| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gangwen Han, Li Bian, Fulun Li, Ana Cotrim, Donna Wang, Jianbo Lu, Yu Deng, Gregory Bird, Anastasia Sowers, James B Mitchell, J Silvio Gutkind, Rui Zhao, David Raben, Peter ten Dijke, Yosef Refaeli, Qinghong Zhang, Xiao-Jing Wan. Preventive and therapeutic effects of Smad7 on radiation-induced oral mucositis. Nature medicine. vol 19. issue 4. 2013-06-04. PMID:23475202. |
smad7 dampened both pathways to attenuate inflammation, growth inhibition and apoptosis. |
2013-06-04 |
2023-08-12 |
mouse |
| Suntaek Hong, Hye-Youn Kim, Jooyoung Kim, Huyen Trang Ha, Young-Mi Kim, Eunjin Bae, Tae Hyung Kim, Kang Choon Lee, Seong-Jin Ki. Smad7 protein induces interferon regulatory factor 1-dependent transcriptional activation of caspase 8 to restore tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis. The Journal of biological chemistry. vol 288. issue 5. 2013-03-28. PMID:23255602. |
smad7 protein induces interferon regulatory factor 1-dependent transcriptional activation of caspase 8 to restore tumor necrosis factor-related apoptosis-inducing ligand (trail)-mediated apoptosis. |
2013-03-28 |
2023-08-12 |
Not clear |
| Marisol Quezada, Jikui Wang, Valerie Hoang, Elizabeth A McGe. Smad7 is a transforming growth factor-beta-inducible mediator of apoptosis in granulosa cells. Fertility and sterility. vol 97. issue 6. 2012-08-07. PMID:22656308. |
smad7 is a transforming growth factor-beta-inducible mediator of apoptosis in granulosa cells. |
2012-08-07 |
2023-08-12 |
Not clear |
| Woo-Kwang Jeon, Hey-Young Hong, Won-Chan Seo, Kyu-Hyoung Lim, Hui-Young Lee, Woo-Jin Kim, Seo-Young Song, Byung-Chul Ki. Smad7 sensitizes A549 lung cancer cells to cisplatin-induced apoptosis through heme oxygenase-1 inhibition. Biochemical and biophysical research communications. vol 420. issue 2. 2012-05-25. PMID:22421218. |
smad7 sensitizes a549 lung cancer cells to cisplatin-induced apoptosis through heme oxygenase-1 inhibition. |
2012-05-25 |
2023-08-12 |
human |
| Woo-Kwang Jeon, Hey-Young Hong, Won-Chan Seo, Kyu-Hyoung Lim, Hui-Young Lee, Woo-Jin Kim, Seo-Young Song, Byung-Chul Ki. Smad7 sensitizes A549 lung cancer cells to cisplatin-induced apoptosis through heme oxygenase-1 inhibition. Biochemical and biophysical research communications. vol 420. issue 2. 2012-05-25. PMID:22421218. |
consistently, smad7 sensitized a549 cells to cisplatin-induced apoptosis and these effects were dependent on ho-1 and akt inhibition. |
2012-05-25 |
2023-08-12 |
human |
| Marco A Briones-Orta, Angeles C Tecalco-Cruz, Marcela Sosa-Garrocho, Cassandre Caligaris, Marina Macías-Silv. Inhibitory Smad7: emerging roles in health and disease. Current molecular pharmacology. vol 4. issue 2. 2011-09-30. PMID:21222648. |
because of this inhibitory function, smad7 can antagonize diverse cellular processes regulated by tgf-β such as cell proliferation, differentiation, apoptosis, adhesion and migration. |
2011-09-30 |
2023-08-12 |
human |
| Hyun-A Seong, Ravi Manoharan, Hyunjung H. B-MYB positively regulates serine-threonine kinase receptor-associated protein (STRAP) activity through direct interaction. The Journal of biological chemistry. vol 286. issue 9. 2011-05-04. PMID:21148321. |
functionally, b-myb enhances strap-mediated inhibition of tgf-β signaling pathways, such as apoptosis and growth inhibition, by modulating complex formation between the tgf-β receptor and smad3 or smad7. |
2011-05-04 |
2023-08-12 |
Not clear |
| Zuo-Liang Chen, Guan-Hong Deng, Hong-Bai Chen, Jun Chen. [Expression of TGF-beta1, Smad7 and cell apoptosis in epithelium of oral lichen planus]. Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology. vol 43. issue 2. 2011-03-10. PMID:18683731. |
[expression of tgf-beta1, smad7 and cell apoptosis in epithelium of oral lichen planus]. |
2011-03-10 |
2023-08-12 |
Not clear |
| Zuo-Liang Chen, Guan-Hong Deng, Hong-Bai Chen, Jun Chen. [Expression of TGF-beta1, Smad7 and cell apoptosis in epithelium of oral lichen planus]. Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology. vol 43. issue 2. 2011-03-10. PMID:18683731. |
to examine the expression of tgf-beta1, smad7 and cell apoptosis in oral lichen planus (olp) and to evaluate the possible pathogenesis of oral lichen planus. |
2011-03-10 |
2023-08-12 |
Not clear |
| Aimin Leng, Ting Liu, Yongzheng He, Qian Li, Guiying Zhan. Smad4/Smad7 balance: a role of tumorigenesis in gastric cancer. Experimental and molecular pathology. vol 87. issue 1. 2009-07-28. PMID:19341727. |
apoptosis and survival of cancer cells was induced after smad4 and smad7 transduction. |
2009-07-28 |
2023-08-12 |
human |
| Aimin Leng, Ting Liu, Yongzheng He, Qian Li, Guiying Zhan. Smad4/Smad7 balance: a role of tumorigenesis in gastric cancer. Experimental and molecular pathology. vol 87. issue 1. 2009-07-28. PMID:19341727. |
thus, this study provides a mechanism by which a balance between smad4 and smad7 in human gastric cancer is critical for differentiation, metastasis, and apoptosis of tumor cells. |
2009-07-28 |
2023-08-12 |
human |
| S K Halder, G Rachakonda, N G Deane, P K Datt. Smad7 induces hepatic metastasis in colorectal cancer. British journal of cancer. vol 99. issue 6. 2009-03-12. PMID:18781153. |
we previously reported that overexpression of smad7 in colon adenocarcinoma (fet) cells induces tumorigenicity by blocking tgf-beta-induced growth inhibition and apoptosis. |
2009-03-12 |
2023-08-12 |
Not clear |
| Qian Chen, Hanying Chen, Dawei Zheng, Chenzhong Kuang, Hong Fang, Bingyu Zou, Wuqiang Zhu, Guixue Bu, Ting Jin, Zhenzhen Wang, Xin Zhang, Ju Chen, Loren J Field, Michael Rubart, Weinian Shou, Yan Che. Smad7 is required for the development and function of the heart. The Journal of biological chemistry. vol 284. issue 1. 2009-02-24. PMID:18952608. |
further analyses suggest that smad2/3 phosphorylation was elevated in atrioventricular cushion in the heart of smad7 mutant mice, accompanied by increased apoptosis in this region. |
2009-02-24 |
2023-08-12 |
mouse |
| Gabriele Gohla, Kerstin Krieglstein, Björn Spitta. Tieg3/Klf11 induces apoptosis in OLI-neu cells and enhances the TGF-beta signaling pathway by transcriptional repression of Smad7. Journal of cellular biochemistry. vol 104. issue 3. 2008-09-22. PMID:18189266. |
tieg3/klf11 induces apoptosis in oli-neu cells and enhances the tgf-beta signaling pathway by transcriptional repression of smad7. |
2008-09-22 |
2023-08-12 |
Not clear |
| Pradeep Salins, Yang He, Kelly Olson, Gordon Glazner, Tarek Kashour, Francis Amar. TGF-beta1 is increased in a transgenic mouse model of familial Alzheimer's disease and causes neuronal apoptosis. Neuroscience letters. vol 430. issue 1. 2008-04-08. PMID:18063474. |
furthermore, addition of tgf-beta1 to the mcn caused an increase in apoptosis and smad7 levels. |
2008-04-08 |
2023-08-12 |
mouse |
| Pradeep Salins, Yang He, Kelly Olson, Gordon Glazner, Tarek Kashour, Francis Amar. TGF-beta1 is increased in a transgenic mouse model of familial Alzheimer's disease and causes neuronal apoptosis. Neuroscience letters. vol 430. issue 1. 2008-04-08. PMID:18063474. |
when smad7 or beta-catenin levels were reduced by sirna, tgf-beta1-induced apoptosis was suppressed, indicating that both smad7 and beta-catenin are required for tgf-beta1-induced neurotoxicity. |
2008-04-08 |
2023-08-12 |
mouse |
| Peter Broderick, Gabrielle Sellick, Sarah Fielding, Daniel Catovsky, Richard Houlsto. Lack of a relationship between the common 18q24 variant rs12953717 and risk of chronic lymphocytic leukemia. Leukemia & lymphoma. vol 49. issue 2. 2008-04-07. PMID:18231913. |
18q24 harbors mothers against decapentaplegic homolog 7 (smad7), an intracellular antagonist of tgf-beta signaling which participates in a negative feedback loop controlling growth arrest and apoptosis of b-cells. |
2008-04-07 |
2023-08-12 |
Not clear |
| Suntaek Hong, Chan Lee, Seong-Jin Ki. Smad7 sensitizes tumor necrosis factor induced apoptosis through the inhibition of antiapoptotic gene expression by suppressing activation of the nuclear factor-kappaB pathway. Cancer research. vol 67. issue 19. 2007-10-31. PMID:17909069. |
smad7 sensitizes tumor necrosis factor induced apoptosis through the inhibition of antiapoptotic gene expression by suppressing activation of the nuclear factor-kappab pathway. |
2007-10-31 |
2023-08-12 |
human |
| Suntaek Hong, Chan Lee, Seong-Jin Ki. Smad7 sensitizes tumor necrosis factor induced apoptosis through the inhibition of antiapoptotic gene expression by suppressing activation of the nuclear factor-kappaB pathway. Cancer research. vol 67. issue 19. 2007-10-31. PMID:17909069. |
in addition, smad7 mediates the inhibitory activity of tgf-beta on tnf-induced nf-kappab activation and the synergistic activity of tgf-beta on tnf-induced apoptosis. |
2007-10-31 |
2023-08-12 |
human |
| Suntaek Hong, Chan Lee, Seong-Jin Ki. Smad7 sensitizes tumor necrosis factor induced apoptosis through the inhibition of antiapoptotic gene expression by suppressing activation of the nuclear factor-kappaB pathway. Cancer research. vol 67. issue 19. 2007-10-31. PMID:17909069. |
these findings suggest that smad7 sensitizes the tumor cells to tnf-induced apoptosis through the inhibition of expression of antiapoptotic nf-kappab target genes. |
2007-10-31 |
2023-08-12 |
human |