| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tao Wen, Jing Wen, Cuicui Ya. Remimazolam inhibits postoperative cognitive impairment after cardiopulmonary bypass by alleviating neuroinflammation and promoting microglia M2 polarization. Brain research. 2024-05-03. PMID:38702024. |
cpb rats and lps-treated microglia showed increased apoptosis, pro-inflammatory cytokines level, and inflammasome expression as well as decreased microglia activation, while the results were reversed after remimazolam treatment. |
2024-05-03 |
2024-05-06 |
rat |
| Ying Yang, Ying Lai, Xueli Tong, Zipei Li, Yuanyuan Cheng, Li-Wen Tia. Arjunolic acid ameliorates lipopolysaccharide-induced depressive behavior by inhibiting neuroinflammation via microglial SIRT1/AMPK/Notch1 signaling pathway. Journal of ethnopharmacology. 2024-04-26. PMID:38670408. |
neuroinflammation is involved in the pathogenesis of depression disorder by activating microglia cells, increasing proinflammatory cytokines, effecting serotonin synthesis and metabolism, and neuronal apoptosis and neurogenesis. |
2024-04-26 |
2024-04-29 |
Not clear |
| Zhihua Chen, Wei Hu, Jiahong Wang, Donggen Rao, Jianming Zh. Knockdown of lncRNA AU020206 could inhibit microglia apoptosis in ischemic stroke. Cellular and molecular biology (Noisy-le-Grand, France). vol 70. issue 3. 2024-04-23. PMID:38650139. |
knockdown of lncrna au020206 could inhibit microglia apoptosis in ischemic stroke. |
2024-04-23 |
2024-04-26 |
Not clear |
| Zhihua Chen, Wei Hu, Jiahong Wang, Donggen Rao, Jianming Zh. Knockdown of lncRNA AU020206 could inhibit microglia apoptosis in ischemic stroke. Cellular and molecular biology (Noisy-le-Grand, France). vol 70. issue 3. 2024-04-23. PMID:38650139. |
knockdown of lncrna au020206 inhibited microglia apoptosis in ogd cell model. |
2024-04-23 |
2024-04-26 |
Not clear |
| Zhihua Chen, Wei Hu, Jiahong Wang, Donggen Rao, Jianming Zh. Knockdown of lncRNA AU020206 could inhibit microglia apoptosis in ischemic stroke. Cellular and molecular biology (Noisy-le-Grand, France). vol 70. issue 3. 2024-04-23. PMID:38650139. |
we constructed a lncrnas-mediated cerna network and found that lncrna au020206 inhibited microglia apoptosis in ogd cell model. |
2024-04-23 |
2024-04-26 |
Not clear |
| Hongtao Shen, Jiaao Gu, Xing Liu, Mowei Son. Small nucleolar RNA host gene 1 silence inhibits the lipopolysaccharide-induced microglial apoptosis and inflammation. Cellular and molecular biology (Noisy-le-Grand, France). vol 70. issue 3. 2024-04-23. PMID:38650136. |
this study was designed to investigate the role of small nucleolar rna host gene 1 (snhg1) on the apoptosis and inflammatory response of microglial cell bv-2 and its underlying molecular mechanism. |
2024-04-23 |
2024-04-26 |
mouse |
| Sheng-Jie Hou, Ya-Ru Huang, Jie Zhu, Ying-Bo Jia, Xiao-Yun Niu, Jin-Ju Yang, Xiao-Lin Yu, Xiao-Yu Du, Shi-Yu Liang, Fang Cui, Ling-Jie Li, Chen Tian, Rui-Tian Li. Mouse serum albumin induces neuronal apoptosis and tauopathies. Acta neuropathologica communications. vol 12. issue 1. 2024-04-23. PMID:38654316. |
overall, our study here revealed that msa induced tau phosphorylation and neuron apoptosis based on msa-activated microglia and astrocytes, respectively, showing the critical roles of msa in initiating the occurrence of tauopathies and cognitive decline, and providing potential therapeutic targets for msa-induced neuropathology in multiple neurodegenerative disorders. |
2024-04-23 |
2024-04-26 |
mouse |
| Xudong Zhou, Huiping Song, Jingjing He, Wei Han, Qin L. Deciphering microglial activation and neuronal apoptosis post‑traumatic brain injury: The role of TYROBP in inflammation regulation networks. Molecular medicine reports. vol 29. issue 6. 2024-04-19. PMID:38639190. |
activated microglia secrete cytokines, including tnf‑α, cxcl‑8 and ccl2, which trigger an inflammatory response and facilitate neuronal apoptosis. |
2024-04-19 |
2024-04-21 |
mouse |
| Xudong Zhou, Huiping Song, Jingjing He, Wei Han, Qin L. Deciphering microglial activation and neuronal apoptosis post‑traumatic brain injury: The role of TYROBP in inflammation regulation networks. Molecular medicine reports. vol 29. issue 6. 2024-04-19. PMID:38639190. |
tyrobp gene knockout in microglia was demonstrated to reduce this interaction and reduce neuronal cell apoptosis rates. |
2024-04-19 |
2024-04-21 |
mouse |
| Shuang Zhao, Guiling Mo, Qiang Wang, Jin Xu, Shihui Yu, Zhibin Huang, Wei Liu, Wenqing Zhan. Role of RB1 in neurodegenerative diseases: inhibition of post-mitotic neuronal apoptosis via Kmt5b. Cell death discovery. vol 10. issue 1. 2024-04-18. PMID:38637503. |
we showed that rb1-deficient mutants exhibit a significant hindbrain neuronal apoptosis, resulting in increased microglia infiltration. |
2024-04-18 |
2024-04-21 |
human |
| Yue Tao, Xiaodong Yi, Yanyan Gu, Rongyi Yang, Zixu Li, Xiangyong Guo, Donglin Zhao, Ying Zhan. Neurotoxicity of dibutyl phthalate in zebrafish larvae: Decreased energy acquisition by neurons. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-04-15. PMID:38621509. |
after 72 hours of exposure to dbp, microglia in the brain were over-activated, reactive oxygen species (ros) formation was increased, and apoptosis was observed. |
2024-04-15 |
2024-04-18 |
zebrafish |
| Chang Liu, Qi Yan, Xuying Ding, Meijun Zhao, Chen Chen, Qian Zheng, Huiying Yang, Yining Xi. Functional modification of recombinant brain-derived neurotrophic factor and its protective effect against neurotoxicity. International journal of biological macromolecules. 2024-04-15. PMID:38621565. |
protein characterization showed that p-tbdnf significantly improved the stability of the recombinant protein and possessed the ability to penetrate the bbb, and in cellular experiments, p-tbdnf prevented mptp-induced nerve cell oxidative stress damage, apoptosis and inflammatory response, and its mechanism of action was closely related to the activation of tyrosine kinase b (trkb) receptor and inhibition of microglia activation. |
2024-04-15 |
2024-04-18 |
mouse |
| Jie Zeng, Wei-Wei Gao, Hao Yang, Ya-Nang Wang, Yang Mei, Ting-Ting Liu, Min Wang, Li Tang, Dong-Chuan Ma, Wei L. Sodium tanshinone IIA sulfonate suppresses microglia polarization and neuroinflammation possibly via regulating miR-125b-5p/STAT3 axis to ameliorate neuropathic pain. European journal of pharmacology. 2024-03-29. PMID:38552937. |
sts pretreatment inhibited lps-stimulated pro-inflammatory cytokine secretion, reduced stat3 pathway related-proteins and apoptosis, increased mir-125b-5p and proopiomelanocortin expression, and enhanced microglia transformation from m1 to m2 phenotype in bv-2 cells. |
2024-03-29 |
2024-04-01 |
rat |
| Guopeng Chen, Yuhui Zhang, Ruiling Li, Liuyin Jin, Keke Hao, Jingtong Rong, Hao Duan, Yiwei Du, Lihua Yao, Dan Xiang, Zhongchun Li. Environmental enrichment attenuates depressive-like behavior in maternal rats by inhibiting neuroinflammation and apoptosis and promoting neuroplasticity. Neurobiology of stress. vol 30. 2024-03-25. PMID:38524250. |
maternal rats subjected to ms developed depression-like behavior and cognitive dysfunction together with evidence of significant neuroinflammation including microglia activation, neuronal apoptosis, and impaired synaptic plasticity. |
2024-03-25 |
2024-03-27 |
rat |
| Seyedeh Naghmeh Nourirad, Amhr-Hossein Bayat, Moitaba Sani, Amirreza Beirami, Maral Hasanzadeh, Susan Roustaee, Mobina Fathi, Kimia Vakili, Siavash Parvardeh, Gholam Hossein Meftahi, Nahid Sarahian, Fariba Khodagholi, Abbas Aliaghaei, Hojjat-Allah Abbaszadeh, Meysam Hassani Moghadda. Memory loss induced by lisdexamfetamine in the rat: A behavioral, electrophysiological, and histopathological Study. Behavioural brain research. 2024-03-18. PMID:38499158. |
also, in addition to an increase in expression of caspase-3 in the hippocampus, which indicates the susceptibility to apoptosis in ldx-treated rats, the number of microglia and astrocytes went up significantly in the ldx group. |
2024-03-18 |
2024-03-21 |
rat |
| Lanqing Zhao, Jinwei L. Microglial uptake of hADSCs-Exo mitigates neuroinflammation in ICH. Cellular signalling. 2024-03-18. PMID:38499232. |
in the ich mouse model, hadscs-exo significantly improved neurological function, reduced hemorrhage volume, decreased neuronal apoptosis, and regulated microglia polarization. |
2024-03-18 |
2024-03-21 |
mouse |
| Zhiwei Luan, Jingsong Liu, Mi Li, Yangyang Wang, Yansong Wan. Exosomes derived from umbilical cord-mesenchymal stem cells inhibit the NF-κB/MAPK signaling pathway and reduce the inflammatory response to promote recovery from spinal cord injury. Journal of orthopaedic surgery and research. vol 19. issue 1. 2024-03-16. PMID:38491537. |
moreover, exosomes could inhibit apoptosis and inflammatory reaction and reactive oxygen species (ros) production of bv2 microglia in vitro and in vivo. |
2024-03-16 |
2024-03-19 |
human |
| Zijian Zheng, Shushan Zhang, Xinjie Liu, Xiangrong Wang, Cheng Xue, Xiao Wu, Xinran Zhang, Xinping Xu, Zheng Liu, Longping Yao, Guohui L. LRRK2 regulates ferroptosis through the system Xc-GSH-GPX4 pathway in the neuroinflammatory mechanism of Parkinson's disease. Journal of cellular physiology. 2024-03-13. PMID:38477420. |
neuroinflammation mediated by activated microglia and apoptosis of dopaminergic (da) neurons in the midbrain are its primary pathological manifestations. |
2024-03-13 |
2024-03-15 |
mouse |
| Yuqin Peng, Qingfan Ren, Huanrong Ma, Chuman Lin, Mingjia Yu, Yongchuan Li, Jiancong Chen, Haihao Xu, Peng Zhao, Suyue Pan, Jia Tao, Kaibin Huan. Covalent organic framework based cytoprotective therapy after ischemic stroke. Redox biology. vol 71. 2024-03-05. PMID:38442647. |
this was achieved by eliminating ros, preventing neuronal loss and apoptosis, suppressing neuroinflammation, modulating microglia activation, and ameliorating blood-brain barrier (bbb) disruption. |
2024-03-05 |
2024-03-08 |
Not clear |
| Swapan K Ra. TUNEL-n-DIFL Method for Detection and Estimation of Apoptosis Specifically in Neurons and Glial Cells in Mixed Culture and Animal Models of Central Nervous System Diseases and Injuries. Methods in molecular biology (Clifton, N.J.). vol 2761. 2024-03-01. PMID:38427225. |
in situ detection and estimation of amount of apoptosis specifically in neurons or glial cells (astrocytes, oligodendrocytes, and microglia) can unveil valuable information for designing therapeutics for protection of the cns cells and functional recovery. |
2024-03-01 |
2024-03-03 |
Not clear |