| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Kozuma, H Kojima, S Yuki, H Suzuki, T Nagasaw. Continuous expression of Bcl-xL protein during megakaryopoiesis is post-translationally regulated by thrombopoietin-mediated Akt activation, which prevents the cleavage of Bcl-xL. Journal of thrombosis and haemostasis : JTH. vol 5. issue 6. 2007-07-20. PMID:17389006. |
one of the important biological activities of thrombopoietin (tpo) is to prevent the apoptosis of megakaryocytes. |
2007-07-20 |
2023-08-12 |
Not clear |
| L Zhang, S Sharma, J M Hershman, G A Brent, S M Dubinett, M Huan. Iodide sensitizes genetically modified non-small cell lung cancer cells to ionizing radiation. Cancer gene therapy. vol 13. issue 1. 2006-08-03. PMID:16052231. |
ectopic expression of the sodium iodide symporter (nis) and thyroperoxidase (tpo) genes in nsclc cells facilitated concentration of iodide in nsclc cells, which markedly induced apoptosis in vitro and in vivo. |
2006-08-03 |
2023-08-12 |
Not clear |
| Francis Corazza, Christophe Hermans, Stéphanie D'Hondt, Alina Ferster, Alain Kentos, Yves Benoît, Eric Sariba. Circulating thrombopoietin as an in vivo growth factor for blast cells in acute myeloid leukemia. Blood. vol 107. issue 6. 2006-05-31. PMID:16317100. |
in vitro significant tpo-associated blast cell proliferation or decreased apoptosis was observed only in patients with c-mpl+ aml compared with all or c-mpl- aml and was highly correlated with low in vivo tpo levels (p < .001). |
2006-05-31 |
2023-08-12 |
Not clear |
| A V Sirotkin, P Sanislo, H-J Schaeffer, I Florkovicová, J Kotwica, J Bulla, L Hetény. Thrombopoietin regulates proliferation, apoptosis, secretory activity and intracellular messengers in porcine ovarian follicular cells: involvement of protein kinase A. The Journal of endocrinology. vol 183. issue 3. 2005-02-01. PMID:15590985. |
thrombopoietin regulates proliferation, apoptosis, secretory activity and intracellular messengers in porcine ovarian follicular cells: involvement of protein kinase a. thrombopoietin (tpo) is known to be involved in megakariocytopoesis, but its role in the control of ovarian function is unknown. |
2005-02-01 |
2023-08-12 |
Not clear |
| A V Sirotkin, P Sanislo, H-J Schaeffer, I Florkovicová, J Kotwica, J Bulla, L Hetény. Thrombopoietin regulates proliferation, apoptosis, secretory activity and intracellular messengers in porcine ovarian follicular cells: involvement of protein kinase A. The Journal of endocrinology. vol 183. issue 3. 2005-02-01. PMID:15590985. |
the aims of this study were to determine whether tpo can regulate the proliferation, apoptosis and secretory activity of ovarian cells, to identify possible intracellular mediators of tpo action, especially protein kinase a (pka), and to define their interrelationships within ovarian cells. |
2005-02-01 |
2023-08-12 |
Not clear |
| A V Sirotkin, P Sanislo, H-J Schaeffer, I Florkovicová, J Kotwica, J Bulla, L Hetény. Thrombopoietin regulates proliferation, apoptosis, secretory activity and intracellular messengers in porcine ovarian follicular cells: involvement of protein kinase A. The Journal of endocrinology. vol 183. issue 3. 2005-02-01. PMID:15590985. |
we investigated the effect of tpo treatment (0, 1, 10 or 100 ng/ml) on the following characteristics of cultured porcine ovarian follicles, determined using sds-page and western blotting, immunocytochemistry, ria and elisa: the expression of intracellular peptides associated with proliferation (pcna), apoptosis (bax), tyrosine kinase (tk, phosphotyrosine), cdc2/p34 kinase, pka and the transcription factor creb-1, and the secretion of progesterone, androstenedione, estradiol-17beta, oxytocin, inhibin a, inhibin b, igf-i, transforming growth factor-2beta (tgf-2beta) and igf-binding protein 3 (igfbp-3). |
2005-02-01 |
2023-08-12 |
Not clear |
| Olafur Eysteinn Sigurjonsson, Kristbjorn Orri Gudmundsson, Vilhelmina Haraldsdottir, Thorunn Rafnar, Bjarni A Agnarsson, Sveinn Gudmundsso. Flt3/Flk-2 ligand in combination with thrombopoietin decreases apoptosis in megakaryocyte development. Stem cells and development. vol 13. issue 2. 2004-12-03. PMID:15186734. |
our results show that bone marrow cd34+ cells cultured with tpo and fl differentiate at a slower rate into cd41+ cells and are delayed in apoptosis at the later stages of the cultures compared to cells cultured with tpo alone. |
2004-12-03 |
2023-08-12 |
Not clear |
| Olafur Eysteinn Sigurjonsson, Kristbjorn Orri Gudmundsson, Vilhelmina Haraldsdottir, Thorunn Rafnar, Bjarni A Agnarsson, Sveinn Gudmundsso. Flt3/Flk-2 ligand in combination with thrombopoietin decreases apoptosis in megakaryocyte development. Stem cells and development. vol 13. issue 2. 2004-12-03. PMID:15186734. |
our data also show that fl in synergy with tpo may inhibit apoptosis in megakaryocyte development by up-regulating bcl-2 and inducing conformational changes of p53, in mk progenitors. |
2004-12-03 |
2023-08-12 |
Not clear |
| Olafur Eysteinn Sigurjonsson, Kristbjorn Orri Gudmundsson, Vilhelmina Haraldsdottir, Thorunn Rafnar, Bjarni A Agnarsson, Sveinn Gudmundsso. Flt3/Flk-2 ligand in combination with thrombopoietin decreases apoptosis in megakaryocyte development. Stem cells and development. vol 13. issue 2. 2004-12-03. PMID:15186734. |
fl in combination with tpo slows down maturation and consequently delays apoptosis of mk progenitor cells. |
2004-12-03 |
2023-08-12 |
Not clear |
| Ling Zhang, Sherven Sharma, Li X Zhu, Takahiko Kogai, Jerome M Hershman, Gregory A Brent, Steven M Dubinett, Min Huan. Nonradioactive iodide effectively induces apoptosis in genetically modified lung cancer cells. Cancer research. vol 63. issue 16. 2003-09-24. PMID:12941836. |
to enhance tumor apoptosis, we transduced non-small cell lung cancer cells with retroviral vectors containing the sodium iodide symporter (nis) and thyroperoxidase (tpo) genes. |
2003-09-24 |
2023-08-12 |
mouse |
| Jeong-Ah Kim, Yu-Jin Jung, Ju-Young Seoh, So-Youn Woo, Jeong-Sun Seo, Hyung-Lae Ki. Gene expression profile of megakaryocytes from human cord blood CD34(+) cells ex vivo expanded by thrombopoietin. Stem cells (Dayton, Ohio). vol 20. issue 5. 2003-03-12. PMID:12351811. |
previously, we investigated the process of megakaryocytopoiesis during ex vivo expansion of human cord blood (cb) cd34(+) cells using thrombopoietin (tpo) and found that megakaryocytopoiesis was closely associated with apoptosis. |
2003-03-12 |
2023-08-12 |
human |
| Gaël A Millot, William Vainchenker, Dominique Duménil, Fédor Svinarchu. Distinct effects of thrombopoietin depending on a threshold level of activated Mpl in BaF-3 cells. Journal of cell science. vol 115. issue Pt 11. 2002-12-03. PMID:12006617. |
however, pi3k pathway inhibition did not increase apoptosis when baf-3 cells proliferated in response to tpo, indicating a compensating mechanism from other mpl signaling pathways in this case. |
2002-12-03 |
2023-08-12 |
Not clear |
| M Drouet, F Mourcin, N Grenier, J F Mayol, V Leroux, F Hérodin, J J Sott. [The effects of ionizing radiation on stem cells and hematopoietic progenitors: the place of apoptosis and the therapeutic potential of anti-apoptosis treatments]. Canadian journal of physiology and pharmacology. vol 80. issue 7. 2002-09-27. PMID:12184322. |
apoptosis may be significantly reduced with a combination of 4 cytokines (4f): stem cell factor (scf), flt-3 ligand (fl), thrombopoietin (tpo), and interleukin-3 (il-3), each at 50 ng x ml(-1) (15% survival versus <3% untreated cells, 24 h post-irradiation at 2.5 gy). |
2002-09-27 |
2023-08-12 |
Not clear |
| Jeong-Hae Kie, Woo-Ick Yang, Mi-Kyung Lee, Tae-Jung Kwon, Yoo-Hong Min, Hyun-Ok Kim, Hyo-Seop Ahn, Seock-Ah Im, Hyung-Lae Kim, Hae-Young Park, Kyung-Ha Ryu, Wha-Soon Chung, Myeong-Heon Shin, Yu-Jin Jung, So-Youn Woo, Hae-Kyung Park, Ju-Young Seo. Decrease in apoptosis and increase in polyploidization of megakaryocytes by stem cell factor during ex vivo expansion of human cord blood CD34+ cells using thrombopoietin. Stem cells (Dayton, Ohio). vol 20. issue 1. 2002-04-22. PMID:11796924. |
previously, we have reported that tpo induces a characteristic pattern of apoptosis, and the tpo-induced apoptosis is closely associated with megakaryocyte (mk) differentiation. |
2002-04-22 |
2023-08-12 |
human |
| S-Y Woo, J-H Kie, K-H Ryu, H-S Moon, W-S Chung, D-H Hwang, S-K Kim, T-H Han, M-J Hahn, Y-H Chong, H-K Park, J-Y Seo. Megakaryothrombopoiesis during ex vivo expansion of human cord blood CD34+ cells using thrombopoietin. Scandinavian journal of immunology. vol 55. issue 1. 2002-03-06. PMID:11841696. |
previously, we have found that tpo induces a characteristic pattern of apoptosis during ex vivo expansion of human cord blood (cb) cd34+ cells and that the tpo-induced apoptotic cells belong to megakaryocyte (mk) lineage. |
2002-03-06 |
2023-08-12 |
human |
| S-Y Woo, J-H Kie, K-H Ryu, H-S Moon, W-S Chung, D-H Hwang, S-K Kim, T-H Han, M-J Hahn, Y-H Chong, H-K Park, J-Y Seo. Megakaryothrombopoiesis during ex vivo expansion of human cord blood CD34+ cells using thrombopoietin. Scandinavian journal of immunology. vol 55. issue 1. 2002-03-06. PMID:11841696. |
therefore, it is suggested that platelet production and the accompanying processes, rather than apoptosis only, be hastened during the ex vivo expansion of cb cd34+ cells when using tpo. |
2002-03-06 |
2023-08-12 |
human |
| E Battinelli, S R Willoughby, T Foxall, C R Valeri, J Loscalz. Induction of platelet formation from megakaryocytoid cells by nitric oxide. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 25. 2002-01-10. PMID:11734646. |
to determine whether there is an association between no-induced apoptosis and platelet production, we exposed meg-01 cells to s-nitrosoglutathione (gsno) with or without thrombopoeitin (tpo) pretreatment and used flow cytometry and electron microscopy to assess platelet-sized particle formation. |
2002-01-10 |
2023-08-12 |
Not clear |
| M Huang, R K Batra, T Kogai, Y Q Lin, J M Hershman, A Lichtenstein, S Sharma, L X Zhu, G A Brent, S M Dubinet. Ectopic expression of the thyroperoxidase gene augments radioiodide uptake and retention mediated by the sodium iodide symporter in non-small cell lung cancer. Cancer gene therapy. vol 8. issue 8. 2001-12-04. PMID:11571539. |
our results show that transfection of nsclc cells with both human nis and tpo genes resulted in an increase in radioiodide uptake and retention and enhanced tumor cell apoptosis. |
2001-12-04 |
2023-08-12 |
human |
| M T Petrucci, M R Ricciardi, C Gregorj, C Ariola, F Mazzola, M Fogli, R M Lemoli, A Tafur. Thrombopoietin, interleukin-11, and early-acting megakaryocyte growth factors in human myeloid leukemia cells. Leukemia & lymphoma. vol 40. issue 1-2. 2001-09-27. PMID:11426619. |
in this study we report our data on effects of early-acting megakaryocyte growth factors, particularly the c-mpl ligand also known as thrombopoietin (tpo) and interleukin-11 (il-11), on cell proliferation and apoptosis (apo) of primary acute myeloid leukemia (aml) cells. |
2001-09-27 |
2023-08-12 |
human |
| H C Hasselbalch, H T Mourits-Andersen, B A Jensen, M K Jensen, O J Nielse. [The chronic Philadelphia chromosome-negative myeloproliferative syndrome I. Pathogenesis and pathophysiology]. Ugeskrift for laeger. vol 163. issue 18. 2001-07-12. PMID:11379259. |
by inhibiting apoptosis, this growth factor may be responsible for the autonomous proliferation of the megakaryocyte cell lineage in pv and idiopathic myelofibrosis (imf), which are featured by highly elevated circulating tpo levels. |
2001-07-12 |
2023-08-12 |
Not clear |