| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qiu-Li Zhang, Wei Wang, Jin Li, Shi-Yuan Tian, Tian-Zi Zhan. Decreased miR-187 induces retinal ganglion cell apoptosis through upregulating SMAD7 in glaucoma. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 75. 2016-11-08. PMID:26463627. |
decreased mir-187 induces retinal ganglion cell apoptosis through upregulating smad7 in glaucoma. |
2016-11-08 |
2023-08-13 |
Not clear |
| Jianhua Xu, Qin Ai, Hanhai Cao, Quan Li. MiR-185-3p and miR-324-3p Predict Radiosensitivity of Nasopharyngeal Carcinoma and Modulate Cancer Cell Growth and Apoptosis by Targeting SMAD7. Medical science monitor : international medical journal of experimental and clinical research. vol 21. 2016-04-06. PMID:26390174. |
mir-185-3p and mir-324-3p predict radiosensitivity of nasopharyngeal carcinoma and modulate cancer cell growth and apoptosis by targeting smad7. |
2016-04-06 |
2023-08-13 |
Not clear |
| Jianhua Xu, Qin Ai, Hanhai Cao, Quan Li. MiR-185-3p and miR-324-3p Predict Radiosensitivity of Nasopharyngeal Carcinoma and Modulate Cancer Cell Growth and Apoptosis by Targeting SMAD7. Medical science monitor : international medical journal of experimental and clinical research. vol 21. 2016-04-06. PMID:26390174. |
in addition, mir-185-3p and mir-324-3p can modulate growth and apoptosis of npc cells, partly via smad7. |
2016-04-06 |
2023-08-13 |
Not clear |
| Jianhua Xu, Qin Ai, Hanhai Cao, Quan Li. MiR-185-3p and miR-324-3p Predict Radiosensitivity of Nasopharyngeal Carcinoma and Modulate Cancer Cell Growth and Apoptosis by Targeting SMAD7. Medical science monitor : international medical journal of experimental and clinical research. vol 21. 2016-04-06. PMID:26390174. |
mir-185-3p and mir-324-3p can modulate npc cell growth and apoptosis, at least partly through targeting smad7. |
2016-04-06 |
2023-08-13 |
Not clear |
| Li Bian, Gangwen Han, Carolyn W Zhao, Pamela J Garl, Xiao-Jing Wan. The role of Smad7 in oral mucositis. Protein & cell. vol 6. issue 3. 2015-12-03. PMID:25566830. |
smad7, the negative regulator of tgfβ signaling, inhibits both nf-κb and tgfβ activation and thus plays a pivotal role in the prevention and treatment of oral mucositis by attenuating growth inhibition, apoptosis, and inflammation while promoting epithelial migration. |
2015-12-03 |
2023-08-13 |
Not clear |
| Dandan Tong, Hui Qu, Xiangning Meng, Yang Jiang, Duanyang Liu, Shengqian Ye, He Chen, Yan Jin, Songbin Fu, Jingshu Gen. S-allylmercaptocysteine promotes MAPK inhibitor-induced apoptosis by activating the TGF-β signaling pathway in cancer cells. Oncology reports. vol 32. issue 3. 2015-11-03. PMID:24970681. |
immunohistochemistry and western blot assays showed that samc induced the apoptosis of cancer cells by activating tgf-β1, tβrii, p-smad2/3, smad4 and smad7 signals, and promoting bim expression while decreasing bcl-2 expression and finally activating the mitochondrial apoptosis pathway proteins caspase-3 and caspase-9 in the hepg2 cell line. |
2015-11-03 |
2023-08-13 |
Not clear |
| Dandan Tong, Hui Qu, Xiangning Meng, Yang Jiang, Duanyang Liu, Shengqian Ye, He Chen, Yan Jin, Songbin Fu, Jingshu Gen. S-allylmercaptocysteine promotes MAPK inhibitor-induced apoptosis by activating the TGF-β signaling pathway in cancer cells. Oncology reports. vol 32. issue 3. 2015-11-03. PMID:24970681. |
in contrast, in the sw620 cell line, the apoptosis induced by samc only affected tgf-β1 and smad7 signals, and promoted the expression of bax and bad and finally activated the mitochondrial apoptosis pathway protein caspase-9. |
2015-11-03 |
2023-08-13 |
Not clear |
| Busheng Zhang, Mi Zhou, Canbo Li, Jingxin Zhou, Haiqing Li, Dan Zhu, Zhe Wang, Anqing Chen, Qiang Zha. MicroRNA-92a inhibition attenuates hypoxia/reoxygenation-induced myocardiocyte apoptosis by targeting Smad7. PloS one. vol 9. issue 6. 2015-10-08. PMID:24941323. |
microrna-92a inhibition attenuates hypoxia/reoxygenation-induced myocardiocyte apoptosis by targeting smad7. |
2015-10-08 |
2023-08-13 |
rat |
| Ningning Liu, Tong Jiao, Yan Huang, Wenjun Liu, Zhiwei Li, Xin Y. Hepatitis B virus regulates apoptosis and tumorigenesis through the microRNA-15a-Smad7-transforming growth factor beta pathway. Journal of virology. vol 89. issue 5. 2015-04-20. PMID:25540364. |
in conclusion, we demonstrated that hbv can upregulate smad7 expression and inhibit tgf-β signaling, which makes the cells resistant to tgf-β-induced apoptosis and promotes tumorigenesis. |
2015-04-20 |
2023-08-13 |
mouse |
| Jiying Liu, Wang Yao, Yong Yao, Xing Du, Jilong Zhou, Baiquan Ma, Honglin Liu, Qifa Li, Zengxiang Pa. MiR-92a inhibits porcine ovarian granulosa cell apoptosis by targeting Smad7 gene. FEBS letters. vol 588. issue 23. 2015-01-28. PMID:25448599. |
mir-92a inhibits porcine ovarian granulosa cell apoptosis by targeting smad7 gene. |
2015-01-28 |
2023-08-13 |
Not clear |
| Jiying Liu, Wang Yao, Yong Yao, Xing Du, Jilong Zhou, Baiquan Ma, Honglin Liu, Qifa Li, Zengxiang Pa. MiR-92a inhibits porcine ovarian granulosa cell apoptosis by targeting Smad7 gene. FEBS letters. vol 588. issue 23. 2015-01-28. PMID:25448599. |
smad7 has a key role in apoptosis of mammalian ovarian granulosa cells (gcs), as it antagonizes and fine-tunes transforming growth factor β (tgfβ) signaling. |
2015-01-28 |
2023-08-13 |
Not clear |
| Jiying Liu, Wang Yao, Yong Yao, Xing Du, Jilong Zhou, Baiquan Ma, Honglin Liu, Qifa Li, Zengxiang Pa. MiR-92a inhibits porcine ovarian granulosa cell apoptosis by targeting Smad7 gene. FEBS letters. vol 588. issue 23. 2015-01-28. PMID:25448599. |
this study demonstrates that mir-92a regulates gc apoptosis in pig ovaries by targeting smad7 directly. |
2015-01-28 |
2023-08-13 |
Not clear |
| Jiying Liu, Wang Yao, Yong Yao, Xing Du, Jilong Zhou, Baiquan Ma, Honglin Liu, Qifa Li, Zengxiang Pa. MiR-92a inhibits porcine ovarian granulosa cell apoptosis by targeting Smad7 gene. FEBS letters. vol 588. issue 23. 2015-01-28. PMID:25448599. |
in addition, knockdown of smad7 prevented gc apoptosis in cells that expressed the mir-92a inhibitor. |
2015-01-28 |
2023-08-13 |
Not clear |
| Mayu Arase, Kana Horiguchi, Shogo Ehata, Masato Morikawa, Shuichi Tsutsumi, Hiroyuki Aburatani, Kohei Miyazono, Daizo Koinum. Transforming growth factor-β-induced lncRNA-Smad7 inhibits apoptosis of mouse breast cancer JygMC(A) cells. Cancer science. vol 105. issue 8. 2014-11-04. PMID:24863656. |
small interfering rna for lncrna-smad7 did not alter the process of tgf-β-induced epithelial-mesenchymal transition, phosphorylation of smad2 or expression of the smad7 gene, suggesting that the contribution of this lncrna to tgf-β functions may be restricted to apoptosis. |
2014-11-04 |
2023-08-13 |
mouse |
| Johanna Dzieran, Jasmin Fabian, Teng Feng, Cédric Coulouarn, Iryna Ilkavets, Anastasia Kyselova, Kai Breuhahn, Steven Dooley, Nadja M Meindl-Beinke. Comparative analysis of TGF-β/Smad signaling dependent cytostasis in human hepatocellular carcinoma cell lines. PloS one. vol 8. issue 8. 2014-06-15. PMID:23991075. |
we demonstrate that tgf-β inhibits proliferation and induces apoptosis in cell lines with low endogenous levels of tgf-β and smad7 and strong transcriptional smad3 activity (plc/prf/5, hepg2, hep3b, huh7), previously characterized to express early tgf-β signatures correlated with better outcome in hcc patients. |
2014-06-15 |
2023-08-12 |
human |
| Minli Wang, Janapriya Saha, Francis A Cucinott. Smad7 foci are present in micronuclei induced by heavy particle radiation. Mutation research. vol 756. issue 1-2. 2013-11-07. PMID:23643526. |
our data suggest a unique role of smad7 in ir-induced mn formation, which may associate with dna repair, apoptosis and genomic instability. |
2013-11-07 |
2023-08-12 |
human |
| Barbara M Braunger, Stefan Pielmeier, Cora Demmer, Victoria Landstorfer, Daniela Kawall, Natalie Abramov, Marco Leibinger, Ingo Kleiter, Dietmar Fischer, Herbert Jägle, Ernst R Tam. TGF-β signaling protects retinal neurons from programmed cell death during the development of the mammalian eye. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 35. 2013-10-28. PMID:23986258. |
in contrast, a conditional deletion of tgf-β-inhibiting smad7 in retinal neurons significantly enhanced smad3 phosphorylation and significantly decreased apoptosis of retinal neurons in embryos and pups. |
2013-10-28 |
2023-08-12 |
mouse |
| Jia Wang, Jingmin Zhao, Eagle S H Chu, Myth T S Mok, Minnie Y Y Go, Kwan Man, Rainer Heuchel, Hui Yao Lan, Zhijie Chang, Joseph J Y Sung, Jun Y. Inhibitory role of Smad7 in hepatocarcinogenesis in mice and in vitro. The Journal of pathology. vol 230. issue 4. 2013-09-13. PMID:23625826. |
smad7 increased cell apoptosis (p < 0.01) by mediating an intrinsic [caspase-9, caspase-3 and poly(adp-ribose) polymerase] apoptotic pathway. |
2013-09-13 |
2023-08-12 |
mouse |
| Jia Wang, Jingmin Zhao, Eagle S H Chu, Myth T S Mok, Minnie Y Y Go, Kwan Man, Rainer Heuchel, Hui Yao Lan, Zhijie Chang, Joseph J Y Sung, Jun Y. Inhibitory role of Smad7 in hepatocarcinogenesis in mice and in vitro. The Journal of pathology. vol 230. issue 4. 2013-09-13. PMID:23625826. |
smad7 suppresses hcc cell growth by inhibiting proliferation and g1 -s phase transition and inducing apoptosis through attenuation of nf-κb and tgfβ signalling. |
2013-09-13 |
2023-08-12 |
mouse |
| Rui Zhang, Heng Huang, Peijuan Cao, Zhenzhen Wang, Yan Chen, Yi Pa. Sma- and Mad-related protein 7 (Smad7) is required for embryonic eye development in the mouse. The Journal of biological chemistry. vol 288. issue 15. 2013-06-07. PMID:23426374. |
depletion of smad7 caused various degrees of coloboma and microphthalmia with alterations in cell apoptosis and proliferation in eyes. |
2013-06-07 |
2023-08-12 |
mouse |