| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pei Yu, Jinqing Yang, Yan Zhan. Identification and characterization of two novel PTCH1 splice variants. Biochemical and biophysical research communications. vol 487. issue 1. 2017-06-12. PMID:28390897. |
finally, all these isoforms have been revealed to inhibit gli1 activation by either the classical hh signaling pathway or a new pathway not reliant on both smo and apoptosis. |
2017-06-12 |
2023-08-13 |
mouse |
| Huifa Ma, Yongsheng Tian, Xiangyang Y. Targeting Smoothened Sensitizes Gastric Cancer to Chemotherapy in Experimental Models. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2017-04-24. PMID:28350784. |
upregulating smo expression induced paclitaxel resistance in gastric cells lines via enhancing cell proliferation and inhibiting apoptosis. |
2017-04-24 |
2023-08-13 |
mouse |
| Zhengwei Xu, Chen Huang, Dingjun Ha. MicroRNA-1271 inhibits proliferation and promotes apoptosis of multiple myeloma cells through inhibiting smoothened-mediated Hedgehog signaling pathway. Oncology reports. vol 37. issue 2. 2017-03-23. PMID:27959416. |
conversely, the restoration of smo expression markedly abolished the effect of mir-1271 overexpression on cell proliferation, apoptosis and hh signaling pathway in mm cells. |
2017-03-23 |
2023-08-13 |
Not clear |
| Suping Qin, Dexu Sun, Hui Li, Xiangyang Li, Wei Pan, Chao Yan, Renxian Tang, Xiaomei Li. The Effect of SHH-Gli Signaling Pathway on the Synovial Fibroblast Proliferation in Rheumatoid Arthritis. Inflammation. vol 39. issue 2. 2017-01-06. PMID:26552406. |
shh, ptch, smo, and gli molecules were highly expressed in rat ra-synovial fibroblast (ra-sf); after blocking the shh-gli signaling pathway with a gli specific inhibitor, gli-antagonist 61 (gant61), ra-sf proliferation was inhibited in a dose-dependent manner and the apoptosis rate of ra-sf was increased as well; the expression levels of fibroblast growth factor receptor 1 (fgfr1) and fgfr3 declined in sf cells after gant61 treatment. |
2017-01-06 |
2023-08-13 |
human |
| Feng Ai, Yanwei Zhang, Bangtian Pen. miR-20a regulates proliferation, differentiation and apoptosis in P19 cell model of cardiac differentiation by targeting Smoothened. Biology open. vol 5. issue 9. 2016-09-16. PMID:27543062. |
accordingly, we inferred that mir-20a might act as a regulator of smo, and regulate proliferation, differentiation and apoptosis in p19 cells. |
2016-09-16 |
2023-08-13 |
Not clear |
| Feng Ai, Yanwei Zhang, Bangtian Pen. miR-20a regulates proliferation, differentiation and apoptosis in P19 cell model of cardiac differentiation by targeting Smoothened. Biology open. vol 5. issue 9. 2016-09-16. PMID:27543062. |
moreover, we verified that mir-20a directly targeted smo and knockdown of smo and mir-20a overexpression had similar effects on p19 cell proliferation, differentiation and apoptosis, which verified the speculation that mir-20a inhibits proliferation and differentiation and enhances apoptosis in p19 cells by directly targeting smo. |
2016-09-16 |
2023-08-13 |
Not clear |
| Shang-Ling Zhu, Min-Qi Luo, Wei-Xiang Peng, Qiu-Xia Li, Zhi-Ying Feng, Zhao-Xia Li, Ming-Xia Wang, Xiao-Xue Feng, Fang Liu, Jian-Lin Huan. Sonic hedgehog signalling pathway regulates apoptosis through Smo protein in human umbilical vein endothelial cells. Rheumatology (Oxford, England). vol 54. issue 6. 2015-07-28. PMID:25406358. |
sonic hedgehog signalling pathway regulates apoptosis through smo protein in human umbilical vein endothelial cells. |
2015-07-28 |
2023-08-13 |
human |
| Shang-Ling Zhu, Min-Qi Luo, Wei-Xiang Peng, Qiu-Xia Li, Zhi-Ying Feng, Zhao-Xia Li, Ming-Xia Wang, Xiao-Xue Feng, Fang Liu, Jian-Lin Huan. Sonic hedgehog signalling pathway regulates apoptosis through Smo protein in human umbilical vein endothelial cells. Rheumatology (Oxford, England). vol 54. issue 6. 2015-07-28. PMID:25406358. |
the aim of this study was to investigate the expression of smoothened protein (smo), a sonic hedgehog (shh) signalling component, in synovium of ra and its role in the survival and apoptosis of endothelial cells. |
2015-07-28 |
2023-08-13 |
human |
| Wu Hui, Chen Kuisheng, Zhang Hongxin, Ding Yanzhi, Zhao Zhihua, Zhang H. Influence of smoothened siRNA on human esophageal cancer cell line EC9706 proliferation and apoptosis. Pakistan journal of pharmaceutical sciences. vol 27. issue 5 Suppl. 2015-01-22. PMID:25262515. |
apply sirna technology to take smoothened (smo) genetic locus, the possibility of hhsignaling pathway, and also inhibits esophageal squamous carcinoma cell proliferation and induction of apoptosis. |
2015-01-22 |
2023-08-13 |
human |
| Wu Hui, Chen Kuisheng, Zhang Hongxin, Ding Yanzhi, Zhao Zhihua, Zhang H. Influence of smoothened siRNA on human esophageal cancer cell line EC9706 proliferation and apoptosis. Pakistan journal of pharmaceutical sciences. vol 27. issue 5 Suppl. 2015-01-22. PMID:25262515. |
utilizing smosirna transfected esophageal squamous carcinoma ec9706 cells, adopting rt-pcr and western blot technology to detect smo, gli1 mrna and protein expression in each group of cells, employing mtt and fcm to detect the influence of smosirna on cell proliferation and apoptosis. |
2015-01-22 |
2023-08-13 |
human |
| Wu Hui, Chen Kuisheng, Zhang Hongxin, Ding Yanzhi, Zhao Zhihua, Zhang H. Influence of smoothened siRNA on human esophageal cancer cell line EC9706 proliferation and apoptosis. Pakistan journal of pharmaceutical sciences. vol 27. issue 5 Suppl. 2015-01-22. PMID:25262515. |
smo gene played a role in regulating and controlling esophageal squamous carcinoma cell proliferation and apoptosis and smo was likely to be an effective target spot for tumor gene therapy. |
2015-01-22 |
2023-08-13 |
human |
| Pınar Obakan, Elif Damla Arısan, Pelin Özfiliz, Ajda Çoker-Gürkan, Narçin Palavan-Ünsa. Purvalanol A is a strong apoptotic inducer via activating polyamine catabolic pathway in MCF-7 estrogen receptor positive breast cancer cells. Molecular biology reports. vol 41. issue 1. 2014-08-26. PMID:24190492. |
especially induction of polyamine catabolic enzymes spermidine/spermine n1-acetyltransferase (ssat), polyamine oxidase (pao) and spermine oxidase (smo) induced toxic by-products in correlation with the induction of apoptosis in cancer cells. |
2014-08-26 |
2023-08-12 |
Not clear |
| Joon Won Yoon, Marisa Gallant, Marilyn L G Lamm, Stephen Iannaccone, Karl-Frederic Vieux, Maria Proytcheva, Elizabeth Hyjek, Philip Iannaccone, David Walterhous. Noncanonical regulation of the Hedgehog mediator GLI1 by c-MYC in Burkitt lymphoma. Molecular cancer research : MCR. vol 11. issue 6. 2014-04-17. PMID:23525267. |
exposure to sonic or indian hedgehog or cyclopamine (smo inhibitor) does not modulate gli1 expression, cell proliferation, or apoptosis in most burkitt lymphoma cell lines. |
2014-04-17 |
2023-08-12 |
human |
| Feng Chai, Jiangang Zhou, Cheng Chen, Song Xie, Xiao Chen, Ping Su, Jun Sh. The Hedgehog inhibitor cyclopamine antagonizes chemoresistance of breast cancer cells. OncoTargets and therapy. vol 6. 2013-11-19. PMID:24250231. |
cyclopamine blocks hedgehog signaling by antagonizing smo function, which induces tumor apoptosis. |
2013-11-19 |
2023-08-12 |
Not clear |
| Ali H Zaidi, Yoshihiro Komatsu, Lori A Kelly, Usha Malhotra, Christina Rotoloni, Juliann E Kosovec, Haris Zahoor, Rory Makielski, Astha Bhatt, Toshitaka Hoppo, Blair A Job. Smoothened inhibition leads to decreased proliferation and induces apoptosis in esophageal adenocarcinoma cells. Cancer investigation. vol 31. issue 7. 2013-09-30. PMID:23915072. |
results showed that the smo antagonist led to reduced hh pathway activity, resulting in decreased cell proliferation and induction of apoptosis via the intrinsic pathway in the esophageal cancer cells. |
2013-09-30 |
2023-08-12 |
Not clear |
| Sadegh Babashah, Majid Sadeghizadeh, Abbas Hajifathali, Mostafa Rezaei Tavirani, Mina Soufi Zomorod, Mojtaba Ghadiani, Masoud Soleiman. Targeting of the signal transducer Smo links microRNA-326 to the oncogenic Hedgehog pathway in CD34+ CML stem/progenitor cells. International journal of cancer. vol 133. issue 3. 2013-07-25. PMID:23341351. |
additionally, overexpression of mir-326 led to downregulation of smo, resulted in decreased cell proliferation and elevated rate of apoptosis in cml cd34(+) cells. |
2013-07-25 |
2023-08-12 |
Not clear |
| Kranthi Kunkalla, Yadong Liu, Changju Qu, Vasiliki Leventaki, Nitin K Agarwal, Rajesh R Singh, Francisco Veg. Functional inhibition of BCL2 is needed to increase the susceptibility to apoptosis to SMO inhibitors in diffuse large B-cell lymphoma of germinal center subtype. Annals of hematology. vol 92. issue 6. 2013-07-09. PMID:23370596. |
functional inhibition of bcl2 is needed to increase the susceptibility to apoptosis to smo inhibitors in diffuse large b-cell lymphoma of germinal center subtype. |
2013-07-09 |
2023-08-12 |
Not clear |
| Kranthi Kunkalla, Yadong Liu, Changju Qu, Vasiliki Leventaki, Nitin K Agarwal, Rajesh R Singh, Francisco Veg. Functional inhibition of BCL2 is needed to increase the susceptibility to apoptosis to SMO inhibitors in diffuse large B-cell lymphoma of germinal center subtype. Annals of hematology. vol 92. issue 6. 2013-07-09. PMID:23370596. |
here, we explored the possibility of overcoming the resistance to apoptosis to smo inhibitors in five dlbcl cells of gc type using the combination of the smo inhibitor hhantag (genentech inc) with the bh3 mimetic abt-737 (abbott laboratories). |
2013-07-09 |
2023-08-12 |
Not clear |
| Kranthi Kunkalla, Yadong Liu, Changju Qu, Vasiliki Leventaki, Nitin K Agarwal, Rajesh R Singh, Francisco Veg. Functional inhibition of BCL2 is needed to increase the susceptibility to apoptosis to SMO inhibitors in diffuse large B-cell lymphoma of germinal center subtype. Annals of hematology. vol 92. issue 6. 2013-07-09. PMID:23370596. |
combining low doses of abt-737 with increasing concentrations of hhantag in gc dlbcl cell lines resulted in significantly increase of apoptosis in comparison to treatments with the smo inhibitor alone. |
2013-07-09 |
2023-08-12 |
Not clear |
| Kranthi Kunkalla, Yadong Liu, Changju Qu, Vasiliki Leventaki, Nitin K Agarwal, Rajesh R Singh, Francisco Veg. Functional inhibition of BCL2 is needed to increase the susceptibility to apoptosis to SMO inhibitors in diffuse large B-cell lymphoma of germinal center subtype. Annals of hematology. vol 92. issue 6. 2013-07-09. PMID:23370596. |
we concluded that in gc dlbcl cell lines, in contrast to those of abc type, functional inhibition of bcl2 family members is usually needed to overcome the resistance to apoptosis to smo inhibitors. |
2013-07-09 |
2023-08-12 |
Not clear |