| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B J Snider, J L Moss, F J Revilla, C-S Lee, V C Wheeler, M E Macdonald, D W Cho. Neocortical neurons cultured from mice with expanded CAG repeats in the huntingtin gene: unaltered vulnerability to excitotoxins and other insults. Neuroscience. vol 120. issue 3. 2003-12-04. PMID:12895502. |
these neurons also exhibited similar vulnerability to oxidative stress (24 h exposure to 10-100 microm paraquat or 1-10 microm menadione), apoptosis (48 h exposure to 30-100 nm staurosporine or 1 microm dizocilpine maleate (mk-801) and proteasome inhibition (48 h exposure to 0.3-3 microm mg-132). |
2003-12-04 |
2023-08-12 |
mouse |
| Ian S Hitchcock, Timothy M Skerry, Martin R Howard, Paul G Geneve. NMDA receptor-mediated regulation of human megakaryocytopoiesis. Blood. vol 102. issue 4. 2003-09-11. PMID:12649130. |
in functional studies, addition of a selective nmda receptor antagonist, mk-801 inhibited proplatelet formation, without affecting proliferation or apoptosis. |
2003-09-11 |
2023-08-12 |
mouse |
| Zhen Pang, Vimala Bondada, Tomoko Sengoku, Robert Siman, James W Gedde. Calpain facilitates the neuron death induced by 3-nitropropionic acid and contributes to the necrotic morphology. Journal of neuropathology and experimental neurology. vol 62. issue 6. 2003-07-16. PMID:12834108. |
similar to mk-801, calpain inhibitors (z-val-phe.h and z-leu-phe-conhet) shifted the cell death morphology towards apoptosis and delayed, but did not prevent, the 3np-induced cell death. |
2003-07-16 |
2023-08-12 |
rat |
| Rei-Cheng Yang, Huei-Chuan Shih, Hseng-Kuang Hsu, Hwei-Chiu Chang, Chin Hs. Estradiol enhances the neurotoxicity of glutamate in GT1-7 cells through an estrogen receptor-dependent mechanism. Neurotoxicology. vol 24. issue 1. 2003-03-21. PMID:12564383. |
the results showed that: (1) estradiol (10 nm, incubated for 3 days) significantly enhanced the glutamate-induced neuronal death; (2) the percentages of necrosis and apoptosis were elevated after glutamate treatment, and estradiol significantly enhanced the glutamate-induced cell death; (3) glutamate-induced dna fragmentation was enhanced by e2-pretreatment; (4) the induction of cell death and increase of ldh efflux after glutamate treatment were also enhanced by e2-pretreatment; (5) both the tamoxifen and ici 182,780 abolished the estradiol-enhanced nmdar expression and neurotoxicity of glutamate; (6) higher dose of mk-801 (2 microm) was needed in e2-pretreated cells than in non-e2-pretreated group to block the glutamate-induced neurotoxicity. |
2003-03-21 |
2023-08-12 |
Not clear |
| Pei I Ho, Daniela Ortiz, Eugene Rogers, Thomas B She. Multiple aspects of homocysteine neurotoxicity: glutamate excitotoxicity, kinase hyperactivation and DNA damage. Journal of neuroscience research. vol 70. issue 5. 2003-01-23. PMID:12424737. |
the nmda channel antagonist mk-801 reduced tau phosphorylation but not apoptosis after hc treatment, suggesting that hc-mediated apoptosis was not due to calcium influx. |
2003-01-23 |
2023-08-12 |
Not clear |
| Ramanjit Gill, Marc Soriano, Klas Blomgren, Henrik Hagberg, Remy Wybrecht, Marie-Therese Miss, Sandra Hoefer, Geo Adam, Olivier Niederhauser, John A Kemp, Hansruedi Loetsche. Role of caspase-3 activation in cerebral ischemia-induced neurodegeneration in adult and neonatal brain. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 22. issue 4. 2002-05-09. PMID:11919513. |
furthermore, in postnatal-day-7 animals treated with mk-801, in which it has been suggested that excessive apoptosis is induced, the authors were unable to detect activation of devdase activity but were able to induce it in vitro by the addition of cytochrome c/datp and ca2+ to the cytosolic fraction. |
2002-05-09 |
2023-08-12 |
rat |
| H K Hsu, R C Yang, H C Shih, Y L Hsieh, U Y Chen, C Hs. Prenatal exposure of testosterone prevents SDN-POA neurons of postnatal male rats from apoptosis through NMDA receptor. Journal of neurophysiology. vol 86. issue 5. 2002-02-06. PMID:11698527. |
in addition, a noncompetitive antagonist of nmda receptor, mk-801, was used to find out whether blockage of nmda receptor affects the naturally occurring apoptosis in sdn-poa. |
2002-02-06 |
2023-08-12 |
rat |
| S F Giardina, P M Bear. Excitotoxic profiles of novel, low-affinity kainate receptor agonists in primary cultures of murine cerebellar granule cells. Neuropharmacology. vol 41. issue 4. 2001-11-01. PMID:11543762. |
iw exposure resulted in apoptosis at lower concentrations (<30 microm) and necrosis at higher concentrations, both of which were attenuated by cnqx (50 microm), but not mk-801 (10 microm). |
2001-11-01 |
2023-08-12 |
Not clear |
| G T Whiteside, R Munglan. Cell death in the superficial dorsal horn in a model of neuropathic pain. Journal of neuroscience research. vol 64. issue 2. 2001-07-12. PMID:11288144. |
preemptive treatment with mk-801 reduced the extent of apoptosis resulting from cci to the level seen in control animals. |
2001-07-12 |
2023-08-12 |
rat |
| G T Whiteside, R Munglan. Cell death in the superficial dorsal horn in a model of neuropathic pain. Journal of neuroscience research. vol 64. issue 2. 2001-07-12. PMID:11288144. |
furthermore, mk-801 prevents the onset of hyperalgesia and reduces the extent of apoptotic cell death, suggesting, perhaps, that apoptosis contributes to the initiation/maintenance of hyperalgesia. |
2001-07-12 |
2023-08-12 |
rat |
| R Tremblay, B Chakravarthy, K Hewitt, J Tauskela, P Morley, T Atkinson, J P Durki. Transient NMDA receptor inactivation provides long-term protection to cultured cortical neurons from a variety of death signals. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 19. 2001-02-22. PMID:11007874. |
moreover, mk-801 protected neurons from staurosporine-induced apoptosis, although caspase activation in these cells was unimpeded. |
2001-02-22 |
2023-08-12 |
Not clear |
| H H Hansen, C Ikonomidou, P Bittigau, S H Hansen, H S Hanse. Accumulation of the anandamide precursor and other N-acylethanolamine phospholipids in infant rat models of in vivo necrotic and apoptotic neuronal death. Journal of neurochemistry. vol 76. issue 1. 2001-02-08. PMID:11145976. |
to address this question, we monitored a range of cortical nape species in three infant rat models of in vivo neurodegeneration: (i) necrosis caused by intrastriatal injection of nmda (25 nmol); (ii) apoptosis induced by systemic administration of the nmda-receptor antagonist (+)mk-801 (3 x 0.5 mg/kg, i.p. |
2001-02-08 |
2023-08-12 |
rat |
| G W Kim, J C Copin, M Kawase, S F Chen, S Sato, G T Gobbel, P H Cha. Excitotoxicity is required for induction of oxidative stress and apoptosis in mouse striatum by the mitochondrial toxin, 3-nitropropionic acid. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 20. issue 1. 2000-01-13. PMID:10616800. |
also, the n-methyl-d-aspartate (nmda) receptor antagonist, mk-801, prevented apoptosis in the striatum after 3-np treatment for 5 days, whereas the non-nmda receptor antagonist, 2,3-dihydroxy-6-nitro-7-sulphamoyl-benzo(f)quinoxaline, was ineffective. |
2000-01-13 |
2023-08-12 |
mouse |
| J S Noh, E Y Kim, J S Kang, H R Kim, Y J Oh, B J Gwa. Neurotoxic and neuroprotective actions of catecholamines in cortical neurons. Experimental neurology. vol 159. issue 1. 1999-10-07. PMID:10486189. |
while treatment with 100 microm n-acetyl-l-cysteine attenuated da neurotoxicity, neither the glutamate antagonists (10 microm mk-801 plus 50 microm cnqx) nor several antioxidants [trolox, 100 microm; mn (iii) tetrakis (4-benzoic acid) porphyrin chloride, 100 microm; mn (iii) tetrakis (1-methyl-4-pyridyl) prophyrin pentachloride, 100 microm; n-tert-butyl-alpha-phenylnitrone, 3 mm] prevented the ca-induced apoptosis. |
1999-10-07 |
2023-08-12 |
mouse |
| F Ogden, M A DeCoster, N G Baza. Recombinant plasma-type platelet-activating factor acetylhydrolase attenuates NMDA-induced hippocampal neuronal apoptosis. Journal of neuroscience research. vol 53. issue 6. 1998-12-22. PMID:9753196. |
the noncompetitive nmda receptor antagonist mk-801(300 nm) completely inhibited apoptosis caused by nmda. |
1998-12-22 |
2023-08-12 |
Not clear |
| M Endres, S Namura, M Shimizu-Sasamata, C Waeber, L Zhang, T Gómez-Isla, B T Hyman, M A Moskowit. Attenuation of delayed neuronal death after mild focal ischemia in mice by inhibition of the caspase family. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 18. issue 3. 1998-03-26. PMID:9498840. |
despite a decrease in infarct size after mk-801 pretreatment, the amount of dna laddering did not decrease 72 hours after reperfusion, thereby suggesting a mechanism distinct from inhibition of apoptosis. |
1998-03-26 |
2023-08-12 |
mouse |
| P Lies. Ethanol-exposed central neurons fail to migrate and undergo apoptosis. Journal of neuroscience research. vol 48. issue 5. 1997-07-28. PMID:9185667. |
these results imply that ethanol-treated granule neurons resemble the granule neurons of the homozygous weaver mouse cerebellum with respect to their apoptosis, laminin expression, and partial rescue by approtinin and mk-801. |
1997-07-28 |
2023-08-12 |
mouse |
| W W Lin, C W Wang, D M Chuan. Effects of depolarization and NMDA antagonists on the role survival of cerebellar granule cells: a pivotal role for protein kinase C isoforms. Journal of neurochemistry. vol 68. issue 6. 1997-06-17. PMID:9166755. |
the nmda receptor antagonists mk-801 and 2-amino-5-phosphopentanoic acid markedly prevented the age-induced apoptosis of cgcs, and the cells survived >18 div under these conditions. |
1997-06-17 |
2023-08-12 |
Not clear |
| E Bonfoco, M Leist, B Zhivotovsky, S Orrenius, S A Lipton, P Nicoter. Cytoskeletal breakdown and apoptosis elicited by NO donors in cerebellar granule cells require NMDA receptor activation. Journal of neurochemistry. vol 67. issue 6. 1996-12-23. PMID:8931482. |
competitive and uncompetitive nmda receptor antagonists, such as d-aminophosphonovaleric acid and mk-801, did not influence tyrosine nitration but prevented the accumulation of intracellular ca2+, cytoskeletal breakdown, and apoptosis induced by either snoc or snap in cgcs. |
1996-12-23 |
2023-08-12 |
Not clear |
| E Bonfoco, S Ceccatelli, L Manzo, P Nicoter. Colchicine induces apoptosis in cerebellar granule cells. Experimental cell research. vol 218. issue 1. 1995-06-05. PMID:7537689. |
in contrast, pretreatment with the n-methyl-d-aspartate receptor-antagonist, mk-801, or l-type ca2+ channel blockers did not prevent colchicine-induced cgc apoptosis. |
1995-06-05 |
2023-08-12 |
rat |