| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Weitao Hu, Guilan Chen, Wenbin Yuan, Chen Guo, Fasheng Liu, Shouhua Zhang, Zigang Ca. Iprodione induces hepatotoxicity in zebrafish by mediating ROS generation and upregulating p53 signalling pathway. Ecotoxicology and environmental safety. vol 270. 2024-01-05. PMID:38181604. |
to summarize, iprodione induces apoptosis through the upregulation of p53 mediated by oxidative stress signals, leading to liver toxicity in zebrafish. |
2024-01-05 |
2024-01-08 |
human |
| Aishee Ghosh, Sonal Singh, Utsa Saha, Snehasmita Jena, Faizan Zareen Simnani, Dibyangshee Singh, Abha Gupta, Aditya Nandi, Adrija Sinha, Tanmaya Nayak, Prabhat Kumar Rout, Pritam Kumar Panda, Deobrat Singh, Vishakha Raina, Suresh K Verm. Proximal discrepancies in intrinsic atomic interaction determines comparative in vivo biotoxicity of Chlorpyrifos and 3,5,6-trichloro-2-pyridinol in embryonic zebrafish. The Science of the total environment. 2024-01-04. PMID:38176558. |
experimental cellular and molecular analysis showed higher induction of morphological abnormalities, oxidative stress and apoptosis in tcp exposed embryos compared to cp exposure due to upregulation of metabolic enzymes like zhe1a, sod1 and p53. |
2024-01-04 |
2024-01-07 |
human |
| Arijit Mondal, Sabyasachi Banerjee, Wearank Terang, Anusha Bishayee, Jie Zhang, Li Ren, Milton Nascimento da Silva, Anupam Bishaye. Capsaicin: A chili pepper bioactive phytocompound with a potential role in suppressing cancer development and progression. Phytotherapy research : PTR. 2024-01-04. PMID:38176910. |
furthermore, capsaicin alone or in combination can promote apoptosis in carcinoma cells by enhancing the p53 and c-myc gene expressions. |
2024-01-04 |
2024-01-07 |
human |
| Grégoire Jean-Baptiste Philippe, Yen-Hua Huang, Anna Mittermeier, Christopher J Brown, Quentin Kaas, Siti Radhiah Ramlan, Conan K Wang, David Lane, Alexander Loewer, Sónia Troeira Henriques, David J Crai. Delivery to, and Reactivation of, the p53 Pathway in Cancer Cells Using a Grafted Cyclotide Conjugated with a Cell-Penetrating Peptide. Journal of medicinal chemistry. 2024-01-04. PMID:38174919. |
conjugation allowed cell internalization at micromolar concentration and led to elevated intracellular p53 levels in a549, mcf7, and mcf10a cells, as well as inducing apoptosis in a549 cells without causing membrane disruption. |
2024-01-04 |
2024-01-06 |
Not clear |
| Yue Li, Linlin Xu, Chaoju Hao, Si Yang, Jinglei Wang, Jiaxiang Che. ARTS is essential for di-2-ethylhexyl phthalate (DEHP)-induced apoptosis of mouse Leydig cells. Ecotoxicology and environmental safety. vol 270. 2024-01-03. PMID:38171099. |
overexpression of p53 could induce apoptosis of tm3 cells; while knockdown of p53 could not only rescue dehp-induced apoptosis of the cells, but also inhibit dehp-caused upregulation of arts. |
2024-01-03 |
2024-01-06 |
mouse |
| Yue Li, Linlin Xu, Chaoju Hao, Si Yang, Jinglei Wang, Jiaxiang Che. ARTS is essential for di-2-ethylhexyl phthalate (DEHP)-induced apoptosis of mouse Leydig cells. Ecotoxicology and environmental safety. vol 270. 2024-01-03. PMID:38171099. |
meanwhile, we showed that oxidative stress could induce apoptosis of tm3 cells, accompanied with the increased protein levels of p53 and arts; while inhibition of oxidative stress dramatically alleviated dehp-induced apoptosis and the up-regulation of p53 and arts. |
2024-01-03 |
2024-01-06 |
mouse |
| Jianning Zhu, Hao Shen, Guohao Li, Lin Chen, Peng Kang, Yonglian Guo, Zhongyuan L. Theaflavin pretreatment ameliorates renal ischemia/reperfusion injury by attenuating apoptosis and oxidative stress in vivo and in vitro. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 171. 2024-01-03. PMID:38171247. |
the application of theaflavin significantly promoted the translocation of p53 from cytoplasm to nucleus, upregulated the expression of glutathione peroxidase 1 (gpx-1) in cells, and inhibited oxidative stress damage and apoptosis. |
2024-01-03 |
2024-01-06 |
mouse |
| Min Hak Lee, Ki-Hwan Um, Seok Won Lee, Ye Ji Sun, Da-Hye Gu, Young Ok Jo, Sung Hyun Kim, Wongi Seol, Hyorin Hwang, Kyunghwa Baek, Jin Woo Cho. Bi-directional regulation of AIMP2 and its splice variant on PARP-1-dependent neuronal cell death; Therapeutic implication for Parkinson's disease. Acta neuropathologica communications. vol 12. issue 1. 2024-01-03. PMID:38172953. |
instead, aimp2 possesses an antagonistic splice variant, designated dx2, which counteracts aimp2-induced apoptosis in the p53 or inflammatory pathway. |
2024-01-03 |
2024-01-06 |
Not clear |
| Eman H Yousef, Mohamed E El-Mesery, Maha R Habeeb, Laila A Eiss. Diosgenin potentiates the anticancer effect of doxorubicin and volasertib via regulating polo-like kinase 1 and triggering apoptosis in hepatocellular carcinoma cells. Naunyn-Schmiedeberg's archives of pharmacology. 2024-01-02. PMID:38165424. |
dg showed promising chemo-modulatory effects to vola and dox against hcc that may be attributed partly to the downregulation of plk1 and pcna, upregulation of tumor suppressor protein p53, and apoptosis induction. |
2024-01-02 |
2024-01-05 |
human |
| Shohei Miyata, Takashi Ishii, Susumu Kitanak. Reduction of HIF-1α/PD-L1 by Catalytic Topoisomerase Inhibitor Induces Cell Death Through Caspase Activation in Cancer Cells Under Hypoxia. Anticancer research. vol 44. issue 1. 2024-01-02. PMID:38159998. |
under severe hypoxia, cellular apoptosis is induced through hypoxia-inducible factor 1, alpha subunit (hif-1α)-dependent p53 accumulation and p53 phosphorylation via ataxia telangiectasia mutated and ataxia telangiectasia and rad3-related (atr) activation via replication stress-induced dna damage response (ddr) activation. |
2024-01-02 |
2024-01-05 |
Not clear |
| Dongliu Luo, Xinyu Tang, Yixuan Wang, Shuqi Ying, Yujiao He, Hongjin Lin, Pervez Ahmed Khoso, Shu L. Selenium deficiency exacerbated Bisphenol A-induced intestinal toxicity in chickens: Apoptosis and cell cycle arrest mediated by ROS/P53. The Science of the total environment. 2023-12-31. PMID:38160834. |
the results showed that bpa exposure and/or se deficiency increased jejunum oxidative stress and dna damage, activated p53 pathway, led to mitochondrial dysfunction, and induced apoptosis and cell cycle arrest. |
2023-12-31 |
2024-01-05 |
chicken |
| Dongliu Luo, Xinyu Tang, Yixuan Wang, Shuqi Ying, Yujiao He, Hongjin Lin, Pervez Ahmed Khoso, Shu L. Selenium deficiency exacerbated Bisphenol A-induced intestinal toxicity in chickens: Apoptosis and cell cycle arrest mediated by ROS/P53. The Science of the total environment. 2023-12-31. PMID:38160834. |
using protein-protein molecular docking, we found a strong binding ability between p53 and peroxisome proliferator-activated receptor γ coactivator-1, thereby regulating mitochondrial dysfunctional apoptosis. |
2023-12-31 |
2024-01-05 |
chicken |
| Ga-Ram Kim, Joon Hee Kang, Hyeon Joo Kim, Eunji Im, Jinsu Bae, Woo Sun Kwon, Sun Young Rha, Hyun Cheol Chung, Eun Yi Cho, Soo-Youl Kim, Yong-Chul Ki. Discovery of novel 1H-benzo[d]imidazole-4,7-dione based transglutaminase 2 inhibitors as p53 stabilizing anticancer agents in renal cell carcinoma. Bioorganic chemistry. vol 143. 2023-12-28. PMID:38154386. |
because most p53 in rcc has no mutations, apoptosis can be increased by inhibiting the binding between tg2 and p53 to increase the stability of p53. |
2023-12-28 |
2023-12-31 |
Not clear |
| Xiaoye Guo, Yiming Zhang, Qian Li, Fangxin Shi, Yifan HuangFu, Jing Li, Xingzhen La. The influence of a modified p53 C-terminal peptide by using a tumor-targeting sequence on cellular apoptosis and tumor treatment. Apoptosis : an international journal on programmed cell death. 2023-12-25. PMID:38145442. |
the influence of a modified p53 c-terminal peptide by using a tumor-targeting sequence on cellular apoptosis and tumor treatment. |
2023-12-25 |
2023-12-27 |
Not clear |
| Agnes Fietz, Francesca Corsi, José Hurst, Sven Schnichel. Blue Light Damage and p53: Unravelling the Role of p53 in Oxidative-Stress-Induced Retinal Apoptosis. Antioxidants (Basel, Switzerland). vol 12. issue 12. 2023-12-23. PMID:38136192. |
blue light damage and p53: unravelling the role of p53 in oxidative-stress-induced retinal apoptosis. |
2023-12-23 |
2023-12-25 |
Not clear |
| Agnes Fietz, Francesca Corsi, José Hurst, Sven Schnichel. Blue Light Damage and p53: Unravelling the Role of p53 in Oxidative-Stress-Induced Retinal Apoptosis. Antioxidants (Basel, Switzerland). vol 12. issue 12. 2023-12-23. PMID:38136192. |
activated p53 acts as a transcription factor to regulate the expression of genes involved in cell cycle arrest, dna repair, and apoptosis. |
2023-12-23 |
2023-12-25 |
Not clear |
| Xuxia Ren, Zexu Cui, Qiaoqiao Zhang, Zhiguang Su, Wei Xu, Jinhui Wu, Hao Jian. JunB condensation attenuates vascular endothelial damage under hyperglycemic condition. Journal of molecular cell biology. 2023-12-23. PMID:38140943. |
in this study, identified by atac-seq and rna-seq, junb reverses the inhibition of proliferation and the promotion of apoptosis in human umbilical vein endothelial cells treated with high glucose, mainly through the cell cycle and p53 signaling pathways. |
2023-12-23 |
2023-12-25 |
human |
| Shiyong Zhu, Xuenan Li, Xueyan Dai, Jinlong L. Prenatal cadmium exposure impairs neural tube closure via inducing excessive apoptosis in neuroepithelium. Journal of environmental sciences (China). vol 138. 2023-12-22. PMID:38135421. |
and p53 accumulation induced excessive apoptosis in neuroepithelium during embryonic development progresses. |
2023-12-22 |
2023-12-25 |
Not clear |
| Salvador Perez Montero, Pranab K Paul, Aida di Gregorio, Sarah Bowling, Solomon Shepherd, Nadia Fernandes, Ana Lima, Rubén Pérez-Carrasco, Tristan A Rodrigue. Mutation of p53 increases the competitive ability of pluripotent stem cells. Development (Cambridge, England). 2023-12-22. PMID:38131530. |
here, we show that embryonic cells lacking the tumour suppressor p53 are super-competitors that eliminate their wild-type neighbours through the direct induction of apoptosis. |
2023-12-22 |
2023-12-24 |
Not clear |
| Olga Szewczyk-Roszczenko, Nikolai A Barle. The Role of p53 in Nanoparticle-Based Therapy for Cancer. Cells. vol 12. issue 24. 2023-12-22. PMID:38132123. |
due to the paramount importance of p53 in the onset of cell cycle arrest and apoptosis, the p53 gene is found either silenced or mutated in the vast majority of cancers. |
2023-12-22 |
2023-12-24 |
Not clear |