| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paola Bellosta, Peter Gallan. Myc Function in Drosophila. Genes & cancer. vol 1. issue 6. 2021-10-20. PMID:21072325. |
in addition, drosophila myc also controls dna replication and influences apoptosis, both cell-autonomously and non-autonomously, in a process known as cell competition. |
2021-10-20 |
2023-08-12 |
human |
| Stefano Amente, Luigi Lania, Barbara Majell. Epigenetic reprogramming of Myc target genes. American journal of cancer research. vol 1. issue 3. 2021-10-20. PMID:21969221. |
myc protein plays a fundamental role in regulation of cell cycle, proliferation, differentiation and apoptosis by modulating the expression of a large number of targets. |
2021-10-20 |
2023-08-12 |
Not clear |
| David G Covel. Bioinformatic analysis linking genomic defects to chemosensitivity and mechanism of action. PloS one. vol 16. issue 4. 2021-09-13. PMID:33909629. |
the results of this analysis find a relatively small set of defective genes, inclusive of abl1, axl, braf, cdc25a, cdkn2a, igf1r, kras, mecom, mmp1, myc, notch1, nras, pik3cg, ptk2, rptor, sptbn1, stat2, tnks and zhx2, as possible candidates for roles in chemosensitivity for compound moas that target primarily, but not exclusively, kinases, nucleic acid synthesis, protein synthesis, apoptosis and tubulin. |
2021-09-13 |
2023-08-13 |
Not clear |
| Ekaterina Mikhailovna Stasevich, Matvey Mikhailovich Murashko, Lyudmila Sergeevna Zinevich, Denis Eriksonovich Demin, Anton Markovich Schwart. The Role of Non-Coding RNAs in the Regulation of the Proto-Oncogene MYC in Different Types of Cancer. Biomedicines. vol 9. issue 8. 2021-08-30. PMID:34440124. |
overexpressed myc has been shown to stimulate the main processes of oncogenesis: uncontrolled growth, unlimited cell divisions, avoidance of apoptosis and immune response, changes in cellular metabolism, genomic instability, metastasis, and angiogenesis. |
2021-08-30 |
2023-08-13 |
Not clear |
| Zongze He, Chen Yang, Yunsen He, Bo Gong, Cheng Yin, Jie Feng, Longyi Chen, Jian Tang, Yong Che. CAMTA1, a novel antitumor gene, regulates proliferation and the cell cycle in glioma by inhibiting AKT phosphorylation. Cellular signalling. vol 79. 2021-08-23. PMID:33316386. |
moreover, overexpression of camta1 in glioma cells notably inhibited cell growth, migration, invasion and cell cycle and enhanced temozolomide (tmz)-induced cell apoptosis in glioma cells, while camta1 overexpression decreased the itga5, itgb1, p-akt, p-fak, and myc protein levels, suggesting that the signaling pathways of these proteins might be involved in the cellular functions of camta1 in glioma. |
2021-08-23 |
2023-08-13 |
human |
| Yahui Li, Yingjie Feng, Xiaohui Si, Chenjin Zhao, Fanping Wang, Xinqing Ni. Genetic Expression Screening of Arsenic Trioxide-Induced Cytotoxicity in KG-1a Cells Based on Bioinformatics Technology. Frontiers in genetics. vol 12. 2021-08-21. PMID:34413873. |
thus, our study suggests that ato not only inhibits the expression of myc, pcna, and mcm7 but also leads to cell cycle arrest and apoptosis in kg-1a cells. |
2021-08-21 |
2023-08-13 |
Not clear |
| Markus Hartl, Klaus Biste. MYC Analysis in Cancer and Evolution. Methods in molecular biology (Clifton, N.J.). vol 2318. 2021-08-06. PMID:34019288. |
myc regulates fundamental cellular processes like growth control, metabolism, proliferation, differentiation, and apoptosis. |
2021-08-06 |
2023-08-13 |
human |
| Dan Lu, Catherine Wilson, Trevor D Littlewoo. Methods for Determining Myc-Induced Apoptosis. Methods in molecular biology (Clifton, N.J.). vol 2318. 2021-08-06. PMID:34019292. |
elevated and deregulated expression of the myc protein promotes apoptosis in both cultured cells and in some tissues in vivo. |
2021-08-06 |
2023-08-13 |
Not clear |
| Jisu Kim, Jeong Nam Kim, Inmyoung Park, Sardana Sivtseva, Zhanna Okhlopkova, Ismayil S Zulfugarov, Sang-Woo Ki. Dracocephalum palmatum Stephan extract induces caspase‑ and mitochondria‑dependent apoptosis via Myc inhibition in diffuse large B cell lymphoma. Oncology reports. vol 44. issue 6. 2021-08-02. PMID:33125144. |
dracocephalum palmatum stephan extract induces caspase‑ and mitochondria‑dependent apoptosis via myc inhibition in diffuse large b cell lymphoma. |
2021-08-02 |
2023-08-13 |
Not clear |
| Carolina Rosselot, Sharon Baumel-Alterzon, Yansui Li, Gabriel Brill, Luca Lambertini, Liora S Katz, Geming Lu, Adolfo Garcia-Ocaña, Donald K Scot. The many lives of Myc in the pancreatic β-cell. The Journal of biological chemistry. vol 296. 2021-07-30. PMID:33239359. |
nearly all these studies in β-cells used pathophysiological or supraphysiological levels of myc and reported enhanced β-cell death, dedifferentiation, or the formation of insulinomas if cooverexpressed with bcl-xl, an inhibitor of apoptosis. |
2021-07-30 |
2023-08-13 |
Not clear |
| R I Mancuso, M A Foglio, S T Olalla Saa. Artemisinin-type drugs for the treatment of hematological malignancies. Cancer chemotherapy and pharmacology. vol 87. issue 1. 2021-06-23. PMID:33141328. |
the main mechanism of action of ars and its derivatives (artesunate, dihydroartemisinin, artemether) toward leukemia, multiple myeloma, and lymphoma cells comprises oxidative stress response, inhibition of proliferation, induction of various types of cell death as apoptosis, autophagy, ferroptosis, inhibition of angiogenesis, and signal transducers, as nf-κb, myc, amongst others. |
2021-06-23 |
2023-08-13 |
Not clear |
| Colleen T Harrington, Elena Sotillo, Aude Robert, Katharina E Hayer, Agata M Bogusz, James Psathas, Duonan Yu, Deanne Taylor, Chi V Dang, Peter S Klein, Michael D Hogarty, Birgit Geoerger, Wafik S El-Deiry, Joëlle Wiels, Andrei Thomas-Tikhonenk. Correction: Transient stabilization, rather than inhibition, of MYC amplifies extrinsic apoptosis and therapeutic responses in refractory B-cell lymphoma. Leukemia. vol 34. issue 5. 2021-06-20. PMID:31758088. |
correction: transient stabilization, rather than inhibition, of myc amplifies extrinsic apoptosis and therapeutic responses in refractory b-cell lymphoma. |
2021-06-20 |
2023-08-13 |
Not clear |
| Renumathy Dhanasekaran, Jangho Park, Alekesey Yevtodiyenko, David I Bellovin, Stacey J Adam, Anand Rajan Kd, Meital Gabay, Hanan Fernando, Julia Arzeno, Vinodhini Arjunan, Sergei Gryanzov, Dean W Felshe. MYC ASO Impedes Tumorigenesis and Elicits Oncogene Addiction in Autochthonous Transgenic Mouse Models of HCC and RCC. Molecular therapy. Nucleic acids. vol 21. 2021-06-10. PMID:32805488. |
treatment with myc aso in vivo, but not with a control aso, decreased proliferation, induced apoptosis, increased senescence, and remodeled the tumor microenvironment by recruitment of cd4 |
2021-06-10 |
2023-08-13 |
mouse |
| Wesam Bazzar, Matteo Bocci, Eduar Hejll, Vedrana Högqvist Tabor, Per Hydbring, Alf Grandien, Mohammad Alzrigat, Lars-Gunnar Larsso. Pharmacological inactivation of CDK2 inhibits MYC/BCL-XL-driven leukemia in vivo through induction of cellular senescence. Cell cycle (Georgetown, Tex.). vol 20. issue 1. 2021-06-03. PMID:33356836. |
while myc is a potent inducer of apoptosis, it often suppresses cellular senescence, which together with apoptosis is an important barrier against tumor development. |
2021-06-03 |
2023-08-13 |
Not clear |
| Yi Xiao, Xi Ming, Jiaying W. Hsa_circ_0002483 regulates miR-758-3p/MYC axis to promote acute myeloid leukemia progression. Hematological oncology. vol 39. issue 2. 2021-04-21. PMID:33283885. |
mir-758-3p overexpression restrained cell proliferation and promoted cycle arrest and apoptosis via decreasing myc. |
2021-04-21 |
2023-08-13 |
human |
| Higor de Oliveira Ribeiro, Alane Pereira Cortez, Renato Ivan de Ávila, Artur Christian Garcia da Silva, Flávio Silva de Carvalho, Ricardo Menegatti, Luciano Morais Lião, Marize Campos Valadare. Small-molecule MDM2 inhibitor LQFM030-induced apoptosis in p53-null K562 chronic myeloid leukemia cells. Fundamental & clinical pharmacology. vol 34. issue 4. 2021-04-20. PMID:32011031. |
our data suggest that lqfm030 triggered apoptosis in k562 cells via different mechanisms including cell cycle arrest, caspase activation, reduction of mitochondrial activity, decrease in mdm2 expression, and transcriptional modulation of mdmx, p73, myc, and nf-ĸb. |
2021-04-20 |
2023-08-13 |
human |
| Lina Schukur, Tamara Zimmermann, Ole Niewoehner, Grainne Kerr, Scott Gleim, Beatrice Bauer-Probst, Britta Knapp, Giorgio G Galli, Xiaoyou Liang, Angelica Mendiola, John Reece-Hoyes, Melivoia Rapti, Ines Barbosa, Markus Reschke, Thomas Radimerski, Claudio R Thom. Identification of the HECT E3 ligase UBR5 as a regulator of MYC degradation using a CRISPR/Cas9 screen. Scientific reports. vol 10. issue 1. 2021-03-30. PMID:33208877. |
this suggests that ubr5 acts as a buffer in myc amplified settings and protects these cells from apoptosis. |
2021-03-30 |
2023-08-13 |
human |
| Thalita Alves Zanetti, Bruna Isabela Biazi, Giuliana Castello Coatti, Adrivanio Baranoski, Lilian Areal Marques, Amanda Cristina Corveloni, Mario Sergio Mantovan. Dimethoxycurcumin reduces proliferation and induces apoptosis in renal tumor cells more efficiently than demethoxycurcumin and curcumin. Chemico-biological interactions. vol 338. 2021-03-24. PMID:33582110. |
it induced apoptosis by increasing mrna expression of bbc3, myc, and casp7 and activation of caspase 9 and caspase 3/7. |
2021-03-24 |
2023-08-13 |
human |
| Hao Wang, Zhennan Tao, Ming Feng, Xuetao Li, Zhitong Deng, Guozheng Zhao, Haoran Yin, Tingzheng Pan, Guangliang Chen, Zibin Feng, Yanyan Li, Youxin Zho. Dual PLK1 and STAT3 inhibition promotes glioblastoma cells apoptosis through MYC. Biochemical and biophysical research communications. vol 533. issue 3. 2021-03-18. PMID:32962858. |
dual plk1 and stat3 inhibition promotes glioblastoma cells apoptosis through myc. |
2021-03-18 |
2023-08-13 |
Not clear |
| Hao Wang, Zhennan Tao, Ming Feng, Xuetao Li, Zhitong Deng, Guozheng Zhao, Haoran Yin, Tingzheng Pan, Guangliang Chen, Zibin Feng, Yanyan Li, Youxin Zho. Dual PLK1 and STAT3 inhibition promotes glioblastoma cells apoptosis through MYC. Biochemical and biophysical research communications. vol 533. issue 3. 2021-03-18. PMID:32962858. |
compared to monotherapy, combined treatment of glioma cells with plk1 and stat3 inhibitors, bi2536 and stattic, respectively, showed lower expression of myc, synergistic induction of cell invasion and apoptosis in vitro, and tumor inhibition in xenografts. |
2021-03-18 |
2023-08-13 |
Not clear |