| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Boban M Erovic, Luke Harris, Mina Jamali, David P Goldstein, Jonathan C Irish, Sylvia L Asa, Ozgur Met. Biomarkers of parathyroid carcinoma. Endocrine pathology. vol 23. issue 4. 2013-05-23. PMID:23001705. |
we constructed a tissue microarray of parathyroid carcinomas from 10 patients as well as parathyroid adenomas from 25 patients and stained the slides for 34 proteins involved in angiogenesis (platelet-derived growth factor receptor (pdgfr)-α, pdgfr-β, vascular endothelial growth factor receptor-2 (vegfr-2), and epidermal growth factor receptor (egfr)), inflammation (cyclooxygenase (cox)-1 and cox-2), cell adhesion (matrix metalloproteinase (mmp)-1, cd9, and keratin 7), cell cycle (cdc2p34, cyclin d1, retinoblastoma (rb), p27, p21, parafibromin, bmi-1, 14-3-3σ, and p53), and apoptosis (bcl-2a, mcl-1, bcl-xl, and glutathione-s-transferase-isoenzyme π (gst-π)) along with some markers of the sonic hedgehog (smo, shh, gli-1, gli-2, gli-3, and patched), mtor (akt, mammalian target of rapamycin (mtor), and forkhead box o (foxo)-1), and wnt (wisp-1, wisp-2, and β-catenin) signal transduction pathways. |
2013-05-23 |
2023-08-12 |
Not clear |
| Rupesh Chaturvedi, Thibaut de Sablet, Richard M Peek, Keith T Wilso. Spermine oxidase, a polyamine catabolic enzyme that links Helicobacter pylori CagA and gastric cancer risk. Gut microbes. vol 3. issue 1. 2012-08-23. PMID:22555547. |
smo catabolizes the polyamine spermine and produces h₂o₂ that results in both apoptosis and dna damage. |
2012-08-23 |
2023-08-12 |
mouse |
| Rupesh Chaturvedi, Thibaut de Sablet, Richard M Peek, Keith T Wilso. Spermine oxidase, a polyamine catabolic enzyme that links Helicobacter pylori CagA and gastric cancer risk. Gut microbes. vol 3. issue 1. 2012-08-23. PMID:22555547. |
exogenous overexpression of caga confirmed these findings, and knockdown or inhibition of smo blocked caga-mediated apoptosis and dna damage. |
2012-08-23 |
2023-08-12 |
mouse |
| Rupesh Chaturvedi, Thibaut de Sablet, Richard M Peek, Keith T Wilso. Spermine oxidase, a polyamine catabolic enzyme that links Helicobacter pylori CagA and gastric cancer risk. Gut microbes. vol 3. issue 1. 2012-08-23. PMID:22555547. |
the strong association of smo, apoptosis, and dna damage was also demonstrated in humans infected with caga⁺, but not caga⁻ strains. |
2012-08-23 |
2023-08-12 |
mouse |
| Rupesh Chaturvedi, Thibaut de Sablet, Richard M Peek, Keith T Wilso. Spermine oxidase, a polyamine catabolic enzyme that links Helicobacter pylori CagA and gastric cancer risk. Gut microbes. vol 3. issue 1. 2012-08-23. PMID:22555547. |
we also discovered smo (high) gastric epithelial cells from infected animals with dysplasia that are resistant to apoptosis despite high levels of dna damage. |
2012-08-23 |
2023-08-12 |
mouse |
| Donna Brennan, Xiaole Chen, Lan Cheng, My Mahoney, Natalia A Riob. Noncanonical Hedgehog signaling. Vitamins and hormones. vol 88. 2012-08-02. PMID:22391299. |
in this chapter, we discuss the most recent findings that suggest that patched1 can regulate cell proliferation and apoptosis independently of smoothened (smo) and gli and the reports that smo modulates actin cytoskeleton-dependent processes such as fibroblast migration, endothelial cell tubulogenesis, axonal extension, and neurite formation by diverse mechanisms that exclude any involvement of gli-dependent transcription. |
2012-08-02 |
2023-08-12 |
drosophila_melanogaster |
| Manuela Cervelli, Roberto Amendola, Fabio Polticelli, Paolo Mariottin. Spermine oxidase: ten years after. Amino acids. vol 42. issue 2-3. 2012-05-31. PMID:21809080. |
smo participates in drug response, apoptosis, response to stressful stimuli and etiology of several pathological conditions, including cancer. |
2012-05-31 |
2023-08-12 |
Not clear |
| Rupesh Chaturvedi, Thibaut de Sablet, Lori A Coburn, Alain P Gobert, Keith T Wilso. Arginine and polyamines in Helicobacter pylori-induced immune dysregulation and gastric carcinogenesis. Amino acids. vol 42. issue 2-3. 2012-05-31. PMID:21874531. |
macrophage apoptosis is mediated by oxidation of spermine via the enzyme spermine oxidase (smo) that generates hydrogen peroxide (h(2)o(2)), and thus oxidative stress-induced mitochondrial membrane polarization. |
2012-05-31 |
2023-08-12 |
Not clear |
| Rupesh Chaturvedi, Thibaut de Sablet, Lori A Coburn, Alain P Gobert, Keith T Wilso. Arginine and polyamines in Helicobacter pylori-induced immune dysregulation and gastric carcinogenesis. Amino acids. vol 42. issue 2-3. 2012-05-31. PMID:21874531. |
our studies have demonstrated that apoptosis occurs through a perk → pc-fos/c-jun → c-myc → odc → smo pathway. |
2012-05-31 |
2023-08-12 |
Not clear |
| Rupesh Chaturvedi, Thibaut de Sablet, Lori A Coburn, Alain P Gobert, Keith T Wilso. Arginine and polyamines in Helicobacter pylori-induced immune dysregulation and gastric carcinogenesis. Amino acids. vol 42. issue 2-3. 2012-05-31. PMID:21874531. |
in gastric epithelial cells, activation of oxidative stress by h. pylori is dependent on smo induction and results in both apoptosis and dna damage, such that inhibition or knockdown of smo markedly attenuates these events. |
2012-05-31 |
2023-08-12 |
Not clear |
| Rupesh Chaturvedi, Mohammad Asim, Judith Romero-Gallo, Daniel P Barry, Svea Hoge, Thibaut de Sablet, Alberto G Delgado, Lydia E Wroblewski, M Blanca Piazuelo, Fang Yan, Dawn A Israel, Robert A Casero, Pelayo Correa, Alain P Gobert, D Brent Polk, Richard M Peek, Keith T Wilso. Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA. Gastroenterology. vol 141. issue 5. 2012-01-20. PMID:21839041. |
spermine oxidase (smo) metabolizes the polyamine spermine into spermidine and generates h(2)o(2), which causes apoptosis and dna damage. |
2012-01-20 |
2023-08-12 |
Not clear |
| Da-jian Zhu, Chi-hua Fang, Zhen-xiang Rong, Sheng-jun Li. [Effects of specific small interfering RNA on Smoothened expression and LoVo cell proliferation and apoptosis]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 27. issue 9. 2010-06-09. PMID:17884791. |
to study the effects of specific small interfering rna (sirna) on smoothened (smo) gene expression and the proliferation and apoptosis of colorectal cancer lovo cells. |
2010-06-09 |
2023-08-12 |
Not clear |
| Ivana Stanic', Annalisa Facchini, Rosa Maria Borzì, Claudio Stefanelli, Flavio Flamign. The polyamine analogue N1,N11-diethylnorspermine can induce chondrocyte apoptosis independently of its ability to alter metabolism and levels of natural polyamines. Journal of cellular physiology. vol 219. issue 1. 2009-02-27. PMID:19097065. |
treatment of human c-28/i2 chondrocytes with n(1),n(11)-diethylnorspermine (denspm), a polyamine analogue with clinical relevance as an experimental anticancer agent, rapidly induced spermidine/spermine n(1)-acetyltransferase (ssat) and spermine oxidase (smo), key enzymes of polyamine catabolism and down-regulated ornithine decarboxylase, the first enzyme of polyamine biosynthesis, thus depleting all main polyamines within 24 h. the treatment with denspm did not provoke cell death and caspase activation when given alone for 24 h, but caused a caspase-3 and -9 dependent apoptosis in chondrocytes further exposed to cycloheximide (chx). |
2009-02-27 |
2023-08-12 |
human |
| Yoshinori Abe, Eri Oda-Sato, Kei Tobiume, Keiko Kawauchi, Yoichi Taya, Koji Okamoto, Moshe Oren, Nobuyuki Tanak. Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 12. 2008-04-22. PMID:18359851. |
moreover, smo partially inhibited p53-dependent apoptosis and cell growth inhibition in oncogene-expressing mefs. |
2008-04-22 |
2023-08-12 |
mouse |
| Shuhong Huang, Jing He, Xiaoli Zhang, Yuehong Bian, Ling Yang, Guorui Xie, Kefei Zhang, Wendell Tang, Arwen A Stelter, Qian Wang, Hongwei Zhang, Jingwu Xi. Activation of the hedgehog pathway in human hepatocellular carcinomas. Carcinogenesis. vol 27. issue 7. 2006-08-22. PMID:16501253. |
specific inhibition of hedgehog signaling in these three cell lines by smoothened (smo) antagonist, kaad-cyclopamine, or with shh neutralizing antibodies decreases expression of hedgehog target genes, inhibits cell growth and results in apoptosis. |
2006-08-22 |
2023-08-12 |
human |
| Hangxiu Xu, Rupesh Chaturvedi, Yulan Cheng, Francoise I Bussiere, Mohammad Asim, Micheal D Yao, Darryn Potosky, Stephen J Meltzer, Juong G Rhee, Sung S Kim, Steven F Moss, Amy Hacker, Yanlin Wang, Robert A Casero, Keith T Wilso. Spermine oxidation induced by Helicobacter pylori results in apoptosis and DNA damage: implications for gastric carcinogenesis. Cancer research. vol 64. issue 23. 2005-01-27. PMID:15574757. |
here, we report that h. pylori up-regulates mrna expression, promoter activity, and enzyme activity of smo(paoh1) in human gastric epithelial cells, resulting in dna damage and apoptosis. |
2005-01-27 |
2023-08-12 |
mouse |
| Hangxiu Xu, Rupesh Chaturvedi, Yulan Cheng, Francoise I Bussiere, Mohammad Asim, Micheal D Yao, Darryn Potosky, Stephen J Meltzer, Juong G Rhee, Sung S Kim, Steven F Moss, Amy Hacker, Yanlin Wang, Robert A Casero, Keith T Wilso. Spermine oxidation induced by Helicobacter pylori results in apoptosis and DNA damage: implications for gastric carcinogenesis. Cancer research. vol 64. issue 23. 2005-01-27. PMID:15574757. |
h. pylori-induced h(2)o(2) generation and apoptosis in these cells was equally attenuated by an inhibitor of smo(paoh1), by catalase, and by transient transfection with small interfering rna targeting smo(paoh1). |
2005-01-27 |
2023-08-12 |
mouse |
| Hangxiu Xu, Rupesh Chaturvedi, Yulan Cheng, Francoise I Bussiere, Mohammad Asim, Micheal D Yao, Darryn Potosky, Stephen J Meltzer, Juong G Rhee, Sung S Kim, Steven F Moss, Amy Hacker, Yanlin Wang, Robert A Casero, Keith T Wilso. Spermine oxidation induced by Helicobacter pylori results in apoptosis and DNA damage: implications for gastric carcinogenesis. Cancer research. vol 64. issue 23. 2005-01-27. PMID:15574757. |
conversely, smo(paoh1) overexpression induced apoptosis to the same levels as caused by h. pylori. |
2005-01-27 |
2023-08-12 |
mouse |
| Hangxiu Xu, Rupesh Chaturvedi, Yulan Cheng, Francoise I Bussiere, Mohammad Asim, Micheal D Yao, Darryn Potosky, Stephen J Meltzer, Juong G Rhee, Sung S Kim, Steven F Moss, Amy Hacker, Yanlin Wang, Robert A Casero, Keith T Wilso. Spermine oxidation induced by Helicobacter pylori results in apoptosis and DNA damage: implications for gastric carcinogenesis. Cancer research. vol 64. issue 23. 2005-01-27. PMID:15574757. |
these results identify a pathway for oxidative stress-induced epithelial cell apoptosis and dna damage due to smo(paoh1) activation by h. pylori that may contribute to the pathogenesis of the infection and development of gastric cancer. |
2005-01-27 |
2023-08-12 |
mouse |
| Mohammad Athar, Chengxin Li, Xiuwei Tang, Sumin Chi, Xiaoli Zhang, Arianna L Kim, Stephen K Tyring, Levy Kopelovich, Jennifer Hebert, Ervin H Epstein, David R Bickers, Jingwu Xi. Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis. Cancer research. vol 64. issue 20. 2004-12-03. PMID:15492281. |
our data provide strong evidence that cyclopamine and perhaps other smo antagonists are potent in vivo inhibitors of uvb-induced basal cell carcinomas in ptch1(+/-) mice and likely in humans because the majority of human basal cell carcinomas manifest mutations in ptch1 and that a major mechanism of their inhibitory effect is through up-regulation of fas, which augments apoptosis. |
2004-12-03 |
2023-08-12 |
mouse |