| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Olga Szewczyk-Roszczenko, Nikolai A Barle. The Role of p53 in Nanoparticle-Based Therapy for Cancer. Cells. vol 12. issue 24. 2023-12-22. PMID:38132123. |
furthermore, activated wild-type p53 exhibits a strong bystander effect, thereby activating apoptosis in surrounding cells without being physically present there. |
2023-12-22 |
2023-12-24 |
Not clear |
| Willem P J Cox, Nils Evander, Dorette S Van Ingen Schenau, Gawin R Stoll, Nadia Anderson, Lieke De Groot, Kari J T Grünewald, Rico Hagelaar, Miriam Butler, Roland P Kuiper, Laurens T Van der Meer, Frank N Van Leeuwe. Histone deacetylase inhibition sensitizes p53-deficient B-cell precursor acute lymphoblastic leukemia to chemotherapy. Haematologica. 2023-12-21. PMID:38124624. |
since p53-mediated apoptosis is an endpoint for many cytotoxic drugs, loss of p53 function frequently leads to therapy failure. |
2023-12-21 |
2023-12-23 |
Not clear |
| Sergey Tsymbal, Aleksandr Refeld, Viktor Zatsepin, Oleg Kuchu. The p53 protein is a suppressor of Atox1 copper chaperon in tumor cells under genotoxic effects. PloS one. vol 18. issue 12. 2023-12-21. PMID:38127999. |
the p53 protein is crucial for regulating cell survival and apoptosis in response to dna damage. |
2023-12-21 |
2023-12-24 |
Not clear |
| Sergey Tsymbal, Aleksandr Refeld, Viktor Zatsepin, Oleg Kuchu. The p53 protein is a suppressor of Atox1 copper chaperon in tumor cells under genotoxic effects. PloS one. vol 18. issue 12. 2023-12-21. PMID:38127999. |
however, its influence on therapy effectiveness is controversial: when dna damage is high p53 directs cells toward apoptosis, while under moderate genotoxic stress it saves the cells from death and promote dna repair. |
2023-12-21 |
2023-12-24 |
Not clear |
| Sinem Usluer, Markus Galhuber, Yukti Khanna, Benjamin Bourgeois, Emil Spreitzer, Helene Michenthaler, Andreas Prokesch, Tobias Mad. Disordered regions mediate the interaction of p53 and MRE11. Biochimica et biophysica acta. Molecular cell research. 2023-12-20. PMID:38123020. |
atm phosphorylates the transactivation domain (tad) of the p53 tumor suppressor, which in turn regulates dna repair, growth arrest, apoptosis, and senescence following dna damage. |
2023-12-20 |
2023-12-23 |
Not clear |
| Beixian Zhou, Linxin Wang, Zhixian Ren, Yueyun Liang, Sushan Yang, Yuehan Zhang, Siyao Che, Weiyi Fan. Pyrogallol promotes growth arrest by activating the p53-mediated up-regulation of p21 and p62/SQSTM1-dependent degradation of β-catenin in nonsmall cell lung cancer cells. Environmental toxicology. 2023-12-18. PMID:38108618. |
meanwhile, p53 inhibition has been found to abrogate the pyrogallol-induced apoptosis of the two nsclc cells. |
2023-12-18 |
2023-12-21 |
Not clear |
| A Frega, C Gentili, S Proietti, E Lepore, V Unfer, A Fus. Author Correction: Epigallocatechin gallate, folic acid, vitamin B12, and hyaluronic acid significantly increase apoptosis and p53 expression in HeLa cells. European review for medical and pharmacological sciences. vol 27. issue 23. 2023-12-14. PMID:38095369. |
author correction: epigallocatechin gallate, folic acid, vitamin b12, and hyaluronic acid significantly increase apoptosis and p53 expression in hela cells. |
2023-12-14 |
2023-12-17 |
Not clear |
| Dan Wang, Kun Yan, Hongxing Yu, Haocheng Li, Wei Zhou, Yaqiang Hong, Shuning Guo, Yi Wang, Cheng Xu, Changcun Pan, Yujie Tang, Nian Liu, Wei Wu, Liwei Zhang, Qiaoran X. Fimepinostat impairs NF-κB and PI3K/AKT signaling and enhances gemcitabine efficacy in H3K27M-mutated diffuse intrinsic pontine glioma. Cancer research. 2023-12-14. PMID:38095539. |
h3.3k27m facilitated gemcitabine-induced apoptosis in dipg, and gemcitabine stabilized and activated p53, including increasing chromatin accessibility for p53 at apoptosis-related loci. |
2023-12-14 |
2023-12-17 |
Not clear |
| Liu-Yuan Guan, Shao-Zhen Lin, Peng-Cheng Chen, Jian-Qing Lv, Bo Li, Xi-Qiao Fen. Interfacial Organization and Forces Arising from Epithelial-Cancerous Monolayer Interactions. ACS nano. 2023-12-13. PMID:38091551. |
it is found that the heterogeneous mechanical forces accumulated in the monolayers are able to squeeze cancer cells, leading to three-dimensional interfacial bulges or cell extrusion, initiating the p53 apoptosis signaling pathways of cancer cells. |
2023-12-13 |
2023-12-17 |
human |
| E H Ibrahim, M Y Alshahrani, H A Ghramh, A F El-Kott, M Kilany, K Morsy, R Taha, A A El-Mansi, M A Sayed, H C Chandramoorthy, A E Ahmed, H Alothaid, K A Khan, A M Eldi. Immunomodulatory and anti-cancer potential of cloves (Syzygium aromaticum) bud extract and its phytogenic silver nanoparticles. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 74. issue 5. 2023-12-12. PMID:38085521. |
cae and cae + nanosilver were examined for their active biomolecules using ftir analysis, p53 contents using real-time pcr, apoptosis and cell cycle arrest power on ht-29 cancer cell line via flow cytometerty and immunomodulatory potential utilizing mtt assay. |
2023-12-12 |
2023-12-17 |
Not clear |
| Sara T Alsharif, Ahmed M Gardouh, Mohamed F Mandour, Zood M Alaqais, Lama K Alharbi, Maha J Almarwani, Hatem I Mokhtar, Fatma Azzahraa Hisham, Mohamed Mahmoud Abdellah, Ghena M Mohamed, Eman M Shorog, Abdulrahman H Almaeen, Hebatallah H Atteia, Sawsan A Zaiton. Toxicology mechanisms and methods. 2023-12-12. PMID:38083807. |
the chemotherapeutic potential was mediated through enhancement of tumoral p53-mediated p53 up-regulated modulator of apoptosis (puma) genes. |
2023-12-12 |
2023-12-17 |
mouse |
| Hind Al Khashali, Ban Darweesh, Ravel Ray, Ben Haddad, Caroline Wozniak, Robert Ranzenberger, Stuti Goel, Jeneen Khalil, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evan. Regulation of Vascular Endothelial Growth Factor Signaling by Nicotine in a Manner Dependent on Acetylcholine-and/or β-Adrenergic-Receptors in Human Lung Cancer Cells. Cancers. vol 15. issue 23. 2023-12-09. PMID:38067204. |
the addition of anti-vegf antibodies to a549 and h1299 cells decreased cell viability and increased apoptosis; blocked the activities of pi3k, akt, and nfκb in the absence or presence of nicotine; and resulted in increased p53 activation in a549 cells. |
2023-12-09 |
2023-12-17 |
human |
| E G Novoselova, O V Glushkova, M O Khrenov, S M Lunin, M G Sharapov, R G Goncharov, E K Mubarakshina, T V Novoselova, S B Parfenyu. [The Thymic Hormone Thymosin-1α Reduces the Pro-Inflammatory Response of Raw 264.7 Cells Induced by Endotoxin]. Molekuliarnaia biologiia. vol 57. issue 6. 2023-12-08. PMID:38062956. |
third, tα1 significantly reduced p53 and the activity of the p53 gene, which is a marker of cell apoptosis. |
2023-12-08 |
2023-12-17 |
Not clear |
| Xixi Li, Zhipeng Huang, Hua Chao, Xunxun Li. The mechanism of Semen Persicae-Flos Carthami in treating hypertrophic scar: A study based on network pharmacological analysis and in vitro experiments. Chemical biology & drug design. 2023-12-06. PMID:38056934. |
besides, a modified explant culture method was applied to separate primary hypertrophic scar fibroblasts (hsfs); mtt assay to detect cell viability of hsfs after treatment by sp-fc for 24 h; annexin v-fitc/pi double staining combined with flow cytometry to test apoptosis; western blot to check the protein expression level of p53; and real-time fluorescence quantitative pcr to determine mrna level of p53. |
2023-12-06 |
2023-12-10 |
Not clear |
| Xixi Li, Zhipeng Huang, Hua Chao, Xunxun Li. The mechanism of Semen Persicae-Flos Carthami in treating hypertrophic scar: A study based on network pharmacological analysis and in vitro experiments. Chemical biology & drug design. 2023-12-06. PMID:38056934. |
sp-fc significantly increased the viability of hsfs, reduced the p53 level in hsfs, and promoted apoptosis. |
2023-12-06 |
2023-12-10 |
Not clear |
| Rachel Shemesh, Smadar Laufer-Geva, Yaara Gorzalczany, Alaa Anoze, Ronit Sagi-Eisenberg, Nir Peled, Laila C Roisma. The interaction of mast cells with membranes from lung cancer cells induces the release of extracellular vesicles with a unique miRNA signature. Scientific reports. vol 13. issue 1. 2023-12-06. PMID:38057448. |
we explored the pathways regulated by these mirnas via enrichment analysis using the kegg database, demonstrating that these two mirnas regulate p53 signaling, cancer pathways, and pathways associated with apoptosis and the cell cycle. |
2023-12-06 |
2023-12-10 |
Not clear |
| Se-In Lee, Yuri Seo, Hoang Thi Oanh, Thi Tuyet Hanh Vo, Hyeonbin Go, Myung Hun Kim, Joo-Yong Le. HDAC6 preserves BNIP3 expression and mitochondrial integrity by deacetylating p53 at lysine 320. Biochemical and biophysical research communications. vol 691. 2023-12-03. PMID:38043200. |
hdac6 has been reported as a deacetylase of p53 at multiple lysine residues, associated with the canonical functions of p53, such as apoptosis and tumor suppression. |
2023-12-03 |
2023-12-10 |
mouse |
| Meifeng Li, Jihuan Hu, Jiazhan Zhou, Chuxin Wu, Dongming Li, Huiling Mao, Lingbao Kong, Chengyu Hu, Xiaowen X. Grass carp (Ctenopharyngodon idella) deacetylase SIRT1 targets p53 to suppress apoptosis in a KAT8 dependent or independent manner. Fish & shellfish immunology. 2023-12-03. PMID:38043873. |
grass carp (ctenopharyngodon idella) deacetylase sirt1 targets p53 to suppress apoptosis in a kat8 dependent or independent manner. |
2023-12-03 |
2023-12-10 |
Not clear |
| Meifeng Li, Jihuan Hu, Jiazhan Zhou, Chuxin Wu, Dongming Li, Huiling Mao, Lingbao Kong, Chengyu Hu, Xiaowen X. Grass carp (Ctenopharyngodon idella) deacetylase SIRT1 targets p53 to suppress apoptosis in a KAT8 dependent or independent manner. Fish & shellfish immunology. 2023-12-03. PMID:38043873. |
here, our study revealed that grass carp (ctenopharyngodon idella) sirt1 (cisirt1, mn125614.1) inhibits apoptosis through targeting p53 in a kat8-dependent or a kat8-independent manner. |
2023-12-03 |
2023-12-10 |
Not clear |
| Meifeng Li, Jihuan Hu, Jiazhan Zhou, Chuxin Wu, Dongming Li, Huiling Mao, Lingbao Kong, Chengyu Hu, Xiaowen X. Grass carp (Ctenopharyngodon idella) deacetylase SIRT1 targets p53 to suppress apoptosis in a KAT8 dependent or independent manner. Fish & shellfish immunology. 2023-12-03. PMID:38043873. |
because cisirt1 separately interacted with cikat8 and cip53, we speculated that cisirt1 blocked apoptosis may be by virtue of kat8-p53 axis or directly by p53. |
2023-12-03 |
2023-12-10 |
Not clear |