| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ferhat Sirinyildiz, Simge Una. N-methyl-D-aspartate receptors and thymoquinone induce apoptosis and alteration in mitochondria in colorectal cancer cells. Medical oncology (Northwood, London, England). vol 41. issue 5. 2024-04-23. PMID:38652404. |
apoptosis and mitochondrial dysfunctions induced by low and high doses of tq and mk-801. |
2024-04-23 |
2024-04-26 |
Not clear |
| Bo Pan, Lianlian Xu, Jianjun Weng, Yuting Wang, Hongyan Ji, Bing Han, Xiaoli Zhu, Yanqing Li. Effects of icariin on alleviating schizophrenia-like symptoms by regulating the miR-144-3p/ATP1B2/mTOR signalling pathway. Neuroscience letters. 2022-10-19. PMID:36261079. |
furthermore, brain grey matter atrophy, cytotoxicity, and cell apoptosis caused by mk-801 can be eliminated by icariin. |
2022-10-19 |
2023-08-14 |
rat |
| Andrei-Nicolae Vasilescu, Anne Mallien, Natascha Pfeiffer, Undine E Lang, Peter Gass, Dragos Int. Rapastinel alleviates the neurotoxic effect induced by NMDA receptor blockade in the early postnatal mouse brain. European archives of psychiatry and clinical neuroscience. vol 271. issue 8. 2021-11-03. PMID:32789675. |
here we found a remarkable neuroprotective effect of rapastinel against apoptosis induced by the nmdar antagonist mk-801 in comparison to that elicited by clozapine and the mglu2/3 agonist ly354740. |
2021-11-03 |
2023-08-13 |
mouse |
| Qiang Zhang, Yang Shao, Changsong Zhao, Juan Cai, Sheng Su. N-methyl-D-aspartate receptor antagonist MK-801 prevents apoptosis in rats that have undergone fetal spinal cord transplantation following spinal hemisection. Experimental and therapeutic medicine. vol 8. issue 6. 2021-10-21. PMID:25371724. |
n-methyl-d-aspartate receptor antagonist mk-801 prevents apoptosis in rats that have undergone fetal spinal cord transplantation following spinal hemisection. |
2021-10-21 |
2023-08-13 |
rat |
| Qiang Zhang, Yang Shao, Changsong Zhao, Juan Cai, Sheng Su. N-methyl-D-aspartate receptor antagonist MK-801 prevents apoptosis in rats that have undergone fetal spinal cord transplantation following spinal hemisection. Experimental and therapeutic medicine. vol 8. issue 6. 2021-10-21. PMID:25371724. |
in this study, the effect of mk-801 on the apoptosis of spinal cord neurons in rats that have received a fetal spinal cord (fsc) transplant following spinal hemisection was investigated. |
2021-10-21 |
2023-08-13 |
rat |
| Qiang Zhang, Yang Shao, Changsong Zhao, Juan Cai, Sheng Su. N-methyl-D-aspartate receptor antagonist MK-801 prevents apoptosis in rats that have undergone fetal spinal cord transplantation following spinal hemisection. Experimental and therapeutic medicine. vol 8. issue 6. 2021-10-21. PMID:25371724. |
this indicates that treatment with the nmda receptor antagonist mk-801 prevents apoptosis in the spinal cord neurons of rats that have undergone fsc transplantation following spinal hemisection. |
2021-10-21 |
2023-08-13 |
rat |
| Hao Zhu, Yu Yang, Min Zhu, Xiao Shi, Le Ye, Song Zhang, Hongwei Fang, Wenjuan Y. Alteration in the expression of inflammatory cytokines in primary hippocampal astrocytes in response to MK-801 through ERK1/2 and PI3K signals. Cytokine. vol 138. 2021-07-26. PMID:33187817. |
mk-801 treatment did not induce hippocampal astrocytes apoptosis or proliferation, however, mk-801 enhanced astrocytes viability. |
2021-07-26 |
2023-08-13 |
rat |
| Juan Ding, Yu Shao, Hui-Hui Zhou, Quan-Rui Ma, Yi-Wei Zhang, Yin-Xiu Ding, Yu-Qing He, Juan Li. Effect of NMDA on proliferation and apoptosis in hippocampal neural stem cells treated with MK-801. Experimental and therapeutic medicine. vol 16. issue 2. 2020-09-30. PMID:30116364. |
effect of nmda on proliferation and apoptosis in hippocampal neural stem cells treated with mk-801. |
2020-09-30 |
2023-08-13 |
Not clear |
| Jinlei Xi, Juan Liu, Shijing He, Wanyao Shen, Cizhao Wei, Ke Li, Yufeng Zhang, Jiang Yue, Zheqiong Yan. Effects of norfloxacin exposure on neurodevelopment of zebrafish (Danio rerio) embryos. Neurotoxicology. vol 72. 2020-01-06. PMID:30769002. |
the results indicated that mk-801 could rescue the upregulated cell apoptosis and disrupted balance of neuro-glial differentiation induced by norfloxacin in the brain of zebrafish embryos. |
2020-01-06 |
2023-08-13 |
zebrafish |
| R. J. Beninger, A. Jhamandas, H. Aujla, L. Xue, R. V. Dagnone, R. J. Boegman, K. Jhamanda. Neonatal exposure to the glutamate receptor antagonist MK-801: effects on locomotor activity and pre-pulse inhibition before and after sexual maturity in rats. Neurotoxicity research. vol 4. issue 5-6. 2019-11-20. PMID:12754161. |
mk-801 produced an increase in tunel staining in the hippocampus and other forebrain structures, confirming the induction of apoptosis. |
2019-11-20 |
2023-08-12 |
rat |
| Shuzhen Guo, Anna Tjärnlund-Wolf, Wenjun Deng, Emiri Tejima-Mandeville, Lauren J Lo, Changhong Xing, Ken Arai, MingMing Ning, Yiming Zhou, Eng H L. Comparative transcriptome of neurons after oxygen-glucose deprivation: Potential differences in neuroprotection versus reperfusion. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 38. issue 12. 2019-08-05. PMID:30152713. |
energetic rescue via restoration of oxygen and glucose) or z-vadfmk (to block apoptosis) or mk-801 (to block excitotoxicity). |
2019-08-05 |
2023-08-13 |
Not clear |
| Ioana Inta, Miriam A Vogt, Anne S Vogel, Markus Bettendorf, Peter Gass, Dragos Int. Minocycline exacerbates apoptotic neurodegeneration induced by the NMDA receptor antagonist MK-801 in the early postnatal mouse brain. European archives of psychiatry and clinical neuroscience. vol 266. issue 7. 2017-02-13. PMID:26482736. |
here we tested, if minocycline protects also against apoptosis triggered by the nmdar antagonist mk-801 at postnatal day 7. |
2017-02-13 |
2023-08-13 |
mouse |
| Hongbin Fan, Xiaoquan Li, Wei Wang, Qingwei Lai, Xiaohong Tang, Dianshuai Gao, Xiaoxing Yin, Tiejun X. Effects of NMDA-Receptor Antagonist on the Expressions of Bcl-2 and Bax in the Subventricular Zone of Neonatal Rats with Hypoxia-Ischemia Brain Damage. Cell biochemistry and biophysics. vol 73. issue 2. 2017-01-19. PMID:27352318. |
the effects of intraperitoneal injections of different drugs, namely mk-801 (0.5 mg/kg), nvp-aam077 (5 mg/kg), and ro25-6981 (5 mg/kg), on the expressions of anti-apoptotic protein bcl-2 and apoptosis protein bax in the subventricular zone were analyzed by immunohistochemical staining to explore the roles of nmda subunits (nr2a and nr2b) in hypoxic-ischemic. |
2017-01-19 |
2023-08-13 |
rat |
| Qianfa Long, Cairui Fan, Wang Kai, Qiang Luo, Weichuan Xin, Ping Wang, Ansheng Wang, Zhanyao Wang, Rui Han, Zhou Fei, Bensheng Qiu, Weiping Li. Hypoxia inducible factor-1α expression is associated with hippocampal apoptosis during epileptogenesis. Brain research. vol 1590. 2015-07-09. PMID:25242614. |
the results showed that the administration of mk-801 significantly reduced (p<0.05) hif-1α expression and hippocampal apoptosis during epileptogenesis in comparison with the positive control. |
2015-07-09 |
2023-08-13 |
rat |
| Claudia Alva-Sanchez, Adair Rodriguez, Ivan Villanueva, Brenda Anguiano, Carmen Aceves, Jorge Pacheco-Rosad. The NMDA receptor antagonist MK-801 abolishes the increase in both p53 and Bax/Bcl2 index induced by adult-onset hypothyroidism in rat. Acta neurobiologiae experimentalis. vol 74. issue 1. 2015-04-06. PMID:24718050. |
in this work we measured the expression of specific proteins that control cell proliferation (cycline-d1), cell arrest (p21), damage (p53) or apoptosis (bax and bcl2) in the hippocampus of hypothyroid rats treated with the nmda receptor (nmdar) blocker mk-801 during the induction of hypothyroidism. |
2015-04-06 |
2023-08-13 |
rat |
| Juan M Lima-Ojeda, Miriam A Vogt, Natascha Pfeiffer, Christof Dormann, Georg Köhr, Rolf Sprengel, Peter Gass, Dragos Int. Pharmacological blockade of GluN2B-containing NMDA receptors induces antidepressant-like effects lacking psychotomimetic action and neurotoxicity in the perinatal and adult rodent brain. Progress in neuro-psychopharmacology & biological psychiatry. vol 45. 2014-02-26. PMID:23643674. |
moreover, early in the development mk-801 triggers widespread cortical apoptosis, inducing extensive caspase-3 expression. |
2014-02-26 |
2023-08-12 |
rat |
| Hongjun Xiao, Chen Yang, Yuanyuan He, Na Zhen. Neurotoxicity of quinolinic acid to spiral ganglion cells in rats. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 30. issue 3. 2013-01-24. PMID:20556589. |
apoptosis rate in qa injury group was higher than that in blank control group and mgcl2 protection group (both p<0.05), but there was no significant difference between mk-801 treatment group and blank control group (p>0.05). |
2013-01-24 |
2023-08-12 |
rat |
| Bin Xu, Zhao-Fa Xu, Yu Deng, Wei Liu, Hai-Bo Yang, Yan-Gang We. Protective effects of MK-801 on methylmercury-induced neuronal injury in rat cerebral cortex: involvement of oxidative stress and glutamate metabolism dysfunction. Toxicology. vol 300. issue 3. 2012-10-05. PMID:22722016. |
in addition, pretreatment with mk-801 significantly alleviated the neurocyte apoptosis rate and histopathological damage. |
2012-10-05 |
2023-08-12 |
rat |
| Dragos Inta, Dragana Filipovic, Juan M Lima-Ojeda, Christof Dormann, Natascha Pfeiffer, Fabrizio Gasparini, Peter Gas. The mGlu5 receptor antagonist MPEP activates specific stress-related brain regions and lacks neurotoxic effects of the NMDA receptor antagonist MK-801: significance for the use as anxiolytic/antidepressant drug. Neuropharmacology. vol 62. issue 5-6. 2012-07-23. PMID:22261382. |
moreover, mpep does not elicit to the same extent as mk-801 apoptosis in cortical areas at perinatal stages, as revealed by caspase 3 expression. |
2012-07-23 |
2023-08-12 |
Not clear |
| Simon M Manning, Griffin Boll, Erin Fitzgerald, Debra B Selip, Joseph J Volpe, Frances E Jense. The clinically available NMDA receptor antagonist, memantine, exhibits relative safety in the developing rat brain. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 29. issue 7. 2012-03-19. PMID:21624454. |
however, the antagonist dizocilpine (mk-801) has been reported to increase constitutive neuronal apoptosis in the developing rat brain, limiting its clinical use in the developing brain. |
2012-03-19 |
2023-08-12 |
rat |