| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenjie Yang, Hualin Chen, Lin Ma, Mengchao Wei, Xiaoqiang Xue, Yingjie Li, Zhaoheng Jin, Jie Dong, He Xia. The oncogene MYBL2 promotes the malignant phenotype and suppresses apoptosis through hedgehog signaling pathway in clear cell renal cell carcinoma. Heliyon. vol 10. issue 6. 2024-03-21. PMID:38510035. |
reintroduction of smo expression in mybl2-knocked down cells partially restored cell proliferation and mitigated apoptosis inhibition. |
2024-03-21 |
2024-03-23 |
Not clear |
| Changle Zhao, Xiang Liu, Lei Liu, Jianeng Li, Xingyong Liu, Wenjing Tao, Deshou Wang, Jing We. Smoothened mediates medaka spermatogonia proliferation via Gli1-Rgcc-Cdk1 axis. Biology of reproduction. 2023-08-08. PMID:37552059. |
in ex vivo testicular organ culture and a spermatogonial cell line (sg3) derived from medaka mature testis, smo activation promoted spermatogonia proliferation, while its inhibition induced apoptosis. |
2023-08-08 |
2023-08-14 |
Not clear |
| Changle Zhao, Xiang Liu, Lei Liu, Jianeng Li, Xingyong Liu, Wenjing Tao, Deshou Wang, Jing We. Smoothened mediates medaka spermatogonia proliferation via Gli1-Rgcc-Cdk1 axis. Biology of reproduction. 2023-08-08. PMID:37552059. |
furthermore, gli1 transcriptionally upregulated the expression of rgcc, and rgcc overexpression rescued cell apoptosis caused by smo or gli1 inhibition. |
2023-08-08 |
2023-08-14 |
Not clear |
| Hongyan Liao, Jiagui Huang, Jie Liu, Yue Chen, Huimin Zhu, Xuemei Li, Jun Wen, Qin Xiang, Qin Yan. Resveratrol Inhibits Activation of Microglia after Stroke through Triggering Translocation of Smo to Primary Cilia. Journal of personalized medicine. vol 13. issue 2. 2023-02-25. PMID:36836502. |
moreover, activated smo can improve neurological function via regulating oxidative stress, inflammation, apoptosis, neurogenesis, oligodendrogenesis, axonal remodeling, and so on. |
2023-02-25 |
2023-08-14 |
mouse |
| Rosalinda Mejía-Rodríguez, Daniel Romero-Trejo, Rosa O González, José Segovi. Combined treatments with AZD5363, AZD8542, curcumin or resveratrol induce death of human glioblastoma cells by suppressing the PI3K/AKT and SHH signaling pathways. Biochemistry and biophysics reports. vol 33. 2023-01-30. PMID:36714540. |
we found that the combined treatments with azd5363+azd8542+curcumin and azd8542+curcumin+resveratrol inhibit the pi3k/akt and shh survival pathways by decreasing the activity of akt, the reduction of the expression of smo, pp70s6k, ps6k, gli1, p21 and p27, and the activation of caspase-3 as a marker of apoptosis. |
2023-01-30 |
2023-08-14 |
human |
| Zuolong Liu, Miao Bian, Li Pan. LncRNA CRNDE binds hnRNPA1 to facilitate carbon monoxide poisoning-induced delayed encephalopathy via inhibiting UCHL5-mediated SMO deubiquitination. Metabolic brain disease. 2023-01-17. PMID:36648699. |
uchl5 could inhibit smo ubiquitination and suppress pc-12 cell apoptosis during ogd/r. |
2023-01-17 |
2023-08-14 |
rat |
| Changle Zhao, Zeming Zhang, Ximei Qu, Xiaoming Bai, Xingyong Liu, Wenjing Tao, Linyan Zhou, Deshou Wang, Jing We. Desert hedgehog mediates the proliferation of medaka spermatogonia through Smoothened signaling. Reproduction (Cambridge, England). 2022-02-04. PMID:35119381. |
furthermore, the proliferation of sg3 in the presence of moldhh could be inhibited by smo antagonist (cyclopamine) resulting in apoptosis. |
2022-02-04 |
2023-08-13 |
Not clear |
| Chengliang Yang, Xiaoli Zheng, Ke Ye, Yanan Sun, Yufei Lu, Qingxia Fan, Hong G. miR-135a Inhibits the Invasion and Migration of Esophageal Cancer Stem Cells through the Hedgehog Signaling Pathway by Targeting Smo. Molecular therapy. Nucleic acids. vol 19. 2021-12-02. PMID:31981861. |
after that, the expression of mir-135a and hedgehog (hh) signaling pathway-related genes (smo, gli1, shh, and gli2) in tissues and cells was measured, accompanied by evaluation of cell viability, apoptosis, invasion, and migration. |
2021-12-02 |
2023-08-13 |
Not clear |
| Chengliang Yang, Xiaoli Zheng, Ke Ye, Yanan Sun, Yufei Lu, Qingxia Fan, Hong G. miR-135a Inhibits the Invasion and Migration of Esophageal Cancer Stem Cells through the Hedgehog Signaling Pathway by Targeting Smo. Molecular therapy. Nucleic acids. vol 19. 2021-12-02. PMID:31981861. |
in addition, overexpression of mir-135a or silencing of smo decreased the expression of gli1, gli2, and shh, thus inhibiting ec cell proliferation, migration, and invasion and promoting apoptosis. |
2021-12-02 |
2023-08-13 |
Not clear |
| Feng Ding, Su Yan. Epigallocatechin-3-gallate inhibits proliferation and triggers apoptosis in colon cancer via the hedgehog/phosphoinositide 3-kinase pathways. Canadian journal of physiology and pharmacology. vol 99. issue 9. 2021-08-27. PMID:33617370. |
further study showed that purmorphamine (smoothened (smo) agonist) or insulin like growth factor-1 (igf-1, pi3k agonist) partly abolished the effect of egcg on cell proliferation, migration, and apoptosis. |
2021-08-27 |
2023-08-13 |
mouse |
| Jianmin Liu, Jing Yin, Ping Chen, Daoquan Liu, Weixiang He, Yan Li, Mingzhou Li, Xun Fu, Guang Zeng, Yuming Guo, Xinghuan Wang, Michael E DiSanto, Xinhua Zhan. Smoothened inhibition leads to decreased cell proliferation and suppressed tissue fibrosis in the development of benign prostatic hyperplasia. Cell death discovery. vol 7. issue 1. 2021-05-25. PMID:34006832. |
smo inhibition could induce cell apoptosis, cell cycle arrest at the g0/g1 phase, and a reduction of tissue fibrosis markers, both in vitro and in vivo. |
2021-05-25 |
2023-08-13 |
human |
| Chuihua Sun, Ting Xiao, Ying Xiao, Yunbao L. Silencing of long non‑coding RNA NEAT1 inhibits hepatocellular carcinoma progression by downregulating SMO by sponging microRNA‑503. Molecular medicine reports. vol 23. issue 3. 2021-05-05. PMID:33398379. |
furthermore, overexpression of neat1 or smo could reverse the effects of mir‑503‑mediated inhibition on cell viability, invasion, migration and promotion of apoptosis in the hcc cell lines. |
2021-05-05 |
2023-08-13 |
Not clear |
| Kuo-Shyang Jeng, I-Shyan Sheen, Chuen-Miin Leu, Ping-Hui Tseng, Chiung-Fang Chan. The Role of Smoothened in Cancer. International journal of molecular sciences. vol 21. issue 18. 2021-03-15. PMID:32962123. |
in addition, smo inhibitors can suppress cancer formation, reduce the proliferation of cancer cells, trigger apoptosis and suppress cancer stem cell activity. |
2021-03-15 |
2023-08-13 |
Not clear |
| Zhiyong Xiong, Chaoyang Zhou, Luyang Wang, Ronglan Zhu, Liangchen Zhong, Dengfeng Wan, Qiangping Wan. Circular RNA SMO sponges miR-338-3p to promote the growth of glioma by enhancing the expression of SMO. Aging. vol 11. issue 24. 2020-11-10. PMID:31895689. |
circsmo742 together with smo could promote cells proliferation, migration and invasion while inhibit cells apoptosis, whereas mir-338-3p showed negative impacts on the cell activity. |
2020-11-10 |
2023-08-13 |
Not clear |
| Yu-Ting Qin, Liu Yao, Zhen Yin, Huan Wang, Shuang Chen, Tuerxun Nilupar, Yasen Halida, Yang Liu, Abulizi Patiguli, Ming Jiang, Jian-Ping Ha. [Effect of Sonic Hedgehog Signal Pathway Inhibitor Jervine on Myelodysplastic Syndromes MUTZ-1 Cells]. Zhongguo shi yan xue ye xue za zhi. vol 28. issue 4. 2020-08-26. PMID:32798415. |
to study the effect of smo inhibitor (jervine) on proliferation, apoptosis and cell cycle of mds cell line mutz-1, and its mechanism. |
2020-08-26 |
2023-08-13 |
Not clear |
| Ying Wang, Weina Chen, Chang Han, Jinqiang Zhang, Kyoungsub Song, Hyunjoo Kwon, Srikanta Dash, Lu Yao, Tong W. Adult Hepatocytes Are Hedgehog-Responsive Cells in the Setting of Liver Injury: Evidence for Smoothened-Mediated Activation of NF-κB/Epidermal Growth Factor Receptor/Akt in Hepatocytes that Counteract Fas-Induced Apoptosis. The American journal of pathology. vol 188. issue 11. 2019-08-30. PMID:30366594. |
on the other hand, the smo ko hepatocytes were devoid of hh activation and were more susceptible to jo2-induced apoptosis. |
2019-08-30 |
2023-08-13 |
mouse |
| Ying Wang, Weina Chen, Chang Han, Jinqiang Zhang, Kyoungsub Song, Hyunjoo Kwon, Srikanta Dash, Lu Yao, Tong W. Adult Hepatocytes Are Hedgehog-Responsive Cells in the Setting of Liver Injury: Evidence for Smoothened-Mediated Activation of NF-κB/Epidermal Growth Factor Receptor/Akt in Hepatocytes that Counteract Fas-Induced Apoptosis. The American journal of pathology. vol 188. issue 11. 2019-08-30. PMID:30366594. |
our findings provide important evidence that adult hepatocytes become responsive to hh signaling through up-regulation of smo in the setting of fas-induced liver injury and that such alteration leads to activation of nf-κb/epidermal growth factor receptor/akt, which counteracts fas-induced hepatocyte apoptosis. |
2019-08-30 |
2023-08-13 |
mouse |
| Jian-Chun Lin, Zhong-Guo Liu, Bin Yu, Xian-Rong Zhan. MicroRNA-874 targeting SUFU involves in osteoblast proliferation and differentiation in osteoporosis rats through the Hedgehog signaling pathway. Biochemical and biophysical research communications. vol 506. issue 1. 2019-05-21. PMID:30342851. |
besides, elevated expression of mir-874, shh, ptch, smo, bmp2, runx2 and pcna, as well as increased cell viability, alp activity and calcium nodules but decreased expression of sufu and bax, and reduced cell apoptosis were confirmed when treated with mir-874 mimic. |
2019-05-21 |
2023-08-13 |
mouse |
| Giulia Bernardini, Michela Geminiani, Silvia Gambassi, Maurizio Orlandini, Elena Petricci, Barbara Marzocchi, Marcella Laschi, Maurizio Taddei, Fabrizio Manetti, Annalisa Santucc. Novel smoothened antagonists as anti-neoplastic agents for the treatment of osteosarcoma. Journal of cellular physiology. vol 233. issue 6. 2019-04-15. PMID:29215700. |
our results also indicated that smo inhibition in os cells by such compounds, induces apoptosis with a nanomolar potency. |
2019-04-15 |
2023-08-13 |
Not clear |
| Xiaole Chen, Cintli C Morales-Alcala, Natalia A Riobo-Del Gald. Autophagic Flux Is Regulated by Interaction Between the C-terminal Domain of PATCHED1 and ATG101. Molecular cancer research : MCR. vol 16. issue 5. 2019-02-21. PMID:29453315. |
the hedgehog (hh) receptor patched1 (ptch1) is a well-known tumor suppressor that in its active form represses smoothened (smo) activity, inhibits proliferation, and induces apoptosis. |
2019-02-21 |
2023-08-13 |
Not clear |