| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Malarvannan, Sujith Unnikrishnan, S Monohar, V Ravichandiran, David Pau. Design and optimization strategies of PROTACs and its Application, Comparisons to other targeted protein degradation for multiple oncology therapies. Bioorganic chemistry. vol 154. 2024-11-26. PMID:39591691. |
abbreviations: protacs, proteolysis targeting chimeras; pk, pharmacokinetic; pd, pharmacodynamic; metap-2, (methionine aminopeptidase 2); bcl6, b-cell lymphoma 6; gcn5, general control nonderepressible 5; bkt, bruton's tyrosine kinase; bet, bromodomain and extra-terminal; ar, androgen or androgen receptor; er, estrogen or estrogen receptor; fda, food and drug administration; mcrpc, metastatic castration-resistant prostate cancer; stat3, signal transducer and activator of transcription 3; fak, focal adhesion kinase; poi, protein of interest; peg, polyethylene glycol; ups, ubiquitin-proteasome system; vhl, von hippel-lindau; crbn, cereblon; mdm2, mouse double minute 2 homologue; ciap, cellular inhibitor of apoptosis; rnf, ring finger protein; brd, bromodomain; cdk, cyclin-dependent kinase; pampa, parallel artificial membrane permeability studies; bret, bioluminescence resonance energy transfer; mcl, mantle cell lymphoma; mcl-1, myeloid cell leukemia 1; bcl-x |
2024-11-26 |
2024-11-29 |
mouse |
| ZeWei Zhong, XiaoHua Huang, Qiong Lan, WeiHua Che. Up-Regulated MiR-20b-5p Mitigates Cell Inflammation and Apoptosis in Allergic Rhinitis via STAT3. The Tohoku journal of experimental medicine. 2024-11-20. PMID:39566998. |
up-regulated mir-20b-5p mitigates cell inflammation and apoptosis in allergic rhinitis via stat3. |
2024-11-20 |
2024-11-23 |
Not clear |
| Monika Dawid, Karolina Pich, Natalia Respekta-Długosz, Wiktoria Gieras, Małgorzata Opydo, Tomasz Milewicz, Pascal Froment, Joëlle Dupont, Agnieszka Ra. Visfatin exerts an anti-proliferative and pro-apoptotic effect in the human placenta cells. Biology of reproduction. 2024-11-19. PMID:39561117. |
we studied placenta cells viability, proliferation, cell cycle, proliferation/apoptotic factors and insulin receptor (insr) expression, dna fragmentation, casp3/7 activity, and phosphorylation of erk1/2, akt, ampkα, stat3 with their involvement after pharmacological inhibition in visfatin action on proliferation and apoptosis. |
2024-11-19 |
2024-11-23 |
human |
| Ye Jin Cho, Beom Seok Han, Soyeon Ko, Min Seok Park, Yun Ji Lee, Sang Eun Kim, Pureunchowon Lee, Han Gyeol Go, Shinyoung Park, Hyunho Lee, Sohee Kim, Eun-Ran Park, Kyung Hee Jung, Soon-Sun Hon. Repositioning of aripiprazole, an anti‑psychotic drug, to sensitize the chemotherapy of pancreatic cancer. International journal of molecular medicine. vol 55. issue 1. 2024-11-14. PMID:39540370. |
the results showed that the repositioning of aripiprazole inhibits cancer cell growth by blocking the stat3 signaling pathway and effectively enhancing cisplatin‑induced apoptosis, thereby suggesting that the combination of aripiprazole and cisplatin may be a potent chemotherapeutic strategy for the treatment of pancreatic cancer. |
2024-11-14 |
2024-11-17 |
Not clear |
| Yufei Jia, Yanhong Song, Hang Xue, Xingyue Li, Yinong Zhang, Shiyue Fan, Xu Yang, Zixuan Ding, Yue Qiu, Ziyi Wu, Ping Zha. Sevoflurane Postconditioning Mitigates Neuronal Hypoxic-Ischemic Injury via Regulating Reactive Astrocytic STAT3 Protein Modification. Chemico-biological interactions. 2024-11-13. PMID:39536892. |
the inhibitory effect on astrocytes suppressed stat3 nuclear translocation, reduced astrocyte reactivity, decreased the release of the inflammatory cytokines il6 and il-1β, attenuated neuronal apoptosis following hi insult, and improved neuron viability. |
2024-11-13 |
2024-11-17 |
rat |
| Jieyu Guo, Rongyi Huang, Yan Mei, Siao Lu, Jun Gong, Long Wang, Liqiong Ding, Hongnian Wu, Dan Pan, Wu Li. Application of stress granule core element G3BP1 in various diseases: A review. International journal of biological macromolecules. vol 282. issue Pt 5. 2024-11-12. PMID:39515684. |
as a multifunctional binding protein, g3bp1 has diverse biological functions, influencing cell proliferation, differentiation, apoptosis, and rna metabolism and serving as a crucial regulator in signaling pathways such as rac1-pak1, tsc-mtorc1, nf-κb, and stat3. |
2024-11-12 |
2024-11-17 |
Not clear |
| Qinjie Weng, Mengting Zhao, Jiahuan Zheng, Lijun Yang, Zijie Xu, Zhikang Zhang, Jincheng Wang, Jiajia Wang, Bo Yang, Q Richard Lu, Meidan Ying, Qiaojun H. Correction: STAT3 dictates β-cell apoptosis by modulating PTEN in streptozocin-induced hyperglycemia. Cell death and differentiation. 2024-11-07. PMID:39511405. |
correction: stat3 dictates β-cell apoptosis by modulating pten in streptozocin-induced hyperglycemia. |
2024-11-07 |
2024-11-16 |
Not clear |
| Hisham Al-Ward, Wei Chen, Wenxia Gao, Chunxue Zhang, Xueyan Yang, Yao Xiong, Xinyi Wang, Rafeq Agila, Hui Xu, Yi Eve Su. Can miRNAs in MSCs-EVs Offer a Potential Treatment for Hypoxic-ischemic Encephalopathy? Stem cell reviews and reports. 2024-11-06. PMID:39503828. |
by modulating pathways such as nf-κb, stat3, and pi3k/akt, these mirnas influence neuroinflammatory processes, reduce neuronal apoptosis, and promote tissue repair. |
2024-11-06 |
2024-11-08 |
Not clear |
| Dandan Shi, Jiejing Tao, Shuli Man, Ning Zhang, Long Ma, Lanping Guo, Luqi Huang, Wenyuan Ga. Structure, function, signaling pathways and clinical therapeutics: The translational potential of STAT3 as a target for cancer therapy. Biochimica et biophysica acta. Reviews on cancer. 2024-11-05. PMID:39500413. |
in contrast, the phosphorylated stat3 at serine 727 site (sp-stat3) is found on the mitochondria, affects electron respiration transport chain activity and thereby prevents tumor cell apoptosis. |
2024-11-05 |
2024-11-08 |
human |
| Caiqi Zhao, Yan Bai, Wei Wang, Gaurang M Amonkar, Hongmei Mou, Judith Olejnik, Adam J Hume, Elke Mühlberger, Nicholas W Lukacs, Rachel Fearns, Paul H Lerou, Xingbin A. Activation of STAT3-mediated ciliated cell survival protects against severe infection by respiratory syncytial virus. The Journal of clinical investigation. vol 134. issue 21. 2024-11-01. PMID:39484716. |
activation of stat3 and blockade of apoptosis rendered protection against severe rsv infection in infant bronchial epithelium. |
2024-11-01 |
2024-11-03 |
mouse |
| Raymond J Pickles, Gang Chen, Scott H Randel. Enhanced susceptibility of pediatric airway epithelium to respiratory syncytial virus infection. The Journal of clinical investigation. vol 134. issue 21. 2024-11-01. PMID:39484717. |
using precision cut lung slices (pcls) and air-liquid interface (ali) airway epithelial cell cultures, the authors showed that impaired stat3 activation in rsv-infected pediatric multiciliated cells increased cell apoptosis and viral shedding, which enhanced the spread of infection. |
2024-11-01 |
2024-11-03 |
mouse |
| Raymond J Pickles, Gang Chen, Scott H Randel. Enhanced susceptibility of pediatric airway epithelium to respiratory syncytial virus infection. The Journal of clinical investigation. vol 134. issue 21. 2024-11-01. PMID:39484717. |
bolstering stat3 activation and treatment of neonatal mice with apoptosis inhibitors suppressed virus spread, suggesting that enhancing stat3 activation may provide therapeutic benefit. |
2024-11-01 |
2024-11-03 |
mouse |
| Nimra Irshad, Hammad Naeem, Muhammad Shahbaz, Muhammad Imran, Ahmed Mujtaba, Muzzamal Hussain, Waleed Al Abdulmonem, Suliman A Alsagaby, Tadesse Fenta Yehuala, Mohamed A Abdelgawad, Mohammed M Ghoneim, Ehab M Mostafa, Samy Selim, Soad K Al Jaoun. Mangiferin: An effective agent against human malignancies. Food science & nutrition. vol 12. issue 10. 2024-10-31. PMID:39479608. |
it can control/regulate multiple key signaling pathways, such as signal transducer and activator of transcription 3 (stat3), second mitochondria-derived activator of caspases/direct inhibitor of apoptosis (iap)-binding protein with low propidium iodide (pl) (smac/diablo) nuclear factor kappa b (nf-κb), phosphatidylinositol 3 kinase/protein 3 kinase (pi3k/akt), transforming growth factor beta/suppressor of mothers against decapentaplegic (tgf-β/smad), c-jun n-terminal kinase/p38 mitogen-activated protein kinase (jnk/p38-mapk), and phosphor-i kappa b kinase (p-iκb), which are crucial to the development of cancers. |
2024-10-31 |
2024-11-02 |
human |
| Muhammad Suleman, Safir Ullah Khan, Shahid Ali, Abdullah Alghamdi, Mohammed Alissa, Rayan Y Mushtaq, Sergio Crovell. Probing the Depths of Molecular Complexity: STAT3 as a Key Architect in Colorectal Cancer Pathogenesis. Current gene therapy. 2024-10-30. PMID:39473261. |
numerous studies have demonstrated that the abnormal hyperactivation of stat3 in crc tissues enhances cell proliferation, suppresses apoptosis, promotes angiogenesis, and facilitates tumor invasion and metastasis. |
2024-10-30 |
2024-11-02 |
Not clear |
| Erika Yolanda Hernández Sandoval, Zulma Janeth Dueñas Góme. Irisin and neuroinflammation: Challenges and opportunities. Experimental and molecular pathology. vol 140. 2024-10-28. PMID:39467426. |
the review conducted found several studies describing the effect of irisin on pathways such as stat3, p38, camp/pka/creb, as well as effects on gfap protein expression or apoptosis processes in both in vitro and in vivo models; likewise, these pathways are associated with better bdnf expression. |
2024-10-28 |
2024-10-31 |
Not clear |
| Rui Li, Renfa Liu, Yunxue Xu, Shuhao Zhang, Peipei Yang, Wenlong Zeng, Huiyang Wang, Yijia Liu, Huajing Yang, Xiuli Yue, Zhifei Da. Suppressing Pancreatic Cancer Survival and Immune Escape via Nanoparticle-Modulated STING/STAT3 Axis Regulation. Bioconjugate chemistry. 2024-10-18. PMID:39420541. |
we observed that inhibiting stat3 signaling post-sting activation effectively suppressed tumor growth through signal transducer and activator of transcription 1 (stat1)-mediated apoptosis but led to a potential risk of immune-related adverse events (iraes). |
2024-10-18 |
2024-10-20 |
Not clear |
| Ming Zhou, Yaqi Zhang, Qiong Zhang, Yanchu Ton. METTL14-mediated m6A modification upregulated SOCS3 expression alleviates thyroid cancer progression by regulating the JAK2/STAT3 pathway. Molecular and cellular probes. 2024-10-16. PMID:39413935. |
in addition, mettl14-mediated m6a modification of socs3 inactivated the janus kinase 2 (jak2)-signal transducer and activator of transcription 3 (stat3) pathway, and in the mettl14-overexpressing tc cells, silencing socs3-induced upregulation of cell proliferation, emt and suppression of apoptosis was reversed by jak2/stat3 inhibitor ag490 and wp1066. |
2024-10-16 |
2024-10-19 |
Not clear |
| Tianjun Xing, Zhu Wang, Xiaojie Hao, Jingjun Mu, Bin Wan. Copper Nanoparticles Green-Formulated by Curcuma longa Extract Induce Apoptosis via P53 and STAT3 Signaling Pathways in Bladder Carcinoma Cell. Biological trace element research. 2024-10-13. PMID:39397139. |
copper nanoparticles green-formulated by curcuma longa extract induce apoptosis via p53 and stat3 signaling pathways in bladder carcinoma cell. |
2024-10-13 |
2024-10-16 |
Not clear |
| Tianjun Xing, Zhu Wang, Xiaojie Hao, Jingjun Mu, Bin Wan. Copper Nanoparticles Green-Formulated by Curcuma longa Extract Induce Apoptosis via P53 and STAT3 Signaling Pathways in Bladder Carcinoma Cell. Biological trace element research. 2024-10-13. PMID:39397139. |
the study outlines the production of new copper nanoparticles infused with curcuma longa extract to trigger apoptosis through p53 and signal transducer and activator of transcription 3 (stat3) signaling pathways in bladder carcinoma cells. |
2024-10-13 |
2024-10-16 |
Not clear |
| Liliana Cortés-Ballinas, Tania V López-Pérez, Leticia Rocha-Zavalet. STAT3 and the STAT3‑regulated inhibitor of apoptosis protein survivin as potential therapeutic targets in colorectal cancer (Review). Biomedical reports. vol 21. issue 6. 2024-10-02. PMID:39355529. |
stat3 and the stat3‑regulated inhibitor of apoptosis protein survivin as potential therapeutic targets in colorectal cancer (review). |
2024-10-02 |
2024-10-04 |
Not clear |