| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Song-Hee Lee, Xiao-Han Li, Qin-Yue Lu, Cheng-Lin Zhan, Ji-Dam Kim, Gyu-Hyun Lee, Jae-Min Sim, Xiang-Shun Cu. Nobiletin enhances mitochondrial function by regulating SIRT1/PGC-1α signaling in porcine oocytes during in vitro maturation. Biochemical and biophysical research communications. vol 706. 2024-03-13. PMID:38479243. |
the protein level of p53 decreased, followed by the phosphorylation of b-cell lymphoma 2, suggesting a reduction in mitochondria-mediated apoptosis in the nob10 group. |
2024-03-13 |
2024-03-16 |
Not clear |
| Aastha Mittal, Neelam Mahala, Nikhil Hanamant Dhanawade, Sunil Kumar Dubey, Uma S Dube. Evaluation of the cytotoxic activity of sorafenib-loaded camel milk casein nanoparticles against hepatocarcinoma cells. Biotechnology journal. vol 19. issue 3. 2024-03-12. PMID:38472095. |
gene and protein expression studies done by qpcr and western blotting depicted upregulation of tumor suppressor gene p53, pro-apoptotic bax, and caspase-3 along with downregulated anti-apoptotic bcl-2 gene and protein expression which further emphasized death by apoptosis. |
2024-03-12 |
2024-03-15 |
human |
| Jie Luo, Youde Cai, Dingling Wei, Liping Cao, Qiansong He, Yuanhua W. Formononetin alleviates cerebral ischemia-reperfusion injury in rats by targeting the PARP-1/PARG/Iduna signaling pathway. Brain research. 2024-03-07. PMID:38452845. |
the data show that formononetin can effectively alleviate neurological dysfunction and pathological changes in brain tissue in rats with cerebral ischemia-reperfusion injury, reduce the area of cerebral infarction and neuronal apoptosis, decrease the protein levels of parp-1, parg, caspase-3, p53, and aif in brain tissue, and increase the protein levels of iduna and p-akt. |
2024-03-07 |
2024-03-10 |
rat |
| Lilian Göttig, Simone Jummer, Luisa Staehler, Peter Groitl, Maryam Karimi, Paola Blanchette, Karin Kosulin, Philip E Branton, Sabrina Schreine. The human adenovirus PI3K-Akt activator E4orf1 is targeted by the tumor suppressor p53. Journal of virology. 2024-03-07. PMID:38451084. |
to achieve transformation, the viral early proteins of the e1 and e4 regions must block apoptosis and activate proliferation: the former predominantly through modulating the cellular tumor suppressor p53 and the latter by activating cellular pro-survival and pro-metabolism protein cascades, such as the phosphoinositide 3-kinase (pi3k-akt) pathway, which is activated by hadv e4orf1. |
2024-03-07 |
2024-03-09 |
human |
| Ying Sun, Xiaohui Jin, Zuwang Yang, Zunhan Hu, Qiulu Li, Jingquan Dong, Mian F. Ferulic acid attenuates difenoconazole exposure induced liver injury in carp by modulating oxidative damage, inflammation and apoptosis. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2024-03-05. PMID:38442785. |
additionally, tunel results demonstrated that dfz initiated apoptosis, while dietary supplementation with fa decreased the protein expression levels of bax and cytochrome c (cyt c) and the transcriptional levels of bax, caspase3, caspase9, p53 genes. |
2024-03-05 |
2024-03-08 |
Not clear |
| Hongfu Liu, Dongdong Zhou, Dongqin Liu, Xi Xu, Kai Zhang, Ruxia Hu, Peng Xiong, Changxin Wang, Xiangfu Zeng, Liefeng Wang, Shuyong Zhan. Synergistic antitumor activity between HER2 antibody-drug conjugate and chemotherapy for treating advanced colorectal cancer. Cell death & disease. vol 15. issue 3. 2024-03-05. PMID:38443386. |
the results revealed that combination treatment of rc48 and gem regulated multiple signaling pathways, such as pi3k-akt, mapk, p53, foxo, apoptosis, cell cycle and cell senescence, etc., to exert its antitumor activity in crc cells. |
2024-03-05 |
2024-03-08 |
Not clear |
| Naz Şerifoğlu, Bruno Lopes-Bastos, Miguel Godinho Ferreir. Lack of telomerase reduces cancer incidence and increases lifespan of zebrafish tp53 Scientific reports. vol 14. issue 1. 2024-03-05. PMID:38443436. |
critically short telomeres trigger dna damage responses and activate p53 which leads to apoptosis or replicative senescence. |
2024-03-05 |
2024-03-08 |
zebrafish |
| Yubo Wang, Ruonan Wang, Yanli Zhao, Sheng Cao, Chen Li, Yanjie Wu, Lan Ma, Ying Liu, Yuhong Yao, Yue Jiao, Yukun Chen, Shuangwei Liu, Kun Zhang, Mingming Wei, Cheng Yang, Guang Yan. Discovery of selective and potent ATR degrader for exploration its kinase-independent functions in acute myeloid leukemia cells. Angewandte Chemie (International ed. in English). 2024-03-04. PMID:38433368. |
this would increase the expression of p53 and triggered immediately p53-mediated apoptosis signaling pathway, which was earlier and more effective than atr kinase inhibition. |
2024-03-04 |
2024-03-06 |
Not clear |
| Shuo Han, Shuang Zhao, Haile Ren, Qianqian Jiao, Xianjia Wu, Xinrui Hao, Mingchun Liu, Liping Han, Limei Ha. Novel lncRNA 803 related to Marek's disease inhibits apoptosis of DF-1 cells. Avian pathology : journal of the W.V.P.A. 2024-02-29. PMID:38323582. |
differentially expressed lncrnas in spleens of chickens infected with marek's disease virus at different stages were identified for the first time.the effects of novel lncrna 803 on p53 pathway and apoptosis of df-1 cells were reported for the first time. |
2024-02-29 |
2024-03-02 |
Not clear |
| Shuli Man, Jingxian Bi, Furui Liu, Wenwen Xie, Long M. Vitamin C Inhibited Pulmonary Metastasis through Activating Nrf2/HO-1 Pathway. Molecular nutrition & food research. 2024-02-29. PMID:38419398. |
the results show that intraperitoneal injection of vc inhibits pulmonary metastasis through up-regulating the expression of nrf2, ho-1, cleaved caspases 3 and 9, and causing dna damage and apoptosis which is similar to the pro-oxidant effect of vc in p53 null cells (h1299 cells). |
2024-02-29 |
2024-03-02 |
mouse |
| Jing Chen, Bo Zen. METTL14-Mediated m6a Modification of CDKN2A Promotes the Development of Retinoblastoma by Inhibiting the p53 Pathway. Critical reviews in immunology. vol 44. issue 3. 2024-02-29. PMID:38421707. |
cell colony formation, cck-8 as well as western blotting were used to evaluate the proliferation, apoptosis as well as p53 protein level of rb cell line. |
2024-02-29 |
2024-03-02 |
Not clear |
| Jing Chen, Bo Zen. METTL14-Mediated m6a Modification of CDKN2A Promotes the Development of Retinoblastoma by Inhibiting the p53 Pathway. Critical reviews in immunology. vol 44. issue 3. 2024-02-29. PMID:38421707. |
the proliferation of rb cells can be inhibited by silencing cdkn2a, which promotes apoptosis and p53 protein level. |
2024-02-29 |
2024-03-02 |
Not clear |
| Ismail Koyuncu, Ebru Temiz, Eray Metin Güler, Mustafa Durgun, Ozgür Yuksekdag, Simone Giovannuzzi, Claudiu T Supura. Effective Anticancer Potential of a New Sulfonamide as a Carbonic Anhydrase IX Inhibitor Against Aggressive Tumors. ChemMedChem. 2024-02-27. PMID:38323458. |
the expression of pro-apoptotic regulatory proteins (bad, bax, bid, bim, cyt-c, fas, fasl, tnf-a, tnf-r1, htra, smac, casp-3, -8, p21, p27, and p53) was increased, while the expression of anti-apoptotic proteins, apoptosis inhibitor proteins (iaps), and heat shock proteins (hsps) (bcl-2, bcl-w, ciap-2, hsp27, hsp60, hsp70, survivin, livin, and xiap) was decreased. |
2024-02-27 |
2024-03-01 |
Not clear |
| Shivi Chauhan, Shivani Jaiswal, Vibhuti Jakhmola, Bhavana Singh, Sujata Bhattacharya, Manoj Garg, Shinjinee Sengupt. Potential role of p53 deregulation in modulating immune responses in human malignancies: A paradigm to develop immunotherapy. Cancer letters. 2024-02-26. PMID:38408603. |
this review comprehensively explores the dual role of p53 as both the guardian of the genome and an oncogenic driver, especially in the context of regulation of autophagy, apoptosis, the tumor microenvironment, immune cells, innate immunity, and adaptive immune responses. |
2024-02-26 |
2024-03-02 |
human |
| Dongqiang Luo, Xiaolu Gao, Xianqiong Zhu, Jiongbo Xu, Pengfei Gao, Jiayi Zou, Qiaoming Fan, Ying Xu, Tian Li. Biomarker screening using integrated bioinformatics for the development of "normal-impaired glucose intolerance-type 2 diabetes mellitus". Scientific reports. vol 14. issue 1. 2024-02-24. PMID:38402348. |
integrating mfuzz analysis with differential expression analysis, we identified 76 genes associated with the progression of t2dm, which were primarily enriched in signaling pathways such as apoptosis, p53 signaling, and necroptosis. |
2024-02-24 |
2024-02-27 |
Not clear |
| Mei Li, Meng Wang, Yao Xi, Shantong Qiu, Qiaoying Zeng, Yangyang Pa. Isolation and Identification of a Tibetan Pig Porcine Epidemic Diarrhoea Virus Strain and Its Biological Effects on IPEC-J2 Cells. International journal of molecular sciences. vol 25. issue 4. 2024-02-24. PMID:38396878. |
we then detected the expression of the p53, p38, jnk, bax, and bcl-2 genes in the apoptosis signal pathway. |
2024-02-24 |
2024-02-26 |
Not clear |
| François-Xavier Boittin, Nathalie Guitard, Maeliss Toth, Diane Riccobono, Hélène Théry, Régis Bob. The Protein Kinase A Inhibitor KT5720 Prevents Endothelial Dysfunctions Induced by High-Dose Irradiation. International journal of molecular sciences. vol 25. issue 4. 2024-02-24. PMID:38396945. |
high-dose x-irradiation (15 gy) triggered the late apoptosis of hpmecs independent of the ceramide/p38 map kinase pathway or p53. |
2024-02-24 |
2024-02-26 |
human |
| Yong-Jun Cheng, Zhen Zhuang, Yu-Ling Miao, Shan-Shan Song, Xu-Bin Bao, Chun-Hao Yang, Jin-Xue H. Identification of YCH2823 as a novel USP7 inhibitor for cancer therapy. Biochemical pharmacology. 2024-02-22. PMID:38387527. |
an increase in the expression of p53 and p21, accompanied by g1 phase arrest and apoptosis, was observed upon treatment with ych2823. |
2024-02-22 |
2024-02-25 |
human |
| Yaowen Cui, Zhaolun He, Tingting Chen, Xinjian Ren, Jing Xu, Shouguo Zhang, Tao Peng, Shuchen Liu, Lin Wan. Design, synthesis, biological evaluation and in silico studies of novel quinoline derivatives as potential radioprotective molecules targeting the TLR2 and p53 pathways. European journal of medicinal chemistry. vol 268. 2024-02-20. PMID:38377827. |
in this paper, in order to find the potential novel compounds decreasing the radiation-induced damage by targeting p53 apoptosis pathway and tlr2 passway, a series of novel quinoline derivatives were designed, synthesized, and evaluated their biological activities. |
2024-02-20 |
2024-02-23 |
mouse |
| Yaowen Cui, Zhaolun He, Tingting Chen, Xinjian Ren, Jing Xu, Shouguo Zhang, Tao Peng, Shuchen Liu, Lin Wan. Design, synthesis, biological evaluation and in silico studies of novel quinoline derivatives as potential radioprotective molecules targeting the TLR2 and p53 pathways. European journal of medicinal chemistry. vol 268. 2024-02-20. PMID:38377827. |
the mechanistic studies indicated that compound 5 acted on the p53 pathway to reduce radiation-induced cell apoptosis and at the same time stimulated tlr2 to up-regulate the expressions of radiation protection factors. |
2024-02-20 |
2024-02-23 |
mouse |