| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jolanda Malamud, Gemma Lewis, Michael Moutoussis, Larisa Duffy, Jessica Bone, Ramya Srinivasan, Glyn Lewis, Quentin J M Huy. The selective serotonin reuptake inhibitor sertraline alters learning from aversive reinforcements in patients with depression: evidence from a randomized controlled trial. Psychological medicine. 2024-04-17. PMID:38629200. |
the selective serotonin reuptake inhibitor sertraline alters learning from aversive reinforcements in patients with depression: evidence from a randomized controlled trial. |
2024-04-17 |
2024-04-19 |
Not clear |
| Xin Deng, I-Shuo Huang, Kourtlin Williams, Marcy L Wainwright, Paul V Zimba, Riccardo Mozzachiod. Role of serotonin in the lack of sensitization caused by prolonged food deprivation in Aplysia. Behavioural brain research. 2023-11-03. PMID:37923220. |
under normal feeding conditions (i.e., two days food deprivation, 2dfd), aversive stimuli lead to serotonin (5-ht) release into the hemolymph and neuropil, which mediates sensitization and its cellular correlates including increased excitability of tail sensory neurons (tsns). |
2023-11-03 |
2023-11-08 |
aplysia |
| Satomi Kobayashi, Mie Kajiwara, Yilong Cui, Takeo Sako, Tetsuya Sasabe, Emi Hayashinaka, Yasuhiro Wada, Masayuki Kobayash. Activation of multiple neuromodulatory systems in alert rats acquiring conditioned taste aversion revealed by positron emission tomography. Brain research. 2023-10-07. PMID:37805008. |
conditioned taste aversion (cta) is an essential ability for animals to consume food safely and is regulated by neuromodulatory systems including the dopamine, noradrenaline, serotonin, and acetylcholine systems. |
2023-10-07 |
2023-10-15 |
rat |
| Chen-Cheng Lin, Chiu-Ping Yang, Pao-Yun Cheng, Michael Hsiao, Yia-Ping Li. Escitalopram reversibility of the impacts following chronic stress on central 5-HT profiles - Implications to depression and anxiety. Behavioural brain research. 2023-08-06. PMID:37544369. |
the present study aims to examine whether the intervention of escitalopram (es, 5mg/kg daily for 14 days) can reverse the behavioral phenotypes of both depression-like [by sucrose preference test (spt) and forced swim test (fst)] and anxiety-like [by avoidance latency and escape latency in elevated-t maze (etm)] behaviors, and the brain area-dependent neurochemical changes of 5-ht profiles of the terminal regions regarding both synaptic efflux and tissue levels in rats of chronic mild stress (cms). |
2023-08-06 |
2023-08-14 |
rat |
| Jochen Michely, Ingrid M Martin, Raymond J Dolan, Tobias U Hause. Boosting serotonin increases information gathering by reducing subjective cognitive costs. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-07-31. PMID:37524494. |
serotonin is implicated in the valuation of aversive costs, such as delay or physical effort. |
2023-07-31 |
2023-08-14 |
human |
| Jochen Michely, Ingrid M Martin, Raymond J Dolan, Tobias U Hause. Boosting serotonin increases information gathering by reducing subjective cognitive costs. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-07-31. PMID:37524494. |
this result is consistent with the notion that serotonin alleviates sensitivity to aversive costs in a domain-general fashion, with implications for its potential contribution to a positive impact on motivational deficits in psychiatric disorders. |
2023-07-31 |
2023-08-14 |
human |
| Catherine Marcinkiewcz, Ruixiang Wang, Kanza Khan, Nagalakshmi Balasubramanian, Thomas James, Selvakumar Pushpavathi, David Kim, Samantha Pierson, Qi Wu, Mark Niciu, Marco Heft. Alcohol inhibits sociability via serotonin inputs to the nucleus accumbens. Research square. 2023-07-18. PMID:37461716. |
we report that chronic intermittent ethanol (cie) induces social avoidance in a sex-dependent manner and is associated with hyperactivity of serotonin (5-ht) neurons in the dorsal raphe nucleus (drn). |
2023-07-18 |
2023-08-14 |
mouse |
| Catherine Marcinkiewcz, Ruixiang Wang, Kanza Khan, Nagalakshmi Balasubramanian, Thomas James, Selvakumar Pushpavathi, David Kim, Samantha Pierson, Qi Wu, Mark Niciu, Marco Heft. Alcohol inhibits sociability via serotonin inputs to the nucleus accumbens. Research square. 2023-07-18. PMID:37461716. |
while 5-htdrn neurons are generally thought to enhance social behavior, recent evidence suggests that specific 5-ht pathways can be aversive. |
2023-07-18 |
2023-08-14 |
mouse |
| Catherine Marcinkiewcz, Ruixiang Wang, Kanza Khan, Nagalakshmi Balasubramanian, Thomas James, Selvakumar Pushpavathi, David Kim, Samantha Pierson, Qi Wu, Mark Niciu, Marco Heft. Alcohol inhibits sociability via serotonin inputs to the nucleus accumbens. Research square. 2023-07-18. PMID:37461716. |
we then employed an array of molecular genetic tools in transgenic mice to show that 5-ht drn inputs to nacc dynorphin neurons drive social avoidance in male mice after cie by activating 5-ht2c receptors. |
2023-07-18 |
2023-08-14 |
mouse |
| Ruixiang Wang, Kanza M Khan, Nagalakshmi Balasubramanian, Thomas James, Selvakumar Govindhasamy Pushpavathi, David Kim, Samantha Pierson, Qi Wu, Mark J Niciu, Marco M Hefti, Catherine A Marcinkiewc. Alcohol inhibits sociability via serotonin inputs to the nucleus accumbens. bioRxiv : the preprint server for biology. 2023-07-03. PMID:37398335. |
we report that chronic intermittent ethanol (cie) induces social avoidance in a sex-dependent manner and is associated with hyperactivity of serotonin (5-ht) neurons in the dorsal raphe nucleus (drn). |
2023-07-03 |
2023-08-14 |
Not clear |
| Hayley N Manke, Kenner C Rice, Anthony L Rile. Effects of Methylone Pre-Exposure on Fluoxetine-Induced Conditioned Taste Avoidance in Male and Female Sprague-Dawley Rats. Brain sciences. vol 13. issue 4. 2023-05-16. PMID:37190550. |
to examine the possible role of serotonin (5-ht) in methylone's aversive effects, the present study assessed the effects of methylone pre-exposure on taste avoidance induced by the 5-ht reuptake inhibitor fluoxetine. |
2023-05-16 |
2023-08-14 |
rat |
| Ying S Chao, Jeffrey Parrilla-Carrero, Maya Eid, Oliver P Culver, Tyler B Jackson, Rachel Lipat, Makoto Taniguchi, Thomas C Jho. Innate cocaine-seeking vulnerability arising from loss of serotonin-mediated aversive effects of cocaine in rats. Cell reports. vol 42. issue 5. 2023-04-21. PMID:37083325. |
however, cocaine also blocks serotonin uptake, which we show drives, in rats, individually variable aversive effects that depend on serotonin 2c receptors (5-ht2crs) in the rostromedial tegmental nucleus (rmtg), a major gabaergic afferent to midbrain dopamine neurons. |
2023-04-21 |
2023-08-14 |
rat |
| Getulio Nicola Bressan, Paola Magro Cardoso, Juliane Reckziegel, Roselei Fachinett. Reserpine and PCPA reduce heat tolerance in Drosophila melanogaster. Life sciences. 2023-02-13. PMID:36780938. |
these data suggest that monoamines, particularly serotonin, are associated with the impaired avoidance of noxious heat which could be related to the reduction of heat tolerance in d. melanogaster. |
2023-02-13 |
2023-08-14 |
drosophila_melanogaster |
| Camille de Almeida, Nida Chabbah, Camille Eyraud, Caroline Fasano, Véronique Bernard, Nicolas Pietrancosta, Véronique Fabre, Salah El Mestikawy, Stephanie Dauma. Absence of VGLUT3 expression leads to impaired fear memory in mice. eNeuro. 2023-01-31. PMID:36720646. |
the atypical subtype, vglut3 is responsible for the co-transmission of glutamate with acetylcholine (ach), serotonin (5-ht) or gaba.to understand the involvement of vglut3-dependent cotransmission in aversive memories, we used a pavlovian fear conditioning paradigm in vglut3 |
2023-01-31 |
2023-08-14 |
mouse |
| Hiroyuki Kawai, Youcef Bouchekioua, Naoya Nishitani, Kazuhei Niitani, Shoma Izumi, Hinako Morishita, Chihiro Andoh, Yuma Nagai, Masashi Koda, Masako Hagiwara, Koji Toda, Hisashi Shirakawa, Kazuki Nagayasu, Yu Ohmura, Makoto Kondo, Katsuyuki Kaneda, Mitsuhiro Yoshioka, Shuji Kanek. Median raphe serotonergic neurons projecting to the interpeduncular nucleus control preference and aversion. Nature communications. vol 13. issue 1. 2022-12-22. PMID:36550097. |
although a critical role of serotonergic neurons in the dorsal raphe nucleus (drn) in reward processing has been shown, the lack of rewarding effects with selective serotonin reuptake inhibitors (ssris) implies the presence of a discrete serotonergic system playing an opposite role to the drn in the processing of reward and aversive stimuli. |
2022-12-22 |
2023-08-14 |
mouse |
| Niklas Reich, Christian Hölsche. Beyond Appetite: Acylated Ghrelin As A Learning, Memory and Fear Behavior-modulating Hormone. Neuroscience and biobehavioral reviews. 2022-11-11. PMID:36368526. |
as such, in this review, we i) evaluate what specific stages and forms of memory, as well as which respective brain areas are affected by acylated ghrelin, ii) illustrate the plasticity-associated signaling pathways of ag in the hippocampus, also involving memory resolution-enhancing neurogenesis, iii) elucidate how the peptide modulates neurotransmitter systems (glutamate, γ-aminobutyric acid, dopamine, serotonin), iv) clarify the role of ag in conditioned taste aversion, novelty learning and the formation of spatial, recognition, auditory fear, contextual fear and passive avoidance memories in the hippocampus and amygdala as well as v) solve the mystery behind ag, its impact on the 5-ht system, the recently established link to post-traumatic stress disorder and the either fear-suppressing or fear-potentiating effects under neutral and acutely stressed conditions or chronic stress, respectively. |
2022-11-11 |
2023-08-14 |
Not clear |
| Jaqueline M Franzen, Isabel Werle, Felipe Vanz, Bruno Biscaia de Oliveira, Laura Maria Martins Nascimento, Francisco S Guimarães, Leandro J Bertogli. Cannabidiol attenuates fear memory expression in female rats via hippocampal 5-HT Neuropharmacology. 2022-11-05. PMID:36334768. |
cannabidiol attenuates fear memory expression in female rats via hippocampal 5-ht growing evidence from male rodent and human studies suggests that cannabidiol (cbd) modulates the expression of aversive memories and anxiety-related responses. |
2022-11-05 |
2023-08-14 |
human |
| Verenice Ascencio Gutierrez, Audrey A Carrillo, Gretha J Boersma, Kellie L K Tamashiro, Timothy H Moran, Sergio D Iñiguez, Yada Treesukoso. Effect of early-life stress or fluoxetine exposure on later-life conditioned taste aversion learning in Sprague-Dawley rats. Neuroscience letters. 2022-08-05. PMID:35931277. |
to expand on this line of work, we evaluated how juvenile exposure to chronic variable stress (cvs) or the selective serotonin reuptake inhibitor fluoxetine (flx) influences conditioned taste aversion (cta) learning in adulthood. |
2022-08-05 |
2023-08-14 |
rat |
| Ling Bai, Nilla Sivakumar, Shenliang Yu, Sheyda Mesgarzadeh, Tom Ding, Truong Ly, Timothy V Corpuz, James C R Grove, Brooke C Jarvie, Zachary A Knigh. Enteroendocrine cell types that drive food reward and aversion. eLife. vol 11. 2022-08-01. PMID:35913117. |
conditioned flavor preference is driven by release of cholecystokinin whereas conditioned taste aversion is mediated by serotonin and substance p. these positive and negative valence signals are transmitted by vagal and spinal afferents, respectively. |
2022-08-01 |
2023-08-14 |
mouse |
| Carlos Wert-Carvajal, Melissa Reneaux, Tatjana Tchumatchenko, Claudia Clopat. Dopamine and serotonin interplay for valence-based spatial learning. Cell reports. vol 39. issue 2. 2022-04-13. PMID:35417691. |
da has been related to positive valence, from reward consumption or avoidance behavior, and 5-ht to aversive encoding. |
2022-04-13 |
2023-08-13 |
Not clear |