| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| You Wang, Yuan Wang, Pei Pi, Dan Luo, Min Ning, Gang Y. MiR-203 improved renal cell injury in diabetic nephropathy by targeting SOCS6/SOCS7 and inhibiting JAK/STAT pathway activation. Scientific reports. vol 15. issue 1. 2025-03-29. PMID:40155732. |
western blotting analyzed the protein levels of key signaling molecules including jak1, p-jak1, jak2, p-jak2, stat3, and p-stat3.our findings revealed that high glucose (hg) treatment reduced mir-203 levels, leading to decreased nrk cell proliferation, increased cytokine concentrations (tnf-α, il-1β, il-4, il-6), heightened ros and mda levels, and increased cell apoptosis. |
2025-03-29 |
2025-04-01 |
Not clear |
| Marco Minacori, Sara Fiorini, Monia Perugini, Annamaria Iannetta, Giorgia Meschiari, Silvia Chichiarelli, Fabio Altieri, Pier Giorgio Natali, Margherita Eufem. AhR and STAT3: A Dangerous Duo in Chemical Carcinogenesis. International journal of molecular sciences. vol 26. issue 6. 2025-03-27. PMID:40141386. |
signal transducer and activator of transcription 3 (stat3) is a cytoplasmic transcription factor that regulates cell proliferation, differentiation, apoptosis, angiogenesis, inflammation, and immune responses. |
2025-03-27 |
2025-03-30 |
human |
| Jing Wang, Jiamin Xian, Ruohan Zhang, Zhuoyi Wang, Shuanggou Zhang, Die Zhao, Jun Sheng, Peiyuan Su. α-Mangostin Exhibits Antitumor Activity Against NCI-H1975 Cells via the EGFR/STAT3 Pathway: An Experimental and Molecular Simulation Study. Molecules (Basel, Switzerland). vol 30. issue 6. 2025-03-27. PMID:40142069. |
the results indicated that α-mangostin exerts its antitumor activity by inhibiting cell proliferation and migration, reducing cell cycle arrest, promoting cell apoptosis, and regulating the phosphorylation expression levels of egfr and signal transducer and activator of transcription 3 (stat3). |
2025-03-27 |
2025-03-30 |
Not clear |
| Shiqing Li, Xin Wang, Jiabao Huang, Xiuping Cao, Yana Liu, Shiyan Bai, Tao Zeng, Qi Chen, Chunsen Li, Chunhua Lu, Huanghao Yan. Decoy-PROTAC for specific degradation of "Undruggable" STAT3 transcription factor. Cell death & disease. vol 16. issue 1. 2025-03-22. PMID:40118821. |
experimental results demonstrate that d-protac efficiently mediates the degradation of the stat3 protein across various cancer cell types, leading to the downregulation of crucial downstream stat3 targets, inhibiting tumor cell growth, triggering cell cycle arrest and apoptosis, and suppressing tumor immune evasion. |
2025-03-22 |
2025-03-25 |
human |
| Zehua Wang, Xinming Su, Zhiqing Zhan, Hangxuan Wang, Shuhan Zhou, Jiasheng Mao, Hening Xu, Shiwei Dua. miR-660: A novel regulator in human cancer pathogenesis and therapeutic implications. Gene. 2025-03-22. PMID:40120868. |
mir- 660 targets 19 genes involved in 6 pathways such as pi3k/akt/mtor, stat3, wnt/β- catenin, p53, nf‑κb, and ras, influencing cell cycle, proliferation, apoptosis, and invasion/migration. |
2025-03-22 |
2025-03-26 |
human |
| Haiyan Zeng, Aoxiang Guo, Zhenyang Liu, Shijian Xiang, Fanghao Zhen. Isoliquiritigenin attenuates tumor progression and PD-L1 expression by inhibiting the phosphorylation of STAT3 in melanoma. Medical oncology (Northwood, London, England). vol 42. issue 4. 2025-03-19. PMID:40106004. |
furthermore, the stat3 phosphorylation inhibitor stattic could enhance the effect of isl in suppressing cell proliferation, promoting apoptosis, and restraining the ability of migration and invasion of melanoma cells. |
2025-03-19 |
2025-03-22 |
Not clear |
| Ryosuke Saito, Makoto Fukushima, Mariko Sasaki, Aikou Okamoto, Hideaki Ogiwar. Targeting USP8 causes synthetic lethality through degradation of FGFR2 in ARID1A-deficient ovarian clear cell carcinoma. NPJ precision oncology. vol 9. issue 1. 2025-03-13. PMID:40074856. |
deficiency of arid1a causes abnormalities in the stat3 pathway, which is one of the downstream pathways of fgfr2, but suppression of usp8 attenuates phosphorylation of stat3 pt705 and induces apoptosis. |
2025-03-13 |
2025-03-15 |
mouse |
| Xin Jiang, Yinghang Wang, Saiyue Qiu, Lu Tang, Meixiu Luo, Zhi Pa. Jiawei Danggui Buxue Decoction Reduces Apoptosis and EMT of Renal Interstitial Fibrosis by Regulating JAK2/STAT3 Signaling Pathway. Combinatorial chemistry & high throughput screening. 2025-03-12. PMID:40070325. |
the purpose of this study was to elucidate the potential of jiawei danggui buxue decoction (jdbd) to reduce apoptosis and epithelial-mesenchymal transition (emt) in rif by regulating the janus kinase 2 (jak2)/signal transducer and activator of transcription 3 (stat3) pathway. |
2025-03-12 |
2025-03-14 |
Not clear |
| Jiahui Bao, Zhiliang Li, Dan Zhan. β-elemene: A promising natural compound in lung cancer therapy. European journal of pharmacology. 2025-03-10. PMID:40064226. |
focusing on its roles in modulating cellular pathways, this study details β-elemene's influence on apoptosis, autophagy, ferroptosis, hypoxic responses, metabolic shifts, and cell cycle arrest, as well as its impact on the tumour microenvironment and regulatory pathways (including pi3k/akt, stat3, ampk/mapk) and non-coding rnas. |
2025-03-10 |
2025-03-13 |
Not clear |
| Tina Rahjoo, Alireza Motamedzadeh, Felora Ferdosi, Ehsan Dadgostar, Michael Aschner, Hamed Mirzaei, Sina Ghesmatpour, Fatemeh Nabavizadeh, Fatemeh Rahmati-Dehkordi, Omid Reza Tamtaj. Potential role of thymoquinone to treat gastrointestinal cancers: insights into its molecular mechanisms. Naunyn-Schmiedeberg's archives of pharmacology. 2025-03-05. PMID:40045027. |
thymoquinone inhibits gi cancer progression by inducing cell cycle arrest, apoptosis, and oxidative stress and inhibiting inflammation, migration, invasion, metastasis, histone deacetylases, stat3, pi3k/akt/mtor, and wnt/β-catenin signaling pathways. |
2025-03-05 |
2025-03-08 |
Not clear |
| Monisha Prasad, D Hamsa, Mohammad Fareed, Mohmed Isaqail Karobar. An update on the molecular mechanisms underlying the progression of miR-21 in oral cancer. World journal of surgical oncology. vol 23. issue 1. 2025-03-03. PMID:40025548. |
mir-21 also modulates the tumour microenvironment by promoting angiogenesis and altering immune responses, thus enhancing cancer progression.moreover, mirna - 21 influences the various signalling pathways like pi3k/ akt, tgf-β, nf-κb, and stat3, as well as involved in the cell fate mechanisms known as autophagy and apoptosis. |
2025-03-03 |
2025-03-05 |
Not clear |
| Yue Zhang, Yuzhu Hu, Dongmei Su, Yanjiang Fu, Xiaoya Chen, Xiao Zhang, Shunfei Zheng, Xu Ma, Shanshan H. Downregulation of RORl via STAT3 and P300 Promotes P38 Pathway- Dependent Lens Epithelial Cells Apoptosis in Age-Related Cataract. Biochemical genetics. 2025-02-28. PMID:40019609. |
downregulation of rorl via stat3 and p300 promotes p38 pathway- dependent lens epithelial cells apoptosis in age-related cataract. |
2025-02-28 |
2025-03-02 |
Not clear |
| RETRACTION: Interleukin-6 Protects LNCaP Cells From Apoptosis Induced by Androgen Deprivation Through the Stat3 Pathway. The Prostate. 2025-02-21. PMID:39981980. |
retraction: interleukin-6 protects lncap cells from apoptosis induced by androgen deprivation through the stat3 pathway. |
2025-02-21 |
2025-02-23 |
Not clear |
| RETRACTION: Interleukin-6 Protects LNCaP Cells From Apoptosis Induced by Androgen Deprivation Through the Stat3 Pathway. The Prostate. 2025-02-21. PMID:39981980. |
s. o. lee, w. lou, c. s. johnson, d. l. trump, and a. c. gao, "interleukin-6 protects lncap cells from apoptosis induced by androgen deprivation through the stat3 pathway," the prostate 60, no. |
2025-02-21 |
2025-02-23 |
Not clear |
| Jie Zhang, Wei Dong, Qin Yang, Li-Na Liu, Xi-Lun Cai, Dan Wang, Guo-Ji Yan, Yan-Bin Xiyang, Tao Hu, Jie Zhan. Dysregulation of G6PD by HPV E6 exacerbates cervical cancer by activating the STAT3/PLOD2 pathway. Carcinogenesis. 2025-02-13. PMID:39943705. |
functional experiments, involving the manipulation of g6pd and stat3 activities in cervical cancer cells with hpv e6 modulation, demonstrated that dysregulated g6pd enhanced cell proliferation, migration, and invasion while suppressing apoptosis, primarily through the stat3/plod2 pathway. |
2025-02-13 |
2025-02-15 |
human |
| Shengying Lou, Chenjun Shen, Hao Ni, Chengcheng Fan, Zhihui Zhu, Xueping Hu, Huajun Zhao, Sunliang Cu. Discovery of naphthoquinone-furo-piperidone derivatives as dual targeting agents of STAT3 and NQO1 for the treatment of breast cancer. European journal of medicinal chemistry. vol 287. 2025-02-12. PMID:39938410. |
stat3 has been found closely associated with the occurrence and development of breast cancer, while blocking stat3 pathway can promote apoptosis of breast cancer cells and inhibit cell proliferation. |
2025-02-12 |
2025-02-15 |
Not clear |
| Shengying Lou, Chenjun Shen, Hao Ni, Chengcheng Fan, Zhihui Zhu, Xueping Hu, Huajun Zhao, Sunliang Cu. Discovery of naphthoquinone-furo-piperidone derivatives as dual targeting agents of STAT3 and NQO1 for the treatment of breast cancer. European journal of medicinal chemistry. vol 287. 2025-02-12. PMID:39938410. |
in particular, the promising compound 16c was found to significantly inhibit phosphorylation of stat3 at tyr705 at a concentration of 1 μm and effectively induce apoptosis in mda-mb-231 and mda-mb-468 breast cancer cells. |
2025-02-12 |
2025-02-15 |
Not clear |
| Lie Ma, XuQing Liu, R Roopashree, Syeda Wajida Kazmi, Saade Abdalkareem Jasim, K Phaninder Vinay, Ata Fateh, Fang Yang, Mansour Rajabivahid, Mahmoud Dehghani-Ghorbi, Reza Akhava. Long non-coding RNAs (lncRNAs) in cancer development: new insight from STAT3 signaling pathway to immune evasion. Clinical and experimental medicine. vol 25. issue 1. 2025-02-11. PMID:39932585. |
the signal transducer and activator of transcription 3 (stat3) is a promising target due to its involvement in various cellular functions, including apoptosis, immunosuppression, cell invasion, migration, and proliferation. |
2025-02-11 |
2025-02-13 |
Not clear |
| Lie Ma, XuQing Liu, R Roopashree, Syeda Wajida Kazmi, Saade Abdalkareem Jasim, K Phaninder Vinay, Ata Fateh, Fang Yang, Mansour Rajabivahid, Mahmoud Dehghani-Ghorbi, Reza Akhava. Long non-coding RNAs (lncRNAs) in cancer development: new insight from STAT3 signaling pathway to immune evasion. Clinical and experimental medicine. vol 25. issue 1. 2025-02-11. PMID:39932585. |
long non-coding rnas (lncrnas), a subset of non-coding rnas, are essential for the progression, apoptosis, and metastasis of crc as they regulate key signaling pathways such as stat3 signaling and contribute to gene regulation at the epigenetic, transcriptional, and post-transcriptional levels. |
2025-02-11 |
2025-02-13 |
Not clear |
| Lie Ma, XuQing Liu, R Roopashree, Syeda Wajida Kazmi, Saade Abdalkareem Jasim, K Phaninder Vinay, Ata Fateh, Fang Yang, Mansour Rajabivahid, Mahmoud Dehghani-Ghorbi, Reza Akhava. Long non-coding RNAs (lncRNAs) in cancer development: new insight from STAT3 signaling pathway to immune evasion. Clinical and experimental medicine. vol 25. issue 1. 2025-02-11. PMID:39932585. |
in this study, we comprehensively reviewed the regulatory roles of different lncrnas on stat3 and the mutual effects of this pathway in various aspects of carcinogenesis, including proliferation, apoptosis, metastasis, drug resistance, and angiogenesis. |
2025-02-11 |
2025-02-13 |
Not clear |