xu Wu, Xiaolong Wang, Guohua Zhan. Chronic ethanol exposure induced depressive-like behavior in male C57BL/6 N mice by downregulating GluA1. Physiology & behavior. vol 234. 2021-06-25. PMID:33713693. |
we confirmed that 90- and 180-day ethanol exposure can lead to depressive-like mouse behavior, cell apoptosis, neuronal degeneration, a reduction in glua1 and brain-derived neurotrophic factor (bdnf) expression, and an increase in il-6 and il-1β in the mouse hippocampus. |
2021-06-25 |
2023-08-13 |
mouse |
| Hui Yao, Hui Shen, Hao Yu, Changliang Wang, Runtao Ding, Xinze Lan, Dilichati Tash, Xu Wu, Xiaolong Wang, Guohua Zhan. Chronic ethanol exposure induced depressive-like behavior in male C57BL/6 N mice by downregulating GluA1. Physiology & behavior. vol 234. 2021-06-25. PMID:33713693. |
ethanol exposure decreased cell viability and the expression of bdnf and increased the cell apoptosis rate and the expression of bax, cleaved caspase-3, il-1β and il-6. |
2021-06-25 |
2023-08-13 |
mouse |
| Hui Yao, Hui Shen, Hao Yu, Changliang Wang, Runtao Ding, Xinze Lan, Dilichati Tash, Xu Wu, Xiaolong Wang, Guohua Zhan. Chronic ethanol exposure induced depressive-like behavior in male C57BL/6 N mice by downregulating GluA1. Physiology & behavior. vol 234. 2021-06-25. PMID:33713693. |
glua1 silencing aggravated ethanol-induced changes in cell viability and apoptosis and the expression of bdnf, bax and cleaved caspase-3, and glua1 overexpression attenuated these changes. |
2021-06-25 |
2023-08-13 |
mouse |
| Mohd Aizuddin Mohd Lazaldin, Igor Iezhitsa, Renu Agarwal, Nor Salmah Bakar, Puneet Agarwal, Nafeeza Mohd Ismai. Neuroprotective effects of brain-derived neurotrophic factor against amyloid beta 1-40-induced retinal and optic nerve damage. The European journal of neuroscience. vol 51. issue 12. 2021-06-21. PMID:31883161. |
in conclusion, intravitreal treatment with bdnf prevents aβ1-40-induced retinal cell apoptosis and axon loss in the optic nerve of rats by reducing retinal oxidative stress and restoring retinal bdnf levels. |
2021-06-21 |
2023-08-13 |
rat |
| Gabriele Carullo, Stefano Federico, Nicola Relitti, Sandra Gemma, Stefania Butini, Giuseppe Campian. Retinitis Pigmentosa and Retinal Degenerations: Deciphering Pathways and Targets for Drug Discovery and Development. ACS chemical neuroscience. vol 11. issue 15. 2021-06-21. PMID:32589402. |
this review aims at outlining the recent research efforts in identifying new drug targets for rp, especially focusing on the neuroprotective role of the wnt/β-catenin/gsk3β pathway and apoptosis modulators (in particular parp-1) but also on growth factors such as vegf and bdnf. |
2021-06-21 |
2023-08-13 |
Not clear |
| An-Rong Wang, Lian-Fang Mi, Zhi-Lei Zhang, Ming-Zhe Hu, Ze-Yu Zhao, Bin Liu, Yan-Bin Li, Shu Zhen. Saikosaponin A improved depression-like behavior and inhibited hippocampal neuronal apoptosis after cerebral ischemia through p-CREB/BDNF pathway. Behavioural brain research. vol 403. 2021-06-18. PMID:33493495. |
administration of saikosaponin a significantly ameliorated depressive-like behavior, and inhibited neuronal apoptosis, enhanced the level of p-creb, bdnf and bcl-2, reduced the level of bax, caspase-3 in the hippocampus of psd rats. |
2021-06-18 |
2023-08-13 |
rat |
| An-Rong Wang, Lian-Fang Mi, Zhi-Lei Zhang, Ming-Zhe Hu, Ze-Yu Zhao, Bin Liu, Yan-Bin Li, Shu Zhen. Saikosaponin A improved depression-like behavior and inhibited hippocampal neuronal apoptosis after cerebral ischemia through p-CREB/BDNF pathway. Behavioural brain research. vol 403. 2021-06-18. PMID:33493495. |
these results revealed that saikosaponin a improved depression-like behavior and inhibited hippocampal neuronal apoptosis after cerebral ischemia, presumably through increasing the expression of bdnf, p-creb and bcl-2, as well as decreasing the level of bax, caspase-3. |
2021-06-18 |
2023-08-13 |
rat |
| b' Jessica Le Blanc, Samuel Fleury, Imane Boukhatem, Jean-Christophe B\\xc3\\xa9langer, M\\xc3\\xa9lanie Welman, Marie Lordkipanidz\\xc3\\xa. Platelets Selectively Regulate the Release of BDNF, But Not That of Its Precursor Protein, proBDNF. Frontiers in immunology. vol 11. 2021-06-14. PMID:33324399.' |
bdnf has well-established pro-survival effects, whereas its precursor protein, probdnf, induces apoptosis. |
2021-06-14 |
2023-08-13 |
human |
| Nashwa Amin, Shiyi Xie, Xiaoning Tan, Yili Chen, Qiannan Ren, Benson O A Botchway, Shaohua Hu, Yongchun Ma, Zhiying Hu, Marong Fan. Optimized integration of fluoxetine and 7, 8-dihydroxyflavone as an efficient therapy for reversing depressive-like behavior in mice during the perimenopausal period. Progress in neuro-psychopharmacology & biological psychiatry. vol 101. 2021-06-04. PMID:32243998. |
besides, an obvious increase of the brain-derived neurotrophic factor (bdnf) and trkb levels are observed with down-regulated inflammation and apoptosis. |
2021-06-04 |
2023-08-13 |
mouse |
| Clément Barbereau, Alaa Yehya, Michelle Silhol, Nicolas Cubedo, Jean-Michel Verdier, Tangui Maurice, Mireille Rosse. Neuroprotective brain-derived neurotrophic factor signaling in the TAU-P301L tauopathy zebrafish model. Pharmacological research. vol 158. 2021-06-04. PMID:32417505. |
rescue experiments with exogenous bdnf partially corrected neuronal alterations in tau-p301l by counteracting primary axonal growth impairment but without effect on apoptosis. |
2021-06-04 |
2023-08-13 |
zebrafish |
| Mona Taghizadeh, Nader Maghsoudi, Homa Manaheji, Valery Akparov, Mansoureh Baniasadi, Mola Mohammadi, Samira Danyali, Rasoul Ghasemi, Jalal Zaringhala. Noopept; a nootropic dipeptide, modulates persistent inflammation by effecting spinal microglia dependent Brain Derived Neurotropic Factor (BDNF) and pro-BDNF expression throughout apoptotic process. Heliyon. vol 7. issue 2. 2021-05-27. PMID:33644478. |
by considering those relationships and microglia related nootrophic factors, such as the brain derived neurotrophic factor (bdnf) in cns, we attempted to assess the relationship between microglia dependent bdnf and its precursor with pain behavior through spinal cell apoptosis as well as the effect of noopept on this relationship. |
2021-05-27 |
2023-08-13 |
Not clear |
| Mona Taghizadeh, Nader Maghsoudi, Homa Manaheji, Valery Akparov, Mansoureh Baniasadi, Mola Mohammadi, Samira Danyali, Rasoul Ghasemi, Jalal Zaringhala. Noopept; a nootropic dipeptide, modulates persistent inflammation by effecting spinal microglia dependent Brain Derived Neurotropic Factor (BDNF) and pro-BDNF expression throughout apoptotic process. Heliyon. vol 7. issue 2. 2021-05-27. PMID:33644478. |
thermal hyperalgesia, paw edema, microglial activity, microglia dependent bdnf, pro-bdnf expression, and apoptosis were assessed in different experimental groups by confirmed behavioral and molecular methods on days 0, 7, and 21 of the study. |
2021-05-27 |
2023-08-13 |
Not clear |