| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shuta Tamura, Hiroshi Tazawa, Naoto Hori, Yuncheng Li, Motohiko Yamada, Satoru Kikuchi, Shinji Kuroda, Yasuo Urata, Shunsuke Kagawa, Toshiyoshi Fujiwar. p53-armed oncolytic adenovirus induces autophagy and apoptosis in KRAS and BRAF-mutant colorectal cancer cells. PloS one. vol 18. issue 11. 2023-11-16. PMID:37972012. |
western blot analysis demonstrated that obp-301 induced autophagy and that obp-702 induced autophagy and apoptosis in human crc cells. |
2023-11-16 |
2023-11-20 |
human |
| Si-Min Liang, Gui-Bin Liang, Hui-Ling Wang, Hong Jiang, Xian-Li Ma, Jian-Hua Wei, Ri-Zhen Huang, Ye Zhan. Discovery of 4-(N-dithiobenzyl piperazine)-1,8-naphthalimide as a potent multi-target antitumor agent with good efficacy, limited toxicity, and low resistance. European journal of medicinal chemistry. vol 263. 2023-11-16. PMID:37972528. |
results from the omics research, confocal immunofluorescence, western blot, transmission electron microscopy, and flow cytometry indicated that compound 5j exerted antitumor effects through multiple mechanisms, including ferroptosis, autophagy, apoptosis, and cell cycle arrest. |
2023-11-16 |
2023-11-20 |
Not clear |
| Zhujie Xu, Peng Wang, Zhenyu Wang, Hao Cui, Tianshu Gao, Zhenting Wang, Yi Li. ER-β accelerates the process of primary osteoporosis by promoting VEGFA-mediated apoptosis of osteoblasts. Genomics. 2023-11-15. PMID:37967683. |
and western blot results showed that apoptosis was most likely realized through the regulation of downstream apoptosis markers c-jun (c-jun n-terminal kinase, jnk) and gadd45g (growth arrest and dna damage-inducible protein 45 gamma). |
2023-11-15 |
2023-11-20 |
Not clear |
| Pei-Qi Huang, Kai-Wen Kang, Dan-Yu Huang, Chun-Lin Zhao, Hao Zheng, Yong-Xin Luo, Yan Wen, Ming-Feng Zou, Dong-Li Li, Ri-Hui Wu, Yun-Cai Tian, Yong Tian, Wen-Huan Zhang, Jing-Wei Jin, Sheng Yin, Li-She Ga. Lignan glucosides from Gentiana macrophylla with potential anti-arthritis and hepatoprotective activities. Phytochemistry. 2023-11-11. PMID:37951561. |
flow cytometry and western blot analysis showed that compound 5 ameliorated d-galn induced aml12 cell apoptosis by upregulating the expression of anti-apoptotic bcl-2 protein and down-regulating the expression of pro-apoptotic bax protein. |
2023-11-11 |
2023-11-20 |
human |
| Qian Wu, Wenrui Yang, Yanju Bi, Yujie Yao, Chengzhi Li, Xiaojing L. Baicalein inhibits apoptosis and autophagy induced by chlorpyrifos exposure to kidney of Cyprinus carpio through activation of PI3K/AKT pathway. Pesticide biochemistry and physiology. vol 196. 2023-11-09. PMID:37945259. |
furthermore, cpf induced the increase of ros level and inhibition of pi3k and nrf2 pathways, which in turn triggered oxidative stress, autophagy and apoptosis in carp kidney according to western blot, rt-qpcr and kit assays. |
2023-11-09 |
2023-11-20 |
Not clear |
| Ying-Jie Zhu, Hu-Lin Chen, Xin-Jie Cai, Bang-le Zhan, Xiao-Ming Li. Naringin acts as a TRPV1 antagonist to attenuate UVB-induced senescence and damage in HaCaT cells. Chemical biology & drug design. 2023-11-09. PMID:37945519. |
analysis was performed using the mtt assay to assess cell viability, flow cytometry to measure the apoptosis level, sa-β-gal staining to observe cellular senescence, and western blot to assess protein levels of trpv1, p16, p53, p21, matrix metalloproteinase (mmp)-1, and mmp-9. |
2023-11-09 |
2023-11-20 |
human |
| Kun Xu, Qingwu Qin, Ye Yao, Lin Yuan, Xizi Du, Kai Zhou, Xinyu Wu, Weijie Wang, Chi Li. Anti‑oxidation effect of Genistein in vascular endothelial cell after H Molecular medicine reports. vol 29. issue 1. 2023-11-08. PMID:37937639. |
following gen pretreatment of huvecs, h2o2 was added, and apoptosis was detected by flow cytometry, and the expression of relevant genes and proteins was detected by pcr and westerner blot. |
2023-11-08 |
2023-11-20 |
human |
| Łukasz Kopiasz, Katarzyna Dziendzikowska, Michał Oczkowski, Joanna Harasym, Joanna Gromadzka-Ostrowsk. Low-molar-mass oat beta-glucan impacts autophagy and apoptosis in early stages of induced colorectal carcinogenesis in rats. International journal of biological macromolecules. 2023-11-04. PMID:37924897. |
the expression of autophagy (lc3b, beclin-1) and apoptosis (caspase-3, cleaved caspase-3, bax, bcl-2 and parp-1) markers was determined by immunohistochemistry, western blot and pcr analysis. |
2023-11-04 |
2023-11-08 |
rat |
| Cheng Teng, Jingtao Wu, Zhao Zhang, Jinquan Wang, Ye Yang, Chengji Dong, Long Wu, Zhen Lin, Yuezheng Hu, Jing Wang, Xiaolei Zhang, Zhongke Li. Fucoxanthin ameliorates endoplasmic reticulum stress and inhibits apoptosis and alleviates intervertebral disc degeneration in rats by upregulating Sirt1. Phytotherapy research : PTR. 2023-11-02. PMID:37918392. |
qrt-pcr, western blot, immunofluorescence, and tunel staining were used to detect apoptosis, ers, extracellular matrix (ecm), and sirt1-related pathways. |
2023-11-02 |
2023-11-08 |
rat |
| Dan Wang, Yanling Ma, Baohong Gu, Xuemei Li, Yang Yu, Ying Zhang, Hao Che. Preliminary study of donor volume changes after dual-graft liver transplantation in rats. Frontiers in immunology. vol 14. 2023-11-01. PMID:37908343. |
liver samples from receptors were obtained for morphology, and apoptosis was measured by rt-pcr and western blot. |
2023-11-01 |
2023-11-08 |
rat |
| Jiaxu Zhou, Yilan Song, Xingmei Wang, Xinrui Li, Chang Liu, Chenchen Tian, Chongyang Wang, Liangchang Li, Guanghai Yan, Hong Cu. JTE-013 Alleviates Pulmonary Fibrosis by Affecting the RhoA/YAP Pathway and Mitochondrial Fusion/Fission. Pharmaceuticals (Basel, Switzerland). vol 16. issue 10. 2023-10-30. PMID:37895915. |
jte-013 also significantly reduced the expression of rhoa/yap pathway proteins and mitochondrial fission protein drp1, apoptosis, and the colocalization of α-sma with yap, drp1, and tom20, as detected by immunohistochemistry, immunofluorescence staining, tunel, and western blot. |
2023-10-30 |
2023-11-08 |
mouse |
| C W D'Acunto, H Gbelcová, R Kaplánek, M Pospíšilová, M Havlík, T Rum. Chelators as Antineuroblastomas Agents. Physiological research. vol 72. issue S3. 2023-10-27. PMID:37888971. |
the effect of new chelators characterized by the same functional group, designated as hlz (1-hydrazino phthalazine), on proliferation (wst-1 and methylene blue assay), cell cycle (flow cytometry), apoptosis (proliferation assay after use of specific pharmacological inhibitors and western blot analysis) and ros production (fluorometric assay based on dichlorofluorescein diacetate metabolism) was studied in three neuroblastoma cell lines with different levels of mycn amplification. |
2023-10-27 |
2023-11-08 |
Not clear |
| Rufang Wang, Jinxue Li, Yun Fu, Yongli Li, Yu Qi, Cuiping Li, Fulian Gao, Changzheng L. Ferritinophagy-mediated apoptosis and paraptosis induction involved MAPK and PI3K/AKT pathway in mechanism of an iron chelator. Biochemical pharmacology. vol 218. 2023-10-26. PMID:37866802. |
the analyses from flow cytometry and western blot showed that the growth inhibition of dpdtba against sk-mel-28 and a375 cells involved apoptosis induction and g1 phase arrest. |
2023-10-26 |
2023-11-08 |
Not clear |
| Kai Gao, Wenbo Shao, Tian Wei, Zihan Yan, Nianhu Li, Chaoliang L. Wnt-3a improves functional recovery after spinal cord injury by regulating the inflammatory and apoptotic response in rats via wnt/β-catenin signaling pathway. Brain research. 2023-10-20. PMID:37858855. |
in our study, we evaluated the recovery of motor function after sci by bbb, observed neuronal apoptosis by western blot and tunel, observed the changes of neuronal inflammation by western blot and immunofluorescence staining, and observed the changes of motoneurons and spinal cord area in the anterior horn of the spinal cord via nissl and he staining. |
2023-10-20 |
2023-11-08 |
rat |
| Fei Li, Hongxiang Zhu, Zijuan Chang, Ying L. Gentiopicroside alleviates acute myocardial infarction injury in rats by disrupting Nrf2/NLRP3 signaling. Experimental biology and medicine (Maywood, N.J.). 2023-10-18. PMID:37850391. |
reactive oxygen species (ros) and cell apoptosis were assessed, while nrf2 and the expression of the nlrp3 inflammatory body signal pathway were evaluated using western blot and immunofluorescence techniques. |
2023-10-18 |
2023-11-08 |
rat |
| Didem Yilmaz-Oral, Sena F Sezen, Damla Turkcan, Heba Asker, Ecem Kaya-Sezginer, Omer Faruk Kirlangic, Cagla Zubeyde Kopru, Mualla Pınar Elci, Fatma Zeynep Ozen, Petek Korkusuz, Sema Oren, Cetin Volkan Oztekin, Ilker Ates, Serap Gu. Dual Strategy with Adipose-derived Stem Cells and L-arginine Recovered Cavernosal Functions in a Rat Model of Radical Prostatectomy. Stem cells and development. 2023-10-17. PMID:37847152. |
western blot and immunohistochemistry analyses were used to determine the expression and localization of endothelial nitric oxide synthases (enos), neuronal nos (nnos), transforming growth factor-beta 1 (tgf-1), hypoxia-inducible factor-1 (hif-1), and apoptosis markers (bax and bcl-2). |
2023-10-17 |
2023-11-08 |
rat |
| Fanhua Kong, Lianfu Zhang, Xudong Zhao, Lili Zhao, Peng Wang, Runqi Zhang, Hui Tian, Shengjun M. Resveratrol augments paclitaxel sensitivity by modulating miR-671-5p/STOML2/PINK1/Parkin-mediated autophagy signaling in A549 cell. Journal of biochemical and molecular toxicology. 2023-10-16. PMID:37840424. |
the presence of mir-671-5p, stomatin-like protein 2 (stoml2), and mitophagy biomarkers was evaluated using quantitative teal-time pcr (qrt-pcr) and western blot, the assessment of cell proliferation and apoptosis was conducted through the utilisation of colony formation and flow cytometry assays. |
2023-10-16 |
2023-11-08 |
Not clear |
| Xue Liu, Shiyao Cui, Wenle Li, Hongqing Xie, Liangen Sh. Elucidation of the anti-colon cancer mechanism of Phellinus baumii polyphenol by an integrative approach of network pharmacology and experimental verification. International journal of biological macromolecules. 2023-10-14. PMID:37838121. |
finally, we determined the key regulatory proteins related to apoptosis and the cell cycle by western blot analysis, and proposed the potential mechanism by which pbp exerts an anti-colon cancer effect by inducing the caspase-dependent mitochondrial-mediated intrinsic apoptotic pathway and arresting the cell cycle in s phase in hct116 cells. |
2023-10-14 |
2023-11-08 |
human |
| Su-Ji Jeon, Eun-Young Choi, Eun-Ji Han, Sang-Woo Lee, Jun-Mo Moon, Soo-Hyun Jung, Ji-Youn Jun. Piperlongumine induces apoptosis via the MAPK pathway and ERK‑mediated autophagy in human melanoma cells. International journal of molecular medicine. vol 52. issue 6. 2023-10-13. PMID:37830157. |
pretreatment of a375p cells with the erk inhibitor pd98059 and the jnk inhibitor sp600125 followed by treatment with pl confirmed that apoptosis and autophagy were mediated via the mapk/erk pathway by western blot. |
2023-10-13 |
2023-10-15 |
human |
| Angqing Li, Junyi Zhang, Ke Chen, Jian Wang, Aman Xu, Zhengguang Wan. Donepezil attenuates inflammation and apoptosis in ulcerative colitis via regulating LRP1/AMPK/NF-κB signaling. Pathology international. 2023-10-13. PMID:37830504. |
apoptosis was estimated utilizing terminal deoxynucleotidyl transferase dutp nick-end labeling and western blot. |
2023-10-13 |
2023-10-15 |
mouse |