| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fengdong Zhang, Yanrui Yue, Jian Chen, Pan Xiao, Hui Ma, Jia Feng, Mingming Yang, Yuna Mi. Albumen exosomes alleviate LPS-induced inflammation of intestinal epithelial cells via miR-22/ATM/p53/NF-κB axis. International journal of biological macromolecules. 2024-04-04. PMID:38574929. |
there were 278 mirnas and 45 proteins with higher expression levels in albumen exosomes, and they were mainly involved in immune responses and programmed cell death pathways, including apoptosis and p53 signaling pathway. |
2024-04-04 |
2024-04-07 |
Not clear |
| Meiwen Lv, Xuelian Li, Zhihua Yin, He Yang, Baosen Zho. Comprehensive analysis and validation reveal DEPDC1 as a potential diagnostic biomarker associated with tumor immunity in non-small-cell lung cancer. PloS one. vol 19. issue 4. 2024-04-02. PMID:38564630. |
according to the in vitro mts and apoptotic assays, downregulated depdc1 expression targeting p53 signaling pathway inhibited the proliferation of nsclc cells while promoting apoptosis of nsclc cells. |
2024-04-02 |
2024-04-05 |
Not clear |
| Xiaotong Duan, Jingwen Ao, Ming Yu, Sali Li, Xiaofei Li, Jianyong Zhan. Shuganning Injection Suppresses Apoptosis for Protecting Against Cantharidin-Induced Liver Injury by Network Pharmacology and Experiment Validation. ACS omega. vol 9. issue 12. 2024-04-01. PMID:38559921. |
this study found that sgni could act with 62 core therapeutic targets, regulate multiple biological processes such as apoptosis, and oxidative stress, and influence apoptotic and p53 signaling pathways to treat ctd-dili. |
2024-04-01 |
2024-04-04 |
mouse |
| Eman Mansour, Ahmed A Abd-Rabou, Mohamed A El-Atawy, Hoda A Ahmed, Ahmed F El-Farargy, Heba K Abd El-Mawgou. Induction of breast cancer cell apoptosis by novel thiouracil-fused heterocyclic compounds through boosting of Bax/Bcl-2 ratio and DFT study. Bioorganic chemistry. vol 146. 2024-03-31. PMID:38555798. |
compounds 17, 11, and 19 recorded a significant increase of p53 upregulated modulator of apoptosis (puma) expression levels in the cancerous cells. |
2024-03-31 |
2024-04-03 |
Not clear |
| Zulvikar Syambani Ulhaq, May-Su You, Yun-Jin Jiang, William Ka Fai Ts. p53 inhibitor or antioxidants reduce the severity of ethmoid plate deformities in zebrafish Type 3 Treacher Collins syndrome model. International journal of biological macromolecules. 2024-03-31. PMID:38556235. |
our study confirmed excessive ros production in facial regions, inducing apoptosis and altering p53 pathways. |
2024-03-31 |
2024-04-03 |
zebrafish |
| Chiara Cazzaniga, Anja Göder, Michael David Rainey, Aisling Quinlan, Simone Coughlan, Stefanus Bernard, Corrado Santocanal. CDC7 inhibition drives an inflammatory response and a p53-dependent senescent-like state in breast epithelial cells. The FEBS journal. 2024-03-31. PMID:38555567. |
importantly, cell fate depends on cellular tumour antigen p53 (p53) function as cells no longer enter senescence but are funnelled into apoptosis upon p53 knockout. |
2024-03-31 |
2024-04-02 |
Not clear |
| Xiaolan Guo, Ya Li, Xiangyu Chen, Binghua Sun, Xiaolan Gu. Urocortin-1 promotes colorectal cancer cell migration and proliferation and inhibits apoptosis via inhibition of the p53 signaling pathway. Journal of cancer research and clinical oncology. vol 150. issue 3. 2024-03-28. PMID:38546882. |
urocortin-1 promotes colorectal cancer cell migration and proliferation and inhibits apoptosis via inhibition of the p53 signaling pathway. |
2024-03-28 |
2024-03-31 |
Not clear |
| b' Patrick L McAlpine, Javier Fern\\xc3\\xa1ndez, Claudio J Villar, Felipe Lomb\\xc3\\xb. Organosulfur Compounds in Colorectal Cancer Prevention and Progression. Nutrients. vol 16. issue 6. 2024-03-28. PMID:38542713.' |
here, we focus on their direct effects via the repression of multidrug resistance proteins, triggering of apoptosis (via the inhibition of histone deacetylases, increases in reactive oxygen species, p53 activation, β-catenin inhibition, damage in the mitochondrial membrane, etc. |
2024-03-28 |
2024-03-30 |
Not clear |
| Camilla Albano, Matteo Biolatti, Jasenka Mazibrada, Selina Pasquero, Francesca Gugliesi, Irene Lo Cigno, Federica Calati, Greta Bajetto, Giuseppe Riva, Gloria Griffante, Santo Landolfo, Marisa Gariglio, Marco De Andrea, Valentina Dell'Ost. PAD-mediated citrullination is a novel candidate diagnostic marker and druggable target for HPV-associated cervical cancer. Frontiers in cellular and infection microbiology. vol 14. 2024-03-26. PMID:38529474. |
consistently, p53 and p21, two targets of hpv oncoproteins, are upregulated by the pad inhibitor, which undergoes cell growth arrest and apoptosis. |
2024-03-26 |
2024-03-28 |
human |
| Yongchun Zheng, Xueyan Chen, Chuanbo Ding, Xinglong Liu, Lihua Chi, Shuai Zhan. Abscisic acid ameliorates d-galactose -induced aging in mice by modulating AMPK-SIRT1-p53 pathway and intestinal flora. Heliyon. vol 10. issue 6. 2024-03-25. PMID:38524603. |
in addition, aba regulated the b-cell-lymphoma-2 (bcl-2) family and phosphatidylinositol 3-kinase/protein kinase b (pi3k/akt) signaling pathway, while further regulating the acetylation of p53 protein by modulating the ampk pathway and activating sirt1 protein, thereby inhibiting the apoptosis of brain neurons and thus regulating the aging process. |
2024-03-25 |
2024-03-27 |
mouse |
| Shijing Wang, Yan Zhao, Fei Yao, Pengxue Wei, Lan Ma, Shaochong Zhan. An anti-GD2 aptamer-based bifunctional spherical nucleic acid nanoplatform for synergistic therapy targeting MDM2 for retinoblastoma. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 174. 2024-03-24. PMID:38522240. |
following sna endocytosis by rb cells, sirna and nvp-cgm097 were released from the sna particles by glutathione, which synergistically blocked the mdm2-p53 pathway, increasing p53 protein content and inducing cell apoptosis. |
2024-03-24 |
2024-03-27 |
mouse |
| Wenyu Fan, Jianing Chen, Yunpeng Cao, Jiabo Tan, Jinlong Li, Su Wang, Ping Jin, Xiaojun Son. A novel C-type lectin protein (BjCTL5) interacts with apoptosis stimulating proteins of p53 (ASPP) to activate NF-κB signaling pathway in primitive chordate. Developmental and comparative immunology. 2024-03-23. PMID:38521378. |
a novel c-type lectin protein (bjctl5) interacts with apoptosis stimulating proteins of p53 (aspp) to activate nf-κb signaling pathway in primitive chordate. |
2024-03-23 |
2024-03-26 |
Not clear |
| Xin Gao, Jiaqi Fu, DongHua Yu, Fang Lu, Shumin Li. Integrated network pharmacology and phosphoproteomic analyses of Baichanting in Parkinson's disease model mice. Heliyon. vol 10. issue 6. 2024-03-21. PMID:38509878. |
the main enriched pathways in the network pharmacology results were apoptosis, the p53 signaling pathway and autophagy. |
2024-03-21 |
2024-03-23 |
mouse |
| Xin Gao, Jiaqi Fu, DongHua Yu, Fang Lu, Shumin Li. Integrated network pharmacology and phosphoproteomic analyses of Baichanting in Parkinson's disease model mice. Heliyon. vol 10. issue 6. 2024-03-21. PMID:38509878. |
western blot results showed that bct significantly regulated the protein expression levels of bax, caspase-3, lc3b, p53 and mtor and upregulated autophagy to alleviate apoptosis. |
2024-03-21 |
2024-03-23 |
mouse |
| Zhen Shang, Weipeng Shi, Haitao Fu, Yingze Zhang, Tengbo Y. Identification of key autophagy-related genes and pathways in spinal cord injury. Scientific reports. vol 14. issue 1. 2024-03-20. PMID:38504116. |
go and kegg pathway enrichment analysis showed that these 129 genes were mainly involved in the process of cell apoptosis, angiogenesis, il-1 production, and inflammatory reactions, the tnf signaling pathway and the p53 signaling pathway. |
2024-03-20 |
2024-03-23 |
Not clear |
| Fanchao Li, Fei Zhang, Tao Wang, Zhihong Xie, Hong Luo, Wentao Dong, Jian Zhang, Chao Ren, Wuxun Pen. A self-amplifying loop of TP53INP1 and P53 drives oxidative stress-induced apoptosis of bone marrow mesenchymal stem cells. Apoptosis : an international journal on programmed cell death. 2024-03-16. PMID:38491252. |
a self-amplifying loop of tp53inp1 and p53 drives oxidative stress-induced apoptosis of bone marrow mesenchymal stem cells. |
2024-03-16 |
2024-03-19 |
Not clear |
| Fanchao Li, Fei Zhang, Tao Wang, Zhihong Xie, Hong Luo, Wentao Dong, Jian Zhang, Chao Ren, Wuxun Pen. A self-amplifying loop of TP53INP1 and P53 drives oxidative stress-induced apoptosis of bone marrow mesenchymal stem cells. Apoptosis : an international journal on programmed cell death. 2024-03-16. PMID:38491252. |
our previous transcriptome sequencing results suggested that the expression of p53-induced nuclear protein 1 (tp53inp1) and the tumor suppressor p53 (p53) was significantly upregulated during the process of oxidative stress-induced apoptosis of bmscs. |
2024-03-16 |
2024-03-19 |
Not clear |
| Fanchao Li, Fei Zhang, Tao Wang, Zhihong Xie, Hong Luo, Wentao Dong, Jian Zhang, Chao Ren, Wuxun Pen. A self-amplifying loop of TP53INP1 and P53 drives oxidative stress-induced apoptosis of bone marrow mesenchymal stem cells. Apoptosis : an international journal on programmed cell death. 2024-03-16. PMID:38491252. |
the present study further revealed the role and mechanism of tp53inp1 and p53 in oxidative stress-induced apoptosis in bmscs. |
2024-03-16 |
2024-03-19 |
Not clear |
| Jose A Valverde-Lopez, Lin Li-Bao, Rocío Sierra, Elisa Santos, Giovanna Giovinazzo, Covadonga Díaz-Díaz, Miguel Torre. P53 and BCL-2 family proteins PUMA and NOXA define competitive fitness in pluripotent cell competition. PLoS genetics. vol 20. issue 3. 2024-03-15. PMID:38489392. |
here, we report that p53 and its pro-apoptotic targets puma and noxa regulate apoptosis susceptibility and competitive fitness in pluripotent cells. |
2024-03-15 |
2024-03-18 |
Not clear |
| Megan E Honeywell, Marie S Isidor, Nicholas W Harper, Rachel E Fontana, Gavin A Birdsall, Peter Cruz-Gordillo, Sydney A Porto, Madison Jerome, Cameron S Fraser, Kristopher A Sarosiek, David A Guertin, Jessica B Spinelli, Michael J Le. Functional genomic screens with death rate analyses reveal mechanisms of drug action. Nature chemical biology. 2024-03-14. PMID:38480981. |
loss of p53 switches the mechanism of dna damage-induced death from apoptosis to a non-apoptotic death that requires high respiration. |
2024-03-14 |
2024-03-16 |
human |