| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K H Ryu, S Chun, S Carbonierre, S A Im, H L Kim, M H Shin, H Y Shin, H S Ahn, S Y Woo, J Y Seoh, J K Frase. Apoptosis and megakaryocytic differentiation during ex vivo expansion of human cord blood CD34+ cells using thrombopoietin. British journal of haematology. vol 113. issue 2. 2001-07-05. PMID:11380418. |
previously, we have demonstrated that tpo induces a characteristic pattern of apoptosis during ex vivo expansion of cord blood (cb) cd34+ cells. |
2001-07-05 |
2023-08-12 |
human |
| K H Ryu, S Chun, S Carbonierre, S A Im, H L Kim, M H Shin, H Y Shin, H S Ahn, S Y Woo, J Y Seoh, J K Frase. Apoptosis and megakaryocytic differentiation during ex vivo expansion of human cord blood CD34+ cells using thrombopoietin. British journal of haematology. vol 113. issue 2. 2001-07-05. PMID:11380418. |
these results suggested that the mk progenitors matured as they expanded during ex vivo expansion with tpo and then proceeded to apoptosis. |
2001-07-05 |
2023-08-12 |
human |
| S H Wang, A Myc, R J Koenig, J D Bretz, P L Arscott, J R Bake. 2-Methoxyestradiol, an endogenous estrogen metabolite, induces thyroid cell apoptosis. Molecular and cellular endocrinology. vol 165. issue 1-2. 2000-11-07. PMID:10940494. |
prolonged exposure to 2-me led to apoptosis and to increased release of the autoantigen thyroid peroxidase (tpo). |
2000-11-07 |
2023-08-12 |
Not clear |
| S E Jacobsen, O J Borge, V Ramsfjell, L Cui, J E Cardier, O P Veiby, M J Murphy, S Lo. Thrombopoietin, a direct stimulator of viability and multilineage growth of primitive bone marrow progenitor cells. Stem cells (Dayton, Ohio). vol 14 Suppl 1. 2000-11-02. PMID:11012218. |
when acting alone, tpo stimulates little or no growth, but promotes viability and suppresses apoptosis of murine multipotent (lin- sca-1+) bone marrow progenitor cells in vitro. |
2000-11-02 |
2023-08-12 |
mouse |
| I Blasko, A Sztankay, P Lukas, B Grubeck-Loebenstei. Decreased thyroid peroxidase expression in cultured thyrocytes after external gamma irradiation. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 108. issue 2. 2000-08-10. PMID:10826522. |
in order to assess radiation-induced alterations in cultured thyroid cells, the occurrence of apoptosis and necrosis as well as the expression of thyroid peroxidase (tpo) and of two members of the 70 kd heat shock family, hsp-73 and hsp-72, were analysed following gamma irradiation. |
2000-08-10 |
2023-08-12 |
human |
| J Y Seoh, S Y Woo, S A Im, Y J Kim, H Y Park, S Lee, M A Lee, E S Yoo, J W Huh, K H Ryu, S N Lee, W S Chung, C M Seon. Distinct patterns of apoptosis in association with modulation of CD44 induced by thrombopoietin and granulocyte-colony stimulating factor during ex vivo expansion of human cord blood CD34+ cells. British journal of haematology. vol 107. issue 1. 1999-11-30. PMID:10520039. |
the distinct patterns of apoptosis suggest different mechanisms of tpo and g-csf in inducing apoptosis, which still remains to be elucidated. |
1999-11-30 |
2023-08-12 |
human |
| M Drouet, J Mathieu, N Grenier, E Multon, J J Sotto, F Herodi. The reduction of in vitro radiation-induced Fas-related apoptosis in CD34+ progenitor cells by SCF, FLT-3 ligand, TPO, and IL-3 in combination resulted in CD34+ cell proliferation and differentiation. Stem cells (Dayton, Ohio). vol 17. issue 5. 1999-11-22. PMID:10527462. |
the reduction of in vitro radiation-induced fas-related apoptosis in cd34+ progenitor cells by scf, flt-3 ligand, tpo, and il-3 in combination resulted in cd34+ cell proliferation and differentiation. |
1999-11-22 |
2023-08-12 |
Not clear |
| N Sawai, K Koike, S Ito, Y Kurokawa, H H Mwamtemi, T Kinoshita, K Sakashita, T Higuchi, K Takeuchi, M Shiohara, K Ogami, A Komiyam. Apoptosis of erythroid precursors under stimulation with thrombopoietin: contribution to megakaryocytic lineage choice. Stem cells (Dayton, Ohio). vol 17. issue 1. 1999-04-22. PMID:10215401. |
however, this subpopulation failed to grow/survive and fell into apoptosis in the presence of tpo alone. |
1999-04-22 |
2023-08-12 |
Not clear |
| N Sawai, K Koike, S Ito, Y Kurokawa, H H Mwamtemi, T Kinoshita, K Sakashita, T Higuchi, K Takeuchi, M Shiohara, K Ogami, A Komiyam. Apoptosis of erythroid precursors under stimulation with thrombopoietin: contribution to megakaryocytic lineage choice. Stem cells (Dayton, Ohio). vol 17. issue 1. 1999-04-22. PMID:10215401. |
therefore, these results suggest that the apoptosis of hematopoietic precursors other than megakaryocytic precursors is related to the determination of the terminal differentiation under the influence of tpo. |
1999-04-22 |
2023-08-12 |
Not clear |
| M Osada, T Komeno, K Todokoro, M Takizawa, H Kojima, K Suzukawa, H Ninomiya, T Abe, T Nagasaw. Immature megakaryocytes undergo apoptosis in the absence of thrombopoietin. Experimental hematology. vol 27. issue 1. 1999-02-25. PMID:9923451. |
we examined withdrawal effects of recombinant mouse tpo (rm-tpo) on the apoptosis of mature and immature megakaryocytes in in vitro experiments. |
1999-02-25 |
2023-08-12 |
mouse |
| A Ritchie, A Gotoh, J Gaddy, S E Braun, H E Broxmeye. Thrombopoietin upregulates the promoter conformation of p53 in a proliferation-independent manner coincident with a decreased expression of Bax: potential mechanisms for survival enhancing effects. Blood. vol 90. issue 11. 1997-12-23. PMID:9373250. |
we previously reported a role for tpo as a survival factor in the factor-dependent human cell line m07e by demonstrating that tpo suppresses apoptosis in the absence of induced proliferation. |
1997-12-23 |
2023-08-12 |
human |
| A Ritchie, A Gotoh, J Gaddy, S E Braun, H E Broxmeye. Thrombopoietin upregulates the promoter conformation of p53 in a proliferation-independent manner coincident with a decreased expression of Bax: potential mechanisms for survival enhancing effects. Blood. vol 90. issue 11. 1997-12-23. PMID:9373250. |
in an effort to elucidate the mechanisms through which tpo suppresses apoptosis, we investigated the effects of tpo treatment on p53-mediated apoptosis in m07e cells. |
1997-12-23 |
2023-08-12 |
human |
| G Zauli, M Vitale, E Falcieri, D Gibellini, A Bassini, C Celeghini, M Columbaro, S Capitan. In vitro senescence and apoptotic cell death of human megakaryocytes. Blood. vol 90. issue 6. 1997-10-20. PMID:9310474. |
the addition of tpo but not interleukin-3 or erythropoietin showed some protection of alpha(iib)beta3+ cells from apoptosis at early culture times (days 2 to 4), but it did not show any significant effect at later time points. |
1997-10-20 |
2023-08-12 |
human |
| G Zauli, M Vitale, E Falcieri, D Gibellini, A Bassini, C Celeghini, M Columbaro, S Capitan. In vitro senescence and apoptotic cell death of human megakaryocytes. Blood. vol 90. issue 6. 1997-10-20. PMID:9310474. |
these findings suggest that the terminal phase of the megakaryocyte life span is characterized by the onset of apoptosis, which can be modulated only to a certain extent by tpo. |
1997-10-20 |
2023-08-12 |
human |
| O J Borge, V Ramsfjell, L Cui, S E Jacobse. Ability of early acting cytokines to directly promote survival and suppress apoptosis of human primitive CD34+CD38- bone marrow cells with multilineage potential at the single-cell level: key role of thrombopoietin. Blood. vol 90. issue 6. 1997-10-20. PMID:9310479. |
finally, tpo suppressed apoptosis of cd34+cd38- cells in culture. |
1997-10-20 |
2023-08-12 |
human |
| M Z Ratajczak, J Ratajczak, W Marlicz, C H Pletcher, B Machalinski, J Moore, H Hung, A M Gewirt. Recombinant human thrombopoietin (TPO) stimulates erythropoiesis by inhibiting erythroid progenitor cell apoptosis. British journal of haematology. vol 98. issue 1. 1997-09-03. PMID:9233556. |
recombinant human thrombopoietin (tpo) stimulates erythropoiesis by inhibiting erythroid progenitor cell apoptosis. |
1997-09-03 |
2023-08-12 |
human |
| O J Borge, V Ramsfjell, O P Veiby, M J Murphy, S Lok, S E Jacobse. Thrombopoietin, but not erythropoietin promotes viability and inhibits apoptosis of multipotent murine hematopoietic progenitor cells in vitro. Blood. vol 88. issue 8. 1996-12-02. PMID:8874182. |
finally, the dna strand breakage elongation assay showed that tpo inhibits apoptosis of lin-sca-1+ bone marrow cells. |
1996-12-02 |
2023-08-12 |
Not clear |
| O J Borge, V Ramsfjell, O P Veiby, M J Murphy, S Lok, S E Jacobse. Thrombopoietin, but not erythropoietin promotes viability and inhibits apoptosis of multipotent murine hematopoietic progenitor cells in vitro. Blood. vol 88. issue 8. 1996-12-02. PMID:8874182. |
thus, tpo has a potent ability to promote the viability and suppress apoptosis of primitive multipotent progenitor cells. |
1996-12-02 |
2023-08-12 |
Not clear |
| A Ritchie, S Vadhan-Raj, H E Broxmeye. Thrombopoietin suppresses apoptosis and behaves as a survival factor for the human growth factor-dependent cell line, M07e. Stem cells (Dayton, Ohio). vol 14. issue 3. 1996-10-29. PMID:8724699. |
tpo suppresses growth factor withdrawal-induced apoptosis as evaluated by flow cytometric detection of both in situ terminal deoxynucleotidyl transferase-mediated dutp nick end-labeling and cellular dna content via propidium iodide staining. |
1996-10-29 |
2023-08-12 |
human |