| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| James R Matthews, Alan R Clark. p53 mediates a default programme of mammary gland involution in the absence of STAT3. Oncogene. vol 24. issue 19. 2005-05-31. PMID:15735683. |
previous studies have demonstrated a proapoptotic role for the transcription factor stat3 in involuting murine mammary epithelium, resulting in delayed involution and lower levels of apoptosis in the stat3 null gland relative to wild-type controls. |
2005-05-31 |
2023-08-12 |
Not clear |
| Jiazhi Sun, Michelle A Blaskovich, Richard Jove, Sandra K Livingston, Domenico Coppola, Saïd M Sebt. Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity. Oncogene. vol 24. issue 20. 2005-05-31. PMID:15735720. |
cuc q inhibits selectively the activation of stat3 and induces apoptosis without inhibition of jak2, src, akt, erk, or jnk activation. |
2005-05-31 |
2023-08-12 |
mouse |
| Jiazhi Sun, Michelle A Blaskovich, Richard Jove, Sandra K Livingston, Domenico Coppola, Saïd M Sebt. Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity. Oncogene. vol 24. issue 20. 2005-05-31. PMID:15735720. |
furthermore, cuc q induces apoptosis more potently in human and murine tumors that contain constitutively activated stat3 (i.e., a549, mda-mb-435, and v-src/nih 3t3) as compared to those that do not (i.e., h-ras/nih 3t3, mda-mb-453, and nih 3t3 cells). |
2005-05-31 |
2023-08-12 |
mouse |
| Jiazhi Sun, Michelle A Blaskovich, Richard Jove, Sandra K Livingston, Domenico Coppola, Saïd M Sebt. Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity. Oncogene. vol 24. issue 20. 2005-05-31. PMID:15735720. |
these studies further validate stat3 as a drug discovery target and provide evidence that pharmacological agents that can selectively reduce the p-stat3 levels in human cancer cells result in tumor apoptosis and growth inhibition. |
2005-05-31 |
2023-08-12 |
mouse |
| James Turkson, Shumin Zhang, Jay Palmer, Heidi Kay, Joseph Stanko, Linda B Mora, Said Sebti, Hua Yu, Richard Jov. Inhibition of constitutive signal transducer and activator of transcription 3 activation by novel platinum complexes with potent antitumor activity. Molecular cancer therapeutics. vol 3. issue 12. 2005-05-17. PMID:15634646. |
in malignant cells that harbor constitutively activated stat3, cpa-1, cpa-7, and platinum (iv) tetrachloride inhibit cell growth and induce apoptosis in a manner that reflects the attenuation of persistent stat3 activity. |
2005-05-17 |
2023-08-12 |
mouse |
| Kathrine Abell, Antonio Bilancio, Richard W E Clarkson, Paul G Tiffen, Anton I Altaparmakov, Thomas G Burdon, Tomoichiro Asano, Bart Vanhaesebroeck, Christine J Watso. Stat3-induced apoptosis requires a molecular switch in PI(3)K subunit composition. Nature cell biology. vol 7. issue 4. 2005-05-16. PMID:15793565. |
in the absence of stat3 in vivo, upregulation of p55alpha and p50alpha is abrogated, levels of activated akt are sustained and apoptosis is prevented. |
2005-05-16 |
2023-08-12 |
Not clear |
| Kathrine Abell, Antonio Bilancio, Richard W E Clarkson, Paul G Tiffen, Anton I Altaparmakov, Thomas G Burdon, Tomoichiro Asano, Bart Vanhaesebroeck, Christine J Watso. Stat3-induced apoptosis requires a molecular switch in PI(3)K subunit composition. Nature cell biology. vol 7. issue 4. 2005-05-16. PMID:15793565. |
we propose a novel mechanism in which stat3 regulates apoptosis by inducing expression of distinct pi(3)k regulatory subunits to downregulate pi(3)k-akt-mediated survival signalling. |
2005-05-16 |
2023-08-12 |
Not clear |
| Beverly E Barton, Thomas F Murphy, Ping Shu, Hosea F Huang, Markus Meyenhofer, Arnold Barto. Novel single-stranded oligonucleotides that inhibit signal transducer and activator of transcription 3 induce apoptosis in vitro and in vivo in prostate cancer cell lines. Molecular cancer therapeutics. vol 3. issue 10. 2005-04-21. PMID:15486184. |
previously, we reported that antisense oligonucleotides specific for stat3 were better at inducing apoptosis than inhibitors of jak1 or jak2, the upstream activating kinases of stat3. |
2005-04-21 |
2023-08-12 |
Not clear |
| Beverly E Barton, Thomas F Murphy, Ping Shu, Hosea F Huang, Markus Meyenhofer, Arnold Barto. Novel single-stranded oligonucleotides that inhibit signal transducer and activator of transcription 3 induce apoptosis in vitro and in vivo in prostate cancer cell lines. Molecular cancer therapeutics. vol 3. issue 10. 2005-04-21. PMID:15486184. |
here, we report that novel single-stranded oligonucleotides, which putatively block stat3-dna binding, were better at inducing hormone-resistant prostate cancer apoptosis than antisense stat3 oligonucleotides. |
2005-04-21 |
2023-08-12 |
Not clear |
| Xuchen Zhang, Peiying Shan, Jawed Alam, Xin-Yuan Fu, Patty J Le. Carbon monoxide differentially modulates STAT1 and STAT3 and inhibits apoptosis via a phosphatidylinositol 3-kinase/Akt and p38 kinase-dependent STAT3 pathway during anoxia-reoxygenation injury. The Journal of biological chemistry. vol 280. issue 10. 2005-04-19. PMID:15590660. |
carbon monoxide differentially modulates stat1 and stat3 and inhibits apoptosis via a phosphatidylinositol 3-kinase/akt and p38 kinase-dependent stat3 pathway during anoxia-reoxygenation injury. |
2005-04-19 |
2023-08-12 |
Not clear |
| P Boutet, D Boulanger, L Gillet, A Vanderplasschen, R Closset, F Bureau, P Lekeu. Delayed neutrophil apoptosis in bovine subclinical mastitis. Journal of dairy science. vol 87. issue 12. 2005-04-18. PMID:15545372. |
we first addressed the hypothesis that gmcsf delays bovine neutrophil apoptosis by activation of the signal transducer and activator of transcription (stat) family members stat3 and stat5, which are critical regulators of the expression of various bcl-2 family proteins. |
2005-04-18 |
2023-08-12 |
human |
| Cindy Y F Yau, Jeffery J Wheeler, Kymberley L Sutton, David W Hedle. Inhibition of integrin-linked kinase by a selective small molecule inhibitor, QLT0254, inhibits the PI3K/PKB/mTOR, Stat3, and FKHR pathways and tumor growth, and enhances gemcitabine-induced apoptosis in human orthotopic primary pancreatic cancer xenografts. Cancer research. vol 65. issue 4. 2005-04-04. PMID:15735038. |
inhibition of integrin-linked kinase by a selective small molecule inhibitor, qlt0254, inhibits the pi3k/pkb/mtor, stat3, and fkhr pathways and tumor growth, and enhances gemcitabine-induced apoptosis in human orthotopic primary pancreatic cancer xenografts. |
2005-04-04 |
2023-08-12 |
mouse |
| Sichuan Xi, William E Gooding, Jennifer Rubin Grandi. In vivo antitumor efficacy of STAT3 blockade using a transcription factor decoy approach: implications for cancer therapy. Oncogene. vol 24. issue 6. 2005-03-02. PMID:15592503. |
several approaches have been used to block stat3 in cancer cells resulting in reduced proliferation and apoptosis. |
2005-03-02 |
2023-08-12 |
Not clear |
| Sichuan Xi, William E Gooding, Jennifer Rubin Grandi. In vivo antitumor efficacy of STAT3 blockade using a transcription factor decoy approach: implications for cancer therapy. Oncogene. vol 24. issue 6. 2005-03-02. PMID:15592503. |
blockade of stat3 with the stat3 decoy also induced apoptosis and decreased proliferation, an effect that was augmented when the stat3 decoy was combined with cisplatin, both in vitro and in vivo. |
2005-03-02 |
2023-08-12 |
Not clear |
| C Brender, P Lovato, V H Sommer, A Woetmann, A-M Mathiesen, C Geisler, M Wasik, N Ødu. Constitutive SOCS-3 expression protects T-cell lymphoma against growth inhibition by IFNalpha. Leukemia. vol 19. issue 2. 2005-02-22. PMID:15618960. |
we show that (i) socs-3 expression in tumour cells is equal to or higher than in cytokine-stimulated nonmalignant t cells, (ii) socs-3 is not mutated in ctcl, (iii) overexpression of socs-3 blocks ifnalpha-mediated growth inhibition without affecting stat3 activation, growth, and apoptosis, and (iv) inhibition of socs-3 by a dominant negative stat3 (stat3d) increases the ifnalpha-mediated growth inhibition. |
2005-02-22 |
2023-08-12 |
Not clear |
| Denise Hilfiker-Kleiner, Andres Hilfiker, Martin Fuchs, Karol Kaminski, Arnd Schaefer, Bernhard Schieffer, Anja Hillmer, Andreas Schmiedl, Zhaoping Ding, Edith Podewski, Eva Podewski, Valeria Poli, Michael D Schneider, Rainer Schulz, Joon-Keun Park, Kai C Wollert, Helmut Drexle. Signal transducer and activator of transcription 3 is required for myocardial capillary growth, control of interstitial matrix deposition, and heart protection from ischemic injury. Circulation research. vol 95. issue 2. 2005-02-08. PMID:15192020. |
the transcription factor signal transducer and activator of transcription 3 (stat3) participates in a wide variety of physiological processes and directs seemingly contradictory responses such as proliferation and apoptosis. |
2005-02-08 |
2023-08-12 |
mouse |
| A Stephano. Role of STAT-1 and STAT-3 in ischaemia/reperfusion injury. Journal of cellular and molecular medicine. vol 8. issue 4. 2005-01-31. PMID:15601580. |
for example, stat-1 has been shown to induced apoptosis, whilst stat3 is able protect cardiac myocytes following ischaemia/reperfusion (i/r) injury. |
2005-01-31 |
2023-08-12 |
Not clear |
| Manik Chatterjee, Thorsten Stühmer, Pia Herrmann, Kurt Bommert, Bernd Dörken, Ralf C Bargo. Combined disruption of both the MEK/ERK and the IL-6R/STAT3 pathways is required to induce apoptosis of multiple myeloma cells in the presence of bone marrow stromal cells. Blood. vol 104. issue 12. 2004-12-30. PMID:15297310. |
the interleukin-6 receptor (il-6r)/signal transducer and activator of transcription 3 (stat3) pathway contributes to the pathogenesis of multiple myeloma (mm) and protects mm cells from apoptosis. |
2004-12-30 |
2023-08-12 |
Not clear |
| Amie S Corbin, Ian J Griswold, Paul La Rosée, Kevin W H Yee, Michael C Heinrich, Corinne L Reimer, Brian J Druker, Michael W N Deininge. Sensitivity of oncogenic KIT mutants to the kinase inhibitors MLN518 and PD180970. Blood. vol 104. issue 12. 2004-12-30. PMID:15304388. |
mln518 additionally targets active site mutant cell lines, inhibiting cell proliferation, kit, and signal transducer and activator of transcription-3 (stat3) phosphorylation and inducing apoptosis at concentrations that may be clinically achievable. |
2004-12-30 |
2023-08-12 |
Not clear |
| Christian Liedtke, Christian Trautwei. A protective role of Stat3 in Fas mediated apoptosis of the liver. Journal of hepatology. vol 40. issue 5. 2004-12-15. PMID:15094244. |
a protective role of stat3 in fas mediated apoptosis of the liver. |
2004-12-15 |
2023-08-12 |
Not clear |