| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Ozawa, H Friess, A Tempia-Caliera, J Kleeff, M W Büchle. Growth factors and their receptors in pancreatic cancer. Teratogenesis, carcinogenesis, and mutagenesis. vol 21. issue 1. 2001-02-01. PMID:11135319. |
pancreatic cancers often exhibit alterations in growth inhibitory pathways such as smad4 mutations and smad6 and smad7 overexpression, and evade apoptosis through p53 mutations and aberrant expression of apoptosis regulating genes. |
2001-02-01 |
2023-08-12 |
Not clear |
| S Patil, G M Wildey, T L Brown, L Choy, R Derynck, P H How. Smad7 is induced by CD40 and protects WEHI 231 B-lymphocytes from transforming growth factor-beta -induced growth inhibition and apoptosis. The Journal of biological chemistry. vol 275. issue 49. 2001-01-18. PMID:10995749. |
smad7 is induced by cd40 and protects wehi 231 b-lymphocytes from transforming growth factor-beta -induced growth inhibition and apoptosis. |
2001-01-18 |
2023-08-12 |
Not clear |
| S Patil, G M Wildey, T L Brown, L Choy, R Derynck, P H How. Smad7 is induced by CD40 and protects WEHI 231 B-lymphocytes from transforming growth factor-beta -induced growth inhibition and apoptosis. The Journal of biological chemistry. vol 275. issue 49. 2001-01-18. PMID:10995749. |
ectopic overexpression of smad7 inhibited smad2 activation, tgf-beta-mediated growth inhibition, and apoptosis in wehi 231 cells. |
2001-01-18 |
2023-08-12 |
Not clear |
| S Patil, G M Wildey, T L Brown, L Choy, R Derynck, P H How. Smad7 is induced by CD40 and protects WEHI 231 B-lymphocytes from transforming growth factor-beta -induced growth inhibition and apoptosis. The Journal of biological chemistry. vol 275. issue 49. 2001-01-18. PMID:10995749. |
the inhibitory effects of smad7 overexpression were specific to tgf-beta-induced apoptosis and were without effect on anti-igm-induced cell death. |
2001-01-18 |
2023-08-12 |
Not clear |
| S Patil, G M Wildey, T L Brown, L Choy, R Derynck, P H How. Smad7 is induced by CD40 and protects WEHI 231 B-lymphocytes from transforming growth factor-beta -induced growth inhibition and apoptosis. The Journal of biological chemistry. vol 275. issue 49. 2001-01-18. PMID:10995749. |
these results suggest a mechanism of suppression of tgf-beta-induced apoptosis by cd40, mediated through activation of nf-kappab and, consequently, induction of smad7 expression. |
2001-01-18 |
2023-08-12 |
Not clear |
| J Kleeff, H Friess, P O Berberat, M E Martignoni, K Z'graggen, M W Büchle. Pancreatic cancer--new aspects of molecular biology research. Swiss surgery = Schweizer Chirurgie = Chirurgie suisse = Chirurgia svizzera. vol 6. issue 5. 2001-01-09. PMID:11077487. |
in addition, pdacs often exhibit alterations in growth inhibitory pathways such as smad4 mutations and smad6 and smad7 overexpression, and evade apoptosis through p53 mutations and aberrant expression of apoptosis regulating genes such as members of the bcl family. |
2001-01-09 |
2023-08-12 |
Not clear |
| Y Yamamura, X Hua, S Bergelson, H F Lodis. Critical role of Smads and AP-1 complex in transforming growth factor-beta -dependent apoptosis. The Journal of biological chemistry. vol 275. issue 46. 2000-12-29. PMID:10942775. |
overexpression of a dominant-negative smad3 mutant or smad7, both of which impair smad-mediated signal transduction, inhibits tgf-beta1-dependent apoptosis. |
2000-12-29 |
2023-08-12 |
Not clear |
| M Landström, N E Heldin, S Bu, A Hermansson, S Itoh, P ten Dijke, C H Heldi. Smad7 mediates apoptosis induced by transforming growth factor beta in prostatic carcinoma cells. Current biology : CB. vol 10. issue 9. 2000-09-20. PMID:10801443. |
smad7 mediates apoptosis induced by transforming growth factor beta in prostatic carcinoma cells. |
2000-09-20 |
2023-08-12 |
human |
| M Landström, N E Heldin, S Bu, A Hermansson, S Itoh, P ten Dijke, C H Heldi. Smad7 mediates apoptosis induced by transforming growth factor beta in prostatic carcinoma cells. Current biology : CB. vol 10. issue 9. 2000-09-20. PMID:10801443. |
smad7 expression is increased in rat prostatic epithelial cells undergoing apoptosis as a result of castration [2]. |
2000-09-20 |
2023-08-12 |
human |
| M Landström, N E Heldin, S Bu, A Hermansson, S Itoh, P ten Dijke, C H Heldi. Smad7 mediates apoptosis induced by transforming growth factor beta in prostatic carcinoma cells. Current biology : CB. vol 10. issue 9. 2000-09-20. PMID:10801443. |
here we have shown that tgf-beta1 treatment or ectopic expression of smad7 in human prostatic carcinoma cells (pc-3u) induces apoptosis. |
2000-09-20 |
2023-08-12 |
human |
| M Landström, N E Heldin, S Bu, A Hermansson, S Itoh, P ten Dijke, C H Heldi. Smad7 mediates apoptosis induced by transforming growth factor beta in prostatic carcinoma cells. Current biology : CB. vol 10. issue 9. 2000-09-20. PMID:10801443. |
furthermore, tgf-beta1-induced apoptosis was prevented by inhibition of smad7 expression, by antisense mrna in stably transfected cell lines or upon transient transfection with antisense oligonucleotides in several investigated cell lines. |
2000-09-20 |
2023-08-12 |
human |
| A Ishisaki, K Yamato, S Hashimoto, A Nakao, K Tamaki, K Nonaka, P ten Dijke, H Sugino, T Nishihar. Differential inhibition of Smad6 and Smad7 on bone morphogenetic protein- and activin-mediated growth arrest and apoptosis in B cells. The Journal of biological chemistry. vol 274. issue 19. 1999-06-03. PMID:10224135. |
differential inhibition of smad6 and smad7 on bone morphogenetic protein- and activin-mediated growth arrest and apoptosis in b cells. |
1999-06-03 |
2023-08-12 |
mouse |
| A Ishisaki, K Yamato, S Hashimoto, A Nakao, K Tamaki, K Nonaka, P ten Dijke, H Sugino, T Nishihar. Differential inhibition of Smad6 and Smad7 on bone morphogenetic protein- and activin-mediated growth arrest and apoptosis in B cells. The Journal of biological chemistry. vol 274. issue 19. 1999-06-03. PMID:10224135. |
here we demonstrate that both smad6 and smad7 are human bone morphogenetic protein-2 (hbmp-2)-inducible antagonists of hbmp-2-induced growth arrest and apoptosis in mouse b cell hybridoma hs-72 cells. |
1999-06-03 |
2023-08-12 |
mouse |
| A Ishisaki, K Yamato, S Hashimoto, A Nakao, K Tamaki, K Nonaka, P ten Dijke, H Sugino, T Nishihar. Differential inhibition of Smad6 and Smad7 on bone morphogenetic protein- and activin-mediated growth arrest and apoptosis in B cells. The Journal of biological chemistry. vol 274. issue 19. 1999-06-03. PMID:10224135. |
we previously reported that smad7 is an activin a-inducible antagonist of activin a-induced growth arrest and apoptosis in hs-72 cells. |
1999-06-03 |
2023-08-12 |
mouse |
| A Ishisaki, K Yamato, A Nakao, K Nonaka, M Ohguchi, P ten Dijke, T Nishihar. Smad7 is an activin-inducible inhibitor of activin-induced growth arrest and apoptosis in mouse B cells. The Journal of biological chemistry. vol 273. issue 38. 1998-10-15. PMID:9733712. |
smad7 is an activin-inducible inhibitor of activin-induced growth arrest and apoptosis in mouse b cells. |
1998-10-15 |
2023-08-12 |
mouse |
| A Ishisaki, K Yamato, A Nakao, K Nonaka, M Ohguchi, P ten Dijke, T Nishihar. Smad7 is an activin-inducible inhibitor of activin-induced growth arrest and apoptosis in mouse B cells. The Journal of biological chemistry. vol 273. issue 38. 1998-10-15. PMID:9733712. |
here we demonstrate that the mrna expression of smad7 is induced by activin a in mouse b cell hybridoma hs-72 cells, which undergo growth arrest and apoptosis upon exposure to activin a. |
1998-10-15 |
2023-08-12 |
mouse |
| A Ishisaki, K Yamato, A Nakao, K Nonaka, M Ohguchi, P ten Dijke, T Nishihar. Smad7 is an activin-inducible inhibitor of activin-induced growth arrest and apoptosis in mouse B cells. The Journal of biological chemistry. vol 273. issue 38. 1998-10-15. PMID:9733712. |
furthermore, smad7 expression suppressed activin a-induced apoptosis in hs-72 cells. |
1998-10-15 |
2023-08-12 |
mouse |
| A Ishisaki, K Yamato, A Nakao, K Nonaka, M Ohguchi, P ten Dijke, T Nishihar. Smad7 is an activin-inducible inhibitor of activin-induced growth arrest and apoptosis in mouse B cells. The Journal of biological chemistry. vol 273. issue 38. 1998-10-15. PMID:9733712. |
thus, our data indicate that smad7 is an activin a-inducible antagonist of activin a-induced growth arrest and apoptosis of b lineage cells. |
1998-10-15 |
2023-08-12 |
mouse |