| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Katarina \\xc5\\xbdivan\\xc4\\x8devi\\xc4\\x87, Jovana \\xc5\\xbdivanovi\\xc4\\x87, Katarina Barali\\xc4\\x87, Dragica Bo\\xc5\\xbei\\xc4\\x87, \\xc4\\x90ur\\xc4\\x91ica Mari\\xc4\\x87, Dragana Vukeli\\xc4\\x87, Evica Antonijevi\\xc4\\x87 Miljakovi\\xc4\\x87, Aleksandra Buha Djordjevi\\xc4\\x87, Marijana \\xc4\\x86ur\\xc4\\x8di\\xc4\\x87, Zorica Bulat, Biljana Antonijevi\\xc4\\x87, Danijela \\xc4\\x90uki\\xc4\\x87-\\xc4\\x86osi\\xc4\\x8. Integrative investigation of hematotoxic effects induced by low doses of lead, cadmium, mercury and arsenic mixture: In vivo and in silico approach. The Science of the total environment. 2024-04-23. PMID:38653421.' |
the main extracted pathways for anemia were related to apoptosis and oxidative stress; for thrombocytosis were signaling pathways of jak-stat and tpo. |
2024-04-23 |
2024-04-26 |
rat |
| Jieyu Yan, Haiwang Lai, Boning Zeng, Liqing Wang, Feiyue Xing, Pu Xia. Photoinduced free radical-releasing systems and their anticancer properties. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 2022-05-13. PMID:35553411. |
tpo can inhibit cell growth and development and promote cell apoptosis through a mitochondrial pathway under light irradiation. |
2022-05-13 |
2023-08-13 |
human |
| Jieyu Yan, Haiwang Lai, Boning Zeng, Liqing Wang, Feiyue Xing, Pu Xia. Photoinduced free radical-releasing systems and their anticancer properties. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 2022-05-13. PMID:35553411. |
further studies show that cell apoptosis is induced by free radicals produced from the photolysis of tpo to activate jnk phosphorylation. |
2022-05-13 |
2023-08-13 |
human |
| Yanhong Liu, Shuang Li, Mengdi Pu, Huayan Qin, Hong Wang, Tong Chen, Yunqi Zha. Structural characterization of polysaccharides isolated from Panax notoginseng medicinal residue and its protective effect on myelosuppression induced by cyclophosphamide. Chemistry & biodiversity. 2021-11-24. PMID:34817123. |
nppn could relieve cell cycle arrest, reduce the apoptosis rate of marrow cells, and improve granulocyte-macrophage colony-stimulating (gm-csf), thermoplastic polyolefin (tpo) and erythropoietin (epo) serum level, which contributes to promoting the proliferation of hematopoietic cells. |
2021-11-24 |
2023-08-13 |
mouse |
| Chantiya Chanswangphuwana, David S J Allan, Mala Chakraborty, Robert N Reger, Richard W Child. Augmentation of NK Cell Proliferation and Anti-tumor Immunity by Transgenic Expression of Receptors for EPO or TPO. Molecular therapy : the journal of the American Society of Gene Therapy. vol 29. issue 1. 2021-09-30. PMID:33010232. |
viral transduction of nk-92 cells to express epor or c-mpl receptors conveyed signaling via appropriate pathways, protected cells from apoptosis, augmented cellular proliferation, and increased cell cytotoxic function in response to epo or tpo ligands in vitro. |
2021-09-30 |
2023-08-13 |
mouse |
| Liang Li, Chenju Yi, WenJie Xia, Bihui Huang, Shichao Chen, Junyan Zhong, Xiaoyi Fang, Liuming Yang, Hongwu Xin, Shiying Silvia Zheng, Beng H Chong, Yingyun Fu, Chun Chen, Mo Yan. c-Mpl and TPO expression in the human central nervous system neurons inhibits neuronal apoptosis. Aging. vol 12. issue 8. 2021-02-23. PMID:32341206. |
c-mpl and tpo expression in the human central nervous system neurons inhibits neuronal apoptosis. |
2021-02-23 |
2023-08-13 |
human |
| Samaher Besbes, Shahid Shah, Iman Al-Dybiat, Shahsoltan Mirshahi, Helene Helfer, Haythem Najah, Caroline Fourgeaud, Marc Pocard, Ibtissem Ghedira, Jeannette Soria, Massoud Mirshah. Thrombopoietin Secretion by Human Ovarian Cancer Cells. International journal of cell biology. vol 2017. 2020-10-01. PMID:28465688. |
ovcar-3 cell's supernatant can replace exogenous tpo and inhibited tpo-dependent cell line (ba/f3) apoptosis. |
2020-10-01 |
2023-08-13 |
human |
| Han Wang, Hua Wang, En-Yu Liang, Li-Xia Zhou, Zhan-Ling Dong, Ping Liang, Qi-Fang Weng, Mo Yan. Thrombopoietin protects H9C2 cells from excessive autophagy and apoptosis in doxorubicin-induced cardiotoxicity. Oncology letters. vol 15. issue 1. 2020-09-29. PMID:29403560. |
furthermore, tpo reduced dox-induced apoptosis in h9c2 cells, as reflected by the amount changes of caspase-3. |
2020-09-29 |
2023-08-13 |
Not clear |
| Han Wang, Hua Wang, En-Yu Liang, Li-Xia Zhou, Zhan-Ling Dong, Ping Liang, Qi-Fang Weng, Mo Yan. Thrombopoietin protects H9C2 cells from excessive autophagy and apoptosis in doxorubicin-induced cardiotoxicity. Oncology letters. vol 15. issue 1. 2020-09-29. PMID:29403560. |
taken together, these results revealed that tpo has a protective role in h9c2 cells from dox-induced autophagy as well as apoptosis, and indicated that tpo may act as a cardioprotective drug in dox-treated patients. |
2020-09-29 |
2023-08-13 |
Not clear |
| Jun-Yan Wang, Jie-Yu Ye, En-Yu Liang, Mo Yan. [Thrombopoietin Prevents CoCl Zhongguo shi yan xue ye xue za zhi. vol 26. issue 2. 2018-10-25. PMID:29665927. |
[thrombopoietin prevents cocl to investigate the effect of thrombopoietin (tpo) on chemical hypoxia-induced apoptosis of human umbilical vein endothelial cells (huvec), and to explore its potential mechanism. |
2018-10-25 |
2023-08-13 |
human |
| Esther López, Alejandro Berna-Erro, Javier J López, María P Granados, Nuria Bermejo, Jose M Brull, Ginés M Salido, Juan A Rosado, Pedro C Redond. Role of mTOR1 and mTOR2 complexes in MEG-01 cell physiology. Thrombosis and haemostasis. vol 114. issue 5. 2016-08-29. PMID:26202144. |
by using mtor antagonists and overexpressing fkbp38, we have explored the role of both mtor complexes in proliferation, apoptosis, maturation-like mechanisms, endoplasmic reticulum-stress and the intracellular location of both active mtor complexes during meg-01 cell stimulation with tpo. |
2016-08-29 |
2023-08-13 |
Not clear |
| Anna Kalota, Mary A Selak, Laura A Garcia-Cid, Martin Carrol. Eltrombopag modulates reactive oxygen species and decreases acute myeloid leukemia cell survival. PloS one. vol 10. issue 4. 2016-04-27. PMID:25915523. |
previous studies have demonstrated that the small molecule thrombopoietin (tpo) mimetic, eltrombopag (e), induces apoptosis in acute myeloid leukemia (aml) cells. |
2016-04-27 |
2023-08-13 |
Not clear |
| Fan Bu, Tao Li, Yanling Ding, Lingxian Sun, Tao Tu, Fangfang Zhou, Wenkai Qi, Xinyi Jiang, Jie Fang, Jiabo Hu, Wei Zhu, Xiaochun Su. Cytotoxic effects of 4-methylimidazole on bone marrow mesenchymal stem cells in vitro. American journal of translational research. vol 7. issue 10. 2015-12-22. PMID:26692921. |
the results showed that higher concentrations of 4-mi (≥150 μg/ml) had significant effects on bmscs viability while lower concentrations (≤100 μg/ml) had no significant effects on cell proliferation, apoptosis, migration, differentiation, and expression of relevant marker genes of hematopoietic cytokines, including tpo, scf, vegf and flt3. |
2015-12-22 |
2023-08-13 |
Not clear |
| Philip V Peplo. Influence of growth factors and cytokines on angiogenic function of endothelial progenitor cells: a review of in vitro human studies. Growth factors (Chur, Switzerland). vol 32. issue 3-4. 2015-04-10. PMID:24712317. |
under acidic conditions (ph 6.5), the biological activity of certain growth factors may be impaired, although tpo, scf and il-3 were each able to rescue epcs from acidic exposure apoptosis, a combination of these three factors stimulated cell proliferation and prevented apoptosis. |
2015-04-10 |
2023-08-13 |
human |
| William Beau Mitchell, Mariana P Pinheiro, Nayla Boulad, David Kaplan, Michele N Edison, Bethan Psaila, Marissa Karpoff, Michael J White, Emma C Josefsson, Benjamin T Kile, James B Busse. Effect of thrombopoietin receptor agonists on the apoptotic profile of platelets in patients with chronic immune thrombocytopenia. American journal of hematology. vol 89. issue 12. 2015-01-16. PMID:25132654. |
platelet survival depends upon mediators of apoptosis e.g., bcl-xl, bax, and bak, which are regulated by thrombopoietin (tpo)-mediated akt signaling. |
2015-01-16 |
2023-08-13 |
Not clear |
| K Freson, A Wijgaerts, C van Gee. Update on the causes of platelet disorders and functional consequences. International journal of laboratory hematology. vol 36. issue 3. 2014-12-04. PMID:24750678. |
in this review, we have classified inherited platelet bleeding disorders (ipd) according to their underlying defective pathway: transcription regulation, tpo signaling, cytoskeletal organization, apoptosis, granule trafficking, and receptor signaling. |
2014-12-04 |
2023-08-13 |
Not clear |
| Jiaqing Shen, Rong Wan, Guoyong Hu, Feng Wang, Jie Shen, Xingpeng Wan. Involvement of thrombopoietin in acinar cell necrosis in L-arginine-induced acute pancreatitis in mice. Cytokine. vol 60. issue 1. 2013-02-01. PMID:22698803. |
acinar regeneration and apoptosis in the pancreas were affected by tpo and antibody treatment in necrotizing pancreatitis. |
2013-02-01 |
2023-08-12 |
mouse |
| Olaf Hoffmann, Olga Rung, Ae-Rie Im, Dorette Freyer, Juan Zhang, Josephin Held, Werner Stenzel, Christof Dam. Thrombopoietin contributes to neuronal damage in experimental bacterial meningitis. Infection and immunity. vol 79. issue 2. 2011-03-15. PMID:21149592. |
c-mpl mrna expression was upregulated at 12 h and returned to baseline at 24 h. compared to wild-type mice, mutants with homozygous tpo receptor ablation (c-mpl(-/-)) displayed reduced microglial activation and neuronal apoptosis in the dentate gyrus. |
2011-03-15 |
2023-08-12 |
mouse |
| Shu Mo, Jie Yu, Mo Yang, Zhi-guang Li, Gui-xia Li, Lei Zhan. [Comparison of the effect of Angelica polysaccharide, platelet-derived growth factor and thrombopoietin on megakaryocytopoiesis]. Zhonghua er ke za zhi = Chinese journal of pediatrics. vol 46. issue 1. 2011-03-01. PMID:18353239. |
to investigate the effect of angelica polysaccharide (aps), platelet-derived growth factor (pdgf) and thrombopoietin (tpo) on the proliferation and apoptosis of human megakaryocytic cell line m-07e. |
2011-03-01 |
2023-08-12 |
human |
| A Bossowski, B Czarnocka, K Bardadin, A Moniuszko, A Łyczkowska, J Czerwinska, J Dadan, A Bossowsk. Identification of chosen apoptotic (TIAR and TIA-1) markers expression in thyroid tissues from adolescents with immune and non-immune thyroid diseases. Folia histochemica et cytobiologica. vol 48. issue 2. 2010-11-12. PMID:20675271. |
we conclude that elevated expression of nis and tpo in graves' disease is associated with higher stimulation and activation of apoptosis in thyroid follicular cells during autoimmune process. |
2010-11-12 |
2023-08-12 |
Not clear |