| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Simon M Manning, Griffin Boll, Erin Fitzgerald, Debra B Selip, Joseph J Volpe, Frances E Jense. The clinically available NMDA receptor antagonist, memantine, exhibits relative safety in the developing rat brain. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 29. issue 7. 2012-03-19. PMID:21624454. |
to further evaluate the safety of memantine in the developing brain, we demonstrate here that, in contrast to mk-801, memantine at neuroprotective doses does not increase neuronal constitutive apoptosis. |
2012-03-19 |
2023-08-12 |
rat |
| Ortrud Uckermann, Hella Luksch, Vanya Stefovska, Yvonne Hoehna, Jenny Marzahn, Marlen Theil, Mila Pesic, Tomasz Górkiewicz, Maciej Gawlak, Grzegorz M Wilczynski, Leszek Kaczmarek, Chrysanthy Ikonomido. Matrix metalloproteinases 2 and 9 fail to influence drug-induced neuroapoptosis in developing rat brain. Neurotoxicity research. vol 19. issue 4. 2012-01-20. PMID:20661683. |
the aim of the present study was to investigate potential involvement of selected mmps in the pathogenesis of neuronal apoptosis induced by the nmda antagonist mk-801 (dizocilpine) or the gaba(a) agonist phenobarbital in infant rats, transgenic rats overexpressing mmp-9 and mmp-9 knockout mice. |
2012-01-20 |
2023-08-12 |
mouse |
| Bin Xu, Zhao-Fa Xu, Yu Den. Protective effects of MK-801 on manganese-induced glutamate metabolism disorder in rat striatum. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 62. issue 4. 2010-12-10. PMID:19540097. |
in addition, pre-treatment with mk-801 significantly reduced the striatum cell apoptosis rate. |
2010-12-10 |
2023-08-12 |
rat |
| X Di, J Yan, Y Zhao, J Zhang, Z Shi, Y Chang, B Zha. L-theanine protects the APP (Swedish mutation) transgenic SH-SY5Y cell against glutamate-induced excitotoxicity via inhibition of the NMDA receptor pathway. Neuroscience. vol 168. issue 3. 2010-09-21. PMID:20416364. |
additionally, l-theanine significantly attenuated l-glutamate-induced apoptosis at similar levels to those seen with the nmda receptor inhibitor mk-801 in the stably expressing app swedish mutation sh-sy5y cells which over-generated abeta. |
2010-09-21 |
2023-08-12 |
human |
| Danuta Jantas, Wladyslaw Laso. Different mechanisms of NMDA-mediated protection against neuronal apoptosis: a stimuli-dependent effect. Neurochemical research. vol 34. issue 11. 2009-11-25. PMID:19462233. |
neuroprotective effects of nmda on st-induced apoptosis in cgc were attenuated by inhibitors of erk/mapk-signaling, pd 98059 and u0126 but not by nmda receptor antagonists, ap-5 (100 microm) and mk-801 (1 microm) or by inhibitors of pi3-k/akt pathway (ly 294002 and wortmannin). |
2009-11-25 |
2023-08-12 |
human |
| Danuta Jantas, Wladyslaw Laso. Different mechanisms of NMDA-mediated protection against neuronal apoptosis: a stimuli-dependent effect. Neurochemical research. vol 34. issue 11. 2009-11-25. PMID:19462233. |
in contrast to staurosporine model of apoptosis, ap-5 and mk-801 but not inhibitors of pi3-k/akt and mapk/erk1/2 prevented the nmda-mediated neuroprotection in lp-induced apoptosis of cgc. |
2009-11-25 |
2023-08-12 |
human |
| D Jantas, M Szymanska, B Budziszewska, W Laso. An involvement of BDNF and PI3-K/Akt in the anti-apoptotic effect of memantine on staurosporine-evoked cell death in primary cortical neurons. Apoptosis : an international journal on programmed cell death. vol 14. issue 7. 2009-09-14. PMID:19521778. |
memantine (0.1-2 mum) suppressed neuronal apoptosis evoked by staurosporine in 7 div cortical neurons, whereas other antagonists of nmda receptor, mk-801 (1 mum) and ap-5 (100 mum) were ineffective. |
2009-09-14 |
2023-08-12 |
Not clear |
| Serena Santucci, Nicole Zsürger, Joëlle Chabr. beta-N-methylamino-L-alanine induced in vivo retinal cell death. Journal of neurochemistry. vol 109. issue 3. 2009-06-09. PMID:19309437. |
co-injection with the specific nmda antagonist, mk-801, significantly protected the retinal neurons from l-bmaa/nmda-induced apoptosis. |
2009-06-09 |
2023-08-12 |
mouse |
| Jocelyn C Leung, Natalie Ragland, Tara Marphis, Douglas M Silverstei. NMDA agonists and antagonists induce renal culture cell toxicity. Medicinal chemistry (Shariqah (United Arab Emirates)). vol 4. issue 6. 2009-01-26. PMID:18991741. |
exposure of cells to the non-competitive nmdar blocker mk-801 or the competitive nmdar antagonist cpp induced a time and dose-dependent increase in cell death and apoptosis. |
2009-01-26 |
2023-08-12 |
cattle |
| Tomohiro Abekawa, Koki Ito, Shin Nakagawa, Yasuya Nakato, Tsukasa Koyam. Olanzapine and risperidone block a high dose of methamphetamine-induced schizophrenia-like behavioral abnormalities and accompanied apoptosis in the medial prefrontal cortex. Schizophrenia research. vol 101. issue 1-3. 2008-08-13. PMID:18262394. |
this study aims to propose a comprehensive new model for schizophrenia, which shows ppi disruption at baseline state as an endophenotype, the development of cross-sensitization to an nmda receptor antagonist, mk-801 as a clinical phenotype of the progression into treatment-resistance, and accompanied induction of apoptosis in the medial prefrontal cortex as a critical possibility during the progression. |
2008-08-13 |
2023-08-12 |
Not clear |
| Hongjun Fu, Juan Dou, Wenming Li, Jialie Luo, Kenny C Li, Colin S C Lam, Nelson T K Lee, Mingtao Li, Yifan Ha. Mecamylamine prevents neuronal apoptosis induced by glutamate and low potassium via differential anticholinergic-independent mechanisms. Neuropharmacology. vol 54. issue 4. 2008-06-12. PMID:18222492. |
our results suggest that mecamylamine prevents glutamate-induced apoptosis by blocking nmda receptors at the mk-801 site and lk-induced apoptosis by inhibiting the activation of the jnk/c-jun pathway. |
2008-06-12 |
2023-08-12 |
Not clear |
| Linda Klimaviciusa, Dzhamilja Safiulina, Allen Kaasik, Vija Klusa, Alexander Zharkovsk. The effects of glutamate receptor antagonists on cerebellar granule cell survival and development. Neurotoxicology. vol 29. issue 1. 2008-05-02. PMID:17981335. |
in conclusion, the results of the present study demonstrate that only nonselective channel blocker mk-801 decreases cell viability, induces apoptosis and inhibits neurite outgrowth of cgc in a development-dependent manner. |
2008-05-02 |
2023-08-12 |
Not clear |
| Gennaro Giordano, Collin C White, Isaac Mohar, Terrance J Kavanagh, Lucio G Cost. Glutathione levels modulate domoic acid induced apoptosis in mouse cerebellar granule cells. Toxicological sciences : an official journal of the Society of Toxicology. vol 100. issue 2. 2007-12-20. PMID:17804861. |
the ampa (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid)/kainate receptor antagonist 2,3-dihydroxy-6-nitro-sulfamoylbenzo [f] quinoxaline, but not the n-methyl-d-aspartate receptor antagonist mk-801, prevented domoic acid-induced apoptosis. |
2007-12-20 |
2023-08-12 |
mouse |
| Tzu-Ying Lee, Ke-Li Tsai, Wen-Sen Lee, Chin Hs. The molecular events occur during MK-801-induced cytochrome oxidase subunit II down-regulation in GT1-7 cells. Journal of molecular endocrinology. vol 39. issue 1. 2007-09-14. PMID:17601885. |
blocking of the nmda receptor by dizocilpine ((+)-5-methyl-10,11-dihydro-5h-dibenzo[a,d] cyclohepten-5,10-iminemaleate (mk-801) causes down-regulation of some survival-related genes including cytochrome oxidase subunit ii (coii), a mitochondria-encoded complex iv subunit, which in turn induces atp depletion and the occurrence of apoptosis. |
2007-09-14 |
2023-08-12 |
rat |
| Tzu-Ying Lee, Ke-Li Tsai, Wen-Sen Lee, Chin Hs. The molecular events occur during MK-801-induced cytochrome oxidase subunit II down-regulation in GT1-7 cells. Journal of molecular endocrinology. vol 39. issue 1. 2007-09-14. PMID:17601885. |
treatment of the gnrh cell line (gt1-7) with mk-801 caused 1) a decrease of intracellular calcium concentration ([ca2+]i) after 20 h; 2) significant decreases of the levels of peroxisome proliferator-activated receptor coactivator-1 (pgc-1) mrna and protein after 24 h; 3) down-regulation of coii mrna after 36 h; and 4) the occurrence of neuronal apoptosis after 48 h. accordingly, we hypothesize that blocking of the nmda receptor may cause a decrease of the [ca2+]i, which in turn inhibits the expressions of pgc-1 and coii and then leads to subsequent neuronal apoptosis. |
2007-09-14 |
2023-08-12 |
rat |
| Maria Hernández, Inmaculada Guerrikagoitia, Luis Martínez-Millan, Elena Vecin. NMDA-receptor blockade enhances cell apoptosis in the developing retina of the postnatal rat. The International journal of developmental biology. vol 51. issue 2. 2007-07-27. PMID:17294362. |
with a view to evaluating if nmda glutamate receptors participate in the regulation of apoptosis which occurs during the development of the rat retina, we subcutaneously injected the nmda receptor antagonist mk-801 into rats at different stages of early postnatal development (p2 to p9). |
2007-07-27 |
2023-08-12 |
human |
| Xuan Wu, Feng Tian, Peter Okagaki, Ann M Marin. Inhibition of N-methyl-D-aspartate receptors increases paraoxon-induced apoptosis in cultured neurons. Toxicology and applied pharmacology. vol 208. issue 1. 2006-05-04. PMID:16164961. |
mk-801 increases, whereas nmda blocks paraoxon-induced apoptosis and paraoxon-stimulated caspase-3 activity. |
2006-05-04 |
2023-08-12 |
rat |
| Erik Hankø, Thor W D Hansen, Runar Almaas, Ragnhild Paulsen, Terje Rootwel. Synergistic protection of a general caspase inhibitor and MK-801 in bilirubin-induced cell death in human NT2-N neurons. Pediatric research. vol 59. issue 1. 2006-02-01. PMID:16326984. |
to investigate the role of caspases and excitotoxicity in ucb-induced cell death, we exposed nt2-n neurons to 5 microm ucb (a concentration known to induce apoptosis) or 2 microm staurosporine (positive apoptosis control) and investigated the effects of treatments with the specific caspase-3 inhibitor, zdevd.fmk (20 and 100 microm), or the general caspase inhibitor, zvad.fmk (20 and 100 microm), and/or the n-methyl-d-aspartate (nmda) receptor antagonist mk-801 (10 microm) during a 24- or 48-h exposure. |
2006-02-01 |
2023-08-12 |
human |
| V B Morhenn, M Murakami, T O'Grady, J Nordberg, R L Gall. Characterization of the expression and function of N-methyl-D-aspartate receptor in keratinocytes. Experimental dermatology. vol 13. issue 8. 2005-01-13. PMID:15265015. |
incubation of cultured, human kcs with mk-801 decreases the cell growth and induces an increase in apoptosis. |
2005-01-13 |
2023-08-12 |
human |
| Andrés Jiménez, Elvira G Jordà, Ester Verdaguer, David Pubill, Francesc X Sureda, Anna M Canudas, Elena Escubedo, Jordi Camarasa, Antoni Camins, Mercè Pallà. Neurotoxicity of amphetamine derivatives is mediated by caspase pathway activation in rat cerebellar granule cells. Toxicology and applied pharmacology. vol 196. issue 2. 2004-05-19. PMID:15081269. |
apoptosis was reverted by the presence of z.vad.fmk (100 microm) but not by 10 microm mk-801 or nbqx. |
2004-05-19 |
2023-08-12 |
rat |