| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Swapan K Ra. TUNEL-n-DIFL Method for Detection and Estimation of Apoptosis Specifically in Neurons and Glial Cells in Mixed Culture and Animal Models of Central Nervous System Diseases and Injuries. Methods in molecular biology (Clifton, N.J.). vol 2761. 2024-03-01. PMID:38427225. |
in situ detection and estimation of amount of apoptosis specifically in neurons or glial cells (astrocytes, oligodendrocytes, and microglia) can unveil valuable information for designing therapeutics for protection of the cns cells and functional recovery. |
2024-03-01 |
2024-03-03 |
Not clear |
| Swapan K Ra. TUNEL-n-DIFL Method for Detection and Estimation of Apoptosis Specifically in Neurons and Glial Cells in Mixed Culture and Animal Models of Central Nervous System Diseases and Injuries. Methods in molecular biology (Clifton, N.J.). vol 2761. 2024-03-01. PMID:38427225. |
a primary anti-neun (neurons), anti-gfap (astrocytes), anti-mbp (oligodendrocytes), or anti-ox-42 (microglia) igg antibody and a secondary igg antibody conjugated with one of the above fluorophores (other than that of ani-dig antibody) are used for in situ detection of apoptosis in a specific cns cell type in the mixed culture and animal models of the cns diseases and injuries. |
2024-03-01 |
2024-03-03 |
Not clear |
| Judong Kim, Edward Pajarillo, Asha Rizor, Deok-Soo Son, Jayden Lee, Michael Aschner, Eunsook Le. Correction: LRRK2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia. PloS one. vol 19. issue 3. 2024-03-01. PMID:38427617. |
correction: lrrk2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia. |
2024-03-01 |
2024-03-04 |
Not clear |
| Hongxia Wang, Jialiang Ma, Xiaoling Li, Yanhui Peng, Manxia Wan. FDA compound library screening Baicalin upregulates TREM2 for the treatment of cerebral ischemia-reperfusion injury. European journal of pharmacology. 2024-03-01. PMID:38428662. |
next, we established an in vivo mouse model of cerebral ischemia-reperfusion injury (mcao/r) and an in vitro microglia cell of oxygen-glucose deprivation reperfusion (ogd/r) to investigate the role of baicalin in inflammation injury, oxidative stress, and neuronal apoptosis. |
2024-03-01 |
2024-03-04 |
mouse |
| Tingting Chen, Congyao Wang, Wenhui Zhu, Fenfen Yu, Xia Dong, Yihua Su, Jingwen Huang, Lijun Huo, Pengxia Wa. mm9_circ_014683 regulates microglia polarization through canonical NFκB signaling pathway in diabetic retinopathy. Cellular signalling. 2024-02-28. PMID:38417635. |
inhibiting or overexpressing mm9_circ_014683 showed no effect on the proliferation and apoptosis of microglia. |
2024-02-28 |
2024-03-02 |
mouse |
| Carlos Cruchaga, Muhammad Ali, Yuanyuan Shen, Anh Do, Lihua Wang, Daniel Western, Menghan Liu, Aleksandra Beric, John Budde, Jen Gentsch, Suzanne Schindler, John Morris, David Holtzman, Maria Fernández, Agustín Ruiz, Ignacio Alvarez, Miquel Aguilar, Pau Pastor, Jarod Rutledge, Hamilton Oh, Edward Wilson, Yann Le Guen, Rana Khalid, Chloe Robins, David Pulford, Laura Ibanez, Tony Wyss-Coray, Yun Ju Sun. Multi-cohort cerebrospinal fluid proteomics identifies robust molecular signatures for asymptomatic and symptomatic Alzheimer's disease. Research square. 2024-02-27. PMID:38410465. |
the associated proteins cluster in four different protein pseudo-trajectories groups spanning the ad continuum and were enrichment in specific pathways including neuronal death, apoptosis and tau phosphorylation (early stages), microglia dysregulation and endolysosomal dysfuncton(mid-stages), brain plasticity and longevity (mid-stages) and late microglia-neuron crosstalk (late stages). |
2024-02-27 |
2024-03-02 |
Not clear |
| Rui Jiang, Zhichao Lu, Chenxing Wang, WenJun Tu, Qi Yao, Jiabing Shen, Xingjia Zhu, Ziheng Wang, Yixun Chen, Yang Yang, Kaijiang Kang, Peipei Gon. Astrocyte-derived Interleukin-31 causes poor prognosis in elderly patients with intracerebral hemorrhage. Brain pathology (Zurich, Switzerland). 2024-02-14. PMID:38354695. |
the activation of astrocytes after ich releases a large amount of il31, which binds to microglia through il31r, causing a large number of microglia to converge to the hematoma area, leading to the spread of neuroinflammation, apoptosis of neurons, and ultimately resulting in poorer recovery of nerve function. |
2024-02-14 |
2024-02-17 |
human |
| Zifu Li, Tianxiang Gao, Jing Wang, Xiaoxi Zhang, Yongxin Zhang, Lei Zhang, Pengfei Yang, Jianmin Li. Ferroptosis mediated by TNFSF9 interferes in acute ischaemic stroke reperfusion injury with the progression of acute ischaemic stroke. Journal of neurochemistry. 2024-02-12. PMID:38344886. |
we first examined tnfsf9 changes in peripheral blood from stroke patients with successful reperfusion, and constructed oxygen-glucose deprivation-reperfusion (ogd-r) on bv2 microglia, oxygen-glucose deprivation for 6 h followed by reoxygenation and re-glucose for 24 h, and appropriate over-expression or knockdown of tnfsf9 manipulation on bv2 cells and found that in the case of bv2 cells encountering ogd-r over-expression of tnfsf9 resulted in increased bv2 apoptosis. |
2024-02-12 |
2024-02-15 |
mouse |
| Longyu Zhang, Jiao Xu, Shi Yin, Qiang Wang, Zhiwei Jia, Tianlin We. Albiflorin Attenuates Neuroinflammation and Improves Functional Recovery After Spinal Cord Injury Through Regulating LSD1-Mediated Microglial Activation and Ferroptosis. Inflammation. 2024-02-10. PMID:38340239. |
meanwhile, af attenuated neuron apoptosis and microglia activation, reduced the production of pro-inflammatory cytokines and iron accumulation, and inhibited spinal cord ferroptosis following sci in rats. |
2024-02-10 |
2024-02-14 |
rat |
| Xingxing Wang, Changlin Xu, Cunxin Bian, Pengfei Ge, Jie Lei, Jingfan Wang, Tianhao Xiao, Yuanyuan Fan, Qinyuan Gu, Hong-Ying Li, Jingyi Xu, Zizhong Hu, Ping Xi. M2 microglia-derived exosomes promote vascular remodeling in diabetic retinopathy. Journal of nanobiotechnology. vol 22. issue 1. 2024-02-09. PMID:38336783. |
further in vivo and in vitro experiments showed that exosomes derived from m2 polarized microglia (m2-exo) could reduce pericyte apoptosis and promote endothelial cell proliferation, thereby promoting vascular remodeling and reducing vascular leakage from the diabetic retina. |
2024-02-09 |
2024-02-12 |
mouse |
| Long Peng, Xingjia Zhu, Chenxing Wang, Qiaoji Jiang, Shian Yu, Gaochao Song, Qianqian Liu, Peipei Gon. Indole-3-carbinol (I3C) reduces apoptosis and improves neurological function after cerebral ischemia-reperfusion injury by modulating microglia inflammation. Scientific reports. vol 14. issue 1. 2024-02-07. PMID:38326384. |
indole-3-carbinol (i3c) reduces apoptosis and improves neurological function after cerebral ischemia-reperfusion injury by modulating microglia inflammation. |
2024-02-07 |
2024-02-10 |
rat |
| Xu-Jia Chen, Zhou Deng, Le-Le Zhang, Yan Pan, Jia Fu, Liang Zou, Zhaofang Bai, Xiaohe Xiao, Feiya Shen. Therapeutic potential of the medicinal mushroom Ganoderma lucidum against Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 172. 2024-02-04. PMID:38310653. |
the underlying mechanisms mainly include inhibiting tau hyperphosphorylation, inhibiting aβ formation, affecting activated microglia, regulating nf-κb/mapk signalling pathway, inhibiting neuronal apoptosis, modulating immune system, and inhibiting acetylcholinesterase, etc. |
2024-02-04 |
2024-02-07 |
Not clear |
| Linyu Wu, Zixuan Tan, Lei Su, Fang Dong, Guangyu Xu, Feng Zhan. Transcutaneous electrical acupoint stimulation alleviates cerebral ischemic injury through the TLR4/MyD88/NF-κ B pathway. Frontiers in cellular neuroscience. vol 17. 2024-01-26. PMID:38273974. |
this study was to explore whether transcutaneous electrical acupoint stimulation (teas) treatment could mediate inflammation, apoptosis, and pyroptosis of neuronal cells and microglia activation through the tlr4/myd88/nf-κb pathway in the early stage of ischemic stroke. |
2024-01-26 |
2024-01-28 |
Not clear |
| Ching-Tien Lee, Kun-Der Lin, Cheng-Fang Hsieh, Jiz-Yuh Wan. SGLT2 Inhibitor Canagliflozin Alleviates High Glucose-Induced Inflammatory Toxicity in BV-2 Microglia. Biomedicines. vol 12. issue 1. 2024-01-23. PMID:38255143. |
only cana rescued bv-2 microglia from hg-induced cytotoxicity, including apoptosis or autophagic degradation. |
2024-01-23 |
2024-01-25 |
Not clear |
| Huina Ma, Hehua Huang, Chenyu Li, Shasha Li, Juefang Gan, Chunrong Lian, Yanwu Lin. The antidepressive mechanism of Longya Lilium combined with Fluoxetine in mice with depression-like behaviors. NPJ systems biology and applications. vol 10. issue 1. 2024-01-13. PMID:38218856. |
a decrease of cox-2 curtailed bv-2 microglial cell activation, inflammation, and neuron apoptosis by blunting the pge2/il-22 axis. |
2024-01-13 |
2024-01-16 |
mouse |
| Hanxiao Chang, Zheng Li, Weiwei Zhang, Chao Lin, Yuqi Shen, Guangjian Zhang, Lei Mao, Chencheng Ma, Ning Liu, Hua L. Transfer of cGAMP from neuron to microglia activates microglial type I interferon responses after subarachnoid hemorrhage. Cell communication and signaling : CCS. vol 22. issue 1. 2024-01-03. PMID:38169382. |
based on our results, the transmission of cyclic gmp-amp (cgamp) from neurons to microglia is a key molecular event that triggers type i interferon response, amplifies neuroinflammation, and leads to neuronal apoptosis. |
2024-01-03 |
2024-01-06 |
Not clear |
| Xueyan Zhao, Ziyu Wang, Jiang Wang, Fenglian Xu, Yi Zhang, Dan Han, Weirong Fan. Mesencephalic astrocyte-derived neurotrophic factor (MANF) alleviates cerebral ischemia/reperfusion injury in mice by regulating microglia polarization via A20/NF-κB pathway. International immunopharmacology. vol 127. 2023-12-22. PMID:38134597. |
microglia, resident brain immune cells, is critical in inflammation, apoptosis, neurogenesis and neurological recovery during cerebral ischemia/reperfusion (i/r) injury. |
2023-12-22 |
2023-12-25 |
mouse |
| Xingyu Yang, Ziwei Yu, Li An, Xinyue Jing, Mengqian Yuan, Tiancheng Xu, Zhi Yu, Bin Xu, Mengjiang L. Electroacupuncture stimulation ameliorates cognitive impairment induced by long-term high-fat diet by regulating microglial BDNF. Brain research. vol 1825. 2023-12-17. PMID:38103878. |
the microglia showed obvious morphological damage and apoptosis. |
2023-12-17 |
2023-12-21 |
mouse |
| Xingyu Yang, Ziwei Yu, Li An, Xinyue Jing, Mengqian Yuan, Tiancheng Xu, Zhi Yu, Bin Xu, Mengjiang L. Electroacupuncture stimulation ameliorates cognitive impairment induced by long-term high-fat diet by regulating microglial BDNF. Brain research. vol 1825. 2023-12-17. PMID:38103878. |
overexcitation of peripheral inflammasome complexes induces hippocampal microglia apoptosis, which hinders the effects of es. |
2023-12-17 |
2023-12-21 |
mouse |
| Fan Sun, Wenbing Liu, Xiaodong Li, Xiaowei Wang, Yali Ou, Xuesong Li, Min Sh. Median nerve electrical stimulation improves traumatic brain injury by reducing TACR1 to inhibit nuclear factor-κB and CCL7 activation in microglia. Histology and histopathology. 2023-12-15. PMID:38098319. |
immunofluorescence and flow cytometry assay were used to detect microglia morphology and neuron apoptosis. |
2023-12-15 |
2023-12-17 |
rat |