| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jeonghyeon Seo, Da Eun Lee, Seong Mi Kim, Eunjung Kim, Jin-Kyung Ki. Licochalcone A Exerts Anti-Cancer Activity by Inhibiting STAT3 in SKOV3 Human Ovarian Cancer Cells. Biomedicines. vol 11. issue 5. 2023-05-27. PMID:37238935. |
furthermore, lica induced an increase in ros levels, a reduction in mitochondrial membrane potential, and apoptosis accompanied by an increase in cleaved caspases and cytoplasmic cytochrome c. additionally, lica caused a dramatic decrease in stat3 protein levels, but not mrna levels, in skov3 cells. |
2023-05-27 |
2023-08-14 |
human |
| Zhenyan Hou, Songwen Lin, Tingting Du, Mingjin Wang, Weida Wang, Shen You, Nina Xue, Yichen Liu, Ming Ji, Heng Xu, Xiaoguang Che. S-72, a Novel Orally Available Tubulin Inhibitor, Overcomes Paclitaxel Resistance via Inactivation of the STING Pathway in Breast Cancer. Pharmaceuticals (Basel, Switzerland). vol 16. issue 5. 2023-05-27. PMID:37242532. |
as a characterized tubulin inhibitor, s-72 typically inhibits tubulin polymerization and further triggers mitosis-phase cell cycle arrest and cell apoptosis, in addition to suppressing stat3 signaling. |
2023-05-27 |
2023-08-14 |
Not clear |
| Yan Li, Ying Zhang, Lei Gua. MiR-708 regulates the biological behavior of childhood leukemia cells by binding to the 3'utr end of the target gene and reducing the level of the target gene. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 2. 2023-05-25. PMID:37224029. |
the results showed that the cell proliferation inhibition rate, apoptosis rate, g1 phase ratio, bax protein, and cntfr protein in the mir-708 overexpression group were significantly lower than those in the control group at each time point, while the s phase ratio, bcl-2 protein, cell migration ability, jak3 and stat3 protein were significantly higher than those in the control group (p<0.05). |
2023-05-25 |
2023-08-14 |
human |
| Canli Yuan, Mei Yuan, Wenyu Li, Hai Cheng, Jianping Luo, Qi Zhang, Mengya Shi, Mingshan Niu, Jiajia Yang, Zengtian Sun, Zhiling Yan, Kailin Xu, Zhenyu Li, Yao Ya. The STAT3 inhibitor stattic overcome bortezomib-resistance in multiple myeloma via decreasing PSMB6. Experimental cell research. 2023-05-19. PMID:37207970. |
interestingly, a stat3 inhibitor, stattic, is shown to selectively inhibit psmb6 and induce apoptosis in bortezomib resistant and sensitive mm cells, even with il-6 induction. |
2023-05-19 |
2023-08-14 |
Not clear |
| Rebai Ben Amma. Potential Effects of Geraniol on Cancer and Inflammation-Related Diseases: A Review of the Recent Research Findings. Molecules (Basel, Switzerland). vol 28. issue 9. 2023-05-14. PMID:37175079. |
in addition, gnl induces apoptosis and cell cycle arrest, modulates multiple molecular targets, including p53 and stat3, activates caspases, and modulates inflammation via transcriptional regulation. |
2023-05-14 |
2023-08-14 |
Not clear |
| Xuehua Zhang, Leilei Zhao, Jinlong Xiao, Yudi Wang, Yunmeng Li, Chaoqun Zhu, He Zhang, Yurui Zhang, Xiao Zhu, Yucui Don. 5-Demethylnobiletin mediates cell cycle arrest and apoptosis Frontiers in oncology. vol 13. 2023-05-04. PMID:37139163. |
mechanically, 5-demethylnobiletin trigged g0/g1 phase arrest and apoptosis by inhibiting the erk1/2, akt and stat3 signaling pathway. |
2023-05-04 |
2023-08-14 |
Not clear |
| Carmen Amititeloaie, Liliana Chelaru, Gabriela Luminiţa Geleţu, Anca Sava, Alexandra Jităreanu, Andreea Mihaela Tibeică, Marcel Costulean. Apoptosis of pro-B lymphocytes induced by NR4A1 activation in the presence of gingival fibroblast exosomes and TNFα, caspase 8, STAT3, and Akt pathways modulators. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 64. issue 1. 2023-05-02. PMID:37128789. |
apoptosis of pro-b lymphocytes induced by nr4a1 activation in the presence of gingival fibroblast exosomes and tnfα, caspase 8, stat3, and akt pathways modulators. |
2023-05-02 |
2023-08-14 |
Not clear |
| Carmen Amititeloaie, Liliana Chelaru, Gabriela Luminiţa Geleţu, Anca Sava, Alexandra Jităreanu, Andreea Mihaela Tibeică, Marcel Costulean. Apoptosis of pro-B lymphocytes induced by NR4A1 activation in the presence of gingival fibroblast exosomes and TNFα, caspase 8, STAT3, and Akt pathways modulators. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 64. issue 1. 2023-05-02. PMID:37128789. |
in order to experimentally evaluate the apoptosis of pro-b type lymphocytes, induced as a result of the known activation of orphan nuclear receptor 4a1 (nr4a1), through cytosporone b (csn-b, 10 μm), in the presence or absence of exosomes derived from gingival fibroblasts, we administered as a treatment: 1 μm r-7050 [functional inhibitor of tumor necrosis factor alpha (tnfα)], 1 μm z-ietd-fmk (functional inhibitor of caspase 8), 1 μm gsk690693 (functional inhibitor of akt 1∕2∕3 pathways) and, last but not least, 1 μm scutellarin [functional inhibitor of receptor activator of nuclear factor-kappa b ligand (rankl)] and therefore of the signal transducer and activator of transcription 3 (stat3) pathway. |
2023-05-02 |
2023-08-14 |
Not clear |
| Tingting Xia, Meng Zhang, Wei Lei, Ruilin Yang, Shengping Fu, Zhenhai Fan, Ying Yang, Tao Zhan. Advances in the role of STAT3 in macrophage polarization. Frontiers in immunology. vol 14. 2023-04-21. PMID:37081874. |
the physiological processes of cell growth, proliferation, differentiation, and apoptosis are closely related to stat3, and it has been demonstrated that aberrant stat3 expression has an impact on the onset and progression of a number of inflammatory immunological disorders, fibrotic diseases, and malignancies. |
2023-04-21 |
2023-08-14 |
Not clear |
| Mehrdad Hashemi, Eisa Sabouni, Parham Rahmanian, Maliheh Entezari, Mahsa Mojtabavi, Behnaz Raei, Mohammad Arad Zandieh, Mitra Behroozaghdam, Sepideh Mirzaei, Kiavash Hushmandi, Noushin Nabavi, Shokooh Salimimoghadam, Jun Ren, Mohsen Rashidi, Rasoul Raesi, Afshin Taheriazam, Athanasios Alexiou, Marios Papadakis, Shing Cheng Ta. Deciphering STAT3 signaling potential in hepatocellular carcinoma: tumorigenesis, treatment resistance, and pharmacological significance. Cellular & molecular biology letters. vol 28. issue 1. 2023-04-21. PMID:37085753. |
this review addresses the function of stat3 as an oncogenic factor in hcc, as stat3 is able to prevent apoptosis and thus promote the progression of hcc. |
2023-04-21 |
2023-08-14 |
human |
| Yue Wang, Fengyi Deng, Xing Zhong, Yijun Du, Xingyu Fan, Hong Su, Tianrong Pa. Dulaglutide provides protection against sepsis-induced lung injury in mice by inhibiting inflammation and apoptosis. European journal of pharmacology. 2023-04-16. PMID:37062504. |
collectively, our data demonstrated that glp-1ra exerts a protective effect against sepsis-induced lung injury through mechanisms related to the inhibition of inflammation, apoptosis, and stat3 signaling. |
2023-04-16 |
2023-08-14 |
mouse |
| Aisha Nawaz, Sumera Zaib, Imtiaz Khan, Abrar Ahmed, Kiran Shahzadi, Huma Ria. Silybum marianum: an overview of its phytochemistry and pharmacological activities with emphasis on potential anticancer properties. Anti-cancer agents in medicinal chemistry. 2023-04-14. PMID:37055902. |
sm exhibited anticancer properties due to being capable of modifying the induction of apoptosis, inhibiting the stat3 pathway, decreasing the transcription of various growth factors, impeding the growth of 4t1 cells and inducing cell cycle arrest in various types of cancers, i.e., skin cancer, liver cancer, breast cancer, ovarian cancer etc. |
2023-04-14 |
2023-08-14 |
Not clear |
| Zhengjun Zhou, You Zhou, Zhengxuan Huang, Ming Wang, Jie Jiang, Min Yan, Wei Xiang, Shenjie Li, Yang Yu, Ligang Chen, Jie Zhou, Wei Don. Notopterol improves cognitive dysfunction and depression-like behavior via inhibiting STAT3/NF-ĸB pathway mediated inflammation in glioma-bearing mice. International immunopharmacology. vol 118. 2023-04-02. PMID:37004346. |
in this study, we found that notopterol inhibited growth and increased apoptosis of glioma via inhibiting stat3 activity. |
2023-04-02 |
2023-08-14 |
mouse |
| Nannan Li, Guoxin Lin, Hao Zhang, Jian Sun, Ming Gui, Yan Liu, Wei Li, Zishun Zhan, Yisu Li, Shiqi Pan, Jishi Liu, Juan Tan. Lyn attenuates sepsis-associated acute kidney injury by inhibition of phospho-STAT3 and apoptosis. Biochemical pharmacology. 2023-04-01. PMID:37003346. |
here, we found that lyn protected against renal tubular injury in cecal ligation and puncture (clp) induced aki mouse model by inhibition of signal transducer and activator of transcription 3 (stat3) phosphorylation and cell apoptosis. |
2023-04-01 |
2023-08-14 |
mouse |
| Nannan Li, Guoxin Lin, Hao Zhang, Jian Sun, Ming Gui, Yan Liu, Wei Li, Zishun Zhan, Yisu Li, Shiqi Pan, Jishi Liu, Juan Tan. Lyn attenuates sepsis-associated acute kidney injury by inhibition of phospho-STAT3 and apoptosis. Biochemical pharmacology. 2023-04-01. PMID:37003346. |
moreover, lyn agonist mlr-1023 pretreatment improved renal function, inhibited stat3 phosphorylation and decreased cell apoptosis. |
2023-04-01 |
2023-08-14 |
mouse |
| Wei Wei, Juanhong Wang, Pu Huang, Siqi Gou, Daihua Yu, Lei Zon. Tumor necrosis factor-α induces proliferation and reduces apoptosis of colorectal cancer cells through STAT3 activation. Immunogenetics. 2023-03-18. PMID:36933092. |
tumor necrosis factor-α induces proliferation and reduces apoptosis of colorectal cancer cells through stat3 activation. |
2023-03-18 |
2023-08-14 |
human |
| Wei Wei, Juanhong Wang, Pu Huang, Siqi Gou, Daihua Yu, Lei Zon. Tumor necrosis factor-α induces proliferation and reduces apoptosis of colorectal cancer cells through STAT3 activation. Immunogenetics. 2023-03-18. PMID:36933092. |
in the present study, we investigated whether tnf-α has a role in proliferation and apoptosis of colorectal cancer cells through stat3 activation. |
2023-03-18 |
2023-08-14 |
human |
| Wenliang Gong, Xinyu Li, Yuliang Feng, Ming Ji, Dianjun Zhang, Binjie Chen, Siman Wang, Xiafang Wu, Lulu Cui, Baoman Li, Maosheng Xi. Novel pathogenesis of post-traumatic stress disorder studied in transgenic mice. Journal of psychiatric research. vol 161. 2023-03-18. PMID:36933445. |
additionally, leptin attenuated neuronal apoptosis by increasing the phosphorylation of signal transducer and activator of transcription 3 (stat3), which further elevated the expression of ucp2 and inhibited the mitochondrial production of ros induced by ptsd, thus reducing neuronal apoptosis and ameliorating ptsd-related behaviors. |
2023-03-18 |
2023-08-14 |
mouse |
| Mehrdokht Sadrkhanloo, Mahshid Deldar Abad Paskeh, Mehrdad Hashemi, Rasoul Raesi, Motahhar Motahhary, Sam Saghari, Laleh Sharifi, Saied Bokaie, Sepideh Mirzaei, Maliheh Entezari, Amir Reza Aref, Shokooh Salimimoghadam, Mohsen Rashidi, Afshin Taheriazam, Kiavash Hushmand. STAT3 signaling in prostate cancer progression and therapy resistance: An oncogenic pathway with diverse functions. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 158. 2023-03-14. PMID:36916439. |
induction of stat3 signaling increases glycolysis and proliferation of prostate cancer cells and prevents apoptosis. |
2023-03-14 |
2023-08-14 |
Not clear |
| Jing Zhang, Yang Li, Ji-Guo Wang, Jing-Yu Feng, Guo-Dong Huang, Chang-Guo Lu. Dihydroartemisinin Affects STAT3/DDA1 Signaling Pathway and Reverses Breast Cancer Resistance to Cisplatin. The American journal of Chinese medicine. 2023-03-09. PMID:36891981. |
dha treatment repressed proliferation and induced apoptosis of ddp-resistant cells by suppressing stat3 phosphorylation; the inhibition ability was positively proportional to the dha concentration. |
2023-03-09 |
2023-08-14 |
Not clear |