| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cairu Liu, Haiqin Feng, Lihong Song, Shuirui Li, Yiping Wu, Liping Yan. Synergistic effects of thalidomide and cisplatin are mediated via the PI3K/AKT and JAK1/STAT3 signaling pathways in cervical cancer. Oncology reports. vol 48. issue 4. 2022-08-03. PMID:35920185. |
relative cell viability and apoptosis, as well as the mrna and protein levels of pi3k, akt, jak1 and stat3 were evaluated. |
2022-08-03 |
2023-08-14 |
Not clear |
| Qian-Wen Zheng, Qian-Zhi Ni, Bing Zhu, Xin Liang, Ning Ma, Yi-Kang Wang, Sheng Xu, Hui-Jun Cao, Ji Xia, Feng-Kun Zhang, Er-Bin Zhang, Xiao-Song Qiu, Xu-Fen Ding, Lin Qiu, Xi-Lin Zhang, Zhao-Hui Dong, Zhi-Gang Li, Xue-Li Zhang, Dong Xie, Jing-Jing L. PPDPF promotes lung adenocarcinoma progression via inhibiting apoptosis and NK cell-mediated cytotoxicity through STAT3. Oncogene. 2022-07-29. PMID:35906391. |
ppdpf promotes lung adenocarcinoma progression via inhibiting apoptosis and nk cell-mediated cytotoxicity through stat3. |
2022-07-29 |
2023-08-14 |
Not clear |
| Qian-Wen Zheng, Qian-Zhi Ni, Bing Zhu, Xin Liang, Ning Ma, Yi-Kang Wang, Sheng Xu, Hui-Jun Cao, Ji Xia, Feng-Kun Zhang, Er-Bin Zhang, Xiao-Song Qiu, Xu-Fen Ding, Lin Qiu, Xi-Lin Zhang, Zhao-Hui Dong, Zhi-Gang Li, Xue-Li Zhang, Dong Xie, Jing-Jing L. PPDPF promotes lung adenocarcinoma progression via inhibiting apoptosis and NK cell-mediated cytotoxicity through STAT3. Oncogene. 2022-07-29. PMID:35906391. |
activated stat3 promoted bmpr2 transcription, which further inhibited apoptosis. |
2022-07-29 |
2023-08-14 |
Not clear |
| Sunanda Singh, Genoveva Murillo, Justin Richner, Samara P Singh, Erica Berleth, Vijay Kumar, Rajendra Mehta, Vijay Ramiya, Ashutosh S Pariha. A Broad-Based Characterization of a Cell-Penetrating, Single Domain Camelid Bi-Specific Antibody Monomer That Targets STAT3 and KRAS Dependent Cancers. International journal of molecular sciences. vol 23. issue 14. 2022-07-27. PMID:35886918. |
stat3 and kras regulate cell proliferation, survival, apoptosis, cell migration, and angiogenesis. |
2022-07-27 |
2023-08-14 |
human |
| Pen-An Liao, Pei-Yi Chu, Zhao-Lin Tan, Fei-Ting Hsu, Yang-Cheng Lee, Hsing-Ju W. STAT3 Inactivation and Induction of Apoptosis Associate With Fluoxetine-inhibited Epithelial-mesenchymal Transition and Growth of Triple-negative Breast Cancer Anticancer research. vol 42. issue 8. 2022-07-27. PMID:35896246. |
stat3 inactivation and induction of apoptosis associate with fluoxetine-inhibited epithelial-mesenchymal transition and growth of triple-negative breast cancer breast cancer (bc) is the most common cancer and second leading cause of death in women worldwide. |
2022-07-27 |
2023-08-14 |
Not clear |
| Agnieszka Witalisz-Siepracka, Klara Klein, Bernhard Zdársky, Dagmar Stoibe. The Multifaceted Role of STAT3 in NK-Cell Tumor Surveillance. Frontiers in immunology. vol 13. 2022-07-22. PMID:35865518. |
in cancer, stat3 is mainly described as a tumor promoter driving tumor cell proliferation, resistance to apoptosis, angiogenesis and metastasis and aberrant activation of stat3 is associated with poor prognosis. |
2022-07-22 |
2023-08-14 |
Not clear |
| Jing Yang, Lingling Wang, Xiaoqing Guan, Jiang-Jiang Qi. Inhibiting STAT3 Signaling Pathway by Natural Products for Cancer Prevention and Therapy: In Vitro and In Vivo Activity and Mechanisms of Action. Pharmacological research. 2022-07-22. PMID:35868477. |
signal transducer and activator of transcription 3 (stat3) plays a critical role in signal transmission from the plasma membrane to the nucleus, regulating the expression of genes involved in essential cell functions and controlling the processes of cell cycle progression and apoptosis. |
2022-07-22 |
2023-08-14 |
Not clear |
| Yibin Xu, Yulin Huang, Siyu Zhang, Lijin Guo, Ruiquan Wu, Xiang Fang, Xiaolan Chen, Haiping Xu, Qinghua Ni. CircDCLRE1C Regulated Lipopolysaccharide-Induced Inflammatory Response and Apoptosis by Regulating miR-214b-3p/STAT3 Pathway in Macrophages. International journal of molecular sciences. vol 23. issue 12. 2022-06-24. PMID:35743265. |
in conclusion, our study showed that circdclre1c could aggravate lps-induced inflammation and apoptosis through competitive adsorption of mir-214b-3p, thereby increasing the expression of stat3. |
2022-06-24 |
2023-08-14 |
chicken |
| Rajappa S Kenchappa, Athanassios Dovas, Michael G Argenziano, Christian T Meyer, Lauren E Stopfer, Matei A Banu, Brianna Pereira, Jessica Griffith, Afroz Mohammad, Surabhi Talele, Ashley Haddock, Natanael Zarco, William Elmquist, Forest White, Vito Quaranta, Peter Sims, Peter Canoll, Steven S Rosenfel. Activation of STAT3 through combined SRC and EGFR signaling drives resistance to a mitotic kinesin inhibitor in glioblastoma. Cell reports. vol 39. issue 12. 2022-06-22. PMID:35732128. |
while resistance to kif11 inhibitors in other cell types is due to mechanisms that prevent these drugs from disrupting mitosis, we find that in glioblastoma (gbm), resistance to the kif11 inhibitor ispinesib works instead through suppression of apoptosis driven by activation of stat3. |
2022-06-22 |
2023-08-14 |
mouse |
| Lucia T Angulo-Sanchez, Damian López-Peña, Heriberto Torres-Moreno, Aldo Gutiérrez, Rigoberto Gaitán-Hernández, Martín Esqued. Biosynthesis, Gene Expression, and Pharmacological Properties of Triterpenoids of Ganoderma Species (Agaricomycetes): A Review. International journal of medicinal mushrooms. vol 24. issue 6. 2022-06-13. PMID:35695634. |
the effect of gas against cancer cells has been associated with their capability to inhibit specific targets such as stat3, to induce apoptosis and cell cycle blockage, and to increase natural killer cell activity. |
2022-06-13 |
2023-08-14 |
Not clear |
| Huang Hong, Weilan Cao, Quanpeng Wang, Changbao Liu, Chongjie Huan. Synergistic antitumor effect of Andrographolide and cisplatin through ROS-mediated ER stress and STAT3 inhibition in colon cancer. Medical oncology (Northwood, London, England). vol 39. issue 5. 2022-05-22. PMID:35599281. |
notably, pre-treatment of nac, a ros scavenger, reversed apoptosis induced by combined treatment of ap and cisplatin, while relieving the activation of endoplasmic reticulum stress as well as stat3 inhibition. |
2022-05-22 |
2023-08-13 |
Not clear |
| Yi Bai, Hao Wu, Jinrui Zhang, Sai Zhang, Zhixin Zhang, Hao Wang, Yamin Zhang, Zhongyang She. IL-22 Protects against Biliary Ischemia-Reperfusion Injury after Liver Transplantation via Activating STAT3 and Reducing Apoptosis and Oxidative Stress Levels In Vitro and In Vivo. Oxidative medicine and cellular longevity. vol 2022. 2022-05-20. PMID:35592531. |
il-22 protects against biliary ischemia-reperfusion injury after liver transplantation via activating stat3 and reducing apoptosis and oxidative stress levels in vitro and in vivo. |
2022-05-20 |
2023-08-13 |
human |
| Yi Bai, Hao Wu, Jinrui Zhang, Sai Zhang, Zhixin Zhang, Hao Wang, Yamin Zhang, Zhongyang She. IL-22 Protects against Biliary Ischemia-Reperfusion Injury after Liver Transplantation via Activating STAT3 and Reducing Apoptosis and Oxidative Stress Levels In Vitro and In Vivo. Oxidative medicine and cellular longevity. vol 2022. 2022-05-20. PMID:35592531. |
this study confirmed that il-22 could promote cholangiocyte proliferation, decrease the apoptosis rate of cholangiocytes and tissues, decrease mda levels, and increase sod levels by activating stat3. |
2022-05-20 |
2023-08-13 |
human |
| Ruijie Chen, Yuan-Yuan Zhai, Lining Sun, Zeqing Wang, Xing Xia, Qing Yao, Longfa Ko. Alantolactone-loaded chitosan/hyaluronic acid nanoparticles suppress psoriasis by deactivating STAT3 pathway and restricting immune cell recruitment. Asian journal of pharmaceutical sciences. vol 17. issue 2. 2022-05-18. PMID:35582636. |
chalt effectively abrogated the hyperproliferation by inducing ros-mediated apoptosis with loss of mitochondrial membrane potential, and also inhibited il-6-induced stat3 signaling activation and inflammatory reaction in hacat cell line. |
2022-05-18 |
2023-08-13 |
human |
| Ehsan Khabazian, Faezeh Vakhshiteh, Parisa Norouzi, Yousef Fatahi, Rassoul Dinarvand, Fatemeh Atyab. Cationic liposome decorated with cyclic RGD peptide for targeted delivery of anti-STAT3 siRNA to melanoma cancer cells. Journal of drug targeting. vol 30. issue 5. 2022-05-16. PMID:34482780. |
furthermore, incorporating peptide on the surface of liposomes resulted in considerably high cytotoxicity, a 2.1-times raise in apoptosis induction, and a significantly enhanced stat3 gene suppression as compared with the corresponding non-targeted formulation on b16f10 murine melanoma cells. |
2022-05-16 |
2023-08-16 |
mouse |
| Yaseen Hussain, Abdullah, Khalaf F Alsharif, Michael Aschner, Abdulrahman Theyab, Fazlullah Khan, Luciano Saso, Haroon Kha. Therapeutic Role of Carotenoids in Blood Cancer: Mechanistic Insights and Therapeutic Potential. Nutrients. vol 14. issue 9. 2022-05-14. PMID:35565917. |
carotenoids, through various signaling pathways and mechanisms, such as the activation of ampk, expression of autophagy biochemical markers (p62/lc3-ii), activation of keap1-nrf2/epre/are signaaling pathway, nuclear factor kappa-light-chain-enhancer of activated b cells (nf-κb), increased level of reactive oxygen species, cleaved poly (adp-ribose) polymerase (c-parp), c-caspase-3, -7, decreased level of bcl-xl, cycle arrest at the g0/g1 phase, and decreasing stat3 expression results in apoptosis induction and inhibition of cancer cell proliferation. |
2022-05-14 |
2023-08-13 |
Not clear |
| Noura M Darwish, Mohamed M A Elshaer, Saeedah Musaed Almutairi, Tse-Wei Chen, Mohamed Othman Mohamed, Wael B A Ghaly, Rabab Ahmed Rashee. Omega-3 Polyunsaturated Fatty Acids Provoke Apoptosis in Hepatocellular Carcinoma through Knocking Down the STAT3 Activated Signaling Pathway: In Vivo and In Vitro Study. Molecules (Basel, Switzerland). vol 27. issue 9. 2022-05-14. PMID:35566382. |
omega-3 polyunsaturated fatty acids provoke apoptosis in hepatocellular carcinoma through knocking down the stat3 activated signaling pathway: in vivo and in vitro study. |
2022-05-14 |
2023-08-13 |
rat |
| Noura M Darwish, Mohamed M A Elshaer, Saeedah Musaed Almutairi, Tse-Wei Chen, Mohamed Othman Mohamed, Wael B A Ghaly, Rabab Ahmed Rashee. Omega-3 Polyunsaturated Fatty Acids Provoke Apoptosis in Hepatocellular Carcinoma through Knocking Down the STAT3 Activated Signaling Pathway: In Vivo and In Vitro Study. Molecules (Basel, Switzerland). vol 27. issue 9. 2022-05-14. PMID:35566382. |
signal transducer and activator of transcription 3 (stat3) is involved in hcc progression, migration, and suppression of apoptosis. |
2022-05-14 |
2023-08-13 |
rat |
| Noura M Darwish, Mohamed M A Elshaer, Saeedah Musaed Almutairi, Tse-Wei Chen, Mohamed Othman Mohamed, Wael B A Ghaly, Rabab Ahmed Rashee. Omega-3 Polyunsaturated Fatty Acids Provoke Apoptosis in Hepatocellular Carcinoma through Knocking Down the STAT3 Activated Signaling Pathway: In Vivo and In Vitro Study. Molecules (Basel, Switzerland). vol 27. issue 9. 2022-05-14. PMID:35566382. |
here we report that n-3 pufas may be an ideal cancer chemo-preventive candidate by targeting stat3 signaling, which is involved in cell proliferation and apoptosis. |
2022-05-14 |
2023-08-13 |
rat |
| Jang-Hyuk Yun, Da-Hye Lee, Han-Seok Jeong, Seung-Hoon Kim, Sang-Kyu Ye, Chung-Hyun Ch. STAT3 activation in microglia increases pericyte apoptosis in diabetic retinas through TNF-ɑ/AKT/p70S6 kinase signaling. Biochemical and biophysical research communications. vol 613. 2022-05-13. PMID:35561580. |
stat3 activation in microglia increases pericyte apoptosis in diabetic retinas through tnf-ɑ/akt/p70s6 kinase signaling. |
2022-05-13 |
2023-08-13 |
mouse |