| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fan Sun, Wenbing Liu, Xiaodong Li, Xiaowei Wang, Yali Ou, Xuesong Li, Min Sh. Median nerve electrical stimulation improves traumatic brain injury by reducing TACR1 to inhibit nuclear factor-κB and CCL7 activation in microglia. Histology and histopathology. 2023-12-15. PMID:38098319. |
shtacr1 reversed the effects of lps on inflammation-related factors, m1/m2 microglia markers, microglia activation, neuron apoptosis, p-p65/p65 value and ccl7 level. |
2023-12-15 |
2023-12-17 |
rat |
| . Expression of Concern: LRRK2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia. PloS one. vol 18. issue 12. 2023-12-13. PMID:38091319. |
expression of concern: lrrk2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia. |
2023-12-13 |
2023-12-17 |
Not clear |
| Xin Gao, Gang Su, Miao Chai, Minghui Shen, Zhenzhen Hu, Wei Chen, Juan Gao, Ruixin Li, Tianfei Ma, Yang An, Zhenchang Zhan. Research progress on mechanisms of ischemic stroke: Regulatory pathways involving Microglia. Neurochemistry international. 2023-12-11. PMID:38081419. |
activated microglia participate in the pathological processes after stroke through polarization, autophagy, phagocytosis, pyroptosis, ferroptosis, apoptosis, and necrosis, thereby influencing the injury and repair following stroke. |
2023-12-11 |
2023-12-17 |
Not clear |
| Wei Wei, Lin Zhang, Wenqiang Xin, Yongli Pan, Lars Tatenhorst, Zhongnan Hao, Stefan T Gerner, Sabine Huber, Martin Juenemann, Marius Butz, Hagen B Huttner, Mathias Bähr, Dirk Fitzner, Feng Jia, Thorsten R Doeppne. TREM2 regulates microglial lipid droplet formation and represses post-ischemic brain injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 170. 2023-12-02. PMID:38042110. |
meanwhile, in a neuron-microglia co-culture system under hypoxic conditions, we found that microglia lost their protective effect against neuronal injury and apoptosis when trem2 was knocked down. |
2023-12-02 |
2023-12-10 |
mouse |
| Wei Wei, Lin Zhang, Wenqiang Xin, Yongli Pan, Lars Tatenhorst, Zhongnan Hao, Stefan T Gerner, Sabine Huber, Martin Juenemann, Marius Butz, Hagen B Huttner, Mathias Bähr, Dirk Fitzner, Feng Jia, Thorsten R Doeppne. TREM2 regulates microglial lipid droplet formation and represses post-ischemic brain injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 170. 2023-12-02. PMID:38042110. |
under in vivo conditions, trem2 knockdown mice express lower tgf-β1 expression levels and a lower number of anti-inflammatory m2 phenotype microglia, resulting in increased cerebral infarct size, exacerbated neuronal apoptosis, and aggravated neuronal impairment. |
2023-12-02 |
2023-12-10 |
mouse |
| Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Sing. S1PR2 inhibition mitigates cognitive deficit in diabetic mice by modulating microglial activation via Akt-p53-TIGAR pathway. International immunopharmacology. vol 126. 2023-11-27. PMID:38011768. |
jte013 rescued the palmitate-induced neuronal apoptosis by promoting the anti-inflammatory microglia. |
2023-11-27 |
2023-11-29 |
mouse |
| Madeleine J Smith, Tayla Penny, Yen Pham, Amy E Sutherland, Graham Jenkin, Michael C Fahey, Madison C B Paton, Megan Finch-Edmondson, Suzanne L Miller, Courtney A McDonal. Neuroprotective Action of Tacrolimus before and after Onset of Neonatal Hypoxic-Ischaemic Brain Injury in Rats. Cells. vol 12. issue 22. 2023-11-25. PMID:37998394. |
(3) results: all tacrolimus doses administered pre-hi significantly reduced brain infarct size and neuronal loss, increased the number of resting microglia and reduced cellular apoptosis ( |
2023-11-25 |
2023-11-28 |
rat |
| Qingmei Gong, Yanbo Wang, Xiaowei Wang, Haiyan Pan, Ci Ya. Baicalein promotes the microglia M2 polarization and suppresses apoptosis by targeting HMOX1/PDE4D to alleviate Alzheimer's disease. Immunobiology. vol 228. issue 6. 2023-11-25. PMID:38006681. |
baicalein promotes the microglia m2 polarization and suppresses apoptosis by targeting hmox1/pde4d to alleviate alzheimer's disease. |
2023-11-25 |
2023-11-28 |
mouse |
| Qingmei Gong, Yanbo Wang, Xiaowei Wang, Haiyan Pan, Ci Ya. Baicalein promotes the microglia M2 polarization and suppresses apoptosis by targeting HMOX1/PDE4D to alleviate Alzheimer's disease. Immunobiology. vol 228. issue 6. 2023-11-25. PMID:38006681. |
in cell experiments, it was verified that baicalein significantly shifted the bv-2 microglia phenotype from the pro-inflammatory m1 to the anti-inflammatory m2 phenotype, inhibited the microglial apoptosis and pro-inflammatory factors, promoted the microglial aβ uptake and anti-inflammatory factors after lps stimulated. |
2023-11-25 |
2023-11-28 |
mouse |
| Jun Ma, Hao Yin, Zhongying Ran, Tao Luo, Zexin Jin, Li Zheng, Fuyang Zhan. Knockdown of BCL-3 attenuates inflammatory response in intracerebral hemorrhage through an rBMECs/MGs microenvironment. Neuroscience. 2023-11-25. PMID:38006962. |
finally, in the ich animal model, after knockdown of bcl-3, comprehensive evaluations of inflammatory responses in brain tissue, polarization and recruitment of microglia, and apoptosis were conducted. |
2023-11-25 |
2023-11-28 |
rat |
| Jie Gao, Huiping Zhang, Leiying Zhou, Jiaqi Liu, Enba Zhuo, Yujun Shen, Xuesheng Liu, Qiying She. MANF Alleviates Sevoflurane-Induced Cognitive Impairment in Neonatal Mice by Modulating Microglial Activation and Polarization. Molecular neurobiology. 2023-11-22. PMID:37989984. |
finally, the recombinant human manf (rhmanf, 20 μg) protein was intraperitoneally administrated to neonatal mice before the sevoflurane anesthesia and the cognitive function, levels of pro-inflammatory cytokine and synapse-associated protein psd95, the status of neural apoptosis, microglia activation and oxidative stress in hippocampus of the mice were investigated. |
2023-11-22 |
2023-11-29 |
mouse |
| Jie Gao, Huiping Zhang, Leiying Zhou, Jiaqi Liu, Enba Zhuo, Yujun Shen, Xuesheng Liu, Qiying She. MANF Alleviates Sevoflurane-Induced Cognitive Impairment in Neonatal Mice by Modulating Microglial Activation and Polarization. Molecular neurobiology. 2023-11-22. PMID:37989984. |
mko upregulated the expression of tumor necrosis factor-α (tnf-α), accelerated the neural apoptosis and the activation of microglia in hippocampus in young mice. |
2023-11-22 |
2023-11-29 |
mouse |
| Tianzhi Song, Yishu Zhang, Liangrong Zhu, Yuyan Zhang, Jingmei Son. The role of JAK/STAT signaling pathway in cerebral ischemia-reperfusion injury and the therapeutic effect of traditional Chinese medicine: A narrative review. Medicine. vol 102. issue 46. 2023-11-21. PMID:37986307. |
the inflammatory factors are produced by m1 microglia through the jak/stat pathway, eventually leading to cell apoptosis. |
2023-11-21 |
2023-11-29 |
Not clear |
| Zhongqiu Zhou, Qingqing Ye, Hui Ren, Yuan Zhang, Bing Han, Honghong Yao, Ying Ba. CircDYM attenuates microglial apoptosis via CEBPB/ZC3H4 axis in LPS-induced mouse model of depression. International journal of biological macromolecules. 2023-11-09. PMID:37944732. |
moreover, lps-induced cebpb nuclear entry downregulates the expression of zc3h4, in which promotes autophagy and apoptosis in microglia. |
2023-11-09 |
2023-11-20 |
mouse |
| Ning Huang, Jun Tang, Xiaoyao Yi, Maoxin Zhang, Bin Li, Yuan Cheng, Jin Che. Glioma-derived S100A9 polarizes M2 microglia to inhibit CD8+T lymphocytes for immunosuppression via αvβ3 integrin/AKT1/TGFβ1. Biochimica et biophysica acta. Molecular cell research. 2023-10-31. PMID:37907196. |
furthermore, we demonstrated that s100a9-induced m2 microglia negatively affected cell viability, il-2 and ifn-γ secretion, together with increased early apoptosis in cd8+t lymphocytes via tgfβ1. |
2023-10-31 |
2023-11-08 |
mouse |
| Amaresh K Ranjan, Anil Gulat. Advances in Therapies to Treat Neonatal Hypoxic-Ischemic Encephalopathy. Journal of clinical medicine. vol 12. issue 20. 2023-10-30. PMID:37892791. |
the primary and secondary phases are characterized by episodes of energy and cell metabolism failures, increased cytotoxicity and apoptosis, and activated microglia and inflammation in the brain. |
2023-10-30 |
2023-11-08 |
Not clear |
| Jing Wang, Lili Wang, Qingjian Wu, Yichen Cai, Chengfu Cui, Ming Yang, Baoliang Sun, Leilei Mao, Yuan Wan. Interleukin-4 Modulates Neuroinflammation by Inducing Phenotypic Transformation of Microglia Following Subarachnoid Hemorrhage. Inflammation. 2023-10-29. PMID:37898992. |
furthermore, exogenous administration of il-4 ameliorates post-sah neurofunctional deficits, attenuates cellular apoptosis, fosters m2 microglia phenotype conversion, and mitigates neuroinflammatory responses. |
2023-10-29 |
2023-11-08 |
Not clear |
| Changjiang Gu, Xiangwu Geng, Yicheng Wu, Yuya Dai, Junkai Zeng, Zhenqiang Wang, Huapan Fang, Yanqing Sun, Xiongsheng Che. Engineered Macrophage Membrane-Coated Nanoparticles with Enhanced CCR2 Expression Promote Spinal Cord Injury Repair by Suppressing Neuroinflammation and Neuronal death. Small (Weinheim an der Bergstrasse, Germany). 2023-10-26. PMID:37884477. |
ccr2 overexpression on mm not only enhanced drug-targeted delivery to the injury site, but also attenuated macrophage infiltration, microglia pro-inflammatory polarization, and neuronal apoptosis by trapping ccl2. |
2023-10-26 |
2023-11-08 |
mouse |
| Yuanlong Li, Hua Fan, Xiong Han, Jun Sun, Ming Ni, Xiaodan Hou, Fengqin Fang, Wei Zhang, Peizhi M. Long Non-Coding RNA MALAT1 Protects Against Spinal Cord Injury via Suppressing microRNA-125b-5p Mediated Microglial M1 Polarization, Neuroinflammation, and Neural Apoptosis. Molecular neurobiology. 2023-10-19. PMID:37858031. |
this study aimed to further explore the relationship between lncrna malat1 and mir-125b-5p, as well as their effect on microglial activation, neuroinflammation, and neural apoptosis in spinal cord injury (sci). primary microglia from sprague dawley rats were stimulated with lipopolysaccharide (lps). |
2023-10-19 |
2023-11-08 |
rat |
| Ru Zhao, Tao He, Yiqiao Xing, Jinyuan Lu. COG1410 regulates microglial states and protects retinal ganglion cells in retinal ischemia-reperfusion injury. Experimental eye research. 2023-10-15. PMID:37839665. |
we observed cd16/32-marked and cd206-marked microglia and rgcs using immunofluorescence staining, detected the expression of inflammatory factors by pcr, and evaluated retinal apoptosis with tunel staining. |
2023-10-15 |
2023-11-08 |
mouse |