| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jian Zeng, Bin Jiang, Xia Xiao, Rou Zhan. Inhibition of sphingosine kinase 2 attenuates hypertrophic scar formation via upregulation of Smad7 in human hypertrophic scar fibroblasts. Molecular medicine reports. vol 22. issue 3. 2021-04-26. PMID:32705254. |
the present results also indicated that sphk2 silencing or smad7 overexpression inhibited proliferation, but promoted apoptosis of hsf, coupled with changes in the expression levels of proliferation‑associated proteins, with an increase in p21 and a decrease in cyclin d1 expression levels, and apoptosis‑associated proteins, with an increase in bax and cleaved caspase‑3, and a decrease in bcl‑2, which were reversed following transfection with both sphk2 and smad7 using small interfering rna in hsf. |
2021-04-26 |
2023-08-13 |
human |
| Zhiqiang Li, Pengtao Wang, Jie Zhang, Dongkui Zha. MicroRNA-497-5p downregulation inhibits cell viability, reduces extracellular matrix deposition and induces apoptosis in human hyperplastic scar fibroblasts by regulating Smad7. Experimental and therapeutic medicine. vol 21. issue 4. 2021-03-10. PMID:33680106. |
microrna-497-5p downregulation inhibits cell viability, reduces extracellular matrix deposition and induces apoptosis in human hyperplastic scar fibroblasts by regulating smad7. |
2021-03-10 |
2023-08-13 |
human |
| Zhiqiang Li, Pengtao Wang, Jie Zhang, Dongkui Zha. MicroRNA-497-5p downregulation inhibits cell viability, reduces extracellular matrix deposition and induces apoptosis in human hyperplastic scar fibroblasts by regulating Smad7. Experimental and therapeutic medicine. vol 21. issue 4. 2021-03-10. PMID:33680106. |
moreover, smad7 upregulation significantly inhibited cell viability, decreased extracellular matrix deposition and induced apoptosis in hhsfs compared with the control-plasmid group. |
2021-03-10 |
2023-08-13 |
human |
| Zhiqiang Li, Pengtao Wang, Jie Zhang, Dongkui Zha. MicroRNA-497-5p downregulation inhibits cell viability, reduces extracellular matrix deposition and induces apoptosis in human hyperplastic scar fibroblasts by regulating Smad7. Experimental and therapeutic medicine. vol 21. issue 4. 2021-03-10. PMID:33680106. |
moreover, the results indicated that, compared with the inhibitor control group, mir-497-5p inhibitor inhibited cell viability, decreased extracellular matrix deposition and induced apoptosis in hhsfs, which were significantly reversed by smad7 knockdown. |
2021-03-10 |
2023-08-13 |
human |
| Deliang Ma, Li Qiao, Bingnan Gu. Smad7 suppresses melanoma lung metastasis by impairing Tregs migration to the tumor microenvironment. American journal of translational research. vol 13. issue 2. 2021-02-18. PMID:33594321. |
our results showed that smad7 overexpression slightly impaired b16-f10 cells growth, promoted cell apoptosis and arrested the cell cycle at s phase. |
2021-02-18 |
2023-08-13 |
Not clear |
| Bin Ye, Peng-Yu Mai, Min Zhu, Fang Dai, Ying Liu, Bo Zhan. [Regulatory effect of Qianliexiao Decoction on TGF-β1, Smad4 and Smad 7 signaling pathways and the proliferation and apoptosis of prostate fibroblasts in mice with experimental autoimmune prostatitis]. Zhonghua nan ke xue = National journal of andrology. vol 26. issue 7. 2021-01-29. PMID:33377720. |
to study the effect of intervening in the signal transduction pathways of tgf-β1, smad4 and smad7 with qianliexiao decoction (qlx) on the proliferation and apoptosis of prostate fibroblasts (prf) in mice with experimental autoimmune prostatitis (eap). |
2021-01-29 |
2023-08-13 |
mouse |
| Xue-Feng Li, Shu-Hua Zhang, Gui-Feng Liu, Shao-Nan Y. miR-363 Alleviates Detrusor Fibrosis via the TGF-β1/Smad Signaling Pathway by Targeting Col1a2 in Rat Models of STZ-Induced T2DM. Molecular therapy. Nucleic acids. vol 22. 2020-12-10. PMID:33294298. |
upregulated mir-363 inhibited col1a2 expression, which led to increased expression of b-cell lymphoma 2 (bcl-2) and smad7 and accelerated cell viability, along with decreases in cell apoptosis and col3a1, bcl-2-associated x protein (bax), transforming growth factor (tgf)-β1, and smad4 expressions. |
2020-12-10 |
2023-08-13 |
rat |
| T Feng, J Dzieran, X Yuan, A Dropmann, T Maass, A Teufel, S Marhenke, T Gaiser, F Rückert, I Kleiter, S Kanzler, M P Ebert, A Vogel, P Ten Dijke, S Dooley, N M Meindl-Beinke. Hepatocyte-specific Smad7 deletion accelerates DEN-induced HCC via activation of STAT3 signaling in mice. Oncogenesis. vol 6. issue 1. 2020-10-01. PMID:28134936. |
smad7 ko mice presented with increased psmad2/3 levels and decreased apoptosis in the tumor tissue. |
2020-10-01 |
2023-08-13 |
mouse |
| Chiho Kanamaru, Hiroshi Yasuda, Toshiro Fujit. Involvement of Smad proteins in TGF-beta and activin A-induced apoptosis and growth inhibition of liver cells. Hepatology research : the official journal of the Japan Society of Hepatology. vol 23. issue 3. 2020-09-30. PMID:12076717. |
we also demonstrate that transfection of smad7, an intracellular antagonist of smad signaling, inhibited both tgf-beta- and activin a-induced apoptosis and growth inhibition of these cells. |
2020-09-30 |
2023-08-12 |
human |
| Chen Zhao, Wei Jiang, Nian Zhou, Junyi Liao, Mingming Yang, Ning Hu, Xi Liang, Wei Xu, Hong Chen, Wei Liu, Lewis L Shi, Leonardo Oliveira, Jennifer Moriatis Wolf, Sherwin Ho, Aravind Athiviraham, H M Tsai, Tong-Chuan He, Wei Huan. Sox9 augments BMP2-induced chondrogenic differentiation by downregulating Smad7 in mesenchymal stem cells (MSCs). Genes & diseases. vol 4. issue 4. 2020-09-30. PMID:29503843. |
cell cycle analysis indicates that smad7 induces significant early apoptosis in bmp2-stimulated mscs. |
2020-09-30 |
2023-08-13 |
mouse |
| Hyun-A Seong, Ravi Manoharan, Hyunjung H. Smad proteins differentially regulate obesity-induced glucose and lipid abnormalities and inflammation via class-specific control of AMPK-related kinase MPK38/MELK activity. Cell death & disease. vol 9. issue 5. 2019-11-07. PMID:29700281. |
smads2/3/4 increased, but smad7 decreased, mpk38-mediated apoptosis signal-regulating kinase-1 (ask1)/transforming growth factor-β (tgf-β)/p53 signaling. |
2019-11-07 |
2023-08-13 |
mouse |
| Wang Yao, Zengxiang Pan, Xing Du, Jinbi Zhang, Qifa L. miR-181b-induced SMAD7 downregulation controls granulosa cell apoptosis through TGF-β signaling by interacting with the TGFBR1 promoter. Journal of cellular physiology. vol 233. issue 9. 2019-09-20. PMID:29319157. |
mir-181b-induced smad7 downregulation controls granulosa cell apoptosis through tgf-β signaling by interacting with the tgfbr1 promoter. |
2019-09-20 |
2023-08-13 |
Not clear |
| Wang Yao, Zengxiang Pan, Xing Du, Jinbi Zhang, Qifa L. miR-181b-induced SMAD7 downregulation controls granulosa cell apoptosis through TGF-β signaling by interacting with the TGFBR1 promoter. Journal of cellular physiology. vol 233. issue 9. 2019-09-20. PMID:29319157. |
we also showed that smad7 enhanced porcine gc apoptosis by interrupting tgfbr1 and the tgf-β signaling pathway. |
2019-09-20 |
2023-08-13 |
Not clear |
| Wang Yao, Zengxiang Pan, Xing Du, Jinbi Zhang, Qifa L. miR-181b-induced SMAD7 downregulation controls granulosa cell apoptosis through TGF-β signaling by interacting with the TGFBR1 promoter. Journal of cellular physiology. vol 233. issue 9. 2019-09-20. PMID:29319157. |
by inhibiting smad7, mir-181b could inhibit gc apoptosis by activating the tgf-β signaling pathway. |
2019-09-20 |
2023-08-13 |
Not clear |
| Da-Wei Shen, Yun-Long Li, Yu-Jie Hou, Zhi-Dan Xu, Yong-Zhe Li, Jian-Yong Chan. MicroRNA-543 promotes cell invasion and impedes apoptosis in pituitary adenoma via activating the Wnt/β-catenin pathway by negative regulation of Smad7. Bioscience, biotechnology, and biochemistry. vol 83. issue 6. 2019-07-15. PMID:30973065. |
microrna-543 promotes cell invasion and impedes apoptosis in pituitary adenoma via activating the wnt/β-catenin pathway by negative regulation of smad7. |
2019-07-15 |
2023-08-13 |
Not clear |
| Weidong Yao, Xin Wang, Kun Xia. Protective effect of berberine against cardiac ischemia/reperfusion injury by inhibiting apoptosis through the activation of Smad7. Molecular and cellular probes. vol 38. 2018-12-24. PMID:29278748. |
protective effect of berberine against cardiac ischemia/reperfusion injury by inhibiting apoptosis through the activation of smad7. |
2018-12-24 |
2023-08-13 |
rat |
| Weidong Yao, Xin Wang, Kun Xia. Protective effect of berberine against cardiac ischemia/reperfusion injury by inhibiting apoptosis through the activation of Smad7. Molecular and cellular probes. vol 38. 2018-12-24. PMID:29278748. |
moreover, the treatment of bbr on h/r injury functioned through the smad7-activation-induced attenuating of apoptosis by activating smad7 pathway which resulted suppression of caspase 3 expression and activity. |
2018-12-24 |
2023-08-13 |
rat |
| Man-Lung Yeung, Yanfeng Yao, Lilong Jia, Jasper F W Chan, Kwok-Hung Chan, Kwok-Fan Cheung, Honglin Chen, Vincent K M Poon, Alan K L Tsang, Kelvin K W To, Ming-Kwong Yiu, Jade L L Teng, Hin Chu, Jie Zhou, Qing Zhang, Wei Deng, Susanna K P Lau, Johnson Y N Lau, Patrick C Y Woo, Tak-Mao Chan, Susan Yung, Bo-Jian Zheng, Dong-Yan Jin, Peter W Mathieson, Chuan Qin, Kwok-Yung Yue. MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2. Nature microbiology. vol 1. 2018-01-29. PMID:27572168. |
mers coronavirus induces apoptosis in kidney and lung by upregulating smad7 and fgf2. |
2018-01-29 |
2023-08-13 |
human |
| Man-Lung Yeung, Yanfeng Yao, Lilong Jia, Jasper F W Chan, Kwok-Hung Chan, Kwok-Fan Cheung, Honglin Chen, Vincent K M Poon, Alan K L Tsang, Kelvin K W To, Ming-Kwong Yiu, Jade L L Teng, Hin Chu, Jie Zhou, Qing Zhang, Wei Deng, Susanna K P Lau, Johnson Y N Lau, Patrick C Y Woo, Tak-Mao Chan, Susan Yung, Bo-Jian Zheng, Dong-Yan Jin, Peter W Mathieson, Chuan Qin, Kwok-Yung Yue. MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2. Nature microbiology. vol 1. 2018-01-29. PMID:27572168. |
furthermore, mers-cov induced apoptosis through upregulation of smad7 and fibroblast growth factor 2 (fgf2) expression in both kidney and lung cells. |
2018-01-29 |
2023-08-13 |
human |
| Xiao-xiang Zhai, Ji-cun Ding, Zhi-ming Tan. Resveratrol Inhibits Proliferation and Induces Apoptosis of Pathological Scar Fibroblasts Through the Mechanism Involving TGF-β1/Smads Signaling Pathway. Cell biochemistry and biophysics. vol 71. issue 3. 2016-12-13. PMID:25721869. |
it was, therefore, concluded that res treatment inhibited the pathological scar fibroblast proliferation and induced cell apoptosis through the mechanism involving downregulation of tgf-β1, smad-2,3,4, and upregulation of smad7. |
2016-12-13 |
2023-08-13 |
Not clear |